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Nature Communications, ISSN 2041-1723, 2016, Volume 7, Issue 1, pp. 10791 - 10791
Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inflammation. Through basic and translational approaches... 
AIRWAY EPITHELIAL-CELLS | ASPERGILLUS-FUMIGATUS | III SECRETION APPARATUS | CHRONIC GRANULOMATOUS-DISEASE | ENVIRONMENT INTERACTIONS | MULTIDISCIPLINARY SCIENCES | NLRC4 INFLAMMASOME | HOST-DEFENSE | NLRP3 INFLAMMASOME | LUNG INFECTION | IMMUNE RECOGNITION | Immunohistochemistry | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Middle Aged | Child, Preschool | Male | Cystic Fibrosis - immunology | Young Adult | Calcium-Binding Proteins - immunology | Autophagy - genetics | Interleukin 1 Receptor Antagonist Protein - pharmacology | Child | Cytokines - genetics | Carrier Proteins - immunology | Disease Models, Animal | Apoptosis Regulatory Proteins - immunology | Interleukin 1 Receptor Antagonist Protein - immunology | Respiratory Mucosa - cytology | Cystic Fibrosis - microbiology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Cystic Fibrosis - genetics | Adolescent | Cystic Fibrosis Transmembrane Conductance Regulator - genetics | Mice | Aspergillus fumigatus | Calcium-Binding Proteins - genetics | Infant | Interleukin 1 Receptor Antagonist Protein - genetics | CARD Signaling Adaptor Proteins - genetics | Autophagy - immunology | Apoptosis Regulatory Proteins - genetics | Adult | Female | Pseudomonas aeruginosa | Lung - metabolism | Macrophages - immunology | Cytokines - immunology | In Situ Nick-End Labeling | CARD Signaling Adaptor Proteins - immunology | Cell Line | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Inflammation | Inflammasomes - genetics | Pseudomonas Infections - immunology | Carrier Proteins - genetics | Animals | Epithelial Cells - immunology | Inflammasomes - immunology | Fluorescent Antibody Technique | Polymorphism, Single Nucleotide | Aspergillosis - immunology | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2017, Volume 23, Issue 2, pp. 174 - 184
Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear.... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | INTERLEUKIN-18 LEVELS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIOVASCULAR-DISEASE | RECEPTOR | ESSENTIAL-HYPERTENSION | PROTEINS | T-CELLS | AGE | CELL BIOLOGY | Toll-Like Receptor 5 - genetics | Humans | Middle Aged | Oxidative Stress - immunology | Transcriptome | Immunoblotting | Male | Purinergic P1 Receptor Antagonists - pharmacology | Young Adult | Toll-Like Receptor 8 - immunology | Aging - immunology | Toll-Like Receptor 6 - immunology | Aging - genetics | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | Aged, 80 and over | Caffeine - pharmacology | Hypertension - genetics | Intracellular Signaling Peptides and Proteins - genetics | Interleukin 1 Receptor Antagonist Protein - immunology | Carotid Intima-Media Thickness | Mortality | Neutrophils - drug effects | Hypertension - immunology | Nucleotides - metabolism | Toll-Like Receptor 5 - immunology | Monocytes - drug effects | Regression Analysis | Phenotype | Mice | Calcium-Binding Proteins - genetics | Metabolomics | Pulse Wave Analysis | Neutrophil Activation - drug effects | Cytidine - pharmacology | Interleukin 1 Receptor Antagonist Protein - genetics | Intracellular Signaling Peptides and Proteins - immunology | Cytidine - analogs & derivatives | CARD Signaling Adaptor Proteins - genetics | Toll-Like Receptor 6 - genetics | Adult | Female | Blood Pressure - drug effects | Blood Platelets - drug effects | Macrophages - immunology | Cytokines - immunology | CARD Signaling Adaptor Proteins - immunology | Cell Line | Vascular Stiffness - genetics | Cytokines - metabolism | Oxidative Stress - genetics | Interleukin-1beta - immunology | Adenine - pharmacology | Inflammation - immunology | Inflammasomes - genetics | Vascular Stiffness - immunology | Animals | Inflammasomes - immunology | Toll-Like Receptor 8 - genetics | Inflammation - genetics | Aged | Platelet Activation - drug effects | Genetic aspects | Immune response | Gene expression | Health aspects | Aging | Inflammation | Immune system | Index Medicus
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2008, Volume 118, Issue 1, pp. 205 - 216
Journal Article
Critical reviews in immunology, ISSN 1040-8401, 2017, Volume 37, Issue 2-6, pp. 531 - 559
Journal Article
Plos Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 3, pp. e1003936 - e1003936
Journal Article
Cytokine, ISSN 1043-4666, 02/2015, Volume 71, Issue 2, pp. 215 - 222
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 04/2016, Volume 75, Issue 4, pp. 755 - 762
ObjectivesThe study of the proinflammatory role of uric acid has focused on the effects of its crystals of monosodium urate (MSU). However, little is known... 
METABOLIC SYNDROME | HYPERURICEMIA | STIMULATION | INTERLEUKIN-1-BETA PRODUCTION | GOUTY-ARTHRITIS | CRYSTALS | MICE | RHEUMATOLOGY | MONOSODIUM URATE MONOHYDRATE | HOMINOID EVOLUTION | NALP3 INFLAMMASOME | Interleukin-1beta - drug effects | Humans | Middle Aged | Tumor Necrosis Factor-alpha - genetics | Interleukin 1 Receptor Antagonist Protein - genetics | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Case-Control Studies | Leukocytes, Mononuclear - immunology | Tumor Necrosis Factor-alpha - immunology | Aged, 80 and over | Adult | Histone Code | Cytokines - genetics | Gout - immunology | Interleukin 1 Receptor Antagonist Protein - drug effects | Cytokines - immunology | Interleukin 1 Receptor Antagonist Protein - immunology | Leukocytes, Mononuclear - drug effects | Enzyme-Linked Immunosorbent Assay | Interleukin-6 - genetics | Interleukin-1beta - immunology | Inflammation | Toll-Like Receptor 4 - immunology | Antioxidants - pharmacology | Uric Acid - immunology | Tumor Necrosis Factor-alpha - drug effects | Cytokines - drug effects | Epigenesis, Genetic - genetics | Epigenesis, Genetic - immunology | Uric Acid - pharmacology | Interleukin-10 - genetics | Interleukin-6 - immunology | Toll-Like Receptor 2 - immunology | Aged | Gout - genetics | Histones - metabolism | Methylation | Interleukin-10 - immunology | Epigenetic inheritance | Care and treatment | Hyperuricemia | Interleukins | Gout | Influence | Dosage and administration | Research | Cytokines | Rodents | Rheumatism | Ligands | Production capacity | Uric acid | Metabolic disorders | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 11/2015, Volume 6, Issue 1, pp. 8977 - 8977
Journal Article
Gastroenterology, ISSN 0016-5085, 2011, Volume 140, Issue 2, pp. 697 - 708.e4
Journal Article
Journal Article