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Circulation (New York, N.Y.), ISSN 1524-4539, 03/2017, Volume 135, Issue 12, pp. 1160 - 1173
BACKGROUND:Elabela/toddler (ELA) is a critical cardiac developmental peptide that acts through the G-protein... 
Cardiopulmonary | Receptors, G-protein-coupled | Elabela/Toddler | Pulmonary hypertension | Apelin | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Peptide Hormones - pharmacology | Humans | Hypertension, Pulmonary - physiopathology | Intercellular Signaling Peptides and Proteins - chemistry | Endothelium, Vascular - drug effects | Male | Peptide Hormones - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Peptide Hormones - chemistry | Hypertension, Pulmonary - drug therapy | Binding Sites | Disease Models, Animal | Protein Structure, Tertiary | Amino Acid Sequence | Catheterization | Rats | Down-Regulation - drug effects | Rats, Sprague-Dawley | Molecular Dynamics Simulation | Intercellular Signaling Peptides and Proteins - agonists | Animals | Endothelium, Vascular - metabolism | Intercellular Signaling Peptides and Proteins - pharmacology | Peptide Hormones - therapeutic use | Heart Ventricles - metabolism | Intercellular Signaling Peptides and Proteins - therapeutic use | Heart Ventricles - drug effects | Care and treatment | Research | Toddlers | Gene expression | Health aspects | Index Medicus | Abridged Index Medicus | 10129 | 10018 | apelin | pulmonary hypertension | 10041 | 10012 | Toddler | cardiopulmonary | Elabela | 10113 | Original s | receptors, G-protein-coupled
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 01/2013, Volume 110, Issue 4, pp. 1440 - 1445
.... Here we show pericytes in healthy kidneys have active WNT/β-catenin signaling responses that are markedly up-regulated following kidney injury... 
Receptors | Kidneys | Cytokines | Epithelial cells | Fibrosis | Ligands | Rarefaction | Inflammation | Myofibroblasts | Mesenchymal stem cells | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Pericytes - drug effects | Myofibroblasts - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Pericytes - pathology | G1 Phase Cell Cycle Checkpoints | Proto-Oncogene Proteins c-sis - pharmacology | Kidney Diseases - metabolism | Recombinant Proteins - metabolism | Myofibroblasts - pathology | Signal Transduction | Kidney Diseases - pathology | Mice, Inbred C57BL | Pericytes - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Connective Tissue Growth Factor - pharmacology | Mice, Transgenic | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | beta Catenin - metabolism | Transforming Growth Factor beta - pharmacology | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Wnt Signaling Pathway - genetics | Intercellular Signaling Peptides and Proteins - pharmacology | Cell Proliferation - drug effects | Mice | Cell proliferation | Platelet-derived growth factor | Physiological aspects | Fibroblasts | Research | Transforming growth factors | Health aspects | Proteins | Signal transduction | Tissue | Low density lipoprotein receptors | Biochemistry | Kidney diseases | Index Medicus | Biological Sciences
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 2008, Volume 19, Issue 11, pp. 2098 - 2107
In diabetic nephropathy, connective tissue growth factor (CTGF) is upregulated and bone morphogenetic protein 7 (BMP-7) is downregulated... 
Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Bone Morphogenetic Proteins - physiology | Kidney - pathology | Diabetes Mellitus, Experimental - genetics | Male | Transforming Growth Factor beta - deficiency | RNA, Messenger - metabolism | Intercellular Signaling Peptides and Proteins - physiology | Kidney - metabolism | Diabetic Nephropathies - physiopathology | Smad5 Protein - metabolism | Bone Morphogenetic Proteins - deficiency | Immediate-Early Proteins - deficiency | Female | Intercellular Signaling Peptides and Proteins - deficiency | Bone Morphogenetic Proteins - genetics | Diabetes Mellitus, Experimental - physiopathology | Diabetic Nephropathies - pathology | Gene Expression | Immediate-Early Proteins - physiology | Signal Transduction | Mice, Inbred C57BL | RNA, Messenger - genetics | Intercellular Signaling Peptides and Proteins - genetics | Transforming Growth Factor beta - physiology | Diabetic Nephropathies - genetics | Recombinant Proteins - pharmacology | Mice, Knockout | Animals | Immediate-Early Proteins - genetics | Transforming Growth Factor beta - genetics | Intercellular Signaling Peptides and Proteins - pharmacology | Immediate-Early Proteins - pharmacology | Diabetes Mellitus, Experimental - pathology | Inhibitor of Differentiation Protein 1 - genetics | Protein Binding | Smad1 Protein - metabolism | Mice | Mice, Inbred BALB C | Bone Morphogenetic Protein 7 | Connective Tissue Growth Factor | Index Medicus | Basic Research
Journal Article
Diabetes (New York, N.Y.), ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 2872 - 2882
OBJECTIVE-To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic a-cells and how this sudden massive depletion affects... 
