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1. Full Text Effect of the anticoagulant, storage time and temperature of blood samples on the concentrations of 27 multiplex assayed cytokines – Consequences for defining reference values in healthy humans
by Hennø, Linda Torrissen and Storjord, Elin and Christiansen, Dorte and Bergseth, Grete and Ludviksen, Judith Krey and Fure, Hilde and Barene, Svein and Nielsen, Erik Waage and Mollnes, Tom E and Brekke, Ole-Lars
Cytokine, ISSN 1043-4666, 09/2017, Volume 97, pp. 86 - 95
Cytokines are potentially useful biomarkers of sepsis and other inflammatory conditions. Many cytokines can be released by leukocytes and platelets after... 
Plasma | Anticoagulant | Complement | Cytokines | Lepirudin | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PERIPHERAL-BLOOD | HUMAN WHOLE-BLOOD | IMMUNOLOGY | CELL BIOLOGY | TUMOR-NECROSIS-FACTOR | BIOMATERIAL SURFACES | INFLAMMATION | EXPRESSION | INNATE IMMUNITY | Anticoagulants (Medicine) | room temperature | VDP | EDTA | Klinisk medisinske fag: 750 | Medisinske Fag: 700 | interleukin | Clinical medical disciplines: 750 | Medical disciplines: 700 | ethylenediamine tetraacetic acid
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2. Full Text Interleukin 27 attenuates collagen-induced arthritis
by Niedbala, W and Cai, B and Wei, X and Patakas, A and Leung, B P and McInnes, I B and Liew, F Y
Annals of the Rheumatic Diseases, ISSN 0003-4967, 10/2008, Volume 67, Issue 10, pp. 1474 - 1479
Objective:To investigate the potential role of interleukin (IL) 27 in rheumatoid arthritis (RA) by examining the expression of IL27 in the articular joints of... 
RHEUMATOID-ARTHRITIS | SYNOVIAL-MEMBRANE | INFLAMMATION | IL-17 | IL-27 | CD4(+) T-CELLS | CYTOKINE | RHEUMATOLOGY | SUPPRESSION | AUTOIMMUNE ENCEPHALOMYELITIS | P-28 SUBUNIT | Recombinant Proteins - therapeutic use | T-Lymphocyte Subsets - immunology | Collagen Type II - immunology | Spleen - immunology | Humans | Cells, Cultured | Synovial Membrane - immunology | Male | Arthritis, Experimental - immunology | Interleukin-17 - biosynthesis | Interleukin-17 - therapeutic use | Lymph Nodes - immunology | Autoantibodies - biosynthesis | Disease Progression | Arthritis, Experimental - pathology | CD4-Positive T-Lymphocytes - immunology | Interleukin-17 - metabolism | Animals | Arthritis, Experimental - prevention & control | Mice, Inbred DBA | Mice | Arthritis, Rheumatoid - immunology | Cytokines - blood | Interleukins | Rheumatoid arthritis | Collagen | Physiological aspects | Development and progression | Research | Health aspects | Proteins | Studies | Disease | Cytokines | Pathogenesis | Lymphocytes | Rodents | Arthritis | Inflammation | Gene expression | Inflammatory diseases
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3. Full Text Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
by Kljavin, Noelyn M and Lucas, Sophie and de Sauvage, Frederic J and Yi, Sothy and Batten, Marcel and Ghilardi, Nico and Danilenko, Dimitry M and Li, Ji and Lee, James
Nature Immunology, ISSN 1529-2908, 09/2006, Volume 7, Issue 9, pp. 929 - 936
Interleukin 27 (IL-27) was first characterized as a proinflammatory cytokine with T helper type 1-inducing activity. However, subsequent work has demonstrated... 
IL-2 PRODUCTION | WSX-1 | TRYPANOSOMA-CRUZI | INFLAMMATION | RESISTANCE | TOXOPLASMA-GONDII | I CYTOKINE RECEPTOR | MICE | INFECTION | DIFFERENTIATION | IMMUNOLOGY | Encephalomyelitis, Autoimmune, Experimental - pathology | Lymphocyte Activation | Central Nervous System - pathology | Encephalomyelitis, Autoimmune, Experimental - immunology | Interleukin-17 - genetics | Interferon-gamma - metabolism | Interleukin-17 - biosynthesis | Lymph Nodes - immunology | STAT1 Transcription Factor - genetics | Central Nervous System - immunology | Mice, Knockout | T-Lymphocytes, Helper-Inducer - drug effects | Transforming Growth Factor beta - pharmacology | STAT1 Transcription Factor - metabolism | Animals | Interleukin-6 - pharmacology | Interleukins - physiology | Immune Tolerance - immunology | T-Lymphocytes, Helper-Inducer - immunology | Immune Tolerance - genetics | Mice | Encephalomyelitis, Autoimmune, Experimental - genetics | Interleukins - pharmacology | Receptors, Cytokine - genetics
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4. Full Text A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
by Kamanaka, Masahito and Bettelli, Estelle and Carrier, Yijun and Oukka, Mohamed and Weiner, Howard L and Awasthi, Amit and Flavell, Richard A and Peron, Jean P S and Kuchroo, Vijay K
Nature Immunology, ISSN 1529-2908, 12/2007, Volume 8, Issue 12, pp. 1380 - 1389
Regulatory T cells (T-reg cells) expressing the transcription factor Foxp3 are key in maintaining the balance of immune homeostasis. However, distinct induced... 
