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health aspects (75) 75
proteins (74) 74
autoantibodies (71) 71
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genetic aspects (70) 70
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abridged index medicus (67) 67
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cell biology (62) 62
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Nature Immunology, ISSN 1529-2908, 06/2017, Volume 18, Issue 7, pp. 744 - 752
The single-nucleotide polymorphism rs1990760 in the gene encoding the cytosolic viral sensor IFIH1 results in an amino-acid change (A946T; IFIH1(T946)) that is... 
GENE 5 | HEPATITIS-C VIRUS | RECOGNITION | ROLES | SUSCEPTIBILITY | RIG-I | OF-FUNCTION MUTATIONS | IMMUNOLOGY | ASSOCIATION | IFN-ALPHA | MDA5 | Blotting, Southern | Cardiovirus Infections - genetics | Interferon-Induced Helicase, IFIH1 - genetics | Humans | Middle Aged | Diabetes Mellitus, Experimental - genetics | Autoimmunity - genetics | Immunoblotting | Male | Interferon Type I - immunology | Autoimmune Diseases - genetics | Young Adult | Autoimmunity - immunology | HEK293 Cells | Adult | Female | Diabetes Mellitus, Type 1 - immunology | Virus Diseases - genetics | Real-Time Polymerase Chain Reaction | Genetic Predisposition to Disease | Virus Diseases - immunology | Autoimmune Diseases - immunology | Diabetes Mellitus, Type 1 - genetics | Encephalomyocarditis virus - immunology | Reverse Transcriptase Polymerase Chain Reaction | Cardiovirus Infections - immunology | Interferon-Induced Helicase, IFIH1 - immunology | Diabetes Mellitus, Experimental - immunology | Animals | Adolescent | Mice | Polymorphism, Single Nucleotide | Virus diseases | Autoimmunity | Research | Risk factors | Genetic polymorphisms | Biotechnology | Animal models | Pathogenesis | Risk | Amino acids | Leukocytes (mononuclear) | Infections | Single-nucleotide polymorphism | Ribonucleic acid--RNA | Gene polymorphism | Embryos | Human populations | Rodents | Cell lines | Peripheral blood mononuclear cells | Ligands | Interferon | Mutation | Autoimmune diseases | Combinatorial analysis | Polymorphism | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, pp. e0154285 - e0154285
Objective Autoantibodies to melanoma differentiation-associated gene 5 (MDA5) are specifically expressed in patients with dermatomyositis (DM) and are... 
INTERSTITIAL LUNG-DISEASE | AMYOPATHIC DERMATOMYOSITIS | ANTI-MDA5 | MULTIDISCIPLINARY SCIENCES | CADM-140 | AUTOANTIGEN | SPECTRUM | JAPANESE PATIENTS | ANTI-CADM-140 ANTIBODY | CLASSIFICATION CRITERIA | MYOSITIS | Interferon-Induced Helicase, IFIH1 - genetics | Immunoprecipitation | Dermatomyositis - blood | Autoantibodies - blood | Humans | Middle Aged | Idiopathic Interstitial Pneumonias - diagnosis | Idiopathic Interstitial Pneumonias - blood | Male | Case-Control Studies | Enzyme-Linked Immunosorbent Assay - standards | Dermatomyositis - immunology | Interferon-Induced Helicase, IFIH1 - antagonists & inhibitors | Sensitivity and Specificity | Polymyositis - diagnosis | Adult | Female | Polymyositis - immunology | Diagnosis, Differential | Gene Expression | Connective Tissue Diseases - diagnosis | Dermatomyositis - diagnosis | Interferon-Induced Helicase, IFIH1 - immunology | Connective Tissue Diseases - immunology | Polymyositis - blood | Aged | Connective Tissue Diseases - blood | Idiopathic Interstitial Pneumonias - immunology | Care and treatment | Autoantibodies | Health aspects | Enzyme-linked immunosorbent assay | Methods | Dermatomyositis | Pneumonia | Laboratories | Lung | Antibodies | Arthritis | Assaying | Proteins | Connective tissues | Immunology | Classification | Scleroderma | Lupus | Antigens | Enzymes | Immunoglobulins | Sensitivity analysis | Internal medicine | Dermatology | Lung diseases | Melanoma | Rheumatology | Disease control | Patients | Fever | Medicine | Medical centres | Polymyositis | Medical prognosis | Differentiation | Index Medicus
Journal Article
Journal of Virology, ISSN 0022-538X, 06/2017, Volume 91, Issue 11
Journal Article
Journal of Rheumatology, ISSN 0315-162X, 03/2017, Volume 44, Issue 3, pp. 319 - 325
Journal Article
