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interferon regulatory factor-7 - genetics (73) 73
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activation (41) 41
nf-kappa-b (40) 40
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biological response modifiers (37) 37
transcription factors (37) 37
dendritic cells - immunology (36) 36
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gene-expression (36) 36
microbiology (36) 36
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biology (35) 35
interferon regulatory factor 7 (35) 35
medicine (35) 35
multidisciplinary sciences (35) 35
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infectious diseases (33) 33
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biochemistry & molecular biology (32) 32
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science (31) 31
infection (30) 30
rig-i (29) 29
signal transduction - immunology (29) 29
double-stranded-rna (28) 28
genes (28) 28
plasmacytoid dendritic cells (28) 28
cell line (27) 27
i interferon (27) 27
interferon type i - immunology (27) 27
physiological aspects (27) 27
article (26) 26
immunity, innate (26) 26
genetic aspects (25) 25
immunity (25) 25
kinases (25) 25
macrophages (25) 25
analysis (24) 24
gene expression regulation (24) 24
positive feedback (24) 24
rodents (24) 24
induction (23) 23
interferon regulatory factor-3 - metabolism (23) 23
interferon type i - genetics (23) 23
interferon regulatory factor-3 - genetics (22) 22
dendritic cells - metabolism (21) 21
interferon regulatory factor-7 (21) 21
immunologic diseases. allergy (20) 20
interferon type i - biosynthesis (20) 20
abridged index medicus (19) 19
phosphorylation (19) 19
flow cytometry (18) 18
interferon regulatory factor-7 - deficiency (18) 18
interferon-beta - genetics (18) 18
medicine, research & experimental (18) 18
pathogenesis (18) 18
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signaling (18) 18
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cutting edge (17) 17
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influenza (17) 17
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interferon-beta - metabolism (17) 17
macrophages - immunology (17) 17
review (17) 17
interferon-beta - immunology (16) 16
macrophages - metabolism (16) 16
parasitology (16) 16
receptor, interferon alpha-beta - genetics (16) 16
recognition (16) 16
reverse transcriptase polymerase chain reaction (16) 16
signal transduction - genetics (16) 16
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PLoS Pathogens, ISSN 1553-7366, 11/2013, Volume 9, Issue 11, p. e1003773
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2012, Volume 188, Issue 7, pp. 2967 - 2971
The host response to Chikungunya virus is dependent on the direct action of type I IFN on infected nonhematopoietic cells. Prior studies have demonstrated that... 
PATHOGENESIS | VIRUS | PROTEIN | MODEL | IMMUNOLOGY | DISTINCT | Age Factors | Interferon Regulatory Factor-7 - genetics | Interferon Regulatory Factor-3 - genetics | Interferon Regulatory Factor-7 - physiology | Interferon-alpha - genetics | Bone Marrow Transplantation | Hematopoietic Stem Cells - virology | Fibroblasts - metabolism | Animals, Newborn | Chikungunya Fever | Fibroblasts - virology | Toll-Like Receptor 7 - genetics | Interferon-alpha - biosynthesis | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 7 - deficiency | Hematopoietic Stem Cells - metabolism | Radiation Chimera | Alphavirus Infections - immunology | Chikungunya virus - growth & development | Chikungunya virus - immunology | Interferon Regulatory Factor-3 - physiology | Membrane Glycoproteins - genetics | Mice, Knockout | Host-Pathogen Interactions | Adaptor Proteins, Signal Transducing - physiology | Animals | Interferon Regulatory Factor-3 - deficiency | Myeloid Differentiation Factor 88 - deficiency | Interferon Regulatory Factor-7 - deficiency | Mice | Membrane Glycoproteins - deficiency | Interferon Regulatory Factor-7/deficiency | Toll-Like Receptor 7/genetics | Membrane Glycoproteins/genetics | Hematopoietic Stem Cells/metabolism | Myeloid Differentiation Factor 88/genetics | Life Sciences | Alphavirus Infections/immunology | Immunology | Fibroblasts/metabolism | Chikungunya virus/growth & development | Myeloid Differentiation Factor 88/deficiency | Toll-Like Receptor 7/deficiency | Interferon Regulatory Factor-3/physiology | Interferon Regulatory Factor-3/genetics | Interferon-alpha/biosynthesis | Adaptor Proteins, Signal Transducing/physiology | Hematopoietic Stem Cells/virology | Membrane Glycoproteins/deficiency | Interferon Regulatory Factor-3/deficiency | Chikungunya virus/immunology
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2012, Volume 18, Issue 8, pp. 1224 - 1231
Breast cancer metastasis is a key determinant of long-term patient survival. By comparing the transcriptomes of primary and metastatic tumor cells in a mouse... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENOMIC ANALYSIS | TUMORS | MAMMARY CARCINOMAS | CELL BIOLOGY | ADAPTIVE IMMUNITY | ZOLEDRONIC ACID | MOLECULAR PORTRAITS | I INTERFERONS | PROSTATE-CANCER | GENE-EXPRESSION | SUPPRESSOR-CELLS | Immunologic Surveillance | Mammary Neoplasms, Experimental - immunology | T-Lymphocyte Subsets - immunology | Interferon-alpha - pharmacology | Tumor Escape - genetics | Breast Neoplasms - immunology | Humans | Neoplasm Proteins - physiology | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Interferon Regulatory Factor-7 - genetics | Mammary Neoplasms, Experimental - genetics | Interferon Regulatory Factor-7 - physiology | Killer Cells, Natural - immunology | Female | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Recombinant Proteins - metabolism | Receptors, Interferon - deficiency | Gene Silencing | Severe Combined Immunodeficiency - immunology | Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics | Mice, SCID | Tumor Escape - physiology | Severe Combined Immunodeficiency - genetics | Animals | Breast Neoplasms - genetics | Interferon Regulatory Factor-7 - biosynthesis | Interferon Regulatory Factor-7 - antagonists & inhibitors | Interferon-Stimulated Gene Factor 3, gamma Subunit - physiology | Neoplasm Metastasis - physiopathology | Mice, Inbred NOD | Receptors, Interferon - physiology | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Interferon-Stimulated Gene Factor 3, gamma Subunit - antagonists & inhibitors | Gene silencing | Care and treatment | Cancer cells | Development and progression | Bones | Breast cancer | Genetic aspects | Metastasis | Research | Human immunogenetics | Signal transduction | Bone cancer | Gene expression | Immune system
Journal Article
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 05/2013, Volume 305, Issue 4, pp. E485 - E495
Obesity-related inflammation has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. In this study, we addressed the potential role... 
