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Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2011, Volume 54, Issue 14, pp. 5013 - 5030
On the basis of structures of known topoisomerase II catalytic inhibitors and initial molecular docking studies, bicyclic N-fused aminoimidazoles were... 
DNA TOPOISOMERASE | CELLS | MOLECULAR-DYNAMICS | ETOPOSIDE | DOMAIN | CHEMISTRY, MEDICINAL | MECHANISM | ICRF-187 | ATP-BINDING-SITE | CANCER | FLEXIBLE DOCKING | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Imidazoles - chemistry | Cercopithecus aethiops | Structure-Activity Relationship | Topoisomerase II Inhibitors - chemistry | S Phase | HEK293 Cells | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Imidazoles - chemical synthesis | Intercalating Agents - chemical synthesis | Binding Sites | Vero Cells | Cell Survival - drug effects | Antigens, Neoplasm | DNA-Binding Proteins - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - chemistry | Etoposide - pharmacology | Models, Molecular | Imidazoles - pharmacology | Intercalating Agents - pharmacology | Topoisomerase II Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Intercalating Agents - chemistry | Molecular Dynamics Simulation | Heterocyclic Compounds, 2-Ring - pharmacology | Cell Movement - drug effects | G1 Phase | Animals | Cell Line, Tumor | Adenosine Triphosphatases - chemistry | DNA Topoisomerases, Type II | Fluorouracil - pharmacology | Adenosine Triphosphate - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2017, Volume 126, pp. 24 - 35
A series of new pyrazolo[3,4- ]pyrimidine possessing 4-(1 -benzimidazol-2-yl)-phenylamine moiety at C4 position and primary as well as secondary amines at C6... 
Bovine serum albumin | Antitumor activity | Pyrazolo[3,4-d]pyrimidine | ct-DNA | Benzimidazole | CHEMISTRY, MEDICINAL | ROSCOVITINE | MITOXANTRONE | MECHANISM | PROTEIN-BINDING | COMBINATION | MOLECULAR DOCKING | CANCER | SPECTROSCOPY | IN-VITRO EVALUATION | CYTOTOXICITY | Aniline Compounds - metabolism | Apoptosis - drug effects | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Pyrimidines - chemistry | Pyrimidines - metabolism | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | Topoisomerase Inhibitors - pharmacology | Topoisomerase Inhibitors - chemical synthesis | Cattle | Drug Design | Antineoplastic Agents - pharmacology | Intercalating Agents - chemical synthesis | Aniline Compounds - pharmacology | Antigens, Neoplasm | Chemistry Techniques, Synthetic | DNA-Binding Proteins - antagonists & inhibitors | Intercalating Agents - pharmacology | DNA - metabolism | Pyrimidines - pharmacology | Serum Albumin, Bovine - metabolism | Antineoplastic Agents - chemistry | Intercalating Agents - chemistry | Topoisomerase Inhibitors - metabolism | Intercalating Agents - metabolism | Animals | Cell Line, Tumor | DNA Topoisomerases, Type II | Cell Proliferation - drug effects | Aniline Compounds - chemistry | Topoisomerase Inhibitors - chemistry | Aniline Compounds - chemical synthesis | Drug Screening Assays, Antitumor | Genetic research | Albumin | Pyrimidines | Aniline | DNA | Resveratrol | Index Medicus
Journal Article
Inorganic Chemistry, ISSN 0020-1669, 10/2017, Volume 56, Issue 20, pp. 12232 - 12247
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Inorganic Chemistry, ISSN 0020-1669, 11/2017, Volume 56, Issue 22, pp. 13679 - 13696
The synthesis and characterization of Pt­(II) (1 and 2) and Ru­(II) arene (3 and 4) or polypyridine (5 and 6) complexes is described. With the aim of having a... 
RUTHENIUM(II) COMPLEXES | IN-VITRO | ATOMIC-FORCE MICROSCOPY | ELECTRON-TRANSFER | PLATINUM(II) COMPLEXES | PHOTODYNAMIC THERAPY | SOLID-PHASE SYNTHESIS | LIGAND COPPER(II) COMPLEXES | DNA-BINDING PROPERTIES | SPECTRAL PROPERTIES | CHEMISTRY, INORGANIC & NUCLEAR | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Carboxylic Acids - chemical synthesis | Humans | Ruthenium - chemistry | Organoplatinum Compounds - pharmacology | Carboxylic Acids - chemistry | Light | Antineoplastic Agents - radiation effects | Coordination Complexes - pharmacology | Antineoplastic Agents - pharmacology | Intercalating Agents - chemical synthesis | Carboxylic Acids - radiation effects | Carboxylic Acids - pharmacology | Organoplatinum Compounds - chemistry | Coordination Complexes - radiation effects | Intercalating Agents - radiation effects | Intercalating Agents - pharmacology | Cisplatin - pharmacology | Antineoplastic Agents - chemistry | Coordination Complexes - chemistry | Intercalating Agents - chemistry | Molecular Dynamics Simulation | Organoplatinum Compounds - chemical synthesis | DNA - chemistry | Organoplatinum Compounds - radiation effects | Plasmids | Cell Line, Tumor | Coordination Complexes - chemical synthesis | Molecular Docking Simulation | DNA Damage | Antimitotic agents | Usage | Dosage and administration | Research | Chemical synthesis | Coordination compounds | Antineoplastic agents | Index Medicus
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Inorganic Chemistry, ISSN 0020-1669, 11/2018, Volume 57, Issue 22, pp. 14322 - 14336
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