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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 4, pp. 1440 - 1445
Fibrosis of vital organs is a major public health problem with limited therapeutic options. Mesenchymal cells including microvascular mural cells (pericytes)... 
Receptors | Kidneys | Cytokines | Epithelial cells | Fibrosis | Ligands | Rarefaction | Inflammation | Myofibroblasts | Mesenchymal stem cells | FIBROSIS | CELLS | MULTIDISCIPLINARY SCIENCES | GROWTH-FACTOR | KIDNEY | WNT | PROTEINS | Pericytes - drug effects | Myofibroblasts - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Pericytes - pathology | G1 Phase Cell Cycle Checkpoints | Proto-Oncogene Proteins c-sis - pharmacology | Kidney Diseases - metabolism | Recombinant Proteins - metabolism | Myofibroblasts - pathology | Signal Transduction | Kidney Diseases - pathology | Mice, Inbred C57BL | Pericytes - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Connective Tissue Growth Factor - pharmacology | Mice, Transgenic | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | beta Catenin - metabolism | Transforming Growth Factor beta - pharmacology | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Wnt Signaling Pathway - genetics | Intercellular Signaling Peptides and Proteins - pharmacology | Cell Proliferation - drug effects | Mice | Cell proliferation | Platelet-derived growth factor | Physiological aspects | Fibroblasts | Research | Transforming growth factors | Health aspects | Proteins | Signal transduction | Tissue | Low density lipoprotein receptors | Biochemistry | Kidney diseases | Index Medicus | Biological Sciences
Journal Article
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 02/2013, Volume 38, Issue 2, pp. 275 - 284
Epidermal growth factor receptor (EGFR) is known to be critically involved in tissue development and homeostasis as well as in the pathogenesis of cancer. Here... 
CETUXIMAB | RESPONSES | TOLERANCE | MAST-CELLS | DISEASE | MODEL | IMMUNOLOGY | CARCINOMA | EXPRESSION | METASTATIC COLORECTAL-CANCER | EGF RECEPTOR | Forkhead Transcription Factors - immunology | Cell Communication - immunology | Receptor, Epidermal Growth Factor - genetics | T-Lymphocytes, Regulatory - metabolism | Humans | Colitis - pathology | Homeodomain Proteins - immunology | Amphiregulin | Glycoproteins - pharmacology | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Melanoma, Experimental - immunology | EGF Family of Proteins | Colitis - chemically induced | Peptide Fragments - immunology | Mast Cells - metabolism | Colitis - immunology | Glycoproteins - genetics | Mast Cells - immunology | Receptor, Epidermal Growth Factor - immunology | Peptide Fragments - administration & dosage | Glycoproteins - antagonists & inhibitors | Intercellular Signaling Peptides and Proteins - genetics | Melanoma, Experimental - pathology | Antibodies, Neutralizing - pharmacology | Membrane Proteins - immunology | Mice, Transgenic | Forkhead Transcription Factors - genetics | Mast Cells - drug effects | Homeodomain Proteins - genetics | Gene Expression Regulation - drug effects | Membrane Proteins - administration & dosage | Glycoproteins - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Melanoma, Experimental - genetics | Signal Transduction - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Lymphocyte Activation - drug effects | Colitis - metabolism | Mice | Intercellular Signaling Peptides and Proteins - immunology | Epidermal growth factor | Universities and colleges | T cells | Analysis | Vaccination | Cells | Flow cytometry | Cytokines | Cloning | Melanoma | Kinases | Experiments | Cancer therapies | Rodents | Bone marrow | Software | Tumors | Cancer | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7411, pp. 394 - 398
Cardiac hypertrophy is initiated as an adaptive response to sustained overload but progresses pathologically as heart failure ensues(1). Here we report that... 
PROTEIN | CONTRACTILITY | MYOCYTES | STRETCH | MULTIDISCIPLINARY SCIENCES | IN-VIVO | INVOLVEMENT | GENE-EXPRESSION | APELIN | ANGIOTENSIN-II | CARDIOMYOCYTES | Blood Pressure | Mechanotransduction, Cellular - drug effects | Receptors, G-Protein-Coupled - metabolism | Arrestins - genetics | Cardiomegaly - pathology | Male | Receptors, G-Protein-Coupled - agonists | Mechanotransduction, Cellular - physiology | Arrestins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Female | Intercellular Signaling Peptides and Proteins - deficiency | Mechanoreceptors - metabolism | Apelin | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Cardiomegaly - physiopathology | Adipokines | Mice, Knockout | Aorta - pathology | Myocytes, Cardiac - pathology | Animals | Cardiomegaly - prevention & control | Myocytes, Cardiac - drug effects | Receptors, G-Protein-Coupled - deficiency | Signal Transduction - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | beta-Arrestins | Apelin Receptors | Mice | Receptors, G-Protein-Coupled - genetics | Arrestins - deficiency | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Cardiomegaly - metabolism | Genetically modified mice | Physiological aspects | Development and progression | Research | Heart enlargement | Proteins | Heart failure | Cardiomyocytes | Kinases | Laboratory animals | Rodents | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 02/2011, Volume 470, Issue 7332, pp. 105 - 110
Studies in embryonic development have guided successful efforts to direct the differentiation of human embryonic and induced pluripotent stem cells (PSCs) into... 
VIVO | NEUROGENIN-3 | MULTIDISCIPLINARY SCIENCES | BETA-CELLS | ENDODERM | DEFINED CONDITIONS | GENERATION | SPECIFICATION | FATE | EFFICIENT DIFFERENTIATION | ENDOCRINE-CELLS | Body Patterning - drug effects | Intestines - drug effects | Wnt Proteins - pharmacology | Embryonic Stem Cells - cytology | Humans | Endoderm - embryology | Intestines - embryology | Organogenesis - drug effects | Intestines - anatomy & histology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Time Factors | Endoderm - cytology | Fibroblast Growth Factor 4 - pharmacology | Cell Culture Techniques | Culture Media - chemistry | Induced Pluripotent Stem Cells - cytology | Basic Helix-Loop-Helix Transcription Factors - genetics | Induced Pluripotent Stem Cells - drug effects | Cells, Cultured | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Microvilli - drug effects | Activins - pharmacology | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Endoderm - drug effects | Culture Media - pharmacology | Morphogenesis - drug effects | Wnt3 Protein | Wnt3A Protein | Intestines - cytology | Physiological aspects | Intestines | Genetic aspects | Health aspects | Endoderm | Stem cells | Proteins | Studies | Index Medicus | posterior endoderm | intestine | FGF | transplantation | colon | drug transport | Wnt | progenitor cell
Journal Article
Journal Article
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 06/2006, Volume 21, Issue 6, pp. 934 - 945
Journal Article
STEM CELLS, ISSN 1066-5099, 07/2007, Volume 25, Issue 7, pp. 1737 - 1745
Journal Article