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Nature communications, ISSN 2041-1723, 03/2016, Volume 7, Issue 1, p. 10791
.... Through basic and translational approaches involving murine models and human genetic epidemiology, we show here the importance of the different inflammasomes in regulating inflammatory responses... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Immunohistochemistry | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Middle Aged | Child, Preschool | Male | Cystic Fibrosis - immunology | Young Adult | Calcium-Binding Proteins - immunology | Autophagy - genetics | Interleukin 1 Receptor Antagonist Protein - pharmacology | Child | Cytokines - genetics | Carrier Proteins - immunology | Disease Models, Animal | Apoptosis Regulatory Proteins - immunology | Interleukin 1 Receptor Antagonist Protein - immunology | Respiratory Mucosa - cytology | Cystic Fibrosis - microbiology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Cystic Fibrosis - genetics | Adolescent | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mice | Aspergillus fumigatus | Calcium-Binding Proteins - genetics | Infant | Interleukin 1 Receptor Antagonist Protein - genetics | CARD Signaling Adaptor Proteins - genetics | Autophagy - immunology | Apoptosis Regulatory Proteins - genetics | Adult | Female | Pseudomonas aeruginosa | Lung - metabolism | Macrophages - immunology | Cytokines - immunology | In Situ Nick-End Labeling | CARD Signaling Adaptor Proteins - immunology | Cell Line | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Inflammation | Inflammasomes - genetics | Pseudomonas Infections - immunology | Carrier Proteins - genetics | Animals | Epithelial Cells - immunology | Inflammasomes - immunology | Fluorescent Antibody Technique | Polymorphism, Single Nucleotide | Aspergillosis - immunology
Journal Article
The New England journal of medicine, ISSN 1533-4406, 06/2009, Volume 360, Issue 23, pp. 2426 - 2437
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 2012, Volume 287, Issue 3, pp. 1847 - 1860
...) and, even more importantly, anti-inflammatory interleukin 1 receptor antagonist (IL1Rn). Overexpression of PGC-1 alpha and induction of PGC-1 alpha by fasting, physical... 
necrosis-factor-alpha | skeletal-muscle | metabolic syndrome | nuclear receptors | hepatic gluconeogenesis | insulin-resistance | caloric restriction | diabetes-mellitus | endoplasmic-reticulum stress | human obesity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Enzyme Activators - pharmacology | RNA-Binding Proteins - genetics | AMP-Activated Protein Kinases - metabolism | Liver - pathology | Receptors, Interleukin-15 - biosynthesis | Haptoglobins - biosynthesis | Caloric Restriction | Haptoglobins - genetics | Hepatocytes - pathology | Interleukin 1 Receptor Antagonist Protein - genetics | Male | Hepatocytes - metabolism | Obesity - genetics | Gene Knockdown Techniques | Receptors, Interleukin-15 - genetics | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Inflammation Mediators - metabolism | Trans-Activators - genetics | Mice, Inbred DBA | Fasting - metabolism | Interleukin 1 Receptor Antagonist Protein - biosynthesis | C-Reactive Protein - biosynthesis | Physical Conditioning, Animal | Gene Expression Regulation - genetics | Liver - metabolism | Metformin - pharmacology | Cells, Cultured | Rats | PPAR alpha - genetics | C-Reactive Protein - genetics | Transcription Factors - genetics | Hypoglycemic Agents - pharmacology | Obesity - metabolism | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Animals | Energy Metabolism | Insulin Resistance - genetics | Obesity - therapy | Trans-Activators - metabolism | Mice | PPAR alpha - metabolism | AMP-Activated Protein Kinases - genetics | RNA-Binding Proteins - metabolism | IL15Rα | IL1Rn | Coactivator Transcription | Liver | Inflammation | Cellular Immune Response | Diabetes | Tweak | Metformin | Metabolism | Nuclear Receptors
Journal Article
The New England journal of medicine, ISSN 1533-4406, 04/2007, Volume 356, Issue 15, pp. 1517 - 1526
The expression of interleukin-1–receptor antagonist is reduced in pancreatic islets in type 2 diabetes, and high glucose concentrations induce interleukin-1β... 
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Recombinant Proteins - therapeutic use | Insulin-Secreting Cells - secretion | Glucose Transporter Type 4 - metabolism | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Male | Diabetes Mellitus, Type 2 - metabolism | RNA, Messenger - metabolism | Heat-Shock Proteins - genetics | Insulin Resistance - physiology | Interleukin-6 - blood | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Female | Interleukin 1 Receptor Antagonist Protein - pharmacology | Body Mass Index | Glucose Tolerance Test | Double-Blind Method | Glucose Transporter Type 4 - genetics | Heat-Shock Proteins - metabolism | C-Reactive Protein - secretion | Recombinant Proteins - pharmacology | Transcription Factors - genetics | Gene Expression Regulation - drug effects | Transcription Factors - metabolism | Interleukin 1 Receptor Antagonist Protein - therapeutic use | Insulin-Secreting Cells - drug effects | Interleukin 1 Receptor Antagonist Protein - adverse effects | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Receptors, Interleukin-1 - antagonists & inhibitors | Type 2 diabetes | Interleukin-1 | Research | Drug therapy | Pancreas | Diabetes | Apoptosis | Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
Journal Article
The New England journal of medicine, ISSN 1533-4406, 08/2011, Volume 365, Issue 7, pp. 620 - 628
Journal Article
Nature medicine, ISSN 1546-170X, 01/2017, Volume 23, Issue 2, pp. 174 - 184
...Author(s): David Furman (corresponding author) [1, 2]; Junlei Chang [3]; Lydia Lartigue [4]; Christopher R Bolen [5]; Francois Haddad [6]; Brice Gaudilliere [5... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Toll-Like Receptor 5 - genetics | Humans | Middle Aged | Oxidative Stress - immunology | Transcriptome | Immunoblotting | Male | Purinergic P1 Receptor Antagonists - pharmacology | Young Adult | Toll-Like Receptor 8 - immunology | Aging - immunology | Toll-Like Receptor 6 - immunology | Aging - genetics | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | Aged, 80 and over | Caffeine - pharmacology | Hypertension - genetics | Intracellular Signaling Peptides and Proteins - genetics | Interleukin 1 Receptor Antagonist Protein - immunology | Carotid Intima-Media Thickness | Mortality | Neutrophils - drug effects | Hypertension - immunology | Nucleotides - metabolism | Toll-Like Receptor 5 - immunology | Monocytes - drug effects | Regression Analysis | Phenotype | Mice | Calcium-Binding Proteins - genetics | Metabolomics | Pulse Wave Analysis | Neutrophil Activation - drug effects | Cytidine - pharmacology | Interleukin 1 Receptor Antagonist Protein - genetics | Intracellular Signaling Peptides and Proteins - immunology | Cytidine - analogs & derivatives | CARD Signaling Adaptor Proteins - genetics | Toll-Like Receptor 6 - genetics | Adult | Female | Blood Pressure - drug effects | Blood Platelets - drug effects | Macrophages - immunology | Cytokines - immunology | CARD Signaling Adaptor Proteins - immunology | Cell Line | Vascular Stiffness - genetics | Cytokines - metabolism | Oxidative Stress - genetics | Interleukin-1beta - immunology | Adenine - pharmacology | Inflammation - immunology | Inflammasomes - genetics | Vascular Stiffness - immunology | Animals | Inflammasomes - immunology | Toll-Like Receptor 8 - genetics | Inflammation - genetics | Aged | Platelet Activation - drug effects | Genetic aspects | Immune response | Gene expression | Health aspects | Aging | Inflammation | Immune system
Journal Article
by Freitag, Christine and Butterworth, Adam and Willeit, Johann and Howson, Joanna M.M and Burgess, Stephen and Kaptoge, Stephen and Young, Robin and Ho, Weang Kee and Wood, Angela and Sweeting, Michael and Spackman, Sarah and Staley, James R and Ramond, Anna and Harshfield, Eric and Nielsen, Sune and Grande, Peer and Lange, Leslie and Bown, Matthew and Jones, Gregory and Scott, Robert and Bevan, Steve and Porcu, Eleonora and Thorleifsson, Gudmar and Zeng, Lingyao and Kessler, Thorsten and Nikpay, Majid and Do, Ron and Zhang, Weihua and Hopewell, J and Kleber, Marcus and Delgado, G and Nelson, Christopher P and Goel, Anuj and Bis, Joshua and Dehghan, Abbas and Ligthart, Symen and Smith, Davey and Qu, Liming and Van 'T Hof, Femke and Bakker, Paul and Baas, Annette and Rij, Ane and Tromp, Gerard and Kuivaniemi, Helena and Ritchie, Marylyn D and Verma, Shefali S and Crawford, Dana and Malinowski, Jennifer and Anade, Mariza and Kullo, Iftikhar and Peissig, Peggy L and McCarty, Catherine A and Bottinger, Erwin and Gottesman, Rebecca and Crosslin, David and Carrell, David and Rasmussen-Torvik, Laura and Pacheco, Jennifer A and Huang, Jie and Timpson, Nicholas and Kettunen, Johannes and Ala-Korpela, Mika and Mitchell, Gary and Parsa, Afshin and Wilkinson, Ian B and Gorski, Mathias and Li, Yong and Franceschini, Nora and Keller, Margaux and Ganesh, Santhi and Langefeld, Carl and Bruijn, Lucie and Brown, Matthew and Evans, David M and Baltic, Svetlana and Ferreira, Manuel and Baurecht, Hansjörg and Weidinger, Stephan and Franke, Ane and Lubitz, Steven and Müller-Nurasyid, Martina and Felix, Janine and Smith, Nicholas and Sudman, Marc and Thompson, Susan D and Zeggini, Eleftheria and Panoutsopoulou, Kalliope and Nalls, Michael and Singleton, Anew and Polychronakos, Constantin and Bradfield, Jonathan and Hakonarson, Hakon and Easton, Douglas and Thompson, Deborah and Tomlinson, Ian and Dunlop, Malcolm and Hemminki, Kari and Morgan, Gareth and Eisen, Timothy and Goldschmidt, Hartmut and ... and The Interleukin 1 Genetics Consortium and Australo-Anglo-Amer Spondyloarthri and Chronic Kidney Dis Genetics Consor and Australian Asthma Genetics Consort and Breast Canc Assoc Consortium and Interleukin 1 Genetics Consortium and Aneurysm Consortium and European Prospective Invest Canc and Consortium Juvenile Arthritis Gene and Melanoma Genetics Consortium and Int Parkinson's Dis Consortium and UK 10K Consortium and Myocardial Infarction Genetics Con and Elect Med Records & Genomics Netwo and Arthritis Res UK Osteoarthritis Ge and Atrial Fribrillation Genetics Cons and METASTROKE Consortium and Cohorts Heart & Aging Res Genomic
The lancet. Diabetes & endocrinology, ISSN 2213-8587, 2015, Volume 3, Issue 4, pp. 243 - 253
Journal Article