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Insulin-Secreting Cells - secretion | Apoptosis - drug effects | Cell Count | Glucagon - genetics | Male | Diphtheria Toxin - toxicity | Insulin - blood | Glucagon - blood | Diabetes Mellitus, Experimental - blood | Hypoglycemia - prevention & control | Intercellular Signaling Peptides and Proteins - metabolism | Glucagon-Secreting Cells - drug effects | Insulin-Secreting Cells - metabolism | Hyperglycemia - chemically induced | Glucagon-Secreting Cells - metabolism | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Glucagon-Secreting Cells - secretion | Hyperglycemia - prevention & control | Promoter Regions, Genetic | Signal Transduction | Glucagon-Secreting Cells - pathology | Intercellular Signaling Peptides and Proteins - genetics | Pancreas - drug effects | Pancreas - pathology | Receptors, Glucagon - metabolism | Mice, Transgenic | Pancreas - metabolism | Heparin-binding EGF-like Growth Factor | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Tamoxifen - pharmacology | Diabetes Mellitus, Experimental - pathology | Glucagon - metabolism | Mice | Streptozocin - toxicity | Insulin-Secreting Cells - pathology | Selective Estrogen Receptor Modulators - pharmacology | Index Medicus | Abridged Index Medicus | Islet Studies
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 03/2011, Volume 332, Issue 6028, pp. 478 - 484
.... Atsttrin, an engineered protein composed of three PGRN fragments, exhibited selective TNFR binding... 
Cartilage | Immunization | Antiinflammatories | Medical treatment | REPORTS | Collagens | Antibodies | Bones | Arthritis | Mice | Inflammation | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Recombinant Proteins - therapeutic use | Tumor Necrosis Factor-alpha - metabolism | Arthritis, Experimental - drug therapy | Recombinant Fusion Proteins - pharmacology | Humans | Middle Aged | Recombinant Fusion Proteins - therapeutic use | Intercellular Signaling Peptides and Proteins - chemistry | Male | Receptors, Tumor Necrosis Factor, Type I - metabolism | Recombinant Fusion Proteins - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | T-Lymphocytes, Regulatory - immunology | Arthritis, Experimental - pathology | Young Adult | Intercellular Signaling Peptides and Proteins - metabolism | Cartilage, Articular - metabolism | Receptors, Tumor Necrosis Factor, Type II - metabolism | Adult | Female | Protein Interaction Domains and Motifs | Anti-Inflammatory Agents, Non-Steroidal - metabolism | T-Lymphocytes, Regulatory - physiology | Arthritis, Experimental - physiopathology | Signal Transduction | Intercellular Signaling Peptides and Proteins - genetics | Mice, Transgenic | Arthritis, Experimental - immunology | Mice, Inbred Strains | Receptors, Tumor Necrosis Factor, Type I - genetics | Receptors, Tumor Necrosis Factor, Type II - genetics | Mice, Knockout | Cartilage, Articular - pathology | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Adolescent | Ligands | Aged | Intercellular Signaling Peptides and Proteins - therapeutic use | Care and treatment | Genetic aspects | Properties | Tumor necrosis factor | Growth factors | Index Medicus | Binding | Pathology | Receptors | Pathogenesis
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 07/2016, Volume 291, Issue 29, pp. 15256 - 15266
.... Using a proteomic approach, we have identified angiomotin family proteins, which are known negative regulators of YAP signaling, as novel tankyrase substrates... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Lung Neoplasms - drug therapy | RNA, Small Interfering - genetics | Humans | Lung Neoplasms - metabolism | Intercellular Signaling Peptides and Proteins - chemistry | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | Tankyrases - antagonists & inhibitors | Intercellular Signaling Peptides and Proteins - metabolism | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | HEK293 Cells | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Tankyrases - genetics | Membrane Proteins - genetics | Down-Regulation | Carcinoma, Non-Small-Cell Lung - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | Tankyrases - chemistry | Phosphoproteins - genetics | Gene Knockout Techniques | Membrane Proteins - chemistry | Signal Transduction - drug effects | Erlotinib Hydrochloride - pharmacology | Protein Stability - drug effects | Adaptor Proteins, Signal Transducing - genetics | CRISPR-Cas Systems | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - drug therapy | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus | CRISPR | Cas | yes-associated protein (YAP) | signal transduction | functional genomics | drug resistance | protein degradation | Cell Biology
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 10/2015, Volume 75, Issue 19, pp. 4086 - 4096
.... In this study, we report the development of REGN421 (enoticumab), a fully human IgG1 monoclonal antibody that binds human Dll4 with sub-nanomolar affinity and inhibits Notch signaling... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Species Specificity | Humans | Neoplasm Proteins - physiology | Antibodies, Monoclonal - therapeutic use | Intracellular Signaling Peptides and Proteins - immunology | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Molecular Targeted Therapy | Intercellular Signaling Peptides and Proteins - physiology | Stromal Cells - drug effects | Angiogenesis Inhibitors - therapeutic use | Female | Antineoplastic Agents - pharmacology | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - blood supply | Intracellular Signaling Peptides and Proteins - genetics | Ovarian Neoplasms - drug therapy | Endothelial Cells - metabolism | Membrane Proteins - genetics | Antibodies, Monoclonal - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Stromal Cells - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Angiogenesis Inhibitors - pharmacology | Receptors, Notch - physiology | Membrane Proteins - immunology | Mice, SCID | Xenograft Model Antitumor Assays | Animals | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Neovascularization, Pathologic - drug therapy | Mice | Intercellular Signaling Peptides and Proteins - immunology | Endothelial Cells - drug effects | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, pp. e89064 - e89064
