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PLoS pathogens, ISSN 1553-7374, 2013, Volume 9, Issue 11, p. e1003773
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Nature immunology, ISSN 1529-2908, 02/2016, Volume 17, Issue 2, pp. 140 - 149
Innate sensing of pathogens initiates inflammatory cytokine responses that need to be tightly controlled. We found here that after engagement of Toll-like... 
TRANSREPRESSION | PATHWAYS | CONJUGATION | INTERFERON | ACTIVATION | SUMO | BETA-GENE | NEGATIVE REGULATION | MACROPHAGES | ENHANCER | IMMUNOLOGY | Chromatin - metabolism | Dendritic Cells - immunology | Gene Expression Profiling | Genetic Loci | Shock, Septic - immunology | Lipopolysaccharides - immunology | Shock, Septic - metabolism | Inflammation - metabolism | Inflammation Mediators - metabolism | Toll-Like Receptors - metabolism | Dendritic Cells - metabolism | Disease Models, Animal | Receptor, Interferon alpha-beta - metabolism | Shock, Septic - genetics | Sumoylation - genetics | Disease Resistance | Disease Susceptibility | Cytokines - metabolism | Signal Transduction | Immunomodulation | Gene Expression Regulation | Inflammation - virology | Inflammation - immunology | Immunity, Innate | Mice, Knockout | Animals | Enhancer Elements, Genetic | Interferon-beta - metabolism | Regulatory Elements, Transcriptional | Sumoylation - immunology | Inflammation - genetics | Protein Binding | Mice | SUMO-1 Protein - metabolism | Chromatin - genetics | Analysis | Influence | Interferon | Inflammation | Research | Biological response modifiers | Gene expression | Health aspects | Risk factors | Shock, Septic/metabolism | Inflammation Mediators/metabolism | Sumoylation/immunology | Interferon-beta/metabolism | Dendritic Cells/metabolism | Inflammation/virology | Inflammation/immunology | Life Sciences | Immunology | Receptor, Interferon alpha-beta/metabolism | Inflammation/genetics | SUMO-1 Protein/metabolism | Cytokines/metabolism | Sumoylation/genetics | Chromatin/metabolism | Inflammation/metabolism | Toll-Like Receptors/metabolism | Lipopolysaccharides/immunology | Shock, Septic/immunology | Chromatin/genetics | Shock, Septic/genetics | Dendritic Cells/immunology
Journal Article
BMC biology, ISSN 1741-7007, 2012, Volume 10, Issue 1, pp. 44 - 44
Journal Article
Nature (London), ISSN 1476-4687, 2019, Volume 567, Issue 7747, pp. 262 - 266
Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self DNA in the cytoplasm(1). Upon binding DNA, cGAS... 
SYNTHASE | CYCLIC GMP-AMP | MAVS | PROTEIN | ROLES | MULTIDISCIPLINARY SCIENCES | ADAPTER | SENSOR | Nucleotides, Cyclic - metabolism | Interferons - biosynthesis | Beclin-1 - deficiency | Vesicular Transport Proteins - metabolism | Humans | Endoplasmic Reticulum - metabolism | Autophagy-Related Protein 5 - genetics | Autophagy-Related Protein-1 Homolog - metabolism | DNA Viruses - metabolism | Interferons - immunology | Autophagy | DNA Viruses - genetics | Sea Anemones | Membrane Proteins - deficiency | HEK293 Cells | Membrane Proteins - metabolism | Nucleotidyltransferases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Phosphate-Binding Proteins | Signal Transduction | Membrane Proteins - genetics | DNA, Viral - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Autophagosomes - metabolism | Cytosol - virology | Protein Transport | Carrier Proteins - genetics | Animals | Autophagy-Related Protein-1 Homolog - deficiency | Carrier Proteins - metabolism | Monomeric GTP-Binding Proteins - metabolism | Autophagy-Related Protein 5 - deficiency | Autophagy-Related Protein 5 - metabolism | Beclin-1 - genetics | Golgi Apparatus - metabolism | Mice | Beclin-1 - metabolism | Autophagy-Related Protein-1 Homolog - genetics | Nucleotides, Cyclic - immunology | Evolution, Molecular | Biological research | Autophagy (Cytology) | Enzymes | Physiological aspects | Interferon | Research | Cytoplasm | Biology, Experimental
Journal Article
The Journal of immunology (1950), ISSN 0022-1767, 01/2014, Volume 192, Issue 2, pp. 623 - 629
.... Although the precise origin of the unchecked inflammatory response in obesity is unclear, it is known that overproduction of proinflammatory cytokines by innate immune cells affects metabolism... 
