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Journal of the National Cancer Institute, ISSN 0027-8874, 03/2012, Volume 104, Issue 6, pp. 461 - 475
Background Angiopoietin-2 (Ang2), a ligand for endothelial TEK (Tie2) tyrosine kinase receptor, is induced in hypoxic endothelial cells of tumors, where it... 
LYMPHATIC VESSELS | TRANSGENE EXPRESSION | ANGIOGENESIS | ONCOLOGY | IN-VIVO | GENE-THERAPY | VEGF-C | TUMOR-GROWTH | CANCER | RECEPTOR TYROSINE KINASE | TIE2 RECEPTOR | Immunohistochemistry | Antibodies, Blocking - metabolism | Up-Regulation | Immunoprecipitation | Melanoma - blood supply | Coculture Techniques | Endothelium, Vascular - drug effects | Immunoblotting | Transplantation, Heterologous | Antibodies, Blocking - pharmacology | Angiopoietin-2 - metabolism | Cell Hypoxia | Retinal Vessels - pathology | Lung Neoplasms - secondary | Intercellular Junctions - pathology | Female | Neovascularization, Pathologic - prevention & control | Receptor, TIE-2 - metabolism | Lymphangiogenesis | Lung Neoplasms - blood supply | Microscopy, Electron, Transmission | Retinal Vessels - metabolism | Intercellular Junctions - metabolism | Angiogenesis Inhibitors - pharmacology | Mice, Transgenic | Lymphatic Metastasis | Retinal Vessels - drug effects | Mice, SCID | Melanoma - secondary | Animals | Neovascularization, Pathologic - drug therapy | Intercellular Junctions - drug effects | Endothelium, Vascular - pathology | Mice | Mice, Inbred BALB C | Neovascularization, Pathologic - metabolism | Angiopoietin-2 - antagonists & inhibitors | Endothelial Cells - pathology | Endothelial Cells - drug effects | Junctional complexes (Epithelium) | Lung cancer | Cell junctions | Physiological aspects | Development and progression | Models | Metastasis | Research | Growth factor receptors | Studies | Lungs | Medical treatment | Tumors | Index Medicus
Journal Article
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 02/2016, Volume 105, Issue 2, pp. 754 - 765
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e58057 - e58057
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 3/2011, Volume 68, Issue 5, pp. 877 - 892
The apical junctional complex (AJC), composed of tight and adherens junctions, maintains epithelial barrier function. Since cigarette smoking and chronic... 
Life Sciences | Biochemistry, general | Life Sciences, general | Tight junctions | Adherens junctions | Chronic obstructive pulmonary disease | Airway epithelium | Cigarette smoking | Transcriptional regulation | Biomedicine general | Epithelial polarity | Cell Biology | BRONCHIAL EPITHELIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | MESENCHYMAL TRANSITION | CELL BIOLOGY | LUNG-CANCER | OBSTRUCTIVE PULMONARY-DISEASE | PROTEIN INTERACTIONS | GENE-EXPRESSION | TOBACCO-SMOKE | POLARITY PROTEINS | INTERCELLULAR-JUNCTIONS | Smoking - adverse effects | Transcription, Genetic - drug effects | Epithelial Cells - metabolism | Respiratory Mucosa - drug effects | Oligonucleotide Array Sequence Analysis | Epithelial Cells - drug effects | Humans | Cells, Cultured | Intercellular Junctions - metabolism | Epithelial Cells - ultrastructure | Gene Expression Profiling | Permeability | Pulmonary Disease, Chronic Obstructive - pathology | Down-Regulation - drug effects | Intercellular Junctions - genetics | Signal Transduction - drug effects | Intercellular Junctions - drug effects | Pulmonary Disease, Chronic Obstructive - metabolism | Pulmonary Disease, Chronic Obstructive - genetics | Lung diseases, Obstructive | Anopheles | Analysis | Epithelium | Gene expression | Cigarettes | Smoking | Molecular biology | Respiratory system | Cell adhesion & migration | Indexing in process | Index Medicus | cigarette smoking | epithelial polarity | transcriptional regulation | airway epithelium | tight junctions | adherens junctions | chronic obstructive pulmonary disease
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2012, Volume 109, Issue 13, pp. 4756 - 4761
Small molecules are important tools to measure and modulate intracellular signaling pathways. A longstanding limitation for using chemical compounds in complex... 
