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Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2011, Volume 54, Issue 14, pp. 5013 - 5030
On the basis of structures of known topoisomerase II catalytic inhibitors and initial molecular docking studies, bicyclic N-fused aminoimidazoles were... 
DNA TOPOISOMERASE | CELLS | MOLECULAR-DYNAMICS | ETOPOSIDE | DOMAIN | CHEMISTRY, MEDICINAL | MECHANISM | ICRF-187 | ATP-BINDING-SITE | CANCER | FLEXIBLE DOCKING | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Imidazoles - chemistry | Cercopithecus aethiops | Structure-Activity Relationship | Topoisomerase II Inhibitors - chemistry | S Phase | HEK293 Cells | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Imidazoles - chemical synthesis | Intercalating Agents - chemical synthesis | Binding Sites | Vero Cells | Cell Survival - drug effects | Antigens, Neoplasm | DNA-Binding Proteins - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - chemistry | Etoposide - pharmacology | Models, Molecular | Imidazoles - pharmacology | Intercalating Agents - pharmacology | Topoisomerase II Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Intercalating Agents - chemistry | Molecular Dynamics Simulation | Heterocyclic Compounds, 2-Ring - pharmacology | Cell Movement - drug effects | G1 Phase | Animals | Cell Line, Tumor | Adenosine Triphosphatases - chemistry | DNA Topoisomerases, Type II | Fluorouracil - pharmacology | Adenosine Triphosphate - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
Inorganic Chemistry, ISSN 0020-1669, 11/2018, Volume 57, Issue 22, pp. 14322 - 14336
Journal Article
Nature Chemistry, ISSN 1755-4330, 08/2012, Volume 4, Issue 8, pp. 615 - 620
DNA mismatches represent a novel target in the development of diagnostics and therapeutics for cancer, because deficiencies in DNA mismatch repair are... 
DNA - chemistry | Phenazines - chemistry | Pyridines - chemistry | Models, Molecular | Crystallography, X-Ray | Base Pair Mismatch | Coordination Complexes - chemistry | Ruthenium - chemistry | Intercalating Agents - chemistry
Journal Article
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 04/2013, Volume 121, pp. 88 - 99
Journal Article
Nature Chemistry, ISSN 1755-4330, 08/2012, Volume 4, Issue 8, pp. 621 - 628
The ruthenium complex [Ru(phen)(2)(dppz)](2+) (where phen is phenanthroline and dppz dipyridophenazine is known as a 'light switch' complex because its... 
Oligonucleotides - chemistry | Models, Molecular | Crystallography, X-Ray | Organometallic Compounds - chemistry | Coordination Complexes - chemistry | Ruthenium - chemistry | Intercalating Agents - chemistry
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 07/2016, Volume 160, pp. 125 - 139
Cobalt(II) complexes with a series of non-steroidal anti-inflammatory drugs (diflunisal, flufenamic acid, mefenamic acid and niflumic acid) in the presence of... 
Cobalt(II) complexes | Interaction with calf-thymus DNA | Interaction with albumins | Antioxidant activity | Non-steroidal anti-inflammatory drugs | MEFENAMIC-ACID | TRANSITION-METAL-COMPLEXES | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINUCLEAR COPPER(II) COMPLEX | DNA-BINDING PROPERTIES | CHEMISTRY, INORGANIC & NUCLEAR | TOLFENAMIC ACID STRUCTURE | FLUFENAMIC ACID | BIOLOGICAL EVALUATION | SCHIFF-BASE COMPLEXES | Free Radical Scavengers - chemistry | 2,2'-Dipyridyl - analogs & derivatives | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Crystallography, X-Ray | Mefenamic Acid - chemistry | Aminopyridines - chemistry | Biphenyl Compounds - antagonists & inhibitors | Phenanthrolines - chemistry | Picrates - chemistry | Free Radical Scavengers - chemical synthesis | Biphenyl Compounds - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Intercalating Agents - chemical synthesis | Methanol - chemistry | Serum Albumin - chemistry | Binding Sites | Niflumic Acid - chemistry | 2,2'-Dipyridyl - chemistry | Models, Molecular | Coordination Complexes - chemistry | Intercalating Agents - chemistry | DNA - chemistry | Diflunisal - chemistry | Picrates - antagonists & inhibitors | Cations, Divalent | Flufenamic Acid - chemistry | Coordination Complexes - chemical synthesis | Kinetics | Cobalt - chemistry
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2017, Volume 126, pp. 24 - 35
A series of new pyrazolo[3,4- ]pyrimidine possessing 4-(1 -benzimidazol-2-yl)-phenylamine moiety at C4 position and primary as well as secondary amines at C6... 
Bovine serum albumin | Antitumor activity | Pyrazolo[3,4-d]pyrimidine | ct-DNA | Benzimidazole | CHEMISTRY, MEDICINAL | ROSCOVITINE | MITOXANTRONE | MECHANISM | PROTEIN-BINDING | COMBINATION | MOLECULAR DOCKING | CANCER | SPECTROSCOPY | IN-VITRO EVALUATION | CYTOTOXICITY | Aniline Compounds - metabolism | Apoptosis - drug effects | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Pyrimidines - chemistry | Pyrimidines - metabolism | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | Topoisomerase Inhibitors - pharmacology | Topoisomerase Inhibitors - chemical synthesis | Cattle | Drug Design | Antineoplastic Agents - pharmacology | Intercalating Agents - chemical synthesis | Aniline Compounds - pharmacology | Antigens, Neoplasm | Chemistry Techniques, Synthetic | DNA-Binding Proteins - antagonists & inhibitors | Intercalating Agents - pharmacology | DNA - metabolism | Pyrimidines - pharmacology | Serum Albumin, Bovine - metabolism | Antineoplastic Agents - chemistry | Intercalating Agents - chemistry | Topoisomerase Inhibitors - metabolism | Intercalating Agents - metabolism | Animals | Cell Line, Tumor | DNA Topoisomerases, Type II | Cell Proliferation - drug effects | Aniline Compounds - chemistry | Topoisomerase Inhibitors - chemistry | Aniline Compounds - chemical synthesis | Drug Screening Assays, Antitumor | Genetic research | Albumin | Pyrimidines | Aniline | DNA | Resveratrol | Index Medicus
Journal Article