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PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0177516
... successful cell-therapy for muscle disorders. Here we expanded mouse muscle stem cells and human myoblasts with Notch ligands, DLL1, DLL4, and JAG1 to activate Notch signaling in vitro and to investigate whether these cells could retain... 
PROGENITOR CELLS | SATELLITE CELL NICHE | MESENCHYMAL PROGENITORS | GENE | MYOD | MULTIDISCIPLINARY SCIENCES | EXPANSION | SELF-RENEWAL | DUCHENNE MUSCULAR-DYSTROPHY | HUMAN SKELETAL-MUSCLE | TRANSPLANTATION | Immunohistochemistry | Jagged-1 Protein - metabolism | MyoD Protein - genetics | Receptors, Notch - metabolism | PAX7 Transcription Factor - genetics | Receptors, Notch - genetics | Intracellular Signaling Peptides and Proteins - metabolism | PAX7 Transcription Factor - metabolism | Stem Cells - cytology | Stem Cells - metabolism | Cell Differentiation - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Myoblasts - metabolism | Regeneration - genetics | Myoblasts - cytology | Membrane Proteins - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Real-Time Polymerase Chain Reaction | Membrane Proteins - genetics | Muscle Development - physiology | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | MyoD Protein - metabolism | Signal Transduction - genetics | Regeneration - physiology | Jagged-1 Protein - genetics | Muscle Cells - cytology | Animals | Muscle Development - genetics | Signal Transduction - physiology | Mice | Transplantation | Research | Health aspects | Ligands (Biochemistry) | Analysis | Stem cells | Musculoskeletal diseases | Musculoskeletal system | Cell culture | MyoD protein | Allografts | Cell number | Stem cell transplantation | Ligands | Notch protein | Gene expression | Myoblasts | Signal Transduction | Intercellular Signaling Peptides and Proteins | PAX7 Transcription Factor | Intracellular Signaling Peptides and Proteins | Cellular Biology | Stem Cells | Membrane Proteins | Life Sciences | Regeneration | Muscle Development | Receptors, Notch | Cell Differentiation | Muscle Cells | MyoD Protein | Jagged-1 Protein
Journal Article
The EMBO Journal, ISSN 0261-4189, 2011, Volume 30, Issue 4, pp. 770 - 782
Notch signalling is important for development and tissue homeostasis and activated in many human cancers... 
miR‐200 | ZEB1 | EMT | Notch | stemness | miR-200 | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | PHENOTYPE | E-CADHERIN | MIR-200 FAMILY | REPRESSORS ZEB1 | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | COLORECTAL-CANCER | Receptors, Notch - metabolism | Humans | Receptors, Notch - genetics | Gene Knockdown Techniques | Intercellular Signaling Peptides and Proteins - physiology | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Neoplasms - genetics | Membrane Proteins - physiology | Serrate-Jagged Proteins | Base Sequence | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Transcription Factors - physiology | DNA-Binding Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Models, Biological | Calcium-Binding Proteins - physiology | Homeodomain Proteins - antagonists & inhibitors | Nuclear Proteins - antagonists & inhibitors | Signal Transduction - physiology | MicroRNAs - genetics | Feedback, Physiological - physiology | MicroRNAs - physiology | Homeodomain Proteins - physiology | Calcium-Binding Proteins - genetics | Zinc Finger E-box-Binding Homeobox 1 | Proteins | Signal transduction | Cellular biology | Molecular biology | Gene expression | Cancer
Journal Article
Gastroenterology, ISSN 0016-5085, 2011, Volume 140, Issue 4, pp. 1230 - 1240.e7
Background & Aims Ablation of Notch signaling within the intestinal epithelium results in loss of proliferating crypt progenitors due to their conversion into postmitotic secretory cells... 
Gastroenterology and Hepatology | Gene Regulation | GI Development | Knockout Mice | Intestinal Stem Cells | RECOMBINATION | GAMMA-SECRETASE INHIBITORS | SELF-RENEWAL | KLF4 | INHIBITS TUMOR-GROWTH | GENE | PATHWAY | IN-VIVO | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Intestinal Mucosa - metabolism | Receptors, G-Protein-Coupled - metabolism | Cell Count | Intracellular Signaling Peptides and Proteins - metabolism | Intestinal Mucosa - cytology | Intercellular Signaling Peptides and Proteins - metabolism | Kruppel-Like Transcription Factors - metabolism | Serrate-Jagged Proteins | Membrane Proteins - metabolism | Cell Differentiation - physiology | Intracellular Signaling Peptides and Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Adult Stem Cells - cytology | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch1 - metabolism | Goblet Cells - metabolism | Mice, Knockout | Cell Division - physiology | Adult Stem Cells - metabolism | Animals | Homeostasis - physiology | Signal Transduction - physiology | Mice | Receptor, Notch1 - genetics | Kruppel-Like Transcription Factors - genetics | Calcium-Binding Proteins - genetics | Goblet Cells - cytology | GI development | knockout mice | gene regulation | intestinal stem cells
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2011, Volume 286, Issue 9, pp. 7018 - 7026
The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by phosphorylating them for cytoplasmic sequestration or degradation. In... 