by Deakin, Claire T and Yasin, Shireena A and Simou, Stefania and Arnold, Katie A and Tansley, Sarah L and Betteridge, Zoe E and McHugh, Neil J and Varsani, Hemlata and Holton, Janice L and Jacques, Thomas S and Pilkington, Clarissa A and Nistala, Kiran and Wedderburn, Lucy R and Armon, Kate and Ellis‐Gage, Joe and Roper, Holly and Briggs, Vanja and Watts, Joanna and McCann, Liza and Roberts, Ian and Baildam, Eileen and Hanna, Louise and Lloyd, Olivia and Wadeson, Susan and Riley, Phil and McGovern, Ann and Ryder, Clive and Scott, Janis and Thomas, Beverley and Southwood, Taunton and Al‐Abadi, Eslam and Wyatt, Sue and Jackson, Gillian and Amin, Tania and Wood, Mark and VanRooyen, Vanessa and Burton, Deborah and Davidson, Joyce and Gardner‐Medwin, Janet and Martin, Neil and Ferguson, Sue and Waxman, Liz and Browne, Michael and Friswell, Mark and Swift, Alison and Jandial, Sharmila and Stevenson, Vicky and Wade, Debbie and Sen, Ethan and Smith, Eve and Qiao, Lisa and Watson, Stuart and Duong, Claire and Venning, Helen and Satyapal, Rangaraj and Stretton, Elizabeth and Jordan, Mary and Mosley, Ellen and Frost, Anna and Crate, Lindsay and Warrier, Kishore and Stafford, Stefanie and Hasson, Nathan and Maillard, Sue and Halkon, Elizabeth and Brown, Virginia and Juggins, Audrey and Smith, Sally and Lunt, Sian and Enayat, Elli and Kassoumeri, Laura and Beard, Laura and Glackin, Yvonne and Almeida, Beverley and Marques, Raquel and Dowle, Stefanie and Papadopoulou, Charis and Murray, Kevin and Ioannou, John and Suffield, Linda and Al‐Obaidi, Muthana and Lee, Helen and Leach, Sam and Smith, Helen and McMahon, Anne‐Marie and Chisem, Heather and Kingshott, Ruth and Wilkinson, Nick and Inness, Emma and Kendall, Eunice and Mayers, David and Etherton, Ruth and Bailey, Kathryn and Clinch, Jacqui and Fineman, Natalie and Pluess‐Hall, Helen and Vallance, Lindsay and Akeroyd, Louise and Leahy, Alice and Collier, Amy and ... and UK Juvenile Dermatomyositis Res and UK Juvenile Dermatomyositis Research Group
Arthritis & Rheumatology, ISSN 2326-5191, 11/2016, Volume 68, Issue 11, pp. 2806 - 2816
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 12/2017, Volume 494, Issue 1-2, pp. 227 - 233
Laboratory of genetics and physiology 2 (LGP2) and melanoma differentiation-associated gene 5 (MDA5) cooperatively detect viral RNA in the cytoplasm of... 
Picornavirus | Cardiovirus | PACT | RIG-I-like receptors | LGP2 | Type-I interferon | MDA5 | HELICASE LGP2 | VIRUS | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RIG-I | Picomavirus | DICER | RNA-BINDING-PROTEIN | ANTIVIRAL RESPONSES | BIOPHYSICS | MUTATIONS | ADAPTER PROTEIN | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Cardiovirus Infections - genetics | Cardiovirus Infections - virology | Interferon-Induced Helicase, IFIH1 - genetics | Encephalomyocarditis virus - genetics | Humans | Immunity, Innate - genetics | Cercopithecus aethiops | Gene Knockdown Techniques | Host-Pathogen Interactions - immunology | RNA, Viral - genetics | DEAD-box RNA Helicases - antagonists & inhibitors | Ribonuclease III - immunology | HEK293 Cells | Interferon-beta - genetics | RNA Helicases - genetics | Vero Cells | RNA-Binding Proteins - antagonists & inhibitors | Cell Line | Promoter Regions, Genetic | Ribonuclease III - genetics | RNA-Binding Proteins - immunology | Recombinant Proteins - genetics | Encephalomyocarditis virus - immunology | Ribonuclease III - antagonists & inhibitors | Cardiovirus Infections - immunology | Interferon-Induced Helicase, IFIH1 - immunology | DEAD-box RNA Helicases - genetics | Animals | Host-Pathogen Interactions - genetics | Recombinant Proteins - immunology | DEAD-box RNA Helicases - immunology | RNA, Viral - immunology | Mice | RNA Helicases - immunology | Encephalitis | RNA | Analysis | Genomics | Melanoma | Physiological aspects | Interferon | Biological response modifiers | Health aspects | Recombinant proteins | Protein binding | Index Medicus
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 11/2017, Volume 21, Issue 11, pp. 3087 - 3099
Interleukin ( IL )‐6‐type cytokines have no direct antiviral activity; nevertheless, they display immune‐modulatory functions. Oncostatin M ( OSM ), a member... 
