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Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 9, pp. 7018 - 7026
The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by phosphorylating them for cytoplasmic sequestration or degradation. In... 
YES-ASSOCIATED PROTEIN | EPITHELIAL-MESENCHYMAL TRANSITION | CELL CONTACT INHIBITION | WW DOMAIN | GROWTH-CONTROL | ORGAN SIZE CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ONCOGENIC TRANSFORMATION | BINDING | CANCER | Adaptor Proteins, Signal Transducing - chemistry | Protein Interaction Domains and Motifs - physiology | Humans | Intercellular Signaling Peptides and Proteins - chemistry | Cytoplasm - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Intercellular Signaling Peptides and Proteins - metabolism | HEK293 Cells | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein Structure, Tertiary | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Phosphoproteins - genetics | Cell Division - physiology | Transcription, Genetic - physiology | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Connective Tissue Growth Factor - genetics | Adaptor Proteins, Signal Transducing - metabolism | Connective Tissue Growth Factor - metabolism | Index Medicus | Gene Transcription | Transcription Coactivators | Signal Transduction | AmotL1 | YAP | Transcription Factors | Serine Threonine Protein Kinase | Hippo Pathway | TAZ | Amot
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2011, Volume 30, Issue 4, pp. 770 - 782
Notch signalling is important for development and tissue homeostasis and activated in many human cancers. Nevertheless, mutations in Notch pathway components... 
miR‐200 | ZEB1 | EMT | Notch | stemness | miR-200 | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | PHENOTYPE | E-CADHERIN | MIR-200 FAMILY | REPRESSORS ZEB1 | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | COLORECTAL-CANCER | Receptors, Notch - metabolism | Humans | Receptors, Notch - genetics | Gene Knockdown Techniques | Intercellular Signaling Peptides and Proteins - physiology | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Neoplasms - genetics | Membrane Proteins - physiology | Serrate-Jagged Proteins | Base Sequence | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Transcription Factors - physiology | DNA-Binding Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Models, Biological | Calcium-Binding Proteins - physiology | Homeodomain Proteins - antagonists & inhibitors | Nuclear Proteins - antagonists & inhibitors | Signal Transduction - physiology | MicroRNAs - genetics | Feedback, Physiological - physiology | MicroRNAs - physiology | Homeodomain Proteins - physiology | Calcium-Binding Proteins - genetics | Zinc Finger E-box-Binding Homeobox 1 | Proteins | Signal transduction | Cellular biology | Molecular biology | Gene expression | Cancer | Index Medicus
Journal Article
Science, ISSN 0036-8075, 5/2012, Volume 336, Issue 6081, pp. 579 - 582
Developing animals frequently adjust their growth programs and/or their maturation or metamorphosis to compensate for growth disturbances (such as injury or... 
Insect larvae | Pupariation | Animals | DNA damage | Drosophila | REPORTS | Larval development | Genetic mutation | Metamorphosis | Genotypes | Tumors | DROSOPHILA-MELANOGASTER | PUPARIATION | DISKS | MULTIDISCIPLINARY SCIENCES | GENES | SIZE | Intercellular Signaling Peptides and Proteins - chemistry | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Neoplasms, Experimental - pathology | Intercellular Signaling Peptides and Proteins - metabolism | Metamorphosis, Biological - genetics | Gene Expression Regulation, Developmental | Larva - growth & development | Ecdysone - biosynthesis | Imaginal Discs - growth & development | Neoplasms, Experimental - genetics | Pupa - growth & development | Intracellular Signaling Peptides and Proteins - genetics | Genes, Insect | Amino Acid Sequence | Imaginal Discs - physiology | Intercellular Signaling Peptides and Proteins - genetics | Drosophila Proteins - chemistry | Peptide Initiation Factors - metabolism | Peptide Initiation Factors - genetics | Regeneration | Ethyl Methanesulfonate - pharmacology | Drosophila melanogaster - growth & development | Drosophila Proteins - genetics | Neoplasms, Experimental - metabolism | Apoptosis | Physiological aspects | Animal development | Peptides | Health aspects | Insulin | Insulin-like growth factors | Insects | Maturation | Index Medicus | Endocrine systems | Communication systems | Disks | Adults | Damage | Delay
Journal Article
Gastroenterology, ISSN 0016-5085, 2011, Volume 140, Issue 4, pp. 1230 - 1240.e7
Background & Aims Ablation of Notch signaling within the intestinal epithelium results in loss of proliferating crypt progenitors due to their conversion into... 
Gastroenterology and Hepatology | Gene Regulation | GI Development | Knockout Mice | Intestinal Stem Cells | GAMMA-SECRETASE INHIBITORS | SELF-RENEWAL | INHIBITS TUMOR-GROWTH | LINEAGE COMMITMENT | GOBLET CELLS | GENE | COLORECTAL-CANCER | IN-VIVO | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Intestinal Mucosa - metabolism | Receptors, G-Protein-Coupled - metabolism | Cell Count | Intracellular Signaling Peptides and Proteins - metabolism | Intestinal Mucosa - cytology | Intercellular Signaling Peptides and Proteins - metabolism | Kruppel-Like Transcription Factors - metabolism | Serrate-Jagged Proteins | Membrane Proteins - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Adult Stem Cells - cytology | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch1 - metabolism | Goblet Cells - metabolism | Mice, Knockout | Cell Division - physiology | Adult Stem Cells - metabolism | Animals | Homeostasis - physiology | Signal Transduction - physiology | Mice | Receptor, Notch1 - genetics | Kruppel-Like Transcription Factors - genetics | Calcium-Binding Proteins - genetics | Goblet Cells - cytology | Index Medicus | Abridged Index Medicus | GI development | knockout mice | gene regulation | intestinal stem cells
Journal Article
Cancer Research, ISSN 0008-5472, 03/2009, Volume 69, Issue 6, pp. 2400 - 2407
Despite rapid advances in many fronts, pancreatic cancer (PC) remains one of the most difficult human malignancies to treat due, in part, to de novo and... 