The anti-apoptotic protein Mcl-1 plays a major role in multiple myeloma (MM) cell survival as well as bortezomib- and microenvironmental forms of drug resistance in this disease... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein Kinases - metabolism | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Multiple Myeloma - drug therapy | Benzamides - therapeutic use | Bcl-2-Like Protein 11 | Protein Binding - drug effects | Cytoprotection - drug effects | Benzamides - pharmacology | Membrane Proteins - metabolism | Multiple Myeloma - enzymology | Proto-Oncogene Proteins - metabolism | Mesenchymal Stromal Cells - drug effects | Bortezomib | Syndecan-1 - metabolism | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | bcl-2-Associated X Protein - metabolism | Mesenchymal Stromal Cells - metabolism | Down-Regulation - drug effects | Apoptosis Regulatory Proteins - metabolism | Up-Regulation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Checkpoint Kinase 1 | Protein Kinase Inhibitors - pharmacology | Mesenchymal Stromal Cells - pathology | Pyrazines - pharmacology | Boronic Acids - pharmacology | Drug Resistance, Neoplasm - drug effects | Drug resistance | Apoptosis | Cell culture | Regulations | Cell survival | Bax protein | Transcription | Insulin-like growth factor I | CHK1 protein | Gene regulation | Multiple myeloma | Insulin-like growth factors | Mcl-1 protein | Hemopoiesis | Interleukin 6 | Disease resistance | Stromal cells | Inhibition | BIM protein | Index Medicus
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 02/2013, Volume 38, Issue 2, pp. 275 - 284
Epidermal growth factor receptor (EGFR) is known to be critically involved in tissue development and homeostasis as well as in the pathogenesis of cancer. Here... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Forkhead Transcription Factors - immunology | Cell Communication - immunology | Receptor, Epidermal Growth Factor - genetics | T-Lymphocytes, Regulatory - metabolism | Humans | Colitis - pathology | Homeodomain Proteins - immunology | Amphiregulin | Glycoproteins - pharmacology | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Melanoma, Experimental - immunology | EGF Family of Proteins | Colitis - chemically induced | Peptide Fragments - immunology | Mast Cells - metabolism | Colitis - immunology | Glycoproteins - genetics | Mast Cells - immunology | Receptor, Epidermal Growth Factor - immunology | Peptide Fragments - administration & dosage | Glycoproteins - antagonists & inhibitors | Intercellular Signaling Peptides and Proteins - genetics | Melanoma, Experimental - pathology | Antibodies, Neutralizing - pharmacology | Membrane Proteins - immunology | Mice, Transgenic | Forkhead Transcription Factors - genetics | Mast Cells - drug effects | Homeodomain Proteins - genetics | Gene Expression Regulation - drug effects | Membrane Proteins - administration & dosage | Glycoproteins - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Melanoma, Experimental - genetics | Signal Transduction - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Lymphocyte Activation - drug effects | Colitis - metabolism | Mice | Intercellular Signaling Peptides and Proteins - immunology | Epidermal growth factor | Universities and colleges | T cells | Analysis | Vaccination | Cells | Flow cytometry | Cytokines | Cloning | Melanoma | Kinases | Experiments | Cancer therapies | Rodents | Bone marrow | Software | Tumors | Cancer | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 11/2019, Volume 14, Issue 11, pp. e0223738 - e0223738
The apoptosis-inducing peptide kla (KLAKLAK)(2) possesses the ability to disrupt mitochondrial membranes and induce cancer cell apoptosis, but this peptide has a poor eukaryotic cell-penetrating potential... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | NIH 3T3 Cells | Apoptosis - drug effects | Humans | Intercellular Signaling Peptides and Proteins - chemistry | Antineoplastic Agents - administration & dosage | Peptides - administration & dosage | Antineoplastic Agents - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Peptides - metabolism | MCF-7 Cells | Chemical Phenomena | Female | Antineoplastic Agents - pharmacology | Intercellular Signaling Peptides and Proteins - administration & dosage | A549 Cells | Amino Acid Sequence | Peptides - chemistry | Antineoplastic Agents - chemistry | Peptides - pharmacology | Protein Transport | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Intercellular Signaling Peptides and Proteins - pharmacology | Mice | Cytochrome c | Ethylenediaminetetraacetic acid | Care and treatment | Peptides | Lung cancer | Health aspects | Apoptosis | Cancer | Cytochrome | Membranes | Laboratories | Toxicity | Drug resistance | Tissues | Cancer therapies | Anticancer properties | Depolarization | Proteins | Mitochondria | Education | Bacteria | Biocompatibility | Life sciences | Gram-negative bacteria | Translocation | Polypeptides | Organs | Antimicrobial agents | Breast cancer | Permeability | Chemotherapy | Cytochromes | Antitumor activity | Index Medicus
Journal Article