IMMUNE-SYSTEM | INFLAMMATION | DISEASE | RESISTANCE | FAT | AKT | IMMUNOLOGY | DIET-INDUCED OBESITY | KEY PLAYERS | ADIPOSE-TISSUE | CUTTING EDGE | Tumor Necrosis Factor-alpha - metabolism | Antigens, CD - immunology | T-Lymphocytes, Regulatory - metabolism | Epithelial Cells - metabolism | TOR Serine-Threonine Kinases - metabolism | Obesity - immunology | Insulin - immunology | Interferon-gamma - metabolism | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | Epithelium - immunology | Signal Transduction - immunology | Inflammation - metabolism | Tumor Necrosis Factor-alpha - immunology | Interleukin-10 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Insulin - immunology | Macrophages - immunology | Hyperinsulinism - metabolism | Intra-Abdominal Fat - immunology | Transforming Growth Factor beta - immunology | Epithelium - metabolism | Mice, Inbred C57BL | Apyrase - metabolism | Cells, Cultured | Apyrase - immunology | CTLA-4 Antigen - metabolism | Inflammation - immunology | CTLA-4 Antigen - immunology | Intra-Abdominal Fat - metabolism | Obesity - metabolism | TOR Serine-Threonine Kinases - immunology | Insulin - metabolism | Macrophages - metabolism | Animals | Hyperinsulinism - immunology | Proto-Oncogene Proteins c-akt - immunology | Epithelial Cells - immunology | Interferon-gamma - immunology | Interleukin-10 - antagonists & inhibitors | Receptor, Insulin - metabolism | Mice | Interleukin-10 - immunology | Transforming Growth Factor beta - metabolism
Journal Article
Inflammation research, ISSN 1023-3830, 02/2018, Volume 67, Issue 2, pp. 169 - 177
OBJECTIVE: To investigate the ex vivo pro-inflammatory properties of classical and non-classical monocytes as well as myeloid dendritic cells (mDCs) in... 
Dendrites/metabolism | Humans | Middle Aged | Male | Journal Article | Interleukin-8/metabolism | Immunology | Adult | Female | Classical monocytes | Interferons/metabolism | Pulmonary Fibrosis/metabolism | Myeloid dendritic cells | Inflammation | Sialic Acid Binding Ig-like Lectin 1/metabolism | Pharmacology | Non-classical monocytes | Scleroderma, Systemic/metabolism | Chemokine CCL4/metabolism | Systemic sclerosis | Toll-Like Receptor 4/metabolism | Aged | Myeloid Cells/metabolism | Chemokines | Cytokines/biosynthesis | Chemokine CXCL10/metabolism | Monocytes/metabolism | Dermatology | Rheumatology | Allergology | Neurology | Biomedicine | Pharmacology/Toxicology | BRONCHOALVEOLAR LAVAGE FLUID | SUBSETS | CYTOKINE | IMMUNOLOGY | CELL BIOLOGY | INTERSTITIAL LUNG-DISEASE | PATHOGENESIS | SCLERODERMA | GENE-EXPRESSION | CHEMOKINE FAMILY | RECEPTORS | PULMONARY-FIBROSIS | Dendrites - metabolism | Scleroderma, Systemic - metabolism | Monocytes - metabolism | Toll-Like Receptor 4 - metabolism | Sialic Acid Binding Ig-like Lectin 1 - metabolism | Interferons - metabolism | Myeloid Cells - metabolism | Chemokine CCL4 - metabolism | Pulmonary Fibrosis - metabolism | Interleukin-8 - metabolism | Chemokine CXCL10 - metabolism | Cytokines - biosynthesis | Interferon | Systemic scleroderma | Dendritic cells | Biological response modifiers | Analysis | Scleroderma (Disease) | Cluster analysis | Flow cytometry | Respiratory function | Carbon tetrachloride | Stimulation | Parameter identification | Interleukin 6 | Proteins | Peripheral blood | Toll-like receptors | Immune system | Cytokines | Lung diseases | Clustering | Patients | Cytometry | Monocytes | Production methods | γ-Interferon | CXCL10 protein | Fibrosis | Pulmonary functions | Original Research Paper
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2007, Volume 133, Issue 2, pp. 559 - 573
Background & Aims: Recent studies have revealed that murine intestinal mucosa contains several kinds of lineage markers (lin)– c-kit+ immune precursor cells.... 