PLASMACYTOID DENDRITIC CELLS | IFN-GAMMA | TOLERANCE | HELPER-CELLS | IMMUNOLOGY | TRANSCRIPTION FACTOR | EXPRESSION | AUTOIMMUNE ENCEPHALOMYELITIS | IL-10 | TRANSGENIC MICE | CUTTING EDGE | Interleukin-17 - metabolism | T-Lymphocytes, Regulatory - metabolism | Animals | Lymphocyte Activation | Humans | Interleukin-17 - physiology | Interleukin-10 - immunology | Transforming Growth Factor beta - biosynthesis | Interleukin-10 - physiology | T-Lymphocytes, Regulatory - immunology | Interleukins | Physiological aspects | Homeostasis | Research | T cells | Properties | Immune system
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5. Full Text Interleukin 27: a double-edged sword for offense and defense
by Hiroki Yoshida and Mako Nakaya and Yoshiyuki Miyazaki
Journal of Leukocyte Biology, ISSN 0741-5400, 12/2009, Volume 86, Issue 6, pp. 1295 - 1303
Interleukin 27 has pro‐ and anti‐inflammatory features and is a potent target for therapy of various immune diseases. Cytokine‐mediated immunity plays a... 
IL‐12 | Th1 | immune suppression | inflammation | autoimmune disease | Immune suppression | Autoimmune disease | Inflammation | IL-12 | COLLAGEN-INDUCED ARTHRITIS | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | IL-27 GENE-EXPRESSION | LEISHMANIA-MAJOR | IMMUNOLOGY | PROINFLAMMATORY CYTOKINE PRODUCTION | CUTTING EDGE | CELL BIOLOGY | RECEPTOR WSX-1 | REGULATORY T-CELLS | CENTRAL-NERVOUS-SYSTEM | HEMATOLOGY | TH17 CELLS | Interleukins - therapeutic use | Humans | Autoimmune Diseases - immunology | Hypersensitivity - immunology | Immune Tolerance | Inflammation - immunology | Hypersensitivity - drug therapy | Cell Differentiation - immunology | Animals | Inflammation - drug therapy | T-Lymphocytes, Helper-Inducer - immunology | Interleukins - immunology | Autoimmune Diseases - drug therapy | Cytokines - immunology
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6. Full Text Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
by Stumhofer, Jason S and Laurence, Arian and Wilson, Emma H and Huang, Elaine and Tato, Cristina M and Johnson, Leanne M and Villarino, Alejandro V and Huang, Qiulong and Yoshimura, Akihiko and Sehy, David and Saris, Christiaan J.M and O'Shea, John J and Hennighausen, Lothar and Ernst, Matthias and Hunter, Christopher A
Nature Immunology, ISSN 1529-2908, 09/2006, Volume 7, Issue 9, pp. 937 - 945
Studies have focused on the events that influence the development of interleukin 17 (IL-17)-producing T helper cells (T-H-17 cells) associated with... 
IL-2 PRODUCTION | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | IFN-GAMMA | BONE EROSION | TOXOPLASMIC ENCEPHALITIS | I CYTOKINE RECEPTOR | DEFICIENT MICE | IMMUNOLOGY | JOINT INFLAMMATION | KLEBSIELLA-PNEUMONIAE | CUTTING EDGE | Interleukin-17 - analysis | Toxoplasmosis, Cerebral - pathology | Encephalitis - parasitology | Central Nervous System - immunology | T-Lymphocytes, Helper-Inducer - drug effects | Interleukins - genetics | Lymphocyte Activation - genetics | STAT1 Transcription Factor - metabolism | Central Nervous System - parasitology | Interleukins - physiology | T-Lymphocytes, Helper-Inducer - immunology | Toxoplasmosis, Cerebral - immunology | Interleukins - pharmacology | Interleukin-6 - metabolism | Interleukin-6 - genetics | Encephalitis - pathology | Encephalitis - immunology | STAT1 Transcription Factor - genetics | Mice, Knockout | Toxoplasma | Suppressor of Cytokine Signaling 3 Protein | Animals | CD4 Antigens - analysis | Mice | Suppressor of Cytokine Signaling Proteins - metabolism | Receptors, Cytokine - drug effects
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7. Full Text Protective role of Interleukin 27 ( IL-27 ) gene polymorphisms in patients with ulcerative colitis
by Yamamoto-Furusho, Jesús K and Posadas-Sánchez, Rosalinda and Alvarez-León, Edith and Vargas-Alarcón, Gilberto
Immunology Letters, ISSN 0165-2478, 2016, Volume 172, pp. 79 - 83
Highlights • Four polymorphisms of IL-27p28 gene (rs181206, rs26528, rs17855750, and rs40837) and three of the Epstein-Barr virus-induced gene 3 (EBI3)... 
Allergy and Immunology | Genetic susceptibility | Polymorphisms | Interleukin 27 | Mexicans | Ulcerative colitis | SUSCEPTIBILITY | RISK | IMMUNOLOGY | CANCER | CHINESE POPULATION | INFLAMMATORY-BOWEL-DISEASE | KOREAN POPULATION | ASSOCIