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interferon-induced helicase, ifih1 - genetics (51) 51
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Cell, ISSN 0092-8674, 02/2018, Volume 172, Issue 4, pp. 811 - 824.e14
Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how sensors differentiate self from nonself nucleic acids, such... 
type I interferon | neuronal progenitor cells | RNA editing | innate immunity | PKR | Aicardi-Goutieres syndrome | Alu elements | translation | AGS | ADAR1 | MDA5 | INTERFERON | COMPLEX | INHIBITION | PROTEIN-KINASE PKR | LANDSCAPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING | CELL BIOLOGY | Inflammation - pathology | RNA-Binding Proteins - genetics | Interferon-Induced Helicase, IFIH1 - genetics | Protein Biosynthesis | Nervous System Malformations - immunology | Adenosine Deaminase - metabolism | eIF-2 Kinase - metabolism | Humans | Cell Death - immunology | eIF-2 Kinase - immunology | RNA Polymerase II - metabolism | Neural Stem Cells - cytology | RNA Polymerase II - immunology | Inflammation - metabolism | Neural Stem Cells - immunology | Cell Death - genetics | Nervous System Malformations - metabolism | Autoimmune Diseases of the Nervous System - genetics | HEK293 Cells | RNA, Double-Stranded - metabolism | Autoimmune Diseases of the Nervous System - metabolism | Nervous System Malformations - genetics | eIF-2 Kinase - genetics | Adenosine Deaminase - genetics | RNA-Binding Proteins - immunology | Interferon-Induced Helicase, IFIH1 - metabolism | Inflammation - immunology | Gene Knockout Techniques | Interferon-Induced Helicase, IFIH1 - immunology | Neural Stem Cells - pathology | Autoimmune Diseases of the Nervous System - immunology | RNA, Double-Stranded - genetics | RNA, Double-Stranded - immunology | Inflammation - genetics | RNA Polymerase II - genetics | Alu Elements | Neural Stem Cells - metabolism | Adenosine Deaminase - immunology | RNA-Binding Proteins - metabolism | Prevention | Enzymes | Medical colleges | Messenger RNA | Microbiology | Neurons | Cell death | Communicable diseases | Interferon | Sensors | Biological response modifiers
Journal Article
eLife, ISSN 2050-084X, 03/2016, Volume 5, Issue 2016, p. e11275
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2016, Volume 62, Issue 4, pp. 586 - 602
RIG-I and MDA5 sense virus-derived short 5′ppp blunt-ended or long dsRNA, respectively, causing interferon production. Non-signaling LGP2 appears to positively... 
ASSEMBLES | RNA HELICASE LGP2 | DETERMINANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FILAMENT | CHICKEN | RIG-I | SIGNAL-ACTIVATION | INNATE IMMUNE SENSOR | PARAMYXOVIRUS V PROTEINS | INSIGHTS | CELL BIOLOGY | Interferon-Induced Helicase, IFIH1 - chemistry | RNA-Binding Proteins - genetics | DEAD Box Protein 58 - metabolism | Interferon-Induced Helicase, IFIH1 - genetics | Humans | Structure-Activity Relationship | Avian Proteins - chemistry | Receptors, Pattern Recognition - metabolism | Transfection | DEAD Box Protein 58 - genetics | Adenosine Triphosphate - metabolism | Protein Interaction Domains and Motifs | RNA, Double-Stranded - metabolism | Nucleic Acid Conformation | Binding Sites | RNA, Double-Stranded - chemistry | Cell Line | DEAD Box Protein 58 - chemistry | Avian Proteins - metabolism | Receptors, Pattern Recognition - chemistry | RNA-Binding Proteins - chemistry | Adenosine Triphosphatases - metabolism | Interferon-Induced Helicase, IFIH1 - metabolism | Models, Molecular | Hydrolysis | Animals | Chickens | RNA, Double-Stranded - genetics | Protein Binding | Receptors, Pattern Recognition - genetics | Adenosine Triphosphatases - chemistry | Adenosine Triphosphatases - genetics | Adenosine Diphosphate - metabolism | RNA-Binding Proteins - metabolism | Avian Proteins - genetics | Oligomers | RNA | Crystals | Interferon | Structure | Biological response modifiers | Molecular biology | Life Sciences | Immunology
Journal Article
Nature, ISSN 0028-0836, 08/2018, Volume 560, Issue 7717, pp. 238 - 242
Mitochondria are descendants of endosymbiotic bacteria and retain essential prokaryotic features such as a compact circular genome. Consequently, in mammals,... 
IMPORT | AICARDI-GOUTIERES-SYNDROME | READ ALIGNMENT | HUMAN GENOME | INNATE IMMUNE-RESPONSES | DNA | MULTIDISCIPLINARY SCIENCES | DISEASE | MUTATIONS | EXPRESSION | RNA Helicases - metabolism | Exoribonucleases - genetics | RNA, Mitochondrial - immunology | Exoribonucleases - deficiency | Humans | Multienzyme Complexes - metabolism | Interferon Type I - immunology | bcl-2 Homologous Antagonist-Killer Protein - metabolism | DEAD-box RNA Helicases - deficiency | Herpesvirus 1, Human - immunology | DEAD-box RNA Helicases - metabolism | Single-Cell Analysis | Polyribonucleotide Nucleotidyltransferase - metabolism | Endoribonucleases - metabolism | Gene Expression Regulation - immunology | Mice, Inbred C57BL | bcl-2-Associated X Protein - metabolism | Interferon-Induced Helicase, IFIH1 - metabolism | DEAD-box RNA Helicases - genetics | Animals | RNA, Double-Stranded - immunology | Herpesvirus 1, Human - genetics | Mice | HeLa Cells | Mutation | Exoribonucleases - metabolism | Interferon Type I - antagonists & inhibitors | Physiological aspects | Mitochondrial DNA | Genetic aspects | Immune response | RNA | Immunological research | Transcription | Genes | Infections | Activation | Genomes | Accumulation | DNA helicase | Signal transduction | Mitochondria | Microorganisms | Indigenous species | Polynucleotide phosphorylase | Localization | Bioinformatics | Deoxyribonucleic acid--DNA | Immune system | Enzymes | Double-stranded RNA | RNA polymerase | Metabolism | Mammals | Ribonucleic acid--RNA | Phosphorylase | Vertebrates | Signaling | Microscopy | Interferon | Diabetes | Cytoplasm | Viral infections | RNA helicase | Life Sciences | Immunology
Journal Article
Journal of Virology, ISSN 0022-538X, 06/2017, Volume 91, Issue 11
Journal Article
Journal Article
Fish and Shellfish Immunology, ISSN 1050-4648, 08/2016, Volume 55, pp. 535 - 549
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 50, pp. 20472 - 20480
Self/non-self-discrimination by the innate immune system relies on germline-encoded, non-rearranging receptors expressed by innate immune cells recognizing... 
cellular immune response | dsRNA | PATHWAYS | CELLS | HELICASE LGP2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | double-stranded RNA (dsRNA) | HUMAN CYTOMEGALOVIRUS | RIG-I | PARAMYXOVIRUS V-PROTEINS | VIRULENCE | virus | non-self-discrimination | virus infection | NATURAL CYTOTOXICITY RECEPTORS | NKG2D | NKG2D ligands | self | HUMAN FIBROBLASTS | TARGETS | natural killer cells (NK cells) | pattern recognition receptor (PRR) | Interferon-Induced Helicase, IFIH1 - chemistry | RNA-Binding Proteins - genetics | DEAD Box Protein 58 - metabolism | Interferon-Induced Helicase, IFIH1 - genetics | Lentivirus - immunology | Humans | Lentivirus - physiology | Viral Proteins - metabolism | NK Cell Lectin-Like Receptor Subfamily K - metabolism | DEAD Box Protein 58 - genetics | Killer Cells, Natural - immunology | RNA, Viral - metabolism | Genes, Reporter | RNA - metabolism | Recombinant Proteins - metabolism | Cell Line | DEAD Box Protein 58 - chemistry | Cricetinae | Killer Cells, Natural - virology | Cells, Cultured | Gene Expression Regulation | Interferon-Induced Helicase, IFIH1 - metabolism | Viral Proteins - genetics | Immunity, Innate | NK Cell Lectin-Like Receptor Subfamily K - genetics | Animals | NK Cell Lectin-Like Receptor Subfamily K - agonists | Gene Expression Regulation, Viral | Ligands | Killer Cells, Natural - metabolism | Mutation | RNA-Binding Proteins - metabolism | Amino Acid Substitution | Immunology
Journal Article
Journal Article
Journal Article