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PLoS pathogens, ISSN 1553-7374, 2013, Volume 9, Issue 11, p. e1003773
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
Nature immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1237 - 1246
.... Cooperative binding with ELF4 increases the binding affinity of interferon regulatory factors IRF3 and IRF7, which is mediated by EICE elements... 
ETS TRANSCRIPTION FACTORS | NATURAL-KILLER | IMMUNE-RESPONSES | WEST-NILE-VIRUS | RIG-I | CYTOSOLIC DNA | INFECTION | IMMUNOLOGY | ADAPTER PROTEIN | CD8(+) T-CELLS | INNATE IMMUNITY | Interferon-beta - immunology | Humans | Immunoblotting | Interferon Regulatory Factor-7 - genetics | Transcriptional Activation - immunology | Interferon Regulatory Factor-3 - genetics | Host-Pathogen Interactions - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | RNA Interference | HEK293 Cells | Interferon-beta - genetics | Membrane Proteins - metabolism | Transcription Factors - immunology | Interferon Regulatory Factor-3 - immunology | Cell Line | West Nile Fever - virology | West Nile virus - physiology | DNA-Binding Proteins - immunology | West Nile Fever - immunology | West Nile virus - immunology | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Protein Binding - immunology | Reverse Transcriptase Polymerase Chain Reaction | Interferon Regulatory Factor-7 - metabolism | Mice, Knockout | Transcription Factors - metabolism | Microscopy, Confocal | Animals | Interferon-beta - metabolism | Survival Analysis | Interferon Regulatory Factor-3 - metabolism | Mice | HeLa Cells | Transcription factors | Immune response | Genetic aspects | Interferon | Host-virus relationships | Research | Properties | Identification and classification
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2011, Volume 286, Issue 6, pp. 4517 - 4524
Journal Article
Journal Article
American journal of physiology: endocrinology and metabolism, ISSN 0193-1849, 05/2013, Volume 305, Issue 4, pp. E485 - E495
.... In this study, we addressed the potential role of interferon regulatory factor 7 (IRF7), a master regulator of type I interferon-dependent immune responses, in the regulation of energy metabolism... 
Type 2 diabetes | Inflammation | Fatty liver | Adiposity | IMMUNITY | adiposity | PHYSIOLOGY | I-INTERFERON | POSITIVE FEEDBACK | fatty liver | MECHANISMS | INDUCTION | KINASE IKK-EPSILON | type 2 diabetes | inflammation | ENDOCRINOLOGY & METABOLISM | ENDOPLASMIC-RETICULUM | STRESS | ADIPOSE-TISSUE | Up-Regulation | Liver - pathology | Fatty Liver - pathology | Obesity - immunology | Diet, High-Fat - adverse effects | Male | Muscle, Skeletal - metabolism | Diabetes Mellitus, Type 2 - metabolism | Interferon Regulatory Factor-7 - genetics | Liver - immunology | Muscle, Skeletal - immunology | Diabetes Mellitus, Type 2 - immunology | Non-alcoholic Fatty Liver Disease | Diabetes Mellitus, Type 2 - etiology | Obesity - etiology | Weight Gain | Macrophages - immunology | Intra-Abdominal Fat - immunology | Fatty Liver - metabolism | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Random Allocation | Intra-Abdominal Fat - metabolism | Interferon Regulatory Factor-7 - metabolism | Mice, Knockout | Obesity - metabolism | Obesity - pathology | Animals | Interferon Regulatory Factor-7 - biosynthesis | Energy Metabolism | Endoplasmic Reticulum Stress | Fatty Liver - immunology | Mice, Obese | Mice | Diabetes Mellitus, Type 2 - pathology | Intra-Abdominal Fat - pathology | Muscle, Skeletal - pathology | Fatty Liver - etiology
Journal Article
eLife, ISSN 2050-084X, 2018, Volume 7, p. e34273
Type I interferon (IFN-I) responses are critical for the control of RNA virus infections, however, many viruses, including Dengue (DENV) and Chikungunya... 
IMMUNITY | INFLAMMATION | MACROPHAGES | BIOLOGY | RESISTANCE | ALPHA | MICE | SIGLEC-H | RNA VIRUSES | NF-KAPPA-B | I INTERFERON | Spleen - virology | Spleen - immunology | Dendritic Cells - immunology | Humans | Male | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Dengue - pathology | Interferon Regulatory Factor-3 - genetics | Host-Pathogen Interactions - immunology | RNA, Viral - antagonists & inhibitors | RNA, Viral - genetics | Dengue Virus - immunology | Dengue Virus - pathogenicity | Killer Cells, Natural - immunology | Female | Chikungunya Fever - genetics | Interferon-gamma - genetics | Dendritic Cells - virology | Dengue - immunology | Chikungunya virus - pathogenicity | Dengue - genetics | Disease Models, Animal | Interferon Regulatory Factor-3 - immunology | Signal Transduction | Killer Cells, Natural - virology | Mice, Inbred C57BL | Chikungunya Fever - immunology | Gene Expression Regulation | Interferon Regulatory Factor-7 - immunology | Chikungunya virus - growth & development | Chikungunya virus - immunology | Chikungunya Fever - mortality | Dengue Virus - growth & development | Mice, Knockout | Dengue - mortality | Animals | Interferon Regulatory Factor-3 - deficiency | Chikungunya Fever - pathology | Interferon Regulatory Factor-7 - deficiency | Interferon-gamma - immunology | Survival Analysis | Interferon Type I - genetics | RNA, Viral - immunology | Mice | Physiological aspects | Interferon | Chikungunya fever | Dendritic cells | Health aspects | Dengue | Life Sciences | Immunology
Journal Article