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index medicus (444) 444
humans (438) 438
interferon-induced helicase, ifih1 (399) 399
dead-box rna helicases - genetics (259) 259
animals (234) 234
rig-i (221) 221
dead-box rna helicases - metabolism (218) 218
immunology (177) 177
dead box protein 58 (168) 168
interferon (159) 159
viruses (151) 151
innate immunity (143) 143
mice (141) 141
double-stranded-rna (131) 131
female (121) 121
male (114) 114
signal transduction (110) 110
recognition (107) 107
rna (105) 105
cell line (100) 100
nf-kappa-b (98) 98
dead-box rna helicases - immunology (94) 94
activation (93) 93
immunity, innate (88) 88
mda5 (88) 88
virology (83) 83
virus diseases (80) 80
interferon-induced helicase, ifih1 - genetics (79) 79
genetic aspects (78) 78
cell biology (75) 75
biochemistry & molecular biology (74) 74
cells, cultured (72) 72
health aspects (72) 72
proteins (70) 70
biological response modifiers (69) 69
gene expression (69) 69
article (68) 68
adult (65) 65
melanoma (64) 64
research (61) 61
genes (59) 59
interferon-induced helicase, ifih1 - metabolism (58) 58
rna, double-stranded - metabolism (58) 58
expression (57) 57
interferon-beta - genetics (57) 57
research article (56) 56
antiviral responses (55) 55
poly i-c - pharmacology (55) 55
toll-like receptors (54) 54
infections (53) 53
mice, knockout (53) 53
middle aged (53) 53
hek293 cells (52) 52
toll-like receptor 3 - genetics (51) 51
adapter protein (50) 50
genetic predisposition to disease (50) 50
multidisciplinary sciences (50) 50
immune system (49) 49
inflammation (49) 49
ifih1 (48) 48
mice, inbred c57bl (47) 47
rna, viral - metabolism (47) 47
gene expression regulation (46) 46
toll-like receptor 3 - metabolism (46) 46
infection (45) 45
virus (45) 45
analysis (44) 44
immune response (44) 44
rna helicases - metabolism (44) 44
toll-like receptor-3 (44) 44
adaptor proteins, signal transducing - metabolism (43) 43
physiological aspects (43) 43
ribonucleic acid--rna (43) 43
apoptosis (42) 42
cells (42) 42
diabetes mellitus, type 1 - genetics (42) 42
rna, viral - genetics (42) 42
viral infections (41) 41
autoimmunity (40) 40
cytokines (40) 40
dendritic cells (40) 40
responses (40) 40
abridged index medicus (39) 39
biology (39) 39
inducible gene-i (39) 39
interferon-beta - metabolism (39) 39
microbiology (39) 39
mutation (39) 39
polymorphism, single nucleotide (39) 39
protein binding (39) 39
signal transduction - immunology (39) 39
biochemical phenomena, metabolism, and nutrition (38) 38
disease (37) 37
genotype (37) 37
rna helicases - genetics (37) 37
rna, viral - immunology (37) 37
genetics & heredity (36) 36
genome-wide association (36) 36
host-pathogen interactions (36) 36
induction (36) 36
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Journal Article
Nature Immunology, ISSN 1529-2908, 06/2017, Volume 18, Issue 7, pp. 744 - 752
The single-nucleotide polymorphism rs1990760 in the gene encoding the cytosolic viral sensor IFIH1 results in an amino-acid change (A946T; IFIH1(T946)) that is... 
GENE 5 | HEPATITIS-C VIRUS | RECOGNITION | ROLES | SUSCEPTIBILITY | RIG-I | OF-FUNCTION MUTATIONS | IMMUNOLOGY | ASSOCIATION | IFN-ALPHA | MDA5 | Blotting, Southern | Cardiovirus Infections - genetics | Interferon-Induced Helicase, IFIH1 - genetics | Humans | Middle Aged | Diabetes Mellitus, Experimental - genetics | Autoimmunity - genetics | Immunoblotting | Male | Interferon Type I - immunology | Autoimmune Diseases - genetics | Young Adult | Autoimmunity - immunology | HEK293 Cells | Adult | Female | Diabetes Mellitus, Type 1 - immunology | Virus Diseases - genetics | Real-Time Polymerase Chain Reaction | Genetic Predisposition to Disease | Virus Diseases - immunology | Autoimmune Diseases - immunology | Diabetes Mellitus, Type 1 - genetics | Encephalomyocarditis virus - immunology | Reverse Transcriptase Polymerase Chain Reaction | Cardiovirus Infections - immunology | Interferon-Induced Helicase, IFIH1 - immunology | Diabetes Mellitus, Experimental - immunology | Animals | Adolescent | Mice | Polymorphism, Single Nucleotide | Virus diseases | Autoimmunity | Research | Risk factors | Genetic polymorphisms | Biotechnology | Animal models | Pathogenesis | Risk | Amino acids | Leukocytes (mononuclear) | Infections | Single-nucleotide polymorphism | Ribonucleic acid--RNA | Gene polymorphism | Embryos | Human populations | Rodents | Cell lines | Peripheral blood mononuclear cells | Ligands | Interferon | Mutation | Autoimmune diseases | Combinatorial analysis | Polymorphism
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2017, Volume 114, Issue 31, pp. 8342 - 8347
Journal Article
Cell, ISSN 0092-8674, 02/2018, Volume 172, Issue 4, pp. 811 - 824.e14
Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how sensors differentiate self from nonself nucleic acids, such... 
