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American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 05/2013, Volume 305, Issue 4, pp. E485 - E495
Obesity-related inflammation has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. In this study, we addressed the potential role... 
Type 2 diabetes | Inflammation | Fatty liver | Adiposity | IMMUNITY | adiposity | PHYSIOLOGY | I-INTERFERON | POSITIVE FEEDBACK | fatty liver | MECHANISMS | INDUCTION | KINASE IKK-EPSILON | type 2 diabetes | inflammation | ENDOCRINOLOGY & METABOLISM | ENDOPLASMIC-RETICULUM | STRESS | ADIPOSE-TISSUE | Up-Regulation | Liver - pathology | Fatty Liver - pathology | Obesity - immunology | Diet, High-Fat - adverse effects | Male | Muscle, Skeletal - metabolism | Diabetes Mellitus, Type 2 - metabolism | Interferon Regulatory Factor-7 - genetics | Liver - immunology | Muscle, Skeletal - immunology | Diabetes Mellitus, Type 2 - immunology | Non-alcoholic Fatty Liver Disease | Diabetes Mellitus, Type 2 - etiology | Obesity - etiology | Weight Gain | Macrophages - immunology | Intra-Abdominal Fat - immunology | Fatty Liver - metabolism | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Random Allocation | Intra-Abdominal Fat - metabolism | Interferon Regulatory Factor-7 - metabolism | Mice, Knockout | Obesity - metabolism | Obesity - pathology | Animals | Interferon Regulatory Factor-7 - biosynthesis | Energy Metabolism | Endoplasmic Reticulum Stress | Fatty Liver - immunology | Mice, Obese | Mice | Diabetes Mellitus, Type 2 - pathology | Intra-Abdominal Fat - pathology | Muscle, Skeletal - pathology | Fatty Liver - etiology | Obesity | Pathogenesis | Insulin resistance | Lipids | Interferon | Diabetes | Metabolism | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 2010, Volume 33, Issue 2, pp. 192 - 202
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2011, Volume 365, Issue 2, pp. 127 - 138
Monocytes and dendritic cells regulate adaptive and innate immunity. This study uncovers an association between mutations in the gene encoding interferon... 
RESPONSES | IMMUNITY | MEDICINE, GENERAL & INTERNAL | ICSBP | TUBERCULOSIS | MACROPHAGES | MOUSE | MICE | BINDING | REGULATORY FACTOR-8 | REVEALS | Dendritic Cells - immunology | Humans | Infant | Male | Interferon Regulatory Factors - deficiency | Mycobacterium Infections - immunology | BCG Vaccine - genetics | Genes, Dominant | Leukocytes, Mononuclear - immunology | Mycobacterium Infections - genetics | Adult | Female | Interleukin-12 - biosynthesis | Amino Acid Sequence | Interferon Regulatory Factors - genetics | Models, Molecular | Sequence Alignment | Animals | Antigen-Presenting Cells | Pedigree | Adolescent | BCG Vaccine - immunology | Immunologic Deficiency Syndromes - genetics | Protein Conformation | Mutation | Care and treatment | Gene mutations | Human genome | Immunological deficiency syndromes | Genetic aspects | Interferon | Diagnosis | Research | Transcription factors | Severe combined immunodeficiency | Disease | Transcription | Disseminated infection | Families & family life | Stem cell transplantation | Leukocytes (mononuclear) | Infections | Cell adhesion & migration | Phagocytes | Parents & parenting | Granulocytes | Lymphocytes | Genetic analysis | Combined vaccines | Children | Age | Deoxyribonucleic acid--DNA | Medical research | CD11c antigen | Cytokines | Dendritic cells | BCG | Grants | Hemopoiesis | CD1c antigen | Monocytes | Councils | Antibiotics | Biopsy | Interferon regulatory factor | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 10/2012, Volume 490, Issue 7421, pp. 502 - 507
The AP1 transcription factor Batf3 is required for homeostatic development of CD8 alpha(+) classical dendritic cells that prime CD8 T-cell responses against... 
INTERFERON-REGULATORY FACTOR-4 | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TRANSCRIPTION | CLASS-SWITCH RECOMBINATION | CD8-ALPHA(+) | INFECTION | EXPRESSION | T-CELLS | NEGATIVE REGULATOR | B-ATF | Toxoplasma - immunology | Neoplasm Transplantation | Basic-Leucine Zipper Transcription Factors - metabolism | Dendritic Cells - immunology | Leucine Zippers | Interferon Regulatory Factors - metabolism | Fibrosarcoma - immunology | Male | Fibrosarcoma - metabolism | Interferon Regulatory Factors - deficiency | Antigens, CD - metabolism | CD4-Positive T-Lymphocytes - immunology | Fibrosarcoma - pathology | Antigen Presentation | Repressor Proteins - deficiency | Basic-Leucine Zipper Transcription Factors - deficiency | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - cytology | Interleukin-10 - metabolism | Female | Cell Differentiation | Dendritic Cells - metabolism | Protein Structure, Tertiary | T-Lymphocytes, Helper-Inducer - metabolism | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Gene Expression Regulation | CTLA-4 Antigen - metabolism | Interferon Regulatory Factors - genetics | Repressor Proteins - genetics | Integrin alpha Chains - metabolism | Interleukin-12 - metabolism | Basic-Leucine Zipper Transcription Factors - genetics | CD8 Antigens - immunology | Cell Lineage | CD8 Antigens - metabolism | Animals | Basic-Leucine Zipper Transcription Factors - chemistry | Interleukin-12 - immunology | Cell Line, Tumor | Protein Binding | Dendritic Cells - cytology | Mice | Oncogene Protein p65(gag-jun) - metabolism | Physiological aspects | Transcription factors | Research | Cell development (Biology) | Dendritic cells | T cells | Proteins | Medical research | Immunology | Rodents | Immune system | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 10/2012, Volume 490, Issue 7421, pp. 543 - 546
Interferon regulatory factor 4 (IRF4) is an IRF family transcription factor with critical roles in lymphoid development and in regulating the immune... 
