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Science, ISSN 0036-8075, 2014, Volume 343, Issue 6175, pp. 1119 - 1119
Journal Article
Nature Immunology, ISSN 1529-2908, 06/2013, Volume 14, Issue 6, pp. 593 - 602
We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and... 
IFN | MEMORY | CLONAL EXPANSION | STAT3 | PROLIFERATION | INFECTION | DIFFERENTIATION | IMMUNOLOGY | MODULATION | CUTTING EDGE | LYMPHOCYTES | Oligonucleotide Array Sequence Analysis | Suppressor of Cytokine Signaling 1 Protein | Immunoblotting | MicroRNAs - metabolism | Gene Expression Profiling | Interferon Regulatory Factor-7 - genetics | Interferons - immunology | Orthomyxoviridae - immunology | Orthomyxoviridae Infections - genetics | Signal Transduction - immunology | STAT1 Transcription Factor - metabolism | Flow Cytometry | RNA Interference | CD8-Positive T-Lymphocytes - metabolism | Gene Regulatory Networks - immunology | Immunologic Memory - genetics | Immunologic Memory - immunology | Gene Regulatory Networks - genetics | Interferons - pharmacology | Suppressor of Cytokine Signaling Proteins - immunology | Mice, Inbred C57BL | Suppressor of Cytokine Signaling Proteins - genetics | Interferon Regulatory Factor-7 - immunology | Signal Transduction - genetics | MicroRNAs - immunology | Reverse Transcriptase Polymerase Chain Reaction | STAT1 Transcription Factor - genetics | Interferon Regulatory Factor-7 - metabolism | STAT1 Transcription Factor - immunology | Mice, Knockout | Animals | Interferons - metabolism | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | Suppressor of Cytokine Signaling Proteins - metabolism | CD8-Positive T-Lymphocytes - immunology | Orthomyxoviridae Infections - virology | Orthomyxoviridae Infections - immunology | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2012, Volume 18, Issue 8, pp. 1224 - 1231
Breast cancer metastasis is a key determinant of long-term patient survival. By comparing the transcriptomes of primary and metastatic tumor cells in a mouse... 
MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENOMIC ANALYSIS | TUMORS | MAMMARY CARCINOMAS | CELL BIOLOGY | ADAPTIVE IMMUNITY | ZOLEDRONIC ACID | MOLECULAR PORTRAITS | I INTERFERONS | PROSTATE-CANCER | GENE-EXPRESSION | SUPPRESSOR-CELLS | Immunologic Surveillance | Mammary Neoplasms, Experimental - immunology | T-Lymphocyte Subsets - immunology | Interferon-alpha - pharmacology | Tumor Escape - genetics | Breast Neoplasms - immunology | Humans | Neoplasm Proteins - physiology | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Interferon Regulatory Factor-7 - genetics | Mammary Neoplasms, Experimental - genetics | Interferon Regulatory Factor-7 - physiology | Killer Cells, Natural - immunology | Female | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Recombinant Proteins - metabolism | Receptors, Interferon - deficiency | Gene Silencing | Severe Combined Immunodeficiency - immunology | Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics | Mice, SCID | Tumor Escape - physiology | Severe Combined Immunodeficiency - genetics | Animals | Breast Neoplasms - genetics | Interferon Regulatory Factor-7 - biosynthesis | Interferon Regulatory Factor-7 - antagonists & inhibitors | Interferon-Stimulated Gene Factor 3, gamma Subunit - physiology | Neoplasm Metastasis - physiopathology | Mice, Inbred NOD | Receptors, Interferon - physiology | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | Interferon-Stimulated Gene Factor 3, gamma Subunit - antagonists & inhibitors | Gene silencing | Care and treatment | Cancer cells | Development and progression | Bones | Breast cancer | Genetic aspects | Metastasis | Research | Human immunogenetics | Signal transduction | Bone cancer | Gene expression | Immune system | Index Medicus
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2016, Volume 17, Issue 3, pp. 241 - 249
The gene encoding PTEN is one of the most frequently mutated tumor suppressor-encoding genes in human cancer. While PTEN's function in tumor suppression is... 
