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1. Full Text Role of Dickkopf-1, an antagonist of the Wnt/β-catenin signaling pathway, in estrogen-induced neuroprotection and attenuation of tau phosphorylation
by Zhang, Quan-Guang and Wang, Ruimin and Khan, Mohammad and Mahesh, Virendra and Brann, Darrell W
The Journal of neuroscience, ISSN 0270-6474, 08/2008, Volume 28, Issue 34, pp. 8430 - 8441
Cerebral ischemia | 17β-estradiol | Survivin | Alzheimer's disease | Neuronal cell death | Hippocampus | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurons - pathology | Up-Regulation | Microtubule-Associated Proteins - metabolism | Injections, Intraventricular | Brain Ischemia - metabolism | tau Proteins - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | Wnt Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Neuroprotective Agents - pharmacology | Female | Cell Death - drug effects | Phosphorylation - drug effects | Intercellular Signaling Peptides and Proteins - administration & dosage | Neurons - drug effects | Estradiol - pharmacology | Rats | Brain Ischemia - physiopathology | Hippocampus - pathology | Recombinant Proteins - pharmacology | Down-Regulation - drug effects | Rats, Sprague-Dawley | beta Catenin - metabolism | Recombinant Proteins - administration & dosage | Hippocampus - metabolism | Animals | Signal Transduction - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Proto-Oncogene Proteins c-jun - metabolism | Brain Ischemia - pathology | Hippocampus - physiopathology | Index Medicus | survivin | neuronal cell death | hippocampus | cerebral ischemia
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2. Full Text Regulation of ADMP and BMP2/4/7 at Opposite Embryonic Poles Generates a Self-Regulating Morphogenetic Field
by Reversade, Bruno and De Robertis, E.M
Cell (Cambridge), ISSN 0092-8674, 2005, Volume 123, Issue 6, pp. 1147 - 1160
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Body Patterning - drug effects | Metalloendopeptidases - genetics | Organizers, Embryonic - physiology | Organizers, Embryonic - transplantation | Central Nervous System - metabolism | Bone Morphogenetic Proteins - physiology | Xenopus Proteins - genetics | Follistatin - genetics | Glycoproteins - metabolism | Metalloendopeptidases - metabolism | Oligodeoxyribonucleotides, Antisense - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Central Nervous System - embryology | Intercellular Signaling Peptides and Proteins - metabolism | Membrane Proteins - physiology | Base Sequence | Carrier Proteins - administration & dosage | Tissue Transplantation | Xenopus laevis - genetics | Phosphorylation - drug effects | Intercellular Signaling Peptides and Proteins - administration & dosage | Bone Morphogenetic Proteins - genetics | Glycoproteins - genetics | Bone Morphogenetic Protein 4 | Bone Morphogenetic Proteins - administration & dosage | Xenopus laevis - embryology | Microinjections | Bone Morphogenetic Protein 2 | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Transforming Growth Factor beta - physiology | Metalloendopeptidases - administration & dosage | Bone Morphogenetic Protein Receptors, Type I - metabolism | Glycoproteins - administration & dosage | Body Patterning - physiology | Proteins - genetics | Carrier Proteins - genetics | Animals | Transforming Growth Factor beta - genetics | Organizers, Embryonic - metabolism | Xenopus Proteins - physiology | Smad1 Protein - metabolism | Xenopus Proteins - metabolism | Mutation | Xenopus laevis - physiology | Bone Morphogenetic Protein 7 | Morphogenesis | Genetic research | Research | Genetic regulation | Ubiquitin-proteasome system | Bone morphogenetic proteins | Index Medicus
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3. Full Text Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells
by Zhu, Thant S and Costello, Mark A and Talsma, Caroline E and Flack, Callie G and Crowley, Jessica G and Hamm, Lisa L and He, Xiaobing and Hervey-Jumper, Shawn L and Heth, Jason A and Muraszko, Karin M and DiMeco, Francesco and Vescovi, Angelo L and Fan, Xing
Cancer research (Chicago, Ill.), ISSN 0008-5472, 09/2011, Volume 71, Issue 18, pp. 6061 - 6072
Life Sciences & Biomedicine | Oncology | Science & Technology | Neurology | Tumors of the nervous system. Phacomatoses | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | RNA, Small Interfering - genetics | Nestin | Receptors, Notch - metabolism | Humans | Brain Neoplasms - pathology | Glycoproteins - metabolism | Cell Growth Processes - physiology | Intercellular Signaling Peptides and Proteins - biosynthesis | Receptors, Notch - genetics | Brain Neoplasms - metabolism | Antigens, CD - metabolism | Gene Knockdown Techniques | Membrane Proteins - deficiency | Peptides - metabolism | Neoplastic Stem Cells - metabolism | Receptors, Notch - biosynthesis | Serrate-Jagged Proteins | Neoplastic Stem Cells - pathology | Glioblastoma - metabolism | Intercellular Signaling Peptides and Proteins - deficiency | Receptors, Notch - deficiency | Calcium-Binding Proteins - biosynthesis | Stem Cell Niche | Endothelial Cells - metabolism | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Calcium-Binding Proteins - deficiency | AC133 Antigen | Nerve Tissue Proteins - metabolism | Xenograft Model Antitumor Assays | Membrane Proteins - biosynthesis | Animals | Glioblastoma - pathology | Mice | Endothelial Cells - pathology | RNA, Small Interfering - administration & dosage | Intermediate Filament Proteins - metabolism | Calcium-Binding Proteins - genetics | Brain | glioblastoma multiforme | Tumor cells | Glioblastoma | Endothelial cells | Endothelium | Molecular modelling | Stem cells | Microenvironments | Microvasculature | Notch protein | neurospheres | Cancer | Index Medicus | Notch ligand | Endothelial cell | niche | glioblastoma | cancer stem cell
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4. Full Text Macrophage-derived Wnt opposes notch signaling to specify hepatic progenitor cell fate in chronic liver disease
by Boulter, L and Govaere, O and Bird, T.G and Radulescu, S and Ramachanan, P and Pellicoro, A and Ridgway, R and Seo, S.S and Spee, B and van Rooijen, N and Sansom, O.J and Iredale, J.P and Lowell, S and Roskams, T.A and Forbes, S.J
Nature medicine, ISSN 1078-8956, 2012, Volume 18, Issue 4, pp. 572 - 579
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Wnt3A Protein - metabolism | Ethionine - administration & dosage | Keratins, Hair-Specific - genetics | Receptors, Notch - metabolism | Humans | Middle Aged | Liver Diseases - pathology | Cell Communication - physiology | Male | RNA, Messenger - metabolism | Young Adult | Cell Differentiation - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Liver Regeneration - genetics | Biliary Tract - metabolism | Serrate-Jagged Proteins | Adult | Antigens, Differentiation - metabolism | Female | Membrane Proteins - metabolism | Cell Differentiation - physiology | Hepatocytes - physiology | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation - physiology | Mice, Transgenic | gamma-Glutamyltransferase - metabolism | Biliary Tract - physiopathology | Cell Communication - genetics | Liver Regeneration - physiology | beta Catenin - genetics | Biliary Tract - pathology | Nerve Tissue Proteins - metabolism | Macrophages - metabolism | Animals | Creatine Kinase - metabolism | Signal Transduction - physiology | Stem Cell Niche - physiology | Stem Cells - physiology | Aged | Mice | Chronic Disease | Liver diseases | Physiological aspects | Development and progression | Genetic aspects | Research | Macrophages | Cell differentiation | Wnt proteins | Signal transduction | Cellular biology | Gene expression | Index Medicus
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5. Full Text Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor
by Zaiss, Dietmar M.W and van Loosdregt, Jorg and Gorlani, Andrea and Bekker, Cornelis P.J and Gröne, Andrea and Sibilia, Maria and van Bergen en Henegouwen, Paul M.P and Roovers, Rob C and Coffer, Paul J and Sijts, Alice J.A.M
Immunity (Cambridge, Mass.), ISSN 1074-7613, 02/2013, Volume 38, Issue 2, pp. 275 - 284
Life Sciences & Biomedicine | Immunology | Science & Technology | Forkhead Transcription Factors - immunology | Cell Communication - immunology | Receptor, Epidermal Growth Factor - genetics | T-Lymphocytes, Regulatory - metabolism | Humans | Colitis - pathology | Homeodomain Proteins - immunology | Amphiregulin | Glycoproteins - pharmacology | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Melanoma, Experimental - immunology | EGF Family of Proteins | Colitis - chemically induced | Peptide Fragments - immunology | Mast Cells - metabolism | Colitis - immunology | Glycoproteins - genetics | Mast Cells - immunology | Receptor, Epidermal Growth Factor - immunology | Peptide Fragments - administration & dosage | Glycoproteins - antagonists & inhibitors | Intercellular Signaling Peptides and Proteins - genetics | Melanoma, Experimental - pathology | Antibodies, Neutralizing - pharmacology | Membrane Proteins - immunology | Mice, Transgenic | Forkhead Transcription Factors - genetics | Mast Cells - drug effects | Homeodomain Proteins - genetics | Gene Expression Regulation - drug effects | Membrane Proteins - administration & dosage | Glycoproteins - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Melanoma, Experimental - genetics | Signal Transduction - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Lymphocyte Activation - drug effects | Colitis - metabolism | Mice | Intercellular Signaling Peptides and Proteins - immunology | Epidermal growth factor | Universities and colleges | T cells | Analysis | Vaccination | Cells | Flow cytometry | Cytokines | Cloning | Melanoma | Kinases | Experiments | Cancer therapies | Rodents | Bone marrow | Software | Tumors | Cancer | Index Medicus
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6. Full Text Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo
by Sjölund, Jonas and Johansson, Martin and Manna, Sugata and Norin, Carl and Pietras, Alexander and Beckman, Siv and Nilsson, Elise and Ljungberg, Börje and Axelson, Håkan
The Journal of clinical investigation, ISSN 0021-9738, 01/2008, Volume 118, Issue 1, pp. 217 - 228
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Neoplasm Transplantation | RNA, Small Interfering - genetics | Humans | Carcinoma, Renal Cell - genetics | Male | Intracellular Signaling Peptides and Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Cell Transformation, Neoplastic - genetics | Serrate-Jagged Proteins | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Membrane Proteins - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Carcinoma, Renal Cell - drug therapy | Intracellular Signaling Peptides and Proteins - genetics | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Carcinoma, Renal Cell - pathology | Membrane Proteins - genetics | RNA, Small Interfering - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Signal Transduction - genetics | Receptor, Notch1 - metabolism | Cell Transformation, Neoplastic - metabolism | Cyclin-Dependent Kinase Inhibitor p27 | Carcinoma, Renal Cell - metabolism | Animals | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | Cell Transformation, Neoplastic - drug effects | Receptor, Notch1 - antagonists & inhibitors | Cell Transformation, Neoplastic - pathology | Receptor, Notch1 - genetics | Calcium-Binding Proteins - genetics | Care and treatment | Enzyme inhibitors | Tumor suppressor genes | Dosage and administration | Genetic aspects | Carcinoma, Renal cell | Research | Health aspects | Index Medicus | Abridged Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
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7. Full Text Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension
by Yang, Peiran and Read, Cai and Kuc, Rhoda E and Buonincontri, Guido and Southwood, Mark and Torella, Rubben and Upton, Paul D and Crosby, Alexi and Sawiak, Stephen J and Carpenter, T Adrian and Glen, Robert C and Morrell, Nicholas W and Maguire, Janet J and Davenport, Anthony P
Circulation (New York, N.Y.), ISSN 0009-7322, 03/2017, Volume 135, Issue 12, pp. 1160 - 1173
Cardiopulmonary | Receptors, G-protein-coupled | Elabela/Toddler | Pulmonary hypertension | Apelin | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Care and treatment | Research | Toddlers | Gene expression | Health aspects | Index Medicus | Abridged Index Medicus | 10129 | 10018 | apelin | pulmonary hypertension | 10041 | 10012 | Toddler | cardiopulmonary | Elabela | 10113 | Original s | receptors, G-protein-coupled
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8. Full Text Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still’s disease
by Gabay, Cem and Fautrel, Bruno and Rech, Jürgen and Spertini, François and Feist, Eugen and Kötter, Ina and Hachulla, Eric and Morel, Jacques and Schaeverbeke, Thierry and Hamidou, Mohamed A and Martin, Thierry and Hellmich, Bernhard and Lamprecht, Peter and Schulze-Koops, Hendrik and Courvoisier, Delphine Sophie and Sleight, Andrew and Schiffrin, Eduardo Jorge
Annals of the rheumatic diseases, ISSN 0003-4967, 06/2018, Volume 77, Issue 6, pp. 840 - 847
juvenile idiopathic arthritis | inflammation | adult onset still's disease | Life Sciences & Biomedicine | Rheumatology | Science & Technology | C-reactive protein | Cytokines | Optic neuropathy | Laboratories | Pathogenesis | Body temperature | Clinical trials | Values | Juvenile rheumatoid arthritis | Arthritis | Prednisone | Neuropathy | Patients | Fever | Interleukin 18 | Proteins | Drug dosages | Clinical and Epidemiological Research | adult onset still’s disease | 1506 | 2311
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9. Full Text Gas6/Axl axis contributes to chemoresistance and metastasis in breast cancer through Akt/GSK-3β/β- catenin signaling
by Wang, Cun and Jin, Haojie and Wang, Ning and Fan, Shaohua and Wang, Yanyan and Zhang, Yurong and Wei, Lin and Tao, Xuemei and Gu, Dishui and Zhao, Fangyu and Fang, Jingyuan and Yao, Ming and Qin, Wenxin
Theranostics, ISSN 1838-7640, 2016, Volume 6, Issue 8, pp. 1205 - 1219
Breast cancer | Axl | Drug-resistance | EMT | R428 | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Triazoles - administration & dosage | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Gene Expression Profiling | Antineoplastic Agents - administration & dosage | Proto-Oncogene Proteins - biosynthesis | Antineoplastic Agents - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Heterografts | Doxorubicin - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Benzocycloheptenes - metabolism | Drug Resistance | Doxorubicin - administration & dosage | Signal Transduction | Gene Silencing | Treatment Outcome | Glycogen Synthase Kinase 3 beta - metabolism | beta Catenin - metabolism | Triazoles - metabolism | Animals | Benzocycloheptenes - administration & dosage | Breast Neoplasms - pathology | Mice, Nude | Neoplasm Metastasis - pathology | Cell Line, Tumor | Mice, Inbred BALB C | Protein Kinase Inhibitors - metabolism | Index Medicus
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10. Full Text Blockade of IL-18 signaling diminished neuropathic pain and enhanced the efficacy of morphine and buprenorphine
by Pilat, Dominika and Piotrowska, Anna and Rojewska, Ewelina and Jurga, Agnieszka and Ślusarczyk, Joanna and Makuch, Wioletta and Basta-Kaim, Agnieszka and Przewlocka, Barbara and Mika, Joanna
Molecular and cellular neurosciences, ISSN 1044-7431, 03/2016, Volume 71, pp. 114 - 124
Opioid treatment | IL-18R | IL-18 | IL-18BP | Neuropathic pain | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Spinal Cord - metabolism | Rats, Wistar | Neuralgia - metabolism | Analgesics, Opioid - pharmacology | Male | Intercellular Signaling Peptides and Proteins - metabolism | Neurons - metabolism | Spinal Cord - cytology | Intercellular Signaling Peptides and Proteins - administration & dosage | Neurons - drug effects | Receptors, Interleukin-18 - metabolism | Astrocytes - drug effects | Morphine - pharmacology | Cells, Cultured | Rats | Analgesics, Opioid - therapeutic use | Buprenorphine - pharmacology | Neuralgia - drug therapy | Drug Synergism | Buprenorphine - administration & dosage | Animals | Buprenorphine - therapeutic use | Analgesics, Opioid - administration & dosage | Intercellular Signaling Peptides and Proteins - pharmacology | Receptors, Interleukin-18 - genetics | Interleukin-18 - genetics | Morphine - administration & dosage | Interleukin-18 - metabolism | Morphine - therapeutic use | Astrocytes - metabolism | Care and treatment | Pain | Buprenorphine | Interleukins | RNA | Analysis | Morphine | Protein binding | Index Medicus
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