type I interferon | neuronal progenitor cells | RNA editing | innate immunity | PKR | Aicardi-Goutieres syndrome | Alu elements | translation | AGS | ADAR1 | MDA5 | INTERFERON | COMPLEX | INHIBITION | PROTEIN-KINASE PKR | LANDSCAPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING | CELL BIOLOGY | Inflammation - pathology | RNA-Binding Proteins - genetics | Interferon-Induced Helicase, IFIH1 - genetics | Protein Biosynthesis | Nervous System Malformations - immunology | Adenosine Deaminase - metabolism | eIF-2 Kinase - metabolism | Humans | Cell Death - immunology | eIF-2 Kinase - immunology | RNA Polymerase II - metabolism | Neural Stem Cells - cytology | RNA Polymerase II - immunology | Inflammation - metabolism | Neural Stem Cells - immunology | Cell Death - genetics | Nervous System Malformations - metabolism | Autoimmune Diseases of the Nervous System - genetics | HEK293 Cells | RNA, Double-Stranded - metabolism | Autoimmune Diseases of the Nervous System - metabolism | Nervous System Malformations - genetics | eIF-2 Kinase - genetics | Adenosine Deaminase - genetics | RNA-Binding Proteins - immunology | Interferon-Induced Helicase, IFIH1 - metabolism | Inflammation - immunology | Gene Knockout Techniques | Interferon-Induced Helicase, IFIH1 - immunology | Neural Stem Cells - pathology | Autoimmune Diseases of the Nervous System - immunology | RNA, Double-Stranded - genetics | RNA, Double-Stranded - immunology | Inflammation - genetics | RNA Polymerase II - genetics | Alu Elements | Neural Stem Cells - metabolism | Adenosine Deaminase - immunology | RNA-Binding Proteins - metabolism | Prevention | Enzymes | Medical colleges | Messenger RNA | Microbiology | Neurons | Cell death | Communicable diseases | Interferon | Sensors | Biological response modifiers
Journal Article
Journal Article
American Journal of Medical Genetics Part A, ISSN 1552-4825, 05/2017, Volume 173, Issue 5, pp. 1396 - 1399
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2016, Volume 6, Issue 1, p. 39378
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2017, Volume 12, Issue 2, p. e0171193
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2016, Volume 62, Issue 4, pp. 586 - 602
RIG-I and MDA5 sense virus-derived short 5′ppp blunt-ended or long dsRNA, respectively, causing interferon production. Non-signaling LGP2 appears to positively... 
ASSEMBLES | RNA HELICASE LGP2 | DETERMINANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FILAMENT | CHICKEN | RIG-I | SIGNAL-ACTIVATION | INNATE IMMUNE SENSOR | PARAMYXOVIRUS V PROTEINS | INSIGHTS | CELL BIOLOGY | Interferon-Induced Helicase, IFIH1 - chemistry | RNA-Binding Proteins - genetics | DEAD Box Protein 58 - metabolism | Interferon-Induced Helicase, IFIH1 - genetics | Humans | Structure-Activity Relationship | Avian Proteins - chemistry | Receptors, Pattern Recognition - metabolism | Transfection | DEAD Box Protein 58 - genetics | Adenosine Triphosphate - metabolism | Protein Interaction Domains and Motifs | RNA, Double-Stranded - metabolism | Nucleic Acid Conformation | Binding Sites | RNA, Double-Stranded - chemistry | Cell Line | DEAD Box Protein 58 - chemistry | Avian Proteins - metabolism | Receptors, Pattern Recognition - chemistry | RNA-Binding Proteins - chemistry | Adenosine Triphosphatases - metabolism | Interferon-Induced Helicase, IFIH1 - metabolism | Models, Molecular | Hydrolysis | Animals | Chickens | RNA, Double-Stranded - genetics | Protein Binding | Receptors, Pattern Recognition - genetics | Adenosine Triphosphatases - chemistry | Adenosine Triphosphatases - genetics | Adenosine Diphosphate - metabolism | RNA-Binding Proteins - metabolism | Avian Proteins - genetics | Oligomers | RNA | Crystals | Interferon | Structure | Biological response modifiers | Molecular biology | Life Sciences | Immunology
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2017, Volume 214, Issue 7, pp. 1949 - 1972
Journal Article
American Journal of Medical Genetics Part A, ISSN 1552-4825, 05/2016, Volume 170, Issue 5, pp. 1317 - 1324