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Cell Metabolism, ISSN 1550-4131, 12/2013, Volume 18, Issue 6, pp. 844 - 859
Journal Article
Diabetes Care, ISSN 0149-5992, 04/2010, Volume 33, Issue 4, pp. 861 - 868
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2014, Volume 192, Issue 2, pp. 623 - 629
Chronic inflammation is known to promote metabolic dysregulation in obesity and type 2 diabetes. Although the precise origin of the unchecked inflammatory... 
IMMUNE-SYSTEM | INFLAMMATION | DISEASE | RESISTANCE | FAT | AKT | IMMUNOLOGY | DIET-INDUCED OBESITY | KEY PLAYERS | ADIPOSE-TISSUE | CUTTING EDGE | Tumor Necrosis Factor-alpha - metabolism | Antigens, CD - immunology | T-Lymphocytes, Regulatory - metabolism | Epithelial Cells - metabolism | TOR Serine-Threonine Kinases - metabolism | Obesity - immunology | Insulin - immunology | Interferon-gamma - metabolism | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | Epithelium - immunology | Signal Transduction - immunology | Inflammation - metabolism | Tumor Necrosis Factor-alpha - immunology | Interleukin-10 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Insulin - immunology | Macrophages - immunology | Hyperinsulinism - metabolism | Intra-Abdominal Fat - immunology | Transforming Growth Factor beta - immunology | Epithelium - metabolism | Mice, Inbred C57BL | Apyrase - metabolism | Cells, Cultured | Apyrase - immunology | CTLA-4 Antigen - metabolism | Inflammation - immunology | CTLA-4 Antigen - immunology | Intra-Abdominal Fat - metabolism | Obesity - metabolism | TOR Serine-Threonine Kinases - immunology | Insulin - metabolism | Macrophages - metabolism | Animals | Hyperinsulinism - immunology | Proto-Oncogene Proteins c-akt - immunology | Epithelial Cells - immunology | Interferon-gamma - immunology | Interleukin-10 - antagonists & inhibitors | Receptor, Insulin - metabolism | Mice | Interleukin-10 - immunology | Transforming Growth Factor beta - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Nature immunology, ISSN 1529-2908, 2016, Volume 17, Issue 4, pp. 406 - 413
The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages in some patients, immunoparalysis may be encountered, which is... 
SYSTEMIC INFLAMMATION | MESSENGER-RNA TRANSLATION | ACTIVATION | INTERFERON-GAMMA | IFN-GAMMA | MACROPHAGES | SIRTUIN 1 | DYSFUNCTION | IMMUNOLOGY | EXPRESSION | CELLULAR-METABOLISM | Prospective Studies | Humans | Middle Aged | Transcriptome | Immunoblotting | Male | Monocytes - metabolism | Monocytes - immunology | Lipopolysaccharides - immunology | Antifungal Agents - therapeutic use | Leukocytes - immunology | Young Adult | Sepsis - drug therapy | Immune Tolerance - immunology | Sepsis - metabolism | Adenosine Triphosphate - metabolism | Candidiasis, Invasive - drug therapy | Endotoxemia - immunology | Adult | Aspergillosis - metabolism | Female | Macrophages - immunology | NAD - metabolism | Aspergillosis - drug therapy | Cytokines - immunology | Sepsis - immunology | Interferon-gamma - therapeutic use | Lactic Acid - metabolism | Oxidative Phosphorylation | Oxygen Consumption | Energy Metabolism - immunology | Escherichia coli Infections - metabolism | Candidiasis, Invasive - metabolism | Immunity, Innate - immunology | Macrophages - metabolism | Animals | Candidiasis, Invasive - immunology | Glycolysis | Escherichia coli Infections - immunology | Mice | Endotoxemia - metabolism | Leukocytes - metabolism | Aspergillosis - immunology | Complications and side effects | Energy metabolism | Immune response | Bioenergetics | Abnormalities | Sepsis | Regulation | Leukocytes | Properties | Health aspects | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2013, Volume 190, Issue 9, pp. 4640 - 4649
Dendritic cells (DC) are professional APCs that regulate innate and adaptive immunity. The role of fatty-acid synthesis in DC development and function is... 
CANCER-CELLS | APOPTOSIS | KAPPA-B ACTIVATION | UNFOLDED PROTEIN RESPONSE | CYTOKINE PRODUCTION | SYNTHASE INHIBITION | ER STRESS | MAP KINASE | MACROPHAGES | ENDOPLASMIC-RETICULUM STRESS | IMMUNOLOGY | Fatty Acids - immunology | Leukocytes, Mononuclear - metabolism | Chemokine CCL2 - immunology | Dendritic Cells - immunology | Humans | Caspase 3 - metabolism | Male | Cyclin B1 - metabolism | Interferon-gamma - metabolism | PPAR gamma - metabolism | CD4-Positive T-Lymphocytes - immunology | Mitogen-Activated Protein Kinase Kinases - metabolism | Liver - immunology | CD8-Positive T-Lymphocytes - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Liver - metabolism | CD4-Positive T-Lymphocytes - metabolism | Interleukin-12 - metabolism | B7-2 Antigen - metabolism | Cell Differentiation - immunology | Intercellular Adhesion Molecule-1 - metabolism | Proto-Oncogene Proteins c-akt - immunology | T-Lymphocytes, Cytotoxic - metabolism | Endoplasmic Reticulum - immunology | Interleukin-12 - immunology | Mice | Killer Cells, Natural - metabolism | CD8-Positive T-Lymphocytes - immunology | bcl-X Protein - metabolism | Fatty Acids - biosynthesis | Mitogen-Activated Protein Kinase Kinases - immunology | Caspase 3 - immunology | Endoplasmic Reticulum - metabolism | Genes, MHC Class II - immunology | PPAR gamma - immunology | Cyclin B1 - immunology | Leukocytes, Mononuclear - immunology | bcl-X Protein - immunology | Killer Cells, Natural - immunology | Chemokine CCL2 - metabolism | B7-2 Antigen - immunology | Fatty Acids - metabolism | Dendritic Cells - metabolism | T-Lymphocytes, Cytotoxic - immunology | B7-1 Antigen - immunology | Intercellular Adhesion Molecule-1 - immunology | Mice, Inbred C57BL | B7-1 Antigen - metabolism | Animals | Apoptosis - immunology | Interferon-gamma - immunology | Dendritic Cells - cytology | Index Medicus | Abridged Index Medicus | Fatty-acid synthesis | ER stress | NK cells | T cells | Bone marrow dendritic cells
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 10/2013, Volume 15, Issue 5, pp. R151 - R151
Introduction: T helper (Th)-17 cells are increased in systemic sclerosis (SSc). We therefore assessed whether Th17 cells could modulate the inflammatory and... 
RHEUMATOID-ARTHRITIS | MATRIX METALLOPROTEINASES | SYNOVIAL FIBROBLASTS | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | GENE-EXPRESSION | SKIN FIBROSIS | NECROSIS-FACTOR-ALPHA | RHEUMATOLOGY | NF-KAPPA-B | T-CELLS | PULMONARY-FIBROSIS | Interleukin-8 - genetics | Gene Expression - drug effects | Skin - metabolism | Humans | Scleroderma, Systemic - pathology | Culture Media, Conditioned - pharmacology | Male | Interleukin-17 - pharmacology | Dose-Response Relationship, Drug | Collagen Type I - genetics | Th17 Cells - metabolism | Radioimmunoassay | Inflammation Mediators - metabolism | Female | Chemokine CCL2 - metabolism | Interleukin-8 - metabolism | Matrix Metalloproteinase 1 - genetics | Skin - pathology | Fibroblasts - metabolism | Collagen Type I - metabolism | Enzyme-Linked Immunosorbent Assay | Scleroderma, Systemic - metabolism | Cells, Cultured | Scleroderma, Systemic - genetics | Chemokine CCL2 - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Tumor Necrosis Factor-alpha - pharmacology | Fibroblasts - drug effects | Matrix Metalloproteinase 1 - metabolism | Interferon-gamma - pharmacology | Culture Media, Conditioned - metabolism | Proteins | Medical equipment and supplies industry | Interleukins | Systemic scleroderma | Medical test kit industry | Scleroderma (Disease) | High-definition television | Skin | Biological response modifiers | Enzyme-linked immunosorbent assay | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 11, pp. e112945 - e112945
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants,... 
OXIDATIVE STRESS | QUINOLINIC ACID | MAMMALIAN BRAIN | POOR-PROGNOSIS | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | TRYPTOPHAN 2,3-DIOXYGENASE | TUMORAL IMMUNE RESISTANCE | T-CELLS | IDO EXPRESSION | BRAIN-TUMORS | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Kynurenic Acid - blood | Gene Expression - drug effects | Humans | Kynurenine - biosynthesis | Brain Neoplasms - physiopathology | Picolinic Acids - blood | Quinolinic Acid - blood | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Kynurenic Acid - metabolism | Carboxy-Lyases - genetics | Tryptophan - metabolism | Brain Neoplasms - metabolism | Picolinic Acids - metabolism | Antigens, CD - metabolism | Glioma - metabolism | Glioma - genetics | Kynurenine - blood | Tryptophan - blood | Carboxy-Lyases - metabolism | Tumor Cells, Cultured | Astrocytes - drug effects | Disaccharides | Cells, Cultured | Brain Neoplasms - genetics | Biosynthetic Pathways | Reverse Transcriptase Polymerase Chain Reaction | Glucuronates | Tryptophan Oxygenase - metabolism | Tryptophan Oxygenase - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | Quinolinic Acid - metabolism | CD11b Antigen - metabolism | Glioma - physiopathology | Interferon-gamma - pharmacology | Astrocytes - metabolism | Tryptophan | Niacinamide | Methyl aspartate | Enzymes | Metabolites | Gliomas | NADPH | Neuroprotection | Brain | Brain tumors | Brain cancer | Glioblastoma | Tryptophan 2,3-dioxygenase | Immunity | DNA repair | Picolinic acid | Rodents | Glioma cells | L-Tryptophan | Kynurenic acid | Quinolinic acid | Deoxyribonucleic acid--DNA | Pyridines | Medical research | Hydroxylase | Adenine | Kynurenine-oxoglutarate transaminase | NAD | Acids | γ-Interferon | Nicotinamide adenine dinucleotide | Catabolism | Nicotinamide | Interferon | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Diabetes, ISSN 0012-1797, 03/2016, Volume 65, Issue 3, pp. 598 - 609
Journal Article
International Immunology, ISSN 0953-8178, 4/2007, Volume 19, Issue 4, pp. 345 - 354
Forkhead box P3 (FOXP3) is currently thought to be the most specific marker for naturally occurring CD4+CD25+ T regulatory cells (nTregs). In mice, expression... 
INTERLEUKIN-2 | TGF-BETA | T cell activation | transcription factors | INDUCTION | IMMUNOLOGY | T cells | REGULATORY-CELLS | TRANSCRIPTION FACTOR FOXP3 | COSTIMULATION | GENERATION | FLOW-CYTOMETRY | DIFFERENTIATION | human | EXPRESSION | tolerance | T-Lymphocyte Subsets - immunology | Cysteine - analogs & derivatives | T-Lymphocytes, Regulatory - metabolism | Cell Proliferation | Coculture Techniques | Humans | Clonal Anergy | Receptors, Nerve Growth Factor - metabolism | Interferon-gamma - metabolism | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Flagellin - pharmacology | Lymphocyte Activation - immunology | Forkhead Transcription Factors - metabolism | T-Lymphocyte Subsets - drug effects | Cysteine - pharmacology | Antigens, Differentiation - metabolism | Interleukin-2 - metabolism | Receptors, Tumor Necrosis Factor - metabolism | Cell Line | Cytokines - metabolism | Lectins, C-Type | Toll-Like Receptors - immunology | CD4-Positive T-Lymphocytes - metabolism | Glucocorticoid-Induced TNFR-Related Protein | Antigens, Differentiation, T-Lymphocyte - metabolism | CD28 Antigens - immunology | Antibodies - pharmacology | CTLA-4 Antigen | T-Lymphocytes, Regulatory - drug effects | Interleukin-2 Receptor alpha Subunit - metabolism | Lipoproteins - pharmacology | T-Lymphocyte Subsets - metabolism | Interleukin-7 Receptor alpha Subunit - metabolism | CD3 Complex - immunology | Interleukin-2 - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 7, pp. 1784 - 1794.e6
Background & Aims Premalignant lesions and early stage tumors contain immunosuppressive microenvironments that create barriers for cancer vaccines. Kras G12D/+... 
Gastroenterology and Hepatology | Tumor Microenvironment | Pancreatic Cancer | Listeria Vaccine | Immunity | MONOCYTOGENES | DUCTAL ADENOCARCINOMA | ONCOGENIC KRAS | CANCER | TUMORS | ADOPTIVE TRANSFER | IMMUNOTHERAPY | MOUSE MODEL | TC17 CELLS | SUPPRESSOR-CELLS | GASTROENTEROLOGY & HEPATOLOGY | Pancreatic Neoplasms - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Homeodomain Proteins - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Interferon-gamma - metabolism | Mice, 129 Strain | Carcinoma, Pancreatic Ductal - genetics | T-Lymphocytes, Regulatory - immunology | Cancer Vaccines - therapeutic use | Carcinoma in Situ - genetics | Time Factors | Forkhead Transcription Factors - metabolism | Listeria monocytogenes - metabolism | Disease Models, Animal | Carcinoma in Situ - pathology | Antibodies, Monoclonal - pharmacology | Pancreatic Neoplasms - pathology | Mice, Transgenic | Disease Progression | Interleukin-17 - metabolism | Cyclophosphamide - pharmacology | Pancreatic Neoplasms - immunology | Mice | Mutation | Carcinoma in Situ - metabolism | T-Lymphocytes, Regulatory - metabolism | Carcinoma in Situ - drug therapy | Carcinoma in Situ - immunology | Listeria monocytogenes - immunology | Tumor Suppressor Protein p53 - genetics | Pancreatic Neoplasms - drug therapy | Inflammation Mediators - metabolism | Trans-Activators - genetics | Integrases - metabolism | Carcinoma, Pancreatic Ductal - immunology | Proto-Oncogene Proteins p21(ras) - metabolism | Mice, Inbred C57BL | Receptors, Chemokine - metabolism | Tumor Suppressor Protein p53 - metabolism | Pancreatic Neoplasms - genetics | Carcinoma, Pancreatic Ductal - pathology | Homeodomain Proteins - genetics | Cancer Vaccines - immunology | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Listeria monocytogenes - genetics | Trans-Activators - metabolism | CD11b Antigen - metabolism | Integrases - genetics | Medical colleges | Vaccines | Listeria | Developmental biology | Pancreatic cancer | Contamination | Index Medicus | Abridged Index Medicus
Journal Article