YES-ASSOCIATED PROTEIN | EPITHELIAL-MESENCHYMAL TRANSITION | CELL CONTACT INHIBITION | WW DOMAIN | GROWTH-CONTROL | ORGAN SIZE CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ONCOGENIC TRANSFORMATION | BINDING | CANCER | Adaptor Proteins, Signal Transducing - chemistry | Protein Interaction Domains and Motifs - physiology | Humans | Intercellular Signaling Peptides and Proteins - chemistry | Cytoplasm - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Intercellular Signaling Peptides and Proteins - metabolism | HEK293 Cells | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein Structure, Tertiary | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Phosphoproteins - genetics | Cell Division - physiology | Transcription, Genetic - physiology | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Connective Tissue Growth Factor - genetics | Adaptor Proteins, Signal Transducing - metabolism | Connective Tissue Growth Factor - metabolism | Gene Transcription | Transcription Coactivators | Signal Transduction | AmotL1 | YAP | Transcription Factors | Serine Threonine Protein Kinase | Hippo Pathway | TAZ | Amot
Journal Article
Cellular and molecular life sciences : CMLS, ISSN 1420-9071, 2015, Volume 73, Issue 2, pp. 271 - 290
Insulin, insulin-like growth factors (IGFs) and insulin-like peptides (ILPs) are important regulators of metabolism, growth, reproduction and lifespan, and mechanisms of insulin/IGF signaling (IIS... 
Life Sciences | Biochemistry, general | Neuropeptide release | Life Sciences, general | Insulin-like growth factors | Nutrient sensing | Metabolism | Insulin | Biomedicine general | Cell Biology | IGF BINDING | YELLOW-FEVER MOSQUITO | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOSQUITO AEDES-AEGYPTI | EXTENDS LIFE-SPAN | JUVENILE-HORMONE BIOSYNTHESIS | CELL BIOLOGY | SILKMOTH BOMBYX-MORI | SCHISTOCERCA-GREGARIA | AMINO-ACID-SEQUENCE | CAENORHABDITIS-ELEGANS | GROWTH-FACTORS | Signal Transduction | Intercellular Signaling Peptides and Proteins - genetics | Insect Proteins - genetics | Neuropeptides - metabolism | Hormones | Drosophila Proteins - metabolism | Insecta - genetics | Drosophila - physiology | Insecta - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Insulin - metabolism | Reproduction | Animals | Somatomedins - genetics | Insecta - physiology | Neurons - metabolism | Drosophila - metabolism | Drosophila Proteins - genetics | Neuropeptides - genetics | Insulin - genetics | Insect Proteins - metabolism | Somatomedins - metabolism | Drosophila - genetics | Ecdysteroids | Drosophila | Zoology | Neuropeptides | Glucose | Dextrose | Neurophysiology | Fruit-flies | Insects | Physiological aspects | Cellular signal transduction | Binding proteins | Protein binding | Signal transduction | Nutrition
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2009, Volume 69, Issue 6, pp. 2400 - 2407
Despite rapid advances in many fronts, pancreatic cancer (PC) remains one of the most difficult human malignancies to treat due, in part, to de novo and... 