TERNARY COMPLEX | ACTIVATION | INTERFERON-REGULATORY FACTOR-4 | FACTOR PU.1 | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | DIFFERENTIATION | IL-21 | MODULATION | B-ATF | Up-Regulation | Basic-Leucine Zipper Transcription Factors - metabolism | Interferon Regulatory Factors - metabolism | Molecular Sequence Data | Male | Interferon Regulatory Factors - deficiency | Transcription Factor AP-1 - metabolism | Nucleotide Motifs | Basic-Leucine Zipper Transcription Factors - deficiency | Base Sequence | Interleukins - immunology | Female | Th17 Cells - cytology | Transcription, Genetic | Cell Differentiation | Binding Sites | B-Lymphocytes - metabolism | Proto-Oncogene Proteins - metabolism | Signal Transduction | Lymphocyte Activation | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Interferon Regulatory Factors - genetics | Basic-Leucine Zipper Transcription Factors - genetics | Amino Acid Motifs | Animals | Proto-Oncogene Proteins c-jun - metabolism | Interleukin-10 - genetics | Th17 Cells - immunology | Trans-Activators - metabolism | Mice | Transcription factors | Interferon | Research | Genetic regulation | Properties | T cells | Protein binding | Proteins | Genetic engineering | Gene expression | Lymphocytes | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 11/2013, Volume 39, Issue 5, pp. 833 - 845
Upon infection, CD8 T cells undergo a stepwise process of early activation, expansion, and differentiation into effector cells. How these phases are... 
RESPONSES | ACTIVATION | VIRUS | IRF4 | TRANSCRIPTION | INFECTION | IMMUNOLOGY | NF-KAPPA-B | EXPRESSION | MTOR | ANTIGEN | CD8-Positive T-Lymphocytes - cytology | Cells, Cultured - cytology | Coculture Techniques | Dendritic Cells - immunology | T-Box Domain Proteins - biosynthesis | Interferon Regulatory Factors - deficiency | Bcl-2-Like Protein 11 | Interferon Regulatory Factors - physiology | Receptors, Antigen, T-Cell - immunology | TOR Serine-Threonine Kinases - physiology | Cell Differentiation | Proto-Oncogene Proteins - antagonists & inhibitors | Specific Pathogen-Free Organisms | Lymphocyte Activation | Mice, Inbred C57BL | Gene Expression Regulation | Interferon Regulatory Factors - genetics | Viral Plaque Assay | Mice, Transgenic | Transcription Factors - biosynthesis | Transcription Factors - genetics | T-Box Domain Proteins - genetics | Interferon Regulatory Factors - immunology | Animals | Membrane Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Mice | Orthomyxoviridae Infections - virology | Orthomyxoviridae Infections - immunology | Apoptosis | Cyclin-Dependent Kinase Inhibitor Proteins - antagonists & inhibitors | Positive Regulatory Domain I-Binding Factor 1 | Transcription factors | Peptides | Lymphocytes | Rodents | T cell receptors | Infections | Expansion | Immune system | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2013, Volume 110, Issue 37, pp. 15019 - 15024
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2013, Volume 123, Issue 11, pp. 4641 - 4653
T helper 9 (Th9) cells are specialized for the production of IL-9, promote allergic inflammation in mice, and are associated with allergic disease in humans.... 
LINEAGE COMMITMENT | MEDICINE, RESEARCH & EXPERIMENTAL | HOMEOSTASIS | ACTIVATOR | DIFFERENTIATION | INDUCTION | RECEPTORS | PU.1 | EXPRESSION | T-HELPER-CELLS | PLASTICITY | T-Lymphocyte Subsets - immunology | Basic-Leucine Zipper Transcription Factors - metabolism | Oligonucleotide Array Sequence Analysis | Humans | Interferon Regulatory Factors - metabolism | Hypersensitivity - immunology | Infant | Adoptive Transfer | Interferon Regulatory Factors - deficiency | Interleukin-9 - biosynthesis | Inflammation - metabolism | Hypersensitivity - metabolism | Basic-Leucine Zipper Transcription Factors - deficiency | Hypersensitivity - etiology | T-Lymphocytes, Helper-Inducer - immunology | Hypersensitivity, Immediate - immunology | T-Lymphocyte Subsets - classification | Transcription, Genetic | Cell Lineage - genetics | T-Lymphocytes, Helper-Inducer - metabolism | T-Lymphocytes, Helper-Inducer - classification | Mice, Inbred C57BL | Hypersensitivity, Immediate - genetics | Interferon Regulatory Factors - genetics | Mice, Transgenic | Inflammation - immunology | Basic-Leucine Zipper Transcription Factors - genetics | Inflammation - etiology | Mice, Knockout | Animals | Hypersensitivity, Immediate - metabolism | Interleukin-9 - genetics | T-Lymphocyte Subsets - metabolism | Mice | Mice, Inbred BALB C | Cell Lineage - immunology | Transcription factors | Physiological aspects | Development and progression | Inflammation | Genetic aspects | Research | T cells | Genotype & phenotype | Gene expression | Lymphocytes | Cell adhesion & migration | Index Medicus | Abridged Index Medicus
Journal Article