TARGET | STEM-CELLS | GROWTH INHIBITION | INVASION | TUMOR PROGRESSION | ONCOLOGY | PROSTATE-CANCER | TAMOXIFEN RESISTANCE | DOWN-REGULATION | E-CADHERIN | NF-KAPPA-B | RNA, Small Interfering - genetics | Pancreatic Neoplasms - metabolism | Receptors, Notch - metabolism | Humans | Deoxycytidine - pharmacology | Drug Resistance, Neoplasm | Intercellular Signaling Peptides and Proteins - biosynthesis | NF-kappa B - metabolism | Receptor, Notch2 - genetics | Receptors, Notch - genetics | Proto-Oncogene Proteins - biosynthesis | Cell Movement - physiology | Pancreatic Neoplasms - drug therapy | Intercellular Signaling Peptides and Proteins - metabolism | Transfection | Receptors, Notch - biosynthesis | Serrate-Jagged Proteins | Antimetabolites, Antineoplastic - pharmacology | Membrane Proteins - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Calcium-Binding Proteins - biosynthesis | Signal Transduction | Membrane Proteins - genetics | Down-Regulation | Pancreatic Neoplasms - pathology | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch2 - metabolism | Epithelial Cells - pathology | Pancreatic Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Membrane Proteins - biosynthesis | Phenotype | Receptor, Notch2 - biosynthesis | Mesoderm - pathology | RNA, Messenger | Deoxycytidine - analogs & derivatives | Receptor, Notch4 | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article
Science, ISSN 0036-8075, 01/2014, Volume 343, Issue 6173, pp. 885 - 888
Journal Article
Journal Article
Science, ISSN 0036-8075, 5/2012, Volume 336, Issue 6081, pp. 582 - 585
Little is known about how organ growth is monitored and coordinated with the developmental timing in complex organisms. In insects, impairment of larval tissue... 
Insect larvae | Pupariation | Drosophila | REPORTS | Delay lines | Coordinate systems | Instars | Larval development | Metamorphosis | Developmental delay | Propagation delay | ORGANS | REGENERATION | DISKS | MULTIDISCIPLINARY SCIENCES | PATTERN FORMATION | WING IMAGINAL DISCS | MELANOGASTER | PUPARIATION | Genes, Insect | Sequence Deletion | Larva - metabolism | Intercellular Signaling Peptides and Proteins - genetics | JNK Mitogen-Activated Protein Kinases - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | MAP Kinase Signaling System | Brain - metabolism | Drosophila melanogaster - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Metamorphosis, Biological | Animals | Wings, Animal - growth & development | RNA Interference | Time Factors | Gene Expression Regulation, Developmental | Larva - growth & development | Ecdysone - biosynthesis | Imaginal Discs - growth & development | Drosophila melanogaster - growth & development | Larva - genetics | Drosophila Proteins - genetics | Peptides | Growth | Developmental biology | Physiological aspects | Research | Tissues | Health aspects | Signal transduction | Tissue | Insects | Index Medicus | Endocrine systems | Communication systems | Disks | Adults | Damage | Delay | Brain | Drosophila Proteins | Wing | Intercellular Signaling Peptides and Proteins | Life Sciences | Larva | Imaginal Discs | JNK Mitogen-Activated Protein Kinases | Development Biology | Ecdysone | Drosophila melanogaster
Journal Article
2004, Methods in enzymology, ISBN 0121827941, Volume 389-390, 2 v.
This volume is an in-depth treatment of G-Protein Signaling, Part A, and will cover general methods of analysis of RGS protein analysis, including Expression... 
RGS Proteins | GTP-Binding Protein Regulators | G proteins | analysis | Intercellular Signaling Peptides and Proteins
Book
Neuron, ISSN 0896-6273, 04/2008, Volume 58, Issue 1, pp. 52 - 64
Expression of the Notch effector gene is required for maintenance of neural progenitors in the embryonic brain, but persistent and high levels of expression... 
STEMCELL | DEVBIO | MOLNEURO | STEM-CELLS | MAMMALIAN HAIRY | DELTA-HOMOLOG | LOOP-HELIX FACTORS | NEGATIVE AUTOREGULATION | HES1 EXPRESSION | CENTRAL-NERVOUS-SYSTEM | SOMITE SEGMENTATION | PRESOMITIC MESODERM | NEUROSCIENCES | FEEDBACK LOOP | Transcription Factor HES-1 | Intercellular Signaling Peptides and Proteins - biosynthesis | Neurons - cytology | Receptors, Notch - genetics | Stem Cells - cytology | Intercellular Signaling Peptides and Proteins - physiology | Receptors, Notch - biosynthesis | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Nerve Tissue Proteins - biosynthesis | Neurons - physiology | Female | Cell Differentiation - physiology | Basic Helix-Loop-Helix Transcription Factors - physiology | Nerve Tissue Proteins - physiology | Basic Helix-Loop-Helix Transcription Factors - genetics | Homeodomain Proteins - biosynthesis | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Receptors, Notch - physiology | Mice, Transgenic | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Pregnancy | Animals | Biological Clocks - physiology | Signal Transduction - physiology | Stem Cells - physiology | Mice | Homeodomain Proteins - physiology | Heparan sulfate | Proteins | Signal transduction | Rodents | Cell division | Ligands | Protein expression | Genomes | Gene expression | Index Medicus
Journal Article