TARGET | STEM-CELLS | GROWTH INHIBITION | INVASION | TUMOR PROGRESSION | ONCOLOGY | PROSTATE-CANCER | TAMOXIFEN RESISTANCE | DOWN-REGULATION | E-CADHERIN | NF-KAPPA-B | RNA, Small Interfering - genetics | Pancreatic Neoplasms - metabolism | Receptors, Notch - metabolism | Humans | Deoxycytidine - pharmacology | Drug Resistance, Neoplasm | Intercellular Signaling Peptides and Proteins - biosynthesis | NF-kappa B - metabolism | Receptor, Notch2 - genetics | Receptors, Notch - genetics | Proto-Oncogene Proteins - biosynthesis | Cell Movement - physiology | Pancreatic Neoplasms - drug therapy | Intercellular Signaling Peptides and Proteins - metabolism | Transfection | Receptors, Notch - biosynthesis | Serrate-Jagged Proteins | Antimetabolites, Antineoplastic - pharmacology | Membrane Proteins - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Calcium-Binding Proteins - biosynthesis | Signal Transduction | Membrane Proteins - genetics | Down-Regulation | Pancreatic Neoplasms - pathology | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch2 - metabolism | Epithelial Cells - pathology | Pancreatic Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Membrane Proteins - biosynthesis | Phenotype | Receptor, Notch2 - biosynthesis | Mesoderm - pathology | RNA, Messenger | Deoxycytidine - analogs & derivatives | Receptor, Notch4 | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article
Molecular and cellular biology, ISSN 0270-7306, 2003, Volume 23, Issue 4, pp. 1428 - 1440
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 32, pp. 11212 - 11217
Genetic studies have shown that ubiquitination and endocytosis of the Drosophila ligand Delta in signal-sending cells are required for activation of Notch signaling, but how these events promote Notch... 
T lymphocytes | Molecules | Endocytosis | Receptors | Cell lines | HeLa cells | Antibodies | Ligands | Lipids | Recycling | Ubiquitination | Membrane microdomains | Transendocytosis | Membrane Microdomains - metabolism | Membrane Proteins - genetics | Drosophila | Humans | Intercellular Signaling Peptides and Proteins - genetics | Protein Transport - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Receptor, Notch1 - metabolism | Recombinant Fusion Proteins - metabolism | Endocytosis - physiology | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Membrane Proteins - metabolism | Mice | HeLa Cells | Ubiquitination - physiology | Receptor, Notch1 - genetics | Intracellular Signaling Peptides and Proteins - genetics | Membrane Microdomains - genetics | Physiological aspects | Cellular signal transduction | Genetic aspects | Ligands (Biochemistry) | Membrane Microdomains | Signal Transduction | Intercellular Signaling Peptides and Proteins | Biochemistry, Molecular Biology | Intracellular Signaling Peptides and Proteins | Recombinant Fusion Proteins | Protein Transport | Membrane Proteins | Life Sciences | Receptor, Notch1 | Molecular biology | Hela Cells | Biological Sciences | recycling | transendocytosis | membrane microdomains | ubiquitination
Journal Article
Journal Article
The FASEB Journal, ISSN 0892-6638, 11/2017, Volume 31, Issue 11, pp. 4720 - 4733
.... Here, we show that both bone morphogenetic protein 2 (BMP2) and BMP6 are proangiogenic in vitro and ex vivo and that the BMP type I receptors, activin receptor‐like kinase 3 (ALK3... 
cell migration | ALK2 | ALK3 | p38 MAPK | SMAD1/5 | MIGRATION | ACTIVATION | TGF-BETA | VEGF | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | NOTCH | ALK1 | CELL BIOLOGY | ENDOTHELIAL-CELLS | BIOLOGY | EXPRESSION | BINDING | MAP Kinase Signaling System - physiology | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | HSP27 Heat-Shock Proteins - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Bone Morphogenetic Protein 6 - genetics | Smad5 Protein - metabolism | Bone Morphogenetic Protein 2 - metabolism | Human Umbilical Vein Endothelial Cells - cytology | Smad1 Protein - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Smad5 Protein - genetics | Bone Morphogenetic Protein 2 - genetics | Intercellular Signaling Peptides and Proteins - genetics | Bone Morphogenetic Protein Receptors, Type I - genetics | Vascular Endothelial Growth Factor Receptor-2 - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | Activin Receptors, Type I - metabolism | Bone Morphogenetic Protein Receptors, Type I - metabolism | Activin Receptors, Type I - genetics | Neovascularization, Physiologic - physiology | Bone Morphogenetic Protein 6 - metabolism | HSP27 Heat-Shock Proteins - metabolism | Smad1 Protein - metabolism | Complex formation | Genes | Clinical trials | Cell adhesion & migration | Proteins | Angiogenesis | Signal transduction | Receptors | Pathways | Vascular endothelial growth factor | Protein-tyrosine kinase | Enhancer-of-split protein | Bone morphogenetic protein 6 | Tyrosine | Medical research | Bone morphogenetic protein 2 | Heat shock proteins | Gene expression | Spheroids | Endothelial cells | Bone morphogenetic protein receptor type I | Endothelium | Signaling | Antiangiogenics | Hsp27 protein | Activin | Cell migration | Heat shock | SMAD1 | Research
Journal Article