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Nature Immunology, ISSN 1529-2908, 02/2016, Volume 17, Issue 2, pp. 140 - 149
Innate sensing of pathogens initiates inflammatory cytokine responses that need to be tightly controlled. We found here that after engagement of Toll-like... 
PATHWAYS | INTERFERON | ACTIVATION | SUMO | BETA-GENE | IFN-GAMMA | NEGATIVE REGULATION | ENHANCER | MICE | IMMUNOLOGY | UP-REGULATION | Chromatin - metabolism | Dendritic Cells - immunology | Gene Expression Profiling | Genetic Loci | Shock, Septic - immunology | Lipopolysaccharides - immunology | Shock, Septic - metabolism | Inflammation - metabolism | Inflammation Mediators - metabolism | Toll-Like Receptors - metabolism | Dendritic Cells - metabolism | Disease Models, Animal | Receptor, Interferon alpha-beta - metabolism | Shock, Septic - genetics | Sumoylation - genetics | Disease Resistance | Disease Susceptibility | Cytokines - metabolism | Signal Transduction | Immunomodulation | Gene Expression Regulation | Inflammation - virology | Inflammation - immunology | Immunity, Innate | Mice, Knockout | Animals | Enhancer Elements, Genetic | Interferon-beta - metabolism | Regulatory Elements, Transcriptional | Sumoylation - immunology | Inflammation - genetics | Protein Binding | Mice | SUMO-1 Protein - metabolism | Chromatin - genetics | Analysis | Influence | Interferon | Inflammation | Research | Biological response modifiers | Gene expression | Health aspects | Risk factors | Shock, Septic/metabolism | Inflammation Mediators/metabolism | Sumoylation/immunology | Interferon-beta/metabolism | Dendritic Cells/metabolism | Inflammation/virology | Inflammation/immunology | Life Sciences | Immunology | Receptor, Interferon alpha-beta/metabolism | Inflammation/genetics | SUMO-1 Protein/metabolism | Cytokines/metabolism | Sumoylation/genetics | Chromatin/metabolism | Inflammation/metabolism | Toll-Like Receptors/metabolism | Lipopolysaccharides/immunology | Shock, Septic/immunology | Chromatin/genetics | Shock, Septic/genetics | Dendritic Cells/immunology
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 01/2013, Volume 110, Issue 5, pp. 1851 - 1856
A flagellin-independent caspase-1 activation pathway that does not require NAIP5 or NRLC4 is induced by the intracellular pathogen Legionella pneumophila .... 
Cell death | Innate immunity | Inflammasome | PATTERN-RECOGNITION | innate immunity | cell death | inflammasome | MULTIDISCIPLINARY SCIENCES | NLRP3 INFLAMMASOME ACTIVATION | INFECTION | RECEPTORS | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Adaptor Proteins, Vesicular Transport - genetics | Caspase 1 - metabolism | Immunoblotting | Legionella pneumophila - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Necrosis | Caspases - metabolism | Flagellin - genetics | Flagellin - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Receptor, Interferon alpha-beta - genetics | Macrophages - microbiology | Receptor, Interferon alpha-beta - metabolism | Calcium-Binding Proteins - metabolism | Cytokines - metabolism | Caspases - genetics | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Macrophages - cytology | Legionella pneumophila - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Host-Pathogen Interactions | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Bone Marrow Cells - microbiology | Legionella pneumophila - physiology | Mice | Enzyme Activation | Mutation | Myeloid Differentiation Factor 88 - metabolism | Bone Marrow Cells - metabolism | Apoptosis | Calcium-Binding Proteins - genetics | Legionella pneumophila | Genetic aspects | Research | Macrophages | Properties | Immunological research | Biological Sciences
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2016, Volume 22, Issue 6, pp. 586 - 597
Astrocytes have important roles in the central nervous system (CNS) during health and disease. Through genome-wide analyses we detected a transcriptional... 
MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYELOID CELLS | BLOOD-BRAIN-BARRIER | BETA | CELL BIOLOGY | RESPONSES | MULTIPLE-SCLEROSIS | REGULATORY T-CELLS | DIFFERENTIATION | NF-KAPPA-B | EXPRESSION | Optical Imaging | Cell Proliferation | Central Nervous System - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Immunoblotting | Gene Expression Profiling | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Interferon Type I - immunology | Suppressor of Cytokine Signaling Proteins | Tryptophan - metabolism | Case-Control Studies | Central Nervous System - immunology | Tryptophanase - metabolism | Gene Knockdown Techniques | Indoles - metabolism | STAT1 Transcription Factor - metabolism | Lactobacillus reuteri | Astrocytes - immunology | Chromatin Immunoprecipitation | Polymerase Chain Reaction | Receptors, Aryl Hydrocarbon - metabolism | Chemokine CCL2 - metabolism | Receptor, Interferon alpha-beta - genetics | Multiple Sclerosis - metabolism | Indican - urine | Serotonin | Gastrointestinal Microbiome | Inflammation | Mice, Knockout | Animals | Interferon-beta - pharmacology | Fluorescent Antibody Technique | Multiple Sclerosis - immunology | T-Lymphocytes - immunology | Mice | Myxovirus Resistance Proteins - metabolism | Receptors, Aryl Hydrocarbon - immunology | Nitric Oxide Synthase Type II - metabolism | Microbiota (Symbiotic organisms) | Astrocytes | Physiological aspects | Tryptophan | Interferon | Genetic aspects | Research | Autoimmunity | Multiple sclerosis | Care and treatment | Encephalomyelitis | Central nervous system | Prevention | Metabolites | Analysis | Dosage and administration | Diagnosis | Health aspects | Nervous system | Microorganisms | Immune system
Journal Article
Science, ISSN 0036-8075, 9/2010, Volume 329, Issue 5998, pp. 1530 - 1534
Endosomal Toll-like receptors (TLRs) 7 and 9 recognize viral pathogens and induce signals leading to the activation of nuclear factor KB (NF-KB)-dependent... 
T lymphocytes | Molecules | Cytokines | Microscopy | Genes | REPORTS | Toll like receptors | Agonists | Macrophages | Cells | Endosomes | LOCALIZATION | ACTIVATION | DENDRITIC CELLS | TRAF3 | MULTIDISCIPLINARY SCIENCES | TLR9 | TOLL-LIKE-RECEPTOR-9 | INDUCTION | INTERFERON-ALPHA PRODUCTION | I INTERFERON | AP-3 ADAPTER | Recombinant Fusion Proteins - immunology | Dendritic Cells - immunology | Transcriptional Activation | Interferon Type I - immunology | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Toll-Like Receptor 9 - immunology | Cytoplasmic Vesicles - metabolism | Interferon Type I - metabolism | Membrane Transport Proteins - metabolism | Cytokines - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Cytokines - immunology | Oligodeoxyribonucleotides - immunology | Cytokines - metabolism | Signal Transduction | Vesicle-Associated Membrane Protein 3 - metabolism | Mice, Inbred C57BL | Cells, Cultured | TNF Receptor-Associated Factor 3 - metabolism | Adaptor Protein Complex beta Subunits | Interferon Regulatory Factor-7 - metabolism | Adaptor Protein Complex 3 - metabolism | Protein Transport | Animals | Adaptor Protein Complex 3 - genetics | Interferon Type I - genetics | Mice | Toll-Like Receptor 9 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Lysosomal-Associated Membrane Protein 2 - metabolism | Cellular control mechanisms | Physiological aspects | TLR7 | Research | Health aspects | Immune system | Proteins | Signal transduction | Interferon | Cellular biology | Receptors | Compartments | Bifurcations | Activation
Journal Article
Nature, ISSN 0028-0836, 05/2016, Volume 533, Issue 7604, pp. 493 - 498
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 4, p. e1003989
Modified vaccinia virus Ankara (MVA) is an attenuated poxvirus that has been engineered as a vaccine against infectious agents and cancers. Our goal is to... 
