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Materials Science & Engineering C, ISSN 0928-4931, 04/2016, Volume 61, pp. 1002 - 1017
Small molecules that bind genomic DNA have proven that they can be effective anticancer, antibiotic and antiviral therapeutic agents that affect the well-being... 
Drug discovery | DNA hybridization | Drug–DNA interaction | DNA damage | Electrochemical DNA biosensor | Pharmacogenomics | Drug-DNA interaction | MATERIALS SCIENCE, BIOMATERIALS | ANTICANCER DRUG | SITU ELECTROCHEMICAL EVALUATION | DOUBLE-STRANDED DNA | CARBON NANOTUBES | WASTE-WATER SAMPLES | BREAST-CANCER | PENCIL GRAPHITE ELECTRODE | SURFACE-CONFINED DNA | CYCLIC VOLTAMMETRY | ACTIVATED MITOMYCIN-C | Anti-Bacterial Agents - analysis | Pharmacogenetics | Electrochemical Techniques | Alkylating Agents - pharmacology | Humans | Anti-Bacterial Agents - metabolism | Antineoplastic Agents - analysis | Intercalating Agents - pharmacology | DNA - metabolism | DNA Cleavage - drug effects | Alkylating Agents - metabolism | DNA - chemistry | Intercalating Agents - metabolism | Pharmaceutical Preparations - metabolism | DNA - analysis | Biosensing Techniques | Pharmaceutical Preparations - chemistry | Alkylating Agents - analysis | Nanostructures - chemistry | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Intercalating Agents - analysis | Pharmaceutical Preparations - analysis | Antiviral agents | Usage | DNA replication | Drug interactions | DNA | Genetic research | Electrochemistry | Electric properties | Drugs | Deoxyribonucleic acid | Strands | Materials science | Nanostructure | Cognition | Biosensors | Binding sites
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2009, Volume 44, Issue 10, pp. 4153 - 4161
Sixteen novel N-(3-carboxyl-9-benzyl-β-carboline-1-yl)ethylamino acids ( 6a– p) were synthesized as intercalating lead compounds. In the in vitro cytotoxic... 
Docking | 3D QSAR | Intercalation | N-(3-Carboxyl-9-benzyl-β-carboline-1-yl)ethylamino acid | Anti-tumor activity | DNA-BINDING | DESIGN | CHEMISTRY, MEDICINAL | CARBOLINE DERIVATIVES | CYTOTOXIC EVALUATION | ANTICANCER | N-(3-Carboxyl-9-benzyl-beta-carboline-1-yl)ethylamino acid | DRUGS | TARGETS | AGENTS | HARMINE | Oligonucleotides - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Ethylamines - chemical synthesis | Male | Antineoplastic Agents - therapeutic use | Ethylamines - pharmacokinetics | Spleen - drug effects | Toxicity Tests, Acute | Sarcoma 180 - drug therapy | Carbolines - chemistry | Antineoplastic Agents - pharmacology | Intercalating Agents - chemical synthesis | Spleen - pathology | Binding Sites | Carbolines - therapeutic use | Quantitative Structure-Activity Relationship | Carcinoma - drug therapy | Carbolines - chemical synthesis | Models, Molecular | Intercalating Agents - pharmacology | DNA - metabolism | Antineoplastic Agents - chemistry | Intercalating Agents - chemistry | Mice, Inbred ICR | Intercalating Agents - therapeutic use | DNA - chemistry | Oligonucleotides - metabolism | Animals | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Ethylamines - chemistry | Ethylamines - therapeutic use | Carbolines - pharmacology | Drug Screening Assays, Antitumor | Lead compounds | Analysis | Investigations | Tumors | Index Medicus
Journal Article
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 06/2016, Volume 159, pp. 120 - 132
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 12/2014, Volume 20, Issue 49, pp. 16174 - 16187
Platinum–acridine hybrid agents show low‐nanomolar potency in chemoresistant non‐small cell lung cancer (NSCLC), but high systemic toxicity in vivo. To reduce... 
cellular target | intercalation | DNA adducts | anticancer drugs | cytotoxicity | Anticancer drugs | Cytotoxicity | Intercalation | Cellular target | HYBRID AGENT | MECHANISM | COMPLEXES | CHEMISTRY, MULTIDISCIPLINARY | CHEMOTHERAPY | AQUEOUS-SOLUTION | CELL LUNG-CANCER | EMERGING TARGET | CISPLATIN | BINDING | Acridines - chemistry | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | G-Quadruplexes - drug effects | DNA Adducts - drug effects | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Squamous Cell - genetics | Humans | Intercalating Agents - pharmacology | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Intercalating Agents - chemistry | Organoplatinum Compounds - pharmacology | Animals | Carcinoma, Squamous Cell - drug therapy | Acridines - pharmacology | Drug Design | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Drug Screening Assays, Antitumor | Organoplatinum Compounds - chemistry | Antimitotic agents | Care and treatment | Analysis | DNA | Genetic research | Chromophores | Tumor proteins | Lung cancer, Non-small cell | Antineoplastic agents | Cancer | Platinum | Lung cancer | Deoxyribonucleic acid--DNA | Index Medicus | Construction | Deoxyribonucleic acid | Genotoxicity | Parents | Basicity
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 11/2018, Volume 24, Issue 65, pp. 17239 - 17254
After uptake by U87 MG and A375 cancer cells, cobaltabisdicarbollide [COSAN]− distributes between membrane and nucleus and presents no relevant cytotoxicity... 
metallacarboranes | DNA recognition | intercalations | boron neutron capture therapy (BNCT) | antitumor agents | redox chemistry | COSAN | CELLS | BORON | COMPLEXES | CHEMISTRY, MULTIDISCIPLINARY | CANCER-THERAPY | TRANSITION | PEPTIDES | SPECTROSCOPY | NEUTRON-CAPTURE THERAPY | BINDING | Humans | Boranes - chemistry | Boranes - pharmacokinetics | Electrodes | Tissue Distribution | Thermodynamics | Biological Transport | Intercalating Agents - pharmacokinetics | Surface Properties | Female | Antineoplastic Agents - pharmacology | Molecular Structure | Cell Survival - drug effects | Electrochemical Techniques | Oxidation-Reduction | Organometallic Compounds - pharmacokinetics | Boranes - pharmacology | Intercalating Agents - pharmacology | DNA - metabolism | Antineoplastic Agents - chemistry | Static Electricity | Intercalating Agents - chemistry | Animals | Fibroblasts - drug effects | Cell Line, Tumor | Organometallic Compounds - chemistry | Fibroblasts - cytology | Mice, Inbred BALB C | Organometallic Compounds - pharmacology | Antimitotic agents | Care and treatment | Biological products | Analysis | Liver | DNA | Antineoplastic agents | Protein binding | Blood proteins | Cancer | Nuclear magnetic resonance--NMR | Toxicity | Cytotoxicity | Nuclei (nuclear physics) | Glassy carbon | Strong interactions (field theory) | Proteins | Boron | Biomedical materials | Fibroblasts | Biocompatibility | Oxidation | Deoxyribonucleic acid--DNA | Nuclear capture | Binding | Spleen | Reticuloendothelial system | Incubation | Organs | Boron compounds | Lungs | Aggregates | Ionic strength | In vivo methods and tests | Nuclei (cytology) | Calf thymus | Index Medicus
Journal Article