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Nature immunology, ISSN 1529-2908, 02/2016, Volume 17, Issue 2, pp. 140 - 149
Innate sensing of pathogens initiates inflammatory cytokine responses that need to be tightly controlled. We found here that after engagement of Toll-like... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Chromatin - metabolism | Dendritic Cells - immunology | Gene Expression Profiling | Genetic Loci | Shock, Septic - immunology | Lipopolysaccharides - immunology | Shock, Septic - metabolism | Inflammation - metabolism | Inflammation Mediators - metabolism | Toll-Like Receptors - metabolism | Dendritic Cells - metabolism | Disease Models, Animal | Receptor, Interferon alpha-beta - metabolism | Shock, Septic - genetics | Sumoylation - genetics | Disease Resistance | Disease Susceptibility | Cytokines - metabolism | Signal Transduction | Immunomodulation | Gene Expression Regulation | Inflammation - virology | Inflammation - immunology | Immunity, Innate | Mice, Knockout | Animals | Enhancer Elements, Genetic | Interferon-beta - metabolism | Regulatory Elements, Transcriptional | Sumoylation - immunology | Inflammation - genetics | Protein Binding | Mice | SUMO-1 Protein - metabolism | Chromatin - genetics | Analysis | Influence | Interferon | Inflammation | Research | Biological response modifiers | Gene expression | Health aspects | Risk factors | Index Medicus | Shock, Septic/metabolism | Inflammation Mediators/metabolism | Sumoylation/immunology | Interferon-beta/metabolism | Dendritic Cells/metabolism | Inflammation/virology | Inflammation/immunology | Life Sciences | Receptor, Interferon alpha-beta/metabolism | Inflammation/genetics | SUMO-1 Protein/metabolism | Cytokines/metabolism | Sumoylation/genetics | Chromatin/metabolism | Inflammation/metabolism | Toll-Like Receptors/metabolism | Lipopolysaccharides/immunology | Shock, Septic/immunology | Chromatin/genetics | Shock, Septic/genetics | Dendritic Cells/immunology
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 01/2013, Volume 110, Issue 5, pp. 1851 - 1856
A flagellin-independent caspase-1 activation pathway that does not require NAIP5 or NRLC4 is induced by the intracellular pathogen Legionella pneumophila. Here... 
Cytoskeletal Proteins | Flagellin | Immunoblotting | Legionella pneumophila | Macrophages | Adaptor Proteins, Vesicular Transport | Necrosis | Receptor, Interferon alpha-beta | Caspase 1 | Carrier Proteins | Calcium-Binding Proteins | Cytokines | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 | Mice, Knockout | Host-Pathogen Interactions | Animals | Apoptosis Regulatory Proteins | Bone Marrow Cells | Mice | Caspases | Enzyme Activation | Mutation | Apoptosis | Cell death | Innate immunity | Inflammasome | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Adaptor Proteins, Vesicular Transport - genetics | Caspase 1 - metabolism | Legionella pneumophila - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Caspases - metabolism | Flagellin - genetics | Flagellin - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Receptor, Interferon alpha-beta - genetics | Macrophages - microbiology | Receptor, Interferon alpha-beta - metabolism | Calcium-Binding Proteins - metabolism | Cytokines - metabolism | Caspases - genetics | Myeloid Differentiation Factor 88 - genetics | Macrophages - cytology | Legionella pneumophila - metabolism | Apoptosis Regulatory Proteins - metabolism | Carrier Proteins - genetics | Macrophages - metabolism | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Bone Marrow Cells - microbiology | Legionella pneumophila - physiology | Myeloid Differentiation Factor 88 - metabolism | Bone Marrow Cells - metabolism | Calcium-Binding Proteins - genetics | Genetic aspects | Research | Properties | Immunological research | Proteins | Bacteria | Medical treatment | Cells | Index Medicus | Biological Sciences | innate immunity | cell death | inflammasome
Journal Article
PLoS pathogens, ISSN 1553-7374, 04/2014, Volume 10, Issue 4, pp. e1003989 - e1003989
Modified vaccinia virus Ankara (MVA) is an attenuated poxvirus that has been engineered as a vaccine against infectious agents and cancers. Our goal is to... 
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Dendritic Cells - immunology | Lysosomes - genetics | Immunity, Innate - genetics | Vaccinia virus - genetics | Viral Proteins - metabolism | Endosomes - metabolism | Bone Marrow Cells - virology | Phosphorylation - genetics | Bone Marrow Cells - immunology | Interferon-beta - genetics | Phosphorylation - immunology | Receptor, Interferon alpha-beta - genetics | Nucleotidyltransferases - metabolism | Vaccinia - metabolism | Protein-Serine-Threonine Kinases - metabolism | Receptor, Interferon alpha-beta - metabolism | Endosomes - genetics | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | Viral Proteins - genetics | Mice, Knockout | Interferon-beta - metabolism | Receptor, Interferon alpha-beta - immunology | Vaccinia - immunology | Virulence Factors - metabolism | Mice | Lysosomes - immunology | RNA-Binding Proteins - metabolism | Endosomes - immunology | RNA-Binding Proteins - genetics | Interferon-beta - immunology | Virulence Factors - genetics | Viral Proteins - immunology | Virulence Factors - immunology | Interferon Regulatory Factor-3 - genetics | Vaccinia virus - immunology | Lysosomes - metabolism | Female | Membrane Proteins - metabolism | Dendritic Cells - virology | Dendritic Cells - metabolism | Interferon Regulatory Factor-3 - immunology | Vaccinia virus - metabolism | Protein-Serine-Threonine Kinases - genetics | Membrane Proteins - immunology | Vaccinia - genetics | Animals | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein-Serine-Threonine Kinases - immunology | Nucleotidyltransferases - immunology | Bone Marrow Cells - metabolism | Microbiological research | Dendritic cells | Genetic research | Genetic aspects | Research | Nucleotide sequencing | Vaccinia | Health aspects | DNA sequencing | Index Medicus | Proteins | Studies | Smallpox | Transcription factors | Genes | Deoxyribonucleic acid | DNA | Infections | Genomes | Vaccines | Viral infections | Immune system
Journal Article
BMC gastroenterology, ISSN 1471-230X, 03/2016, Volume 16, Issue 1, pp. 40 - 40
Background: Breastfeeding is associated with a variety of positive health outcomes in children and is recommended exclusively for the first 6 months of life;... 
Peyer's patches | GALT | Jejunum | Nutrition | Ileum | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Interleukin-8 - genetics | Up-Regulation | Jejunum - pathology | Cadherins - metabolism | Calcium - metabolism | Humans | Ileum - metabolism | Interleukin-8 - drug effects | Leukemia Inhibitory Factor - genetics | Vascular Endothelial Growth Factor A - metabolism | Peyer's Patches - drug effects | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Antigens, CD - genetics | Antigens, CD - metabolism | Jejunum - metabolism | Leukemia Inhibitory Factor - metabolism | Jejunum - drug effects | Fas Ligand Protein - drug effects | Ileum - drug effects | Swine | Interleukin-8 - metabolism | Cadherins - genetics | Soy Foods | Cytokines - genetics | Interleukin-6 - metabolism | Infant, Newborn | Milk | Animals, Newborn | Interleukin-6 - genetics | Down-Regulation | Interleukin-27 - genetics | Gastrointestinal Microbiome - drug effects | Diet | Interleukin-10 - genetics | Interleukin-15 - metabolism | Intestine, Small - metabolism | Peyer's Patches - immunology | Fas Ligand Protein - genetics | Fas Ligand Protein - metabolism | Ileum - pathology | Interferon-alpha - drug effects | Intestine, Small - pathology | Interferon-alpha - genetics | Interleukin-10 - metabolism | Interleukin-9 - metabolism | Vascular Endothelial Growth Factor A - drug effects | Interleukin-27 - metabolism | RNA, Messenger - drug effects | Interferon-alpha - metabolism | Cytokines - metabolism | Intestine, Small - microbiology | Jejunum - microbiology | Infant Formula - pharmacology | Animals | Interleukin-15 - genetics | Cytokines - drug effects | Interleukin-9 - genetics | Intestine, Small - drug effects | Leukemia Inhibitory Factor - drug effects | Ileum - microbiology | Interleukin-10 | Analysis | Influence | Research | Gene expression | Breast feeding | Health aspects | Index Medicus
Journal Article
The Journal of experimental medicine, ISSN 0022-1007, 04/2010, Volume 207, Issue 4, pp. 721 - 730
Plasmacytoid dendritic cells (pDCs) play a key role in antiviral immunity, but also contribute to the pathogenesis of certain autoimmune diseases, by producing... 
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Interferon-alpha - pharmacology | Interleukin-1 Receptor-Associated Kinases - metabolism | Dendritic Cells - immunology | Actins - metabolism | rac GTP-Binding Proteins - metabolism | Interleukin-12 Subunit p40 - blood | Male | GTPase-Activating Proteins - metabolism | Endosomes - metabolism | Toll-Like Receptor 9 - agonists | Interferon Type I - biosynthesis | Signal Transduction - immunology | STAT1 Transcription Factor - metabolism | I-kappa B Kinase - metabolism | rac GTP-Binding Proteins - genetics | Interferon Type I - metabolism | Dendritic Cells - drug effects | Female | Influenza A virus - immunology | Neuropeptides - genetics | Phosphorylation - drug effects | Oligodeoxyribonucleotides - metabolism | Dendritic Cells - metabolism | Toll-Like Receptor 7 - agonists | Interferon-alpha - metabolism | Interleukin-12 Subunit p40 - metabolism | Mice, Inbred C57BL | Toll-Like Receptors - immunology | Membrane Glycoproteins - agonists | Neuropeptides - metabolism | Imidazoles - pharmacology | Interferon Regulatory Factor-7 - metabolism | Toll-Like Receptors - agonists | Mice, Knockout | Animals | Herpesvirus 2, Human - immunology | Interferon-beta - metabolism | Signal Transduction - drug effects | Interferon-alpha - blood | Mice | rac1 GTP-Binding Protein | Oligodeoxyribonucleotides - pharmacology | Toll-Like Receptor 9 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Index Medicus | Brief Definitive Report
Journal Article
PLoS pathogens, ISSN 1553-7374, 04/2013, Volume 9, Issue 4, pp. e1003248 - e1003248
Upon recognition of viral components by pattern recognition receptors, such as the toll-like receptors (TLRs) and retinoic acid-inducible gene I (RIG-I)-like... 
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Interleukin-1 Receptor-Associated Kinases - metabolism | RNA Helicases - metabolism | Up-Regulation | Phosphorylation | Interleukin-1 Receptor-Associated Kinases - genetics | Hepacivirus - immunology | Humans | Adaptor Proteins, Vesicular Transport - genetics | Hepacivirus - genetics | Hepacivirus - pathogenicity | JNK Mitogen-Activated Protein Kinases - metabolism | MicroRNAs - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Interferon Regulatory Factor-3 - genetics | MAP Kinase Signaling System | Hepatitis C - immunology | RNA Interference | Protein Kinase C - metabolism | HEK293 Cells | Interferon-alpha - metabolism | Toll-Like Receptor 7 - metabolism | Interferon-alpha - biosynthesis | Myeloid Differentiation Factor 88 - genetics | Proto-Oncogene Proteins c-fos - metabolism | MicroRNAs - immunology | Immune Evasion | Cell Line, Tumor | Viral Nonstructural Proteins - metabolism | MicroRNAs - genetics | RNA, Small Interfering | Serine Endopeptidases - metabolism | Myeloid Differentiation Factor 88 - metabolism | Virus diseases | Immune response | MicroRNA | Cellular control mechanisms | Research | Observations | Hepatitis C virus | Properties | Testing | Index Medicus | Proteins | Hepatitis | Kinases | Viral infections | Immune system
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 01/2018, Volume 78, Issue 1, pp. 195 - 204
The protumoral activity of γδT17 cells has recently emerged in a wide variety of solid malignancies, including breast cancer. These cells exert their... 
T-Lymphocyte Subsets - immunology | Receptors, Antigen, T-Cell, gamma-delta - metabolism | Signal Transduction | Breast Neoplasms - immunology | Mice, Inbred C57BL | Interleukin-17 - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 7 - genetics | Breast Neoplasms - metabolism | Interleukin-17 - metabolism | Animals | Lymphocytes, Tumor-Infiltrating - pathology | Receptor, Interferon alpha-beta - immunology | Breast Neoplasms - pathology | T-Lymphocyte Subsets - metabolism | Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism | Female | Lymphocytes, Tumor-Infiltrating - metabolism | Mice, Inbred BALB C | Receptor, Interferon alpha-beta - genetics | Interleukin-7 - metabolism | Receptor, Interferon alpha-beta - metabolism | CD27 antigen | Cell proliferation | Phenotypes | Breast cancer | Metastasis | Accumulation | Metastases | T-cell receptor | Angiogenesis | Interleukin 7 | Signaling | Interleukin 1 | Interferon | Cancer | Immune system | Index Medicus | T-Lymphocyte Subsets/metabolism | Interleukin-7/metabolism | Tumor Necrosis Factor Receptor Superfamily, Member 7/genetics | Breast Neoplasms/pathology | Lymphocytes, Tumor-Infiltrating/metabolism | Interleukin-17/metabolism | Innate immunity | Receptor, Interferon alpha-beta/immunology | Receptors, Antigen, T-Cell, gamma-delta/metabolism | Life Sciences | Immunology | T-Lymphocyte Subsets/immunology | Tumor Necrosis Factor Receptor Superfamily, Member 7/metabolism | Receptor, Interferon alpha-beta/genetics | Breast Neoplasms/immunology | Receptor, Interferon alpha-beta/metabolism | Lymphocytes, Tumor-Infiltrating/pathology | Breast Neoplasms/metabolism | Interleukin-17/genetics
Journal Article