DOUBLE-STRANDED-RNA | CYCLIC GMP-AMP | KAPPA-B KINASE | COMPLEX CLASS-II | DEPENDENT PROTEIN-KINASE | MICROBIOLOGY | ANTIGEN PRESENTATION | INTERFERON INDUCTION | INTRACELLULAR DNA | VIROLOGY | TOLL-LIKE RECEPTORS | INNATE IMMUNE SENSOR | PARASITOLOGY | Dendritic Cells - immunology | Lysosomes - genetics | Immunity, Innate - genetics | Vaccinia virus - genetics | Viral Proteins - metabolism | Endosomes - metabolism | Bone Marrow Cells - virology | Phosphorylation - genetics | Bone Marrow Cells - immunology | Interferon-beta - genetics | Phosphorylation - immunology | Receptor, Interferon alpha-beta - genetics | Nucleotidyltransferases - metabolism | Vaccinia - metabolism | Protein-Serine-Threonine Kinases - metabolism | Receptor, Interferon alpha-beta - metabolism | Endosomes - genetics | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | Viral Proteins - genetics | Mice, Knockout | Interferon-beta - metabolism | Receptor, Interferon alpha-beta - immunology | Vaccinia - immunology | Virulence Factors - metabolism | Mice | Lysosomes - immunology | RNA-Binding Proteins - metabolism | Endosomes - immunology | RNA-Binding Proteins - genetics | Interferon-beta - immunology | Virulence Factors - genetics | Viral Proteins - immunology | Virulence Factors - immunology | Interferon Regulatory Factor-3 - genetics | Vaccinia virus - immunology | Lysosomes - metabolism | Female | Membrane Proteins - metabolism | Dendritic Cells - virology | Dendritic Cells - metabolism | Interferon Regulatory Factor-3 - immunology | Vaccinia virus - metabolism | Protein-Serine-Threonine Kinases - genetics | Membrane Proteins - immunology | Vaccinia - genetics | Animals | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein-Serine-Threonine Kinases - immunology | Nucleotidyltransferases - immunology | Bone Marrow Cells - metabolism | Microbiological research | Dendritic cells | Genetic research | Genetic aspects | Research | Nucleotide sequencing | Vaccinia | Health aspects | DNA sequencing | Proteins | Studies | Smallpox | Transcription factors | Genes | Deoxyribonucleic acid | DNA | Infections | Genomes | Vaccines | Viral infections | Immune system
Journal Article
Science, ISSN 0036-8075, 1/2005, Volume 307, Issue 5707, pp. 269 - 273
Upon cytokine treatment, members of the signal transducers and activators of transcription (STAT) family of proteins are phosphorylated on tyrosine and serine... 
Proteins | COS cells | Cell growth | Cell lines | Cell cycle | HeLa cells | Antibodies | Reports | Dimers | Acetylation | Cells | SH2 DOMAIN | ACTIVATION | PROTEIN | DNA | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | GENE-EXPRESSION | CBP/P300 | P300/CBP | NF-KAPPA-B | PEPTIDE | Cyclin D1 - metabolism | Interferon-alpha - pharmacology | Acetyltransferases - metabolism | Phosphorylation | Histone Acetyltransferases | Humans | Transcriptional Activation | Cytoplasm - metabolism | Trans-Activators - chemistry | Recombinant Fusion Proteins - metabolism | Cytokines - physiology | DNA-Binding Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Cell Nucleus - metabolism | Trans-Activators - genetics | Lysine - metabolism | Dimerization | bcl-X Protein | Protein Structure, Secondary | Signal Transduction | Histone Deacetylases - metabolism | Nuclear Proteins - metabolism | DNA - metabolism | Recombinant Fusion Proteins - chemistry | DNA-Binding Proteins - genetics | Oncostatin M | DNA-Binding Proteins - chemistry | Proto-Oncogene Proteins c-myc - metabolism | Arginine - chemistry | Peptides - pharmacology | src Homology Domains | Cell Cycle | Cell Line, Tumor | Trans-Activators - metabolism | STAT3 Transcription Factor | HeLa Cells | Mutation | Arginine - metabolism | Cytokines - pharmacology | Research | Cytokines | Gene expression | Prostate cancer | Medical treatment | Deoxyribonucleic acid--DNA
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 04/2010, Volume 207, Issue 4, pp. 721 - 730
Plasmacytoid dendritic cells (pDCs) play a key role in antiviral immunity, but also contribute to the pathogenesis of certain autoimmune diseases, by producing... 
MEDICINE, RESEARCH & EXPERIMENTAL | CPG MOTIFS | LYMPHOCYTE MIGRATION | PROTEIN DOCK2 | RECOGNITION | PREDENDRITIC CELLS | NEUTROPHIL CHEMOTAXIS | KAPPA-B | IMMUNOLOGY | INTERFERON-ALPHA PRODUCTION | BACTERIAL-DNA | MOTILITY | Interferon-alpha - pharmacology | Interleukin-1 Receptor-Associated Kinases - metabolism | Dendritic Cells - immunology | Actins - metabolism | rac GTP-Binding Proteins - metabolism | Interleukin-12 Subunit p40 - blood | Male | GTPase-Activating Proteins - metabolism | Endosomes - metabolism | Toll-Like Receptor 9 - agonists | Interferon Type I - biosynthesis | Signal Transduction - immunology | STAT1 Transcription Factor - metabolism | I-kappa B Kinase - metabolism | rac GTP-Binding Proteins - genetics | Interferon Type I - metabolism | Dendritic Cells - drug effects | Female | Influenza A virus - immunology | Neuropeptides - genetics | Phosphorylation - drug effects | Oligodeoxyribonucleotides - metabolism | Dendritic Cells - metabolism | Toll-Like Receptor 7 - agonists | Interferon-alpha - metabolism | Interleukin-12 Subunit p40 - metabolism | Mice, Inbred C57BL | Toll-Like Receptors - immunology | Membrane Glycoproteins - agonists | Neuropeptides - metabolism | Imidazoles - pharmacology | Interferon Regulatory Factor-7 - metabolism | Toll-Like Receptors - agonists | Mice, Knockout | Animals | Herpesvirus 2, Human - immunology | Interferon-beta - metabolism | Signal Transduction - drug effects | Interferon-alpha - blood | Mice | rac1 GTP-Binding Protein | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Brief Definitive Report
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e13927
Type I interferons (IFNs) function as the first line of defense against viral infections by modulating cell growth, establishing an antiviral state and... 
H5N1 AVIAN INFLUENZA | A VIRUS | IMMUNE-RESPONSE | ANTIVIRAL RESPONSES | NEURAMINIDASE INHIBITORS | VIRAL DISEASE | MULTIDISCIPLINARY SCIENCES | CHRONIC HEPATITIS-C | BETA-INTERFERON | ALPHA-INTERFERON | CORE PROTEIN | Phosphorylation | Gene Expression - drug effects | Influenza A Virus, H5N1 Subtype - physiology | Humans | Influenza A virus - genetics | Influenza A Virus, H1N1 Subtype - physiology | Suppressor of Cytokine Signaling 1 Protein | Immunoblotting | Green Fluorescent Proteins - genetics | Lung - virology | STAT1 Transcription Factor - metabolism | Macrophages - virology | Lung - metabolism | Receptor, Interferon alpha-beta - genetics | Influenza A Virus, H5N1 Subtype - metabolism | Influenza A Virus, H1N1 Subtype - metabolism | Receptor, Interferon alpha-beta - metabolism | Green Fluorescent Proteins - metabolism | Influenza A virus - physiology | Interferons - pharmacology | Tissue Culture Techniques | Cells, Cultured | Suppressor of Cytokine Signaling Proteins - genetics | Viral Nonstructural Proteins - genetics | Macrophages - cytology | Reverse Transcriptase Polymerase Chain Reaction | Viral Nonstructural Proteins - physiology | Host-Pathogen Interactions | Microscopy, Confocal | Macrophages - metabolism | Influenza A virus - metabolism | Lung - drug effects | Interferons - metabolism | Signal Transduction - physiology | Viral Nonstructural Proteins - metabolism | STAT2 Transcription Factor - metabolism | HeLa Cells | Suppressor of Cytokine Signaling Proteins - metabolism | Infection | Avian influenza | Genes | Avian influenza viruses | Development and progression | Interferon | Biological response modifiers | Health aspects | Viruses | Genomes | Infections | Kinases | Macrophages | Drug resistance | Tissues | Influenza A | Inhibition | Stat1 protein | Deoxyribonucleic acid--DNA | Immune system | Stat2 protein | Tyrosine | Translocation | Antiviral state | Stat3 protein | Gene expression | Nuclear transport | Signaling | Monocytes | Lungs | Influenza | Replication | Deoxyribonucleic acid | DNA
Journal Article