TRANSCRIPTION FACTORS | NUCLEAR IMPORT | DOUBLE-STRANDED-RNA | DENDRITIC CELLS | NEGATIVE REGULATION | GENE INDUCTION | INTERFERON REGULATORY FACTOR-3 | TOLL-LIKE RECEPTORS | IMMUNOLOGY | PATTERN-RECOGNITION RECEPTORS | I INTERFERON | Phosphorylation | Cell Proliferation | Immunoprecipitation | Sendai virus | Dendritic Cells - immunology | Humans | Immunoblotting | Phosphatidylinositol 3-Kinases - metabolism | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | MCF-7 Cells | PTEN Phosphohydrolase - immunology | Mass Spectrometry | HEK293 Cells | Respirovirus Infections - immunology | Proto-Oncogene Proteins c-akt - metabolism | Macrophages - immunology | Cytokines - immunology | Interferon Regulatory Factor-3 - immunology | Cell Line | Gene Transfer Techniques | PTEN Phosphohydrolase - genetics | Mutagenesis, Site-Directed | Electrophoresis, Polyacrylamide Gel | Reverse Transcriptase Polymerase Chain Reaction | Immunity, Innate - immunology | Microscopy, Confocal | Vesiculovirus | Animals | Rhabdoviridae Infections - immunology | Fluorescent Antibody Technique | Cell Line, Tumor | Mice | Cell Nucleus | Transcription factors | Immune response | Tumor suppressor genes | Interferon | Genetic aspects | Regulation | Genetic transcription | Properties | Health aspects | Carcinogenesis | Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 11/2013, Volume 9, Issue 11, pp. e1003773 - e1003773
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Index Medicus | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Hypertension, ISSN 0194-911X, 04/2014, Volume 63, Issue 4, pp. 713 - 722
Journal Article
Nature, ISSN 0028-0836, 03/2008, Volume 452, Issue 7185, pp. 323 - 328
Journal Article
Nature Immunology, ISSN 1529-2908, 04/2013, Volume 14, Issue 4, pp. 346 - 355
The production of type I interferon is essential for viral clearance but is kept under tight control to avoid unnecessary tissue damage from hyperinflammatory... 
PLASMACYTOID DENDRITIC CELLS | SYNTHETASE GENE FAMILY | ANTIVIRAL RESPONSE | DOUBLE-STRANDED-RNA | ACTIVATION | IMMUNE-SYSTEM | 2',5'-OLIGOADENYLATE SYNTHETASE | 2'-5'-OLIGOADENYLATE SYNTHETASE | IMMUNOLOGY | NF-KAPPA-B | PATTERN-RECOGNITION RECEPTORS | Protein Biosynthesis | Poly I-C - administration & dosage | Humans | Molecular Sequence Data | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | RNA, Messenger - metabolism | Interferon Type I - biosynthesis | Base Sequence | Bone Marrow Cells - immunology | Protein Interaction Domains and Motifs | Nucleic Acid Conformation | Virus Diseases - genetics | Macrophages - immunology | 2',5'-Oligoadenylate Synthetase - metabolism | Cell Line | Poly I-C - pharmacology | Virus Diseases - immunology | Gene Expression Regulation | Encephalomyocarditis virus - immunology | Interferon Regulatory Factor-7 - metabolism | 2',5'-Oligoadenylate Synthetase - genetics | Mice, Knockout | Homozygote | Macrophages - metabolism | Animals | 5' Untranslated Regions | Protein Binding | Mice | Interferon Inducers - administration & dosage | Bone Marrow Cells - metabolism | Interferon Inducers - pharmacology | Virus diseases | Care and treatment | Immune response | Primers (Molecular genetics) | Ligases | Physiological aspects | Interferon | Genetic aspects | Research | Properties | Genetic translation | Index Medicus
Journal Article