Type 2 diabetes | Inflammation | Fatty liver | Adiposity | IMMUNITY | adiposity | PHYSIOLOGY | I-INTERFERON | POSITIVE FEEDBACK | fatty liver | MECHANISMS | INDUCTION | KINASE IKK-EPSILON | type 2 diabetes | inflammation | ENDOCRINOLOGY & METABOLISM | ENDOPLASMIC-RETICULUM | STRESS | ADIPOSE-TISSUE | Up-Regulation | Liver - pathology | Fatty Liver - pathology | Obesity - immunology | Diet, High-Fat - adverse effects | Male | Muscle, Skeletal - metabolism | Diabetes Mellitus, Type 2 - metabolism | Interferon Regulatory Factor-7 - genetics | Liver - immunology | Muscle, Skeletal - immunology | Diabetes Mellitus, Type 2 - immunology | Non-alcoholic Fatty Liver Disease | Diabetes Mellitus, Type 2 - etiology | Obesity - etiology | Weight Gain | Macrophages - immunology | Intra-Abdominal Fat - immunology | Fatty Liver - metabolism | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Random Allocation | Intra-Abdominal Fat - metabolism | Interferon Regulatory Factor-7 - metabolism | Mice, Knockout | Obesity - metabolism | Obesity - pathology | Animals | Interferon Regulatory Factor-7 - biosynthesis | Energy Metabolism | Endoplasmic Reticulum Stress | Fatty Liver - immunology | Mice, Obese | Mice | Diabetes Mellitus, Type 2 - pathology | Intra-Abdominal Fat - pathology | Muscle, Skeletal - pathology | Fatty Liver - etiology
Journal Article
Journal of Virology, ISSN 0022-538X, 09/2012, Volume 86, Issue 18, pp. 9888 - 9898
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
ANTIBODY-DEPENDENT ENHANCEMENT | VIROLOGY | IFN-ALPHA-BETA | DENDRITIC CELLS | INNATE IMMUNE-RESPONSES | NONHEMATOPOIETIC CELLS | SIGNALING PATHWAY | POSITIVE FEEDBACK | DENGUE VIRUS | HUMAN KERATINOCYTES | VIRAL-INFECTION | Interferon-alpha - pharmacology | Shock, Hemorrhagic - prevention & control | Humans | Adaptor Proteins, Vesicular Transport - deficiency | Adaptor Proteins, Vesicular Transport - genetics | Receptor, Interferon alpha-beta - physiology | Interferon Regulatory Factor-7 - genetics | Interferon Regulatory Factor-3 - genetics | Host-Pathogen Interactions - immunology | Alphavirus Infections - prevention & control | Interferon Regulatory Factor-7 - physiology | Chikungunya virus - physiology | Receptor, Interferon alpha-beta - genetics | Chikungunya virus - pathogenicity | Chikungunya Fever | Virus Replication - drug effects | Adaptor Proteins, Vesicular Transport - physiology | Interferon-alpha - biosynthesis | Receptor, Interferon alpha-beta - deficiency | Mice, Inbred C57BL | Myeloid Differentiation Factor 88 - genetics | Interferon-beta - biosynthesis | Alphavirus Infections - immunology | Chikungunya virus - immunology | Alphavirus Infections - pathology | Interferon Regulatory Factor-3 - physiology | Mice, Knockout | Animals | Interferon Regulatory Factor-3 - deficiency | Myeloid Differentiation Factor 88 - deficiency | Host-Pathogen Interactions - genetics | Interferon Regulatory Factor-7 - deficiency | Myeloid Differentiation Factor 88 - physiology | Mice | Shock, Hemorrhagic - immunology | Life Sciences | Santé publique et épidémiologie | Pathogenesis and Immunity
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 03/2008, Volume 452, Issue 7185, pp. 323 - 328
Journal Article
Hypertension, ISSN 0194-911X, 04/2014, Volume 63, Issue 4, pp. 713 - 722
Journal Article
Journal Article