RIG | STAT | oncostatin M | xD/H‐Box | RNA | innate immunity | helicase | RIG-I | DExD/H-Box RNA helicase | STAT1 | MEDICINE, RESEARCH & EXPERIMENTAL | ANTIVIRAL CYTOKINES | STAT1 SERINE PHOSPHORYLATION | VIRUS-INDUCED EXPRESSION | CELL BIOLOGY | SIGNAL-TRANSDUCTION | TUMOR-NECROSIS-FACTOR | GINGIVAL FIBROBLASTS | INTERFERON-GAMMA | INDUCIBLE GENE-I | M RECEPTOR | INTERLEUKIN-6-TYPE CYTOKINES | Leukemia Inhibitory Factor Receptor alpha Subunit - immunology | RNA, Small Interfering - genetics | Interferon-Induced Helicase, IFIH1 - genetics | Skin - cytology | Skin - metabolism | Humans | Interferon Regulatory Factor-7 - genetics | Lung - cytology | Oncostatin M - pharmacology | DEAD Box Protein 58 - genetics | Interferon-Induced Helicase, IFIH1 - antagonists & inhibitors | Lung - metabolism | Osteoblasts - cytology | Suppressor of Cytokine Signaling 3 Protein - immunology | STAT3 Transcription Factor - genetics | Fibroblasts - metabolism | DEAD Box Protein 58 - antagonists & inhibitors | Signal Transduction | Interferon Regulatory Factor-1 - immunology | Osteoblasts - drug effects | Gene Expression Regulation | Interferon Regulatory Factor-7 - immunology | Suppressor of Cytokine Signaling 3 Protein - genetics | Immunity, Innate | Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics | Leukemia Inhibitory Factor - pharmacology | STAT1 Transcription Factor - genetics | Interferon-Induced Helicase, IFIH1 - immunology | STAT1 Transcription Factor - immunology | Interferon Regulatory Factor-1 - genetics | Leukemia Inhibitory Factor Receptor alpha Subunit - genetics | DEAD Box Protein 58 - immunology | Interleukin-6 - pharmacology | Fibroblasts - drug effects | Lung - drug effects | Interferon-Stimulated Gene Factor 3, gamma Subunit - immunology | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Fibroblasts - cytology | Primary Cell Culture | STAT3 Transcription Factor - immunology | Osteoblasts - metabolism | Interferon-gamma - pharmacology | Skin - drug effects | RNA, Small Interfering - metabolism | Ubiquitin | Tyrosine | Antigens | Phosphatases | Leukemia | Melanoma | Interferon | DNA binding proteins | Biological response modifiers | Tretinoin | Phosphorylation | Transcription factors | Serine | Interleukin | Antigen processing | PML protein | Viruses | Interferon regulatory factor 1 | Synergism | Interleukin 6 | DNA helicase | SUMO protein | Receptors | Antiviral activity | Fibroblasts | Pretreatment | Stat1 protein | Antigen presentation | Cytokines | Immunomodulation | Double-stranded RNA | Stat3 protein | Oncostatin M | Gene expression | Ribonucleic acid--RNA | Immune systems | Interferon regulatory factor 7 | Signaling | Retinoic acid | Interferon regulatory factor | Protein-tyrosine-phosphatase | PTPN2 protein | Index Medicus | RIG‐I | DExD | H‐Box RNA helicase | Original
Journal Article
RNA, ISSN 1355-8382, 06/2019, Volume 25, Issue 6, pp. 713 - 726
Viral and cellular double-stranded RNA (dsRNA) is recognized by cytosolic innate immune sensors, including RIG-I-like receptors. Some cytoplasmic dsRNA is... 
ANTIBODIES | SUPPRESSOR | DOUBLE-STRANDED-RNA | SYSTEMIC-LUPUS-ERYTHEMATOSUS | RNase L | BIOCHEMISTRY & MOLECULAR BIOLOGY | RIG-I | IDENTIFICATION | TRANSLATION | ADAR1 | p53 | mitochondrial dsRNA | innate immunity | INFECTION | EXPRESSION | Endoribonucleases - genetics | Interferon-Induced Helicase, IFIH1 - genetics | RNA, Mitochondrial - immunology | Embryo, Mammalian | Immunity, Innate - genetics | Interferon Regulatory Factor-7 - genetics | Tumor Suppressor Protein p53 - genetics | Transfection | DEAD Box Protein 58 - genetics | Transcription, Genetic | Adenosine Deaminase - deficiency | Carrier Proteins - immunology | Adenosine Deaminase - genetics | Mice, Inbred C57BL | RNA, Mitochondrial - genetics | Interferon Regulatory Factor-7 - immunology | Tumor Suppressor Protein p53 - immunology | Tumor Suppressor Protein p53 - deficiency | Interferon-Induced Helicase, IFIH1 - immunology | Proteins - immunology | Mice, Knockout | Proteins - genetics | Carrier Proteins - genetics | DEAD Box Protein 58 - immunology | Animals | RNA, Double-Stranded - genetics | RNA, Double-Stranded - immunology | Fibroblasts - immunology | Fibroblasts - cytology | Mice | Adenosine Deaminase - immunology | Endoribonucleases - immunology | Immune response | Transcription | p53 Protein | Double-stranded RNA | Innate immunity | Embryo fibroblasts | Mitochondrial DNA | Interferon | Inflammation | Embryos | Ribonuclease L
Journal Article