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Science, ISSN 0036-8075, 4/2011, Volume 332, Issue 6028, pp. 478 - 484
The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors remain... 
Cartilage | Immunization | Antiinflammatories | Medical treatment | REPORTS | Collagens | Antibodies | Bones | Arthritis | Mice | Inflammation | TUMOR-NECROSIS-FACTOR | GENE | MULTIDISCIPLINARY SCIENCES | HOST-DEFENSE | DEGRADATION | OLIGOMERIC MATRIX PROTEIN | GRANULIN-EPITHELIN PRECURSOR | ADAMTS-7 | MUTATIONS | TRANSCRIPTION FACTOR | PSEUDOACHONDROPLASIA | Recombinant Proteins - therapeutic use | Tumor Necrosis Factor-alpha - metabolism | Arthritis, Experimental - drug therapy | Recombinant Fusion Proteins - pharmacology | Humans | Middle Aged | Recombinant Fusion Proteins - therapeutic use | Intercellular Signaling Peptides and Proteins - chemistry | Male | Receptors, Tumor Necrosis Factor, Type I - metabolism | Recombinant Fusion Proteins - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | T-Lymphocytes, Regulatory - immunology | Arthritis, Experimental - pathology | Young Adult | Intercellular Signaling Peptides and Proteins - metabolism | Cartilage, Articular - metabolism | Receptors, Tumor Necrosis Factor, Type II - metabolism | Adult | Female | Protein Interaction Domains and Motifs | Anti-Inflammatory Agents, Non-Steroidal - metabolism | T-Lymphocytes, Regulatory - physiology | Arthritis, Experimental - physiopathology | Signal Transduction | Intercellular Signaling Peptides and Proteins - genetics | Mice, Transgenic | Arthritis, Experimental - immunology | Mice, Inbred Strains | Receptors, Tumor Necrosis Factor, Type I - genetics | Receptors, Tumor Necrosis Factor, Type II - genetics | Mice, Knockout | Cartilage, Articular - pathology | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Adolescent | Ligands | Aged | Intercellular Signaling Peptides and Proteins - therapeutic use | Care and treatment | Genetic aspects | Properties | Tumor necrosis factor | Growth factors
Journal Article
Circulation, ISSN 0009-7322, 03/2017, Volume 135, Issue 12, pp. 1160 - 1173
BACKGROUND:Elabela/toddler (ELA) is a critical cardiac developmental peptide that acts through the G-protein–coupled apelin receptor, despite lack of sequence... 
Cardiopulmonary | Receptors, G-protein-coupled | Elabela/Toddler | Pulmonary hypertension | Apelin | CARDIAC & CARDIOVASCULAR SYSTEMS | ELABELA | apelin | pulmonary hypertension | receptors, G-protein-coupled | HEART | IMMUNOCYTOCHEMICAL LOCALIZATION | PATHWAY | ENDOTHELIAL-CELLS | IN-VIVO | DISEASE | PERIPHERAL VASCULAR DISEASE | CARDIAC CONTRACTILITY | LIGAND | cardiopulmonary | Peptide Hormones - pharmacology | Humans | Hypertension, Pulmonary - physiopathology | Intercellular Signaling Peptides and Proteins - chemistry | Endothelium, Vascular - drug effects | Male | Peptide Hormones - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Peptide Hormones - chemistry | Hypertension, Pulmonary - drug therapy | Binding Sites | Disease Models, Animal | Protein Structure, Tertiary | Amino Acid Sequence | Catheterization | Rats | Down-Regulation - drug effects | Rats, Sprague-Dawley | Molecular Dynamics Simulation | Intercellular Signaling Peptides and Proteins - agonists | Animals | Endothelium, Vascular - metabolism | Intercellular Signaling Peptides and Proteins - pharmacology | Peptide Hormones - therapeutic use | Heart Ventricles - metabolism | Intercellular Signaling Peptides and Proteins - therapeutic use | Heart Ventricles - drug effects | Care and treatment | Research | Toddlers | Gene expression | Health aspects | 10129 | 10018 | 10041 | 10012 | Toddler | Elabela | 10113 | Original s
Journal Article
Journal Article
Journal Article
Acta Biomaterialia, ISSN 1742-7061, 01/2016, Volume 30, pp. 1 - 12
Journal Article
Clinical Orthopaedics and Related Research, ISSN 0009-921X, 10/2011, Volume 469, Issue 10, pp. 2706 - 2715
Full-thickness chondral defects and early osteoarthritis continue to present major challenges for the patient and the orthopaedic surgeon as a result of the... 
Surgical Orthopedics | Medicine & Public Health | Sports Medicine | Surgery | Orthopedics | Conservative Orthopedics | Medicine/Public Health, general | SURGERY | ENDOGENOUS OSTEOGENIC PROTEIN-1 | TGF-BETA | AUTOLOGOUS CONDITIONED SERUM | ARTICULAR-CARTILAGE | TRANSFORMING GROWTH-FACTOR-BETA-1 | CHONDROCYTIC DIFFERENTIATION | GENE-EXPRESSION | OSTEOCHONDRAL DEFECTS | FACTOR-I | ORTHOPEDICS | MESENCHYMAL STEM-CELLS | Platelet-Derived Growth Factor - therapeutic use | Chondrogenesis - drug effects | Humans | Cartilage Diseases - drug therapy | Cartilage Diseases - pathology | Cartilage, Articular - pathology | Intercellular Signaling Peptides and Proteins - metabolism | Regeneration - drug effects | Animals | Transforming Growth Factors - therapeutic use | Cartilage, Articular - metabolism | Bone Morphogenetic Proteins - therapeutic use | Intercellular Signaling Peptides and Proteins - therapeutic use | Cartilage, Articular - drug effects | Drug Therapy, Combination | Insulin-Like Growth Factor I - therapeutic use | Cartilage Diseases - metabolism | Fibroblast Growth Factors - therapeutic use | Osteoarthritis | Fibroblast growth factors | Platelet-derived growth factor | Fibroblast growth factor | Cartilage (articular) | Transforming growth factor- beta | Regeneration | Molecular modelling | Reviews | Chondrocytes | Bone marrow | Extracellular matrix | Microenvironments | Injuries | Cartilage diseases | Clinically Relevant Strategies for Treating Cartilage and Meniscal Pathology | Symposium
Journal Article
Biomaterials, ISSN 0142-9612, 2013, Volume 34, Issue 27, pp. 6412 - 6421
Abstract Endochondral ossification plays a key role in the bone healing process, which requires normal cartilage callus formation. Progranulin (PGRN) growth... 
Advanced Basic Science | Dentistry | Bone resorption | Bone repair | Progranulin | TNF-α | BMP-2 | Endochondral ossification | MATERIALS SCIENCE, BIOMATERIALS | TNF-alpha | ENGINEERING, BIOMEDICAL | DEFECT MODEL | GRANULIN-EPITHELIN PRECURSOR | OLIGOMERIC MATRIX PROTEIN | DEFICIENT MICE | TUMOR-NECROSIS-FACTOR | FRACTURE REPAIR | HOST-DEFENSE | GROWTH-FACTOR | TRANSCRIPTION FACTOR | Recombinant Proteins - therapeutic use | Femur - pathology | Tumor Necrosis Factor-alpha - genetics | Male | Femoral Fractures - pathology | Intercellular Signaling Peptides and Proteins - metabolism | Fracture Healing - drug effects | Gene Deletion | Tumor Necrosis Factor-alpha - immunology | Femur - injuries | Recombinant Proteins - metabolism | Cell Line | Femoral Fractures - immunology | Signal Transduction | Osteogenesis - drug effects | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Femur - drug effects | Mice, Transgenic | Recombinant Proteins - genetics | Femoral Fractures - metabolism | Animals | Recombinant Proteins - immunology | Femoral Fractures - drug therapy | Intercellular Signaling Peptides and Proteins - therapeutic use | Mice | Receptors, Tumor Necrosis Factor - immunology | Intercellular Signaling Peptides and Proteins - immunology | Genetically modified animals | Immunohistochemistry | Genetic engineering | Analysis | Cells | Regeneration | Biomedical materials | Healing | Biocompatibility | Bones | Formations | Recombinant | progranulin | endochondral ossification | bone resorption | bone repair
Journal Article