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Journal Article
Cancer Research, ISSN 0008-5472, 06/2010, Volume 70, Issue 11, pp. 4335 - 4345
Journal Article
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2014, Volume 192, Issue 2, pp. 623 - 629
Chronic inflammation is known to promote metabolic dysregulation in obesity and type 2 diabetes. Although the precise origin of the unchecked inflammatory... 
IMMUNE-SYSTEM | INFLAMMATION | DISEASE | RESISTANCE | FAT | AKT | IMMUNOLOGY | DIET-INDUCED OBESITY | KEY PLAYERS | ADIPOSE-TISSUE | CUTTING EDGE | Tumor Necrosis Factor-alpha - metabolism | Antigens, CD - immunology | T-Lymphocytes, Regulatory - metabolism | Epithelial Cells - metabolism | TOR Serine-Threonine Kinases - metabolism | Obesity - immunology | Insulin - immunology | Interferon-gamma - metabolism | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | Epithelium - immunology | Signal Transduction - immunology | Inflammation - metabolism | Tumor Necrosis Factor-alpha - immunology | Interleukin-10 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Insulin - immunology | Macrophages - immunology | Hyperinsulinism - metabolism | Intra-Abdominal Fat - immunology | Transforming Growth Factor beta - immunology | Epithelium - metabolism | Mice, Inbred C57BL | Apyrase - metabolism | Cells, Cultured | Apyrase - immunology | CTLA-4 Antigen - metabolism | Inflammation - immunology | CTLA-4 Antigen - immunology | Intra-Abdominal Fat - metabolism | Obesity - metabolism | TOR Serine-Threonine Kinases - immunology | Insulin - metabolism | Macrophages - metabolism | Animals | Hyperinsulinism - immunology | Proto-Oncogene Proteins c-akt - immunology | Epithelial Cells - immunology | Interferon-gamma - immunology | Interleukin-10 - antagonists & inhibitors | Receptor, Insulin - metabolism | Mice | Interleukin-10 - immunology | Transforming Growth Factor beta - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 10/2016, Volume 68, Issue 10, pp. 2492 - 2502
ObjectiveAntinuclear antibodies (ANAs) are detected in approximate to 18% of females, yet autoimmune disease develops in only 5-8%. Immunologic differences... 
SYSTEMIC-LUPUS-ERYTHEMATOSUS | INTERFERON | RISK-FACTORS | CYTOKINE PRODUCTION | DENDRITIC CELLS | ANTINUCLEAR ANTIBODIES | RHEUMATOLOGY | EXPRESSION | BLOOD MONONUCLEAR-CELLS | IG-LIKE RECEPTOR-1 | T-CELLS | Interferon-alpha - pharmacology | Multivariate Analysis | Phosphoproteins - drug effects | Interferon-beta - immunology | Antibodies, Antinuclear - immunology | Humans | Middle Aged | Interleukin-17 - immunology | STAT1 Transcription Factor - drug effects | Centromere Protein B - immunology | Male | Monocytes - immunology | Ribosomal Proteins - immunology | Healthy Volunteers | Case-Control Studies | Leukocytes - immunology | Young Adult | Flow Cytometry | Autoimmunity - immunology | Lupus Erythematosus, Systemic - immunology | Ribonucleoproteins - immunology | Tumor Necrosis Factor-alpha - immunology | Aged, 80 and over | Adult | B-Lymphocyte Subsets - immunology | Female | Interleukin-12 Subunit p40 - immunology | Cytokines - immunology | Interleukin 1 Receptor Antagonist Protein - immunology | Immunophenotyping | Logistic Models | Nuclear Proteins - immunology | STAT1 Transcription Factor - immunology | Stem Cell Factor - immunology | Interferon-alpha - immunology | Autoantibodies - immunology | Interferon-gamma - immunology | STAT3 Transcription Factor - drug effects | Sex Factors | Aged | Granulocyte Colony-Stimulating Factor - immunology | STAT3 Transcription Factor - immunology | Plasma Cells - immunology | Index Medicus | Abridged Index Medicus | Systemic Lupus Erythematosus
Journal Article
Mucosal Immunology, ISSN 1933-0219, 01/2016, Volume 9, Issue 1, pp. 24 - 37
HIV-1-associated disruption of intestinal homeostasis is a major factor contributing to chronic immune activation and inflammation. Dendritic cells (DCs) are... 
TRANSLOCATION | RESPONSES | LYMPHOID-TISSUE | INFLAMMATION | PREDICT MORTALITY | IMMUNE ACTIVATION | ANTIRETROVIRAL THERAPY | INTESTINAL LAMINA PROPRIA | IMMUNOLOGY | VIRUS TYPE-1 INFECTION | SIV INFECTION | Antigens, CD - immunology | Immunoglobulins - immunology | Dendritic Cells - immunology | Humans | Middle Aged | Colon - immunology | Male | Immunoglobulins - genetics | Antigens, CD - genetics | Case-Control Studies | Viral Load | Ruminococcus - immunology | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | HIV Infections - microbiology | Prevotella - immunology | HIV Infections - pathology | Prevotella - growth & development | Adult | Female | CD40 Antigens - genetics | Interferon-gamma - genetics | Membrane Glycoproteins - immunology | Ruminococcus - growth & development | Glycoproteins - genetics | Antigens, CD1 - immunology | CD4-Positive T-Lymphocytes - microbiology | CD8-Positive T-Lymphocytes - microbiology | Signal Transduction | Lymphocyte Activation | Gene Expression Regulation | Membrane Glycoproteins - genetics | Glycoproteins - immunology | HIV-1 - immunology | Mucous Membrane - immunology | Interferon-gamma - immunology | Dendritic Cells - microbiology | Colon - microbiology | Antigens, CD1 - genetics | Gastrointestinal Microbiome - immunology | CD8-Positive T-Lymphocytes - immunology | CD40 Antigens - immunology | Mucous Membrane - microbiology | Cell Lineage - immunology | Index Medicus | mucosal immunology | HIV-1 pathogenesis | microbiome | Human intestinal dendritic cells
Journal Article
The Journal of Immunology, ISSN 0022-1767, 10/2009, Volume 183, Issue 8, pp. 5208 - 5220
The role of proinflammatory cytokine production in the pathogenesis of malaria is well established, but the identification of the parasite products that... 
TUMOR-NECROSIS-FACTOR | DENDRITIC CELLS | INTERFERON-GAMMA | TOLL-LIKE RECEPTOR-9 | PLASMODIUM-FALCIPARUM | EXPERIMENTAL CEREBRAL MALARIA | ENDOTHELIAL-CELLS | IMMUNOLOGY | NF-KAPPA-B | INNATE IMMUNE ACTIVATION | INTRACELLULAR COMPARTMENTS | Interleukin-1alpha - immunology | Chemokine CCL2 - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | NF-kappa B - metabolism | Inflammation - parasitology | Endothelial Cells - parasitology | Extracellular Signal-Regulated MAP Kinases - immunology | Plasmodium falciparum | Interleukin-1beta - metabolism | Tumor Necrosis Factor-alpha - immunology | Interleukin-8 - metabolism | Toll-Like Receptors - metabolism | Chemokine CXCL1 - metabolism | Interleukin-6 - metabolism | Carrier Proteins - immunology | Toll-Like Receptors - immunology | Chemokine CXCL1 - immunology | Signal Transduction - drug effects | Interleukin-6 - immunology | Malaria, Falciparum - immunology | Uric Acid - antagonists & inhibitors | Mice | Interleukin-8 - immunology | Inflammation - chemically induced | Tumor Necrosis Factor-alpha - metabolism | NF-kappa B - immunology | Interleukin-1alpha - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Hemeproteins - immunology | Macrophages - parasitology | Signal Transduction - immunology | Myeloid Differentiation Factor 88 - immunology | Cytoskeletal Proteins - metabolism | Chemokine CCL2 - metabolism | Macrophages - immunology | Uric Acid - metabolism | Interleukin-1beta - immunology | Hemeproteins - pharmacology | Inflammation - immunology | Endothelial Cells - immunology | Malaria, Falciparum - parasitology | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Allopurinol - pharmacology | Macrophages - drug effects | Myeloid Differentiation Factor 88 - metabolism | Interferon-gamma - pharmacology | Endothelial Cells - drug effects | Index Medicus | Abridged Index Medicus | Chemokine | TLR9 | Plasmodium | Inflammasome | NALP3 | Cytokine
Journal Article
European Journal of Immunology, ISSN 0014-2980, 02/2014, Volume 44, Issue 2, pp. 370 - 385
IL‐13 has been implicated in the pathogenesis of ulcerative colitis (UC), and may have a role in animal models of gut fibrosis. We studied the involvement of... 
T helper cell type 2 | Crohn's disease | Fibrosis | Ulcerative colitis | CROHNS-DISEASE | DENDRITIC CELLS | ULCERATIVE-COLITIS | INDUCTION | IMMUNOLOGY | MUCOSA | MATRIX METALLOPROTEINASES | GROWTH-FACTOR-BETA | TGF-BETA-1 PRODUCTION | EXPRESSION | T-CELLS | Inflammation - pathology | Humans | Inflammatory Bowel Diseases - immunology | Middle Aged | Interleukin-13 - immunology | Th2 Cells - immunology | Colitis, Ulcerative - immunology | Intestines - immunology | Young Adult | Transforming Growth Factor beta1 - immunology | Interleukin-13 Receptor alpha1 Subunit - immunology | Intestinal Mucosa - immunology | Inflammatory Bowel Diseases - pathology | Leukocytes, Mononuclear - immunology | Fibrosis - immunology | Adult | Macrophages - immunology | Intestines - pathology | Macrophages - pathology | CD28 Antigens - immunology | Colitis, Ulcerative - pathology | Inflammation - immunology | Crohn Disease - immunology | Leukocytes, Mononuclear - pathology | Mucous Membrane - pathology | Mucous Membrane - immunology | Crohn Disease - pathology | Interleukin-13 Receptor alpha2 Subunit - immunology | Interferon-gamma - immunology | Adolescent | CD3 Complex - immunology | Aged | Fibrosis - pathology | Intestinal Mucosa - pathology | Natural Killer T-Cells - immunology | Interleukins | T cells | Intermediate filament proteins | Analysis | Collagen | Inflammatory bowel disease | Rodents | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2008, Volume 205, Issue 7, pp. 1517 - 1522
Some immunologists have characterized T helper (Th)17 T cells as the master mediators of tissue damage in a variety of pathological conditions. New data now... 
MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | GROWTH-FACTOR-BETA | ROR-GAMMA-T | MULTIPLE-SCLEROSIS | IFN-GAMMA | EFFECTOR RESPONSE | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | BIOLOGICAL-ACTIVITIES | IMMUNOLOGY | T-H-17 CELLS | T-HELPER-CELLS | Dendritic Cells - immunology | Humans | Central Nervous System - pathology | Encephalomyelitis, Autoimmune, Experimental - immunology | Interleukin-23 - genetics | Encephalomyelitis, Autoimmune, Experimental - genetics | Disease Susceptibility | Macrophages - pathology | Interleukin-17 - genetics | Interleukin-12 Subunit p35 - genetics | Interleukin-23 - immunology | Mice, Knockout | Models, Immunological | Up-Regulation - immunology | Uveitis - immunology | Mice | Uveitis - genetics | Proteins - antagonists & inhibitors | Eye - pathology | Chemokines, CXC - immunology | Interleukin-17 - immunology | Autoimmunity - genetics | Neutralization Tests | Adoptive Transfer | Paralysis - pathology | Th1 Cells - immunology | Central Nervous System - immunology | Eye - immunology | Nitric Oxide Synthase Type II - immunology | Female | Interferon-gamma - genetics | Macrophages - immunology | Neutrophils - pathology | Inflammation Mediators - immunology | Cell Line | Encephalomyelitis, Autoimmune, Experimental - pathology | Myelin Sheath - immunology | Myelin Sheath - pathology | Gene Expression Regulation - immunology | Uveitis - prevention & control | Mice, Inbred C57BL | Neutrophils - immunology | Paralysis - immunology | Up-Regulation - genetics | Proteins - immunology | Antibodies - pharmacology | Gene Expression Regulation - drug effects | Animals | Interleukin-12 Subunit p35 - immunology | Interleukin-17 - antagonists & inhibitors | Lymphocyte Activation - drug effects | Interferon-gamma - immunology | Antigens - immunology | Autoimmunity - drug effects | Uveitis - pathology | Index Medicus | Commentaries
Journal Article
Immunity, ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 514 - 527
Interleukin-21 (IL-21) has broad actions on T and B cells, but its actions in innate immunity are poorly understood. Here we show that IL-21 induced apoptosis... 
NKT CELLS | HOMEOSTASIS | FOLLICULAR-HELPER-CELLS | HUMAN B-CELLS | STEADY-STATE | INTERLEUKIN-21 | DIFFERENTIATION | IMMUNOLOGY | IMMUNE TOLERANCE | T-CELLS | NEGATIVE REGULATOR | Natural Killer T-Cells - drug effects | Oligonucleotide Array Sequence Analysis | Apoptosis - drug effects | Dendritic Cells - immunology | STAT5 Transcription Factor - immunology | Receptors, Interleukin-21 - genetics | Interferon-gamma - metabolism | CD4-Positive T-Lymphocytes - immunology | Interleukins - genetics | Gene Expression - immunology | STAT3 Transcription Factor - genetics | Apoptosis Regulatory Proteins - immunology | DNA-Binding Proteins - immunology | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | DNA, Intergenic - genetics | Protein Binding - immunology | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Mice, Knockout | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Galactosylceramides - immunology | Mice | STAT3 Transcription Factor - immunology | Gene Expression - drug effects | Galactosylceramides - pharmacology | DNA-Binding Proteins - deficiency | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Receptors, Interleukin-21 - deficiency | Flow Cytometry | Bcl-2-Like Protein 11 | Natural Killer T-Cells - metabolism | DNA, Intergenic - metabolism | Interleukins - immunology | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Dendritic Cells - drug effects | Membrane Proteins - metabolism | Interleukins - pharmacology | Dendritic Cells - metabolism | STAT3 Transcription Factor - metabolism | Proto-Oncogene Proteins - metabolism | Receptors, Interleukin-21 - immunology | Mice, Inbred C57BL | Cells, Cultured | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Membrane Proteins - immunology | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Animals | Apoptosis - immunology | Interferon-gamma - immunology | CD4-Positive T-Lymphocytes - drug effects | DNA, Intergenic - immunology | Natural Killer T-Cells - immunology | Interleukins | Dendritic cells | Analysis | Genomics | Macrophage colony stimulating factor | Biological response modifiers | T cells | Apoptosis | Cytokines | Genes | Genomes | Kinases | Binding sites | Deoxyribonucleic acid--DNA | Index Medicus | apoptosis | dendritic cells | GM-CSF | IL-21
Journal Article