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Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 2014, Volume 60, Issue 2, pp. 487 - 496
The pathogenesis of hepatitis C virus (HCV) infection is strongly influenced by the nature of the host's antiviral immunity. Counterintuitively, elevated serum... 
NATURAL-KILLER-CELLS | INJECTION-DRUG USERS | INTERFERON | VIRUS-INFECTION | NK CELLS | APPARENT RESISTANCE | PROTEIN-10 | REACTIVITY | RIBAVIRIN | GASTROENTEROLOGY & HEPATOLOGY | HCV INFECTION | Dipeptidyl Peptidase 4 - metabolism | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Hepatitis C, Chronic - virology | Male | Interferon-gamma - metabolism | T-Lymphocytes - virology | Young Adult | T-Lymphocytes - metabolism | Chemokine CXCL10 - immunology | Interleukin-10 - metabolism | Killer Cells, Natural - immunology | Adult | Female | Adaptive Immunity - immunology | Dipeptidyl Peptidase 4 - immunology | Chemokine CXCL10 - blood | Killer Cells, Natural - virology | Immunity, Innate - immunology | Interferon-gamma - immunology | Hepatitis C, Chronic - immunology | T-Lymphocytes - immunology | Killer Cells, Natural - metabolism | Interleukin-10 - immunology | Longitudinal Studies | Hepatitis | Infections | Drug therapy | Hepatology | Chemokines | Immune system | Killer Cells, Natural/immunology | Interferon-gamma/immunology | Chemokine CXCL10/blood | Life Sciences | Chemokine CXCL10/immunology | Immunology | Hepatitis C, Chronic/immunology | Interleukin-10/immunology | T-Lymphocytes/metabolism | Dipeptidyl Peptidase 4/immunology | Hepatitis C, Chronic/virology | Immunity, Innate/immunology | Adaptive Immunity/immunology | T-Lymphocytes/immunology | Interferon-gamma/metabolism | T-Lymphocytes/virology | Killer Cells, Natural/metabolism | Killer Cells, Natural/virology | Dipeptidyl Peptidase 4/metabolism | Interleukin-10/metabolism
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2017, Volume 199, Issue 4, pp. 1429 - 1439
IFN-gamma is known to be predominantly produced by lymphoid cells such as certain subsets of T cells, NK cells, and other group 1 innate lymphoid cells. In... 
CHLAMYDIA-PNEUMONIAE | NATURAL-KILLER-CELLS | INTERFERON-GAMMA | DENDRITIC CELLS | NK CELLS | MYCOBACTERIUM-AVIUM | TOXOPLASMA-GONDII | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | LYMPHOID-CELLS | ADAPTIVE IMMUNE-RESPONSES | Immunocompromised Host - immunology | Nitric Oxide Synthase Type II - biosynthesis | Spleen - immunology | Liver - microbiology | DNA-Binding Proteins - deficiency | Interleukin Receptor Common gamma Subunit - immunology | Leukocyte Common Antigens - immunology | Hematopoietic Stem Cells - immunology | Liver - immunology | Nitric Oxide Synthase Type II - immunology | Thy-1 Antigens - genetics | Killer Cells, Natural - immunology | Interferon-gamma - genetics | Macrophages - immunology | Granuloma - microbiology | DNA-Binding Proteins - immunology | Thy-1 Antigens - immunology | Mice, Inbred C57BL | Spleen - cytology | Mycobacterium avium - immunology | DNA-Binding Proteins - genetics | Immunity, Innate | Interleukin Receptor Common gamma Subunit - genetics | Interleukin Receptor Common gamma Subunit - deficiency | Animals | Nitric Oxide Synthase Type II - genetics | Antibodies, Monoclonal - administration & dosage | Interferon-gamma - immunology | Granuloma - immunology | Leukocyte Common Antigens - genetics | Liver - cytology | Mice | Mycobacterium avium - growth & development | Interferon-gamma - biosynthesis | Spleen | Interleukin 2 receptors | Animal models | Lymphoid cells | Cytokines | Liver | Chains | Lymphocytes T | Macrophages | Nitric-oxide synthase | CD45 antigen | Hemopoiesis | RAG2 protein | Interleukin 2 | Lymphocytes | γ-Interferon | Monoclonal antibodies | Interferon
Journal Article
The Journal of infectious diseases, ISSN 1537-6613, 2015, Volume 211, Issue 1, pp. 156 - 165
Background. A predominantly T-helper type 2 (Th2) immune response is critical in the prognosis of pulmonary Pseudomonas aeruginosa infection. But the mucosal... 
human-milk | cytokine production | butyrate | in-vitro | chain fatty-acids | galacto-oligosaccharides | t-cells | lactobacillus | virus-infection | cystic-fibrosis patients | intestinal microbiota | prebiotics | Th1 and M1 polarization | P. aeruginosa lung infection | INFECTIOUS DISEASES | VIRUS-INFECTION | GALACTO-OLIGOSACCHARIDES | MICROBIOLOGY | IMMUNOLOGY | CYTOKINE PRODUCTION | HUMAN-MILK | METABOLISM | CYSTIC-FIBROSIS PATIENTS | CHAIN FATTY-ACIDS | BUTYRATE | T-CELLS | LACTOBACILLUS | Intestines - drug effects | Lung Diseases - microbiology | GATA3 Transcription Factor - immunology | Pseudomonas aeruginosa - growth & development | Microbiota - drug effects | Male | T-Box Domain Proteins - immunology | Lung Diseases - drug therapy | Th1 Cells - immunology | Intestines - immunology | Leukocytes - immunology | Oligosaccharides - pharmacology | Leukocytes - microbiology | Tumor Necrosis Factor-alpha - immunology | Keratinocytes - microbiology | Macrophages - immunology | Macrophages - microbiology | Chemotactic Factors - immunology | Microbiota - immunology | Pseudomonas Infections - drug therapy | Pseudomonas aeruginosa - drug effects | Pseudomonas Infections - microbiology | Keratinocytes - immunology | Pectins - chemistry | Pseudomonas Infections - immunology | Lung Diseases - immunology | Interleukin-4 - immunology | Th1 Cells - microbiology | Animals | Intestines - microbiology | Interferon-gamma - immunology | Mice | Mice, Inbred BALB C | Interleukin-10 - immunology | Pseudomonas Infections/microbiology | Macrophages/microbiology | Oligosaccharides/pharmacology | Macrophages/immunology | Lung Diseases/immunology | Lung Diseases/microbiology | Interferon-gamma/immunology | Keratinocytes/microbiology | Microbiota/drug effects | Life Sciences | Leukocytes/microbiology | Pseudomonas Infections/immunology | Interleukin-10/immunology | Lung Diseases/drug therapy | T-Box Domain Proteins/immunology | Leukocytes/immunology | Pseudomonas aeruginosa/drug effects | Th1 Cells/microbiology | GATA3 Transcription Factor/immunology | Interleukin-4/immunology | Intestines/drug effects | Intestines/microbiology | Keratinocytes/immunology | Chemotactic Factors/immunology | Tumor Necrosis Factor-alpha/immunology | Microbiota/immunology | Pseudomonas aeruginosa/growth & development | Pectins/chemistry | Pseudomonas Infections/drug therapy | Th1 Cells/immunology | Intestines/immunology
Journal Article
Arthritis & rheumatology (Hoboken, N.J.), ISSN 2326-5191, 2016, Volume 68, Issue 10, pp. 2492 - 2502
Objective Antinuclear antibodies (ANAs) are detected in ∼18% of females, yet autoimmune disease develops in only 5–8%. Immunologic differences between... 
SYSTEMIC-LUPUS-ERYTHEMATOSUS | INTERFERON | CYTOKINE PRODUCTION | RISK-FACTORS | DENDRITIC CELLS | ANTINUCLEAR ANTIBODIES | RHEUMATOLOGY | EXPRESSION | SLE | IG-LIKE RECEPTOR-1 | T-CELLS | Interferon-alpha - pharmacology | Multivariate Analysis | Phosphoproteins - drug effects | Interferon-beta - immunology | Antibodies, Antinuclear - immunology | Humans | Middle Aged | Interleukin-17 - immunology | STAT1 Transcription Factor - drug effects | Centromere Protein B - immunology | Male | Monocytes - immunology | Ribosomal Proteins - immunology | Healthy Volunteers | Case-Control Studies | Leukocytes - immunology | Young Adult | Flow Cytometry | Autoimmunity - immunology | Lupus Erythematosus, Systemic - immunology | Ribonucleoproteins - immunology | Tumor Necrosis Factor-alpha - immunology | Aged, 80 and over | Adult | B-Lymphocyte Subsets - immunology | Female | Interleukin-12 Subunit p40 - immunology | Cytokines - immunology | Interleukin 1 Receptor Antagonist Protein - immunology | Immunophenotyping | Logistic Models | Nuclear Proteins - immunology | STAT1 Transcription Factor - immunology | Stem Cell Factor - immunology | Interferon-alpha - immunology | Autoantibodies - immunology | Interferon-gamma - immunology | STAT3 Transcription Factor - drug effects | Sex Factors | Aged | Granulocyte Colony-Stimulating Factor - immunology | STAT3 Transcription Factor - immunology | Plasma Cells - immunology | Systemic Lupus Erythematosus
Journal Article
Blood, ISSN 0006-4971, 02/2015, Volume 125, Issue 9, pp. 1427 - 1434
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2013, Volume 190, Issue 9, pp. 4640 - 4649
Dendritic cells (DC) are professional APCs that regulate innate and adaptive immunity. The role of fatty-acid synthesis in DC development and function is... 
CANCER-CELLS | APOPTOSIS | KAPPA-B ACTIVATION | UNFOLDED PROTEIN RESPONSE | CYTOKINE PRODUCTION | SYNTHASE INHIBITION | ER STRESS | MAP KINASE | MACROPHAGES | ENDOPLASMIC-RETICULUM STRESS | IMMUNOLOGY | Fatty Acids - immunology | Leukocytes, Mononuclear - metabolism | Chemokine CCL2 - immunology | Dendritic Cells - immunology | Humans | Caspase 3 - metabolism | Male | Cyclin B1 - metabolism | Interferon-gamma - metabolism | PPAR gamma - metabolism | CD4-Positive T-Lymphocytes - immunology | Mitogen-Activated Protein Kinase Kinases - metabolism | Liver - immunology | CD8-Positive T-Lymphocytes - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Liver - metabolism | CD4-Positive T-Lymphocytes - metabolism | Interleukin-12 - metabolism | B7-2 Antigen - metabolism | Cell Differentiation - immunology | Intercellular Adhesion Molecule-1 - metabolism | Proto-Oncogene Proteins c-akt - immunology | T-Lymphocytes, Cytotoxic - metabolism | Endoplasmic Reticulum - immunology | Interleukin-12 - immunology | Mice | Killer Cells, Natural - metabolism | CD8-Positive T-Lymphocytes - immunology | bcl-X Protein - metabolism | Fatty Acids - biosynthesis | Mitogen-Activated Protein Kinase Kinases - immunology | Caspase 3 - immunology | Endoplasmic Reticulum - metabolism | Genes, MHC Class II - immunology | PPAR gamma - immunology | Cyclin B1 - immunology | Leukocytes, Mononuclear - immunology | bcl-X Protein - immunology | Killer Cells, Natural - immunology | Chemokine CCL2 - metabolism | B7-2 Antigen - immunology | Fatty Acids - metabolism | Dendritic Cells - metabolism | T-Lymphocytes, Cytotoxic - immunology | B7-1 Antigen - immunology | Intercellular Adhesion Molecule-1 - immunology | Mice, Inbred C57BL | B7-1 Antigen - metabolism | Animals | Apoptosis - immunology | Interferon-gamma - immunology | Dendritic Cells - cytology | Fatty-acid synthesis | ER stress | NK cells | T cells | Bone marrow dendritic cells
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0175153
IL-1 beta is a potent player in cutaneous inflammation and central for the development of a Th17 micro-milieu in autoinflammatory diseases including psoriasis.... 
VITAMIN-D | SYSTEMIC-LUPUS-ERYTHEMATOSUS | INTERFERON-GAMMA | MULTIDISCIPLINARY SCIENCES | PSORIASIN S100A7 | INFLAMMATORY CASPASES | KERATINOCYTES | 1,25-DIHYDROXYVITAMIN D-3 | MOLECULAR-CLONING | EXPRESSION | T-CELLS | Caspases - immunology | Humans | Interleukin-17 - immunology | Interleukin-17 - pharmacology | Interleukin-1beta - genetics | S100 Proteins - immunology | Psoriasis - genetics | S100 Proteins - genetics | Th17 Cells - drug effects | Transfection | Inflammasomes - drug effects | Psoriasis - pathology | Adaptor Proteins, Signal Transducing - immunology | Apoptosis Regulatory Proteins - genetics | Skin - pathology | Skin - immunology | Th17 Cells - pathology | Interleukin-1beta - secretion | Psoriasis - immunology | S100 Calcium Binding Protein A7 | Apoptosis Regulatory Proteins - immunology | DNA - immunology | Signal Transduction | Caspases - genetics | Cells, Cultured | Gene Expression Regulation | Interleukin-17 - genetics | Interleukin-1beta - immunology | Vitamin D - pharmacology | Keratinocytes - cytology | Keratinocytes - immunology | DNA - genetics | Interleukin-17 - antagonists & inhibitors | Keratinocytes - drug effects | Inflammasomes - immunology | Adaptor Proteins, Signal Transducing - genetics | Th17 Cells - immunology | Interferon-gamma - pharmacology | Interleukins | Physiological aspects | Development and progression | Skin diseases | Genetic aspects | Inflammation | Research | Cell culture | Transcription | Interleukin | Helper cells | Lymphocytes T | Inflammatory diseases | Vitamin D | Lymphocytes | Interleukin 1 | Lesions | Deoxyribonucleic acid--DNA | Psoriasis | Cytokines | Dermatology | Keratinocytes | Caspase | Epidermis | Hazards | Gene expression | Caspase-5 | Hospitals | Biopsy | Interferon | Autoimmune diseases | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2014, Volume 192, Issue 2, pp. 623 - 629
Chronic inflammation is known to promote metabolic dysregulation in obesity and type 2 diabetes. Although the precise origin of the unchecked inflammatory... 
IMMUNE-SYSTEM | INFLAMMATION | DISEASE | RESISTANCE | FAT | AKT | IMMUNOLOGY | DIET-INDUCED OBESITY | KEY PLAYERS | ADIPOSE-TISSUE | CUTTING EDGE | Tumor Necrosis Factor-alpha - metabolism | Antigens, CD - immunology | T-Lymphocytes, Regulatory - metabolism | Epithelial Cells - metabolism | TOR Serine-Threonine Kinases - metabolism | Obesity - immunology | Insulin - immunology | Interferon-gamma - metabolism | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | Epithelium - immunology | Signal Transduction - immunology | Inflammation - metabolism | Tumor Necrosis Factor-alpha - immunology | Interleukin-10 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Insulin - immunology | Macrophages - immunology | Hyperinsulinism - metabolism | Intra-Abdominal Fat - immunology | Transforming Growth Factor beta - immunology | Epithelium - metabolism | Mice, Inbred C57BL | Apyrase - metabolism | Cells, Cultured | Apyrase - immunology | CTLA-4 Antigen - metabolism | Inflammation - immunology | CTLA-4 Antigen - immunology | Intra-Abdominal Fat - metabolism | Obesity - metabolism | TOR Serine-Threonine Kinases - immunology | Insulin - metabolism | Macrophages - metabolism | Animals | Hyperinsulinism - immunology | Proto-Oncogene Proteins c-akt - immunology | Epithelial Cells - immunology | Interferon-gamma - immunology | Interleukin-10 - antagonists & inhibitors | Receptor, Insulin - metabolism | Mice | Interleukin-10 - immunology | Transforming Growth Factor beta - metabolism
Journal Article
Journal Article
Mucosal Immunology, ISSN 1933-0219, 01/2016, Volume 9, Issue 1, pp. 24 - 37
HIV-1-associated disruption of intestinal homeostasis is a major factor contributing to chronic immune activation and inflammation. Dendritic cells (DCs) are... 
TRANSLOCATION | RESPONSES | LYMPHOID-TISSUE | INFLAMMATION | PREDICT MORTALITY | IMMUNE ACTIVATION | ANTIRETROVIRAL THERAPY | INTESTINAL LAMINA PROPRIA | IMMUNOLOGY | VIRUS TYPE-1 INFECTION | SIV INFECTION | Antigens, CD - immunology | Immunoglobulins - immunology | Dendritic Cells - immunology | Humans | Middle Aged | Colon - immunology | Male | Immunoglobulins - genetics | Antigens, CD - genetics | Case-Control Studies | Viral Load | Ruminococcus - immunology | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | HIV Infections - microbiology | Prevotella - immunology | HIV Infections - pathology | Prevotella - growth & development | Adult | Female | CD40 Antigens - genetics | Interferon-gamma - genetics | Membrane Glycoproteins - immunology | Ruminococcus - growth & development | Glycoproteins - genetics | Antigens, CD1 - immunology | CD4-Positive T-Lymphocytes - microbiology | CD8-Positive T-Lymphocytes - microbiology | Signal Transduction | Lymphocyte Activation | Gene Expression Regulation | Membrane Glycoproteins - genetics | Glycoproteins - immunology | HIV-1 - immunology | Mucous Membrane - immunology | Interferon-gamma - immunology | Dendritic Cells - microbiology | Colon - microbiology | Antigens, CD1 - genetics | Gastrointestinal Microbiome - immunology | CD8-Positive T-Lymphocytes - immunology | CD40 Antigens - immunology | Mucous Membrane - microbiology | Cell Lineage - immunology | mucosal immunology | HIV-1 pathogenesis | microbiome | Human intestinal dendritic cells
Journal Article