Molecules | Cell culture techniques | Neurons | Epithelial cells | Gap junctions | Cell lines | HeLa cells | Fluorescence | Esters | Kidney cells | Cellular imaging | Microscopy | Pharmacological agents | Enzyme substrates | Fluorophores | fluorophores | cellular imaging | NITROREDUCTASE | MULTIDISCIPLINARY SCIENCES | JUNCTIONAL INTERCELLULAR COMMUNICATION | enzyme substrates | pharmacological agents | DYE TRANSFER | CARBOXYLESTERASE | IN-VIVO | GENE-EXPRESSION | ABLATION | microscopy | ENDOPLASMIC-RETICULUM | PIG-LIVER ESTERASE | LIVING CELLS | Organ Specificity - drug effects | Gap Junctions - metabolism | Small Molecule Libraries - pharmacology | Hydrolysis - drug effects | Coculture Techniques | Humans | Fluorescent Dyes - metabolism | Esters - metabolism | Neurons - cytology | Biocatalysis - drug effects | Neurons - metabolism | Neurons - drug effects | Astrocytes - cytology | Astrocytes - drug effects | Cell Survival - drug effects | Cells - drug effects | Fluorescent Dyes - chemistry | Permeability - drug effects | Esterases - metabolism | Rats | Hippocampus - cytology | Animals | Cells - metabolism | Mice | HeLa Cells | Gap Junctions - drug effects | Microscopy, Fluorescence | Astrocytes - metabolism | Molecular dynamics | Biomolecules | Chemical properties | Research | Enzymes | Signal transduction | Tissue | Cells | Index Medicus | Biological Sciences | Physical Sciences
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 08/2012, Volume 111, Issue 6, pp. 739 - 749
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 04/2012, Volume 37, Issue 5, pp. 1305 - 1320
Growing evidence has implicated glial anomalies in the pathophysiology of major depression disorder (MDD). Gap junctional communication is a main determinant... 
chronic unpredictable stress | glucocorticoid receptor | gap junction | depression | connexin 43 | antidepressant | PSYCHIATRY | FRONTAL-CORTEX | CHRONIC MILD STRESS | NEUROSCIENCES | NEURONAL SIZE | INTERCELLULAR COMMUNICATION | MOOD DISORDERS | EPILEPTIFORM ACTIVITY | GLIAL-CELL DENSITY | CULTURED ASTROCYTES | PHARMACOLOGY & PHARMACY | PSYCHOTIC MAJOR DEPRESSION | OPEN-LABEL TRIAL | Electroshock - adverse effects | Food Preferences - physiology | Male | Glial Fibrillary Acidic Protein - metabolism | Prefrontal Cortex - pathology | Exploratory Behavior - physiology | Prefrontal Cortex - drug effects | Swimming - psychology | Restraint, Physical - adverse effects | Food Deprivation | Connexin 43 - genetics | Disease Models, Animal | Inhibition (Psychology) | Isoquinolines - metabolism | Sucrose - administration & dosage | Fluoxetine - pharmacology | Gap Junctions - pathology | Microscopy, Electron, Transmission | Connexin 43 - metabolism | Social Isolation - psychology | Stress, Psychological - drug therapy | Gene Expression Regulation - physiology | Rats | Thiophenes - pharmacology | Rats, Sprague-Dawley | Hormone Antagonists - pharmacology | Gap Junctions - ultrastructure | Gene Expression Regulation - drug effects | Stress, Psychological - pathology | Carbenoxolone - pharmacology | Animals | Analysis of Variance | Duloxetine Hydrochloride | Gap Junctions - drug effects | Mifepristone - pharmacology | Serotonin Uptake Inhibitors - pharmacology | RNA, Messenger | Sweetening Agents - administration & dosage | Stress, Psychological - physiopathology | Index Medicus | biological psychiatry | mood | stress disorders | unipolar | anxiety | neuropharmacology | bipolar | Original
Journal Article
by Guo, H and Zhang, J and Boudreau, M and Meng, J and Yin, JJ and Liu, J and Xu, HY
PARTICLE AND FIBRE TOXICOLOGY, ISSN 1743-8977, 04/2016, Volume 13, Issue 1, pp. 21 - 21
Background: Administration of silver nanoparticles (AgNPs) to mice could result in their distribution and accumulation in multiple organs, with notable... 
CELL-MEMBRANE | WISTAR RATS | MECHANISM | PERMEABILITY | BIODISTRIBUTION | Peripheral inflammation | Silver nitrate | ROS | IN-VIVO | SHELL NANOSTRUCTURES | MICE | TOXICOLOGY | Inter-endothelial junctions | CYTOTOXICITY | Silver nanoparticles | ION-RELEASE | Silver Nitrate - toxicity | Injections, Intravenous | Kidney - blood supply | Reactive Oxygen Species - metabolism | Cadherins - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Pneumonia - pathology | Nephritis - pathology | Antigens, CD - metabolism | Dose-Response Relationship, Drug | Silver - administration & dosage | Kidney - metabolism | Liver - drug effects | Time Factors | Pneumonia - chemically induced | Intercellular Junctions - pathology | Female | Nephritis - chemically induced | Silver - toxicity | Lung - metabolism | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Cytoskeleton - pathology | Human Umbilical Vein Endothelial Cells - drug effects | Kidney - drug effects | Risk Assessment | Liver - metabolism | Cells, Cultured | Intercellular Junctions - metabolism | Antioxidants - pharmacology | Permeability | Liver - blood supply | Animals | Chemical and Drug Induced Liver Injury - metabolism | Intercellular Junctions - drug effects | Lung - drug effects | Cytoskeleton - metabolism | Human Umbilical Vein Endothelial Cells - pathology | Nephritis - metabolism | Mice, Inbred BALB C | Oxidative Stress - drug effects | Lung - blood supply | Pneumonia - metabolism | Cytoskeleton - drug effects | Metal Nanoparticles | Nanoparticles | Physiological aspects | Research | Properties | Index Medicus
Journal Article