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IUBMB Life, ISSN 1521-6543, 04/2016, Volume 68, Issue 4, pp. 259 - 267
The emergence of complex diseases is promoting a change from one‐target to multitarget drugs and peptides are ideal molecules to fulfill this polypharmacologic... 
autophagy | polypharmacology | antimicrobial peptides | tuberculosis | MYCOBACTERIUM-TUBERCULOSIS | STREPTOCOCCUS-MUTANS | SURVIVAL | CELLS | ANTIBIOTICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | FUTURE | CELL BIOLOGY | DISEASE | ANTIMICROBIAL PEPTIDE | TYPE-2 MACROPHAGES | Tuberculosis, Pulmonary - microbiology | Humans | Tumor Necrosis Factor-alpha - genetics | Mycobacterium tuberculosis - immunology | Tuberculosis, Pulmonary - drug therapy | Molecular Targeted Therapy | Tuberculosis, Pulmonary - genetics | GTP-Binding Proteins - genetics | Mycobacterium tuberculosis - drug effects | Autophagy - drug effects | Interleukins - genetics | T-Lymphocytes - drug effects | Interleukins - immunology | Autophagy-Related Proteins - immunology | Tumor Necrosis Factor-alpha - immunology | Interferon-gamma - genetics | Autophagy-Related Proteins - genetics | T-Lymphocytes - microbiology | GTP-Binding Proteins - immunology | Signal Transduction | Phagocytes - drug effects | Antimicrobial Cationic Peptides - pharmacology | Antitubercular Agents - pharmacology | Gene Expression Regulation | Phagocytes - immunology | Tuberculosis, Pulmonary - immunology | Phagocytes - microbiology | Interferon-gamma - immunology | T-Lymphocytes - immunology | Mycobacterium tuberculosis - growth & development | Peptides | Health aspects | Usage
Journal Article
Journal Article
Journal Article
Molecular Immunology, ISSN 0161-5890, 06/2012, Volume 51, Issue 2, pp. 101 - 111
► We describe a high, synergistic induction of IDO1 expression by the demethylating drug zebularine and IFN-γ in the human monocytic cell line THP-1. ► The... 
DNA methylation | IFN-γ | Transcription factors | Zebularine | IDO1 gene promoter | Human and rat | COLLAGEN-INDUCED ARTHRITIS | DENDRITIC CELLS | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA METHYLTRANSFERASE INHIBITORS | IMMUNOLOGY | TRYPTOPHAN CATABOLISM | T-CELL PROLIFERATION | IFN-gamma | IMMUNE SUPPRESSION | HUMAN GLIOBLASTOMA | GENE-EXPRESSION | INTERFERON REGULATORY FACTOR-1 | Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Promoter Regions, Genetic | Cytidine - administration & dosage | Gene Expression - drug effects | Humans | Cells, Cultured | Rats | Cytidine - analogs & derivatives | Reverse Transcriptase Polymerase Chain Reaction | STAT1 Transcription Factor - genetics | Interferon Regulatory Factor-1 - genetics | Autoimmune Diseases - genetics | Drug Synergism | Gene Expression Regulation - drug effects | DNA Methylation | Animals | Epigenesis, Genetic - genetics | Interferon-gamma - administration & dosage | Real-Time Polymerase Chain Reaction | STAT1 Transcription Factor - biosynthesis | Interferon Regulatory Factor-1 - biosynthesis | Inflammation | Interferon regulatory factor 1 | Tryptophan 2,3-dioxygenase | Promoters | epigenetics | Demethylation | Immunosuppression | Monocytes | Colon cancer | gamma -Interferon | DNA methyltransferase | Autoimmune diseases | Stat1 protein | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Immunologi inom det medicinska området | Immunology in the medical area
Journal Article