Gastroenterology and Hepatology | INFLAMMATORY-BOWEL-DISEASE | GUT CRYPTOPATCHES | NK CELLS | DENDRITIC CELLS | PEYERS-PATCHES | ALPHA-BETA | LYMPH-NODES | DELTA-T-CELLS | GASTROENTEROLOGY & HEPATOLOGY | LYMPHOCYTES-T | FETAL THYMUS | Membrane Glycoproteins - metabolism | Humans | Colitis, Ulcerative - genetics | Crohn Disease - metabolism | Hematopoietic Stem Cells - pathology | Lymphotoxin-alpha - metabolism | Interferon-gamma - metabolism | RNA, Messenger - metabolism | Colitis, Ulcerative - immunology | Antigens, CD - metabolism | Immunoglobulins - metabolism | Lymphotoxin-alpha - genetics | Time Factors | Intestinal Mucosa - immunology | Inhibitor of Differentiation Protein 2 - genetics | Cell Differentiation | Gene Expression | Colitis, Ulcerative - metabolism | Colitis, Ulcerative - pathology | Inhibitor of Differentiation Protein 2 - metabolism | Cell Lineage | Adult Stem Cells - metabolism | Interleukin-2 Receptor alpha Subunit - metabolism | Crohn Disease - pathology | ADP-ribosyl Cyclase 1 - metabolism | Killer Cells, Natural - metabolism | Intestinal Mucosa - pathology | Crohn Disease - genetics | Intestinal Mucosa - metabolism | Antigens, CD34 - metabolism | Killer Cells, Natural - pathology | Proto-Oncogene Proteins c-kit - metabolism | Adult Stem Cells - immunology | DNA-Binding Proteins - metabolism | Hematopoietic Stem Cells - immunology | Trans-Activators - genetics | Killer Cells, Natural - immunology | Adult Stem Cells - pathology | Sialic Acid Binding Ig-like Lectin 3 | Proto-Oncogene Proteins - metabolism | CD56 Antigen - metabolism | Receptors, Interleukin-7 - metabolism | Cells, Cultured | Immunophenotyping | Proto-Oncogene Proteins - genetics | Hematopoietic Stem Cells - metabolism | Integrin alpha Chains - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Crohn Disease - immunology | Transcription Factors - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Trans-Activators - metabolism
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 1, p. e0169648
The structural maintenance of chromosome 5/6 complex (Smc5/6) is a restriction factor that represses hepatitis B virus (HBV) transcription. HBV counters this... 
CELLS | NUCLEAR-BODIES | HEPATITIS-B-VIRUS | REPLICATION | DNA | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | EPIGENETIC REGULATION | COMPONENTS | BINDING | HUMANIZED MICE | Autoantigens - metabolism | Hepatitis B - metabolism | Antigens, Nuclear - metabolism | Humans | Hepatitis B - virology | Male | Hepatocytes - metabolism | Autoantigens - genetics | Hepatitis B - immunology | Hepatocytes - cytology | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Promyelocytic Leukemia Protein - metabolism | Nuclear Proteins - genetics | Cytokines - genetics | Hepatitis B virus - immunology | Promyelocytic Leukemia Protein - genetics | Cytokines - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Chromosomal Proteins, Non-Histone | Nuclear Proteins - metabolism | Mice, SCID | Immunity, Innate - immunology | Animals | Antigens, Nuclear - genetics | Virus Replication | Trans-Activators - metabolism | Mice | Immune response | Analysis | Genetic aspects | Hepatitis B virus | Research | Genetic transcription | Hepatitis B | Cell culture | HBX protein | Pathogenesis | Viruses | Infections | Genomes | Degradation | Proteins | Hepatitis | Hepatology | Localization | Bioinformatics | Chromosomes | Deoxyribonucleic acid--DNA | Immune system | Antigens | Cytokines | Chromosome 5 | Gene expression | Ribonucleic acid--RNA | Hepatocytes | Interferon | Kinetics | RNA | Deoxyribonucleic acid | Ribonucleic acid
Journal Article
Arthritis research & therapy, ISSN 1478-6354, 2013, Volume 15, Issue 5, pp. R151 - R151
Introduction: T helper (Th)-17 cells are increased in systemic sclerosis (SSc). We therefore assessed whether Th17 cells could modulate the inflammatory and... 
RHEUMATOID-ARTHRITIS | MATRIX METALLOPROTEINASES | SYNOVIAL FIBROBLASTS | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | GENE-EXPRESSION | SKIN FIBROSIS | NECROSIS-FACTOR-ALPHA | RHEUMATOLOGY | NF-KAPPA-B | T-CELLS | PULMONARY-FIBROSIS | Interleukin-8 - genetics | Gene Expression - drug effects | Skin - metabolism | Humans | Scleroderma, Systemic - pathology | Culture Media, Conditioned - pharmacology | Male | Interleukin-17 - pharmacology | Dose-Response Relationship, Drug | Collagen Type I - genetics | Th17 Cells - metabolism | Radioimmunoassay | Inflammation Mediators - metabolism | Female | Chemokine CCL2 - metabolism | Interleukin-8 - metabolism | Matrix Metalloproteinase 1 - genetics | Skin - pathology | Fibroblasts - metabolism | Collagen Type I - metabolism | Enzyme-Linked Immunosorbent Assay | Scleroderma, Systemic - metabolism | Cells, Cultured | Scleroderma, Systemic - genetics | Chemokine CCL2 - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Tumor Necrosis Factor-alpha - pharmacology | Fibroblasts - drug effects | Matrix Metalloproteinase 1 - metabolism | Interferon-gamma - pharmacology | Culture Media, Conditioned - metabolism | Proteins | Medical equipment and supplies industry | Interleukins | Systemic scleroderma | Medical test kit industry | Scleroderma (Disease) | High-definition television | Skin | Biological response modifiers | Enzyme-linked immunosorbent assay
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2009, Volume 106, Issue 32, pp. 13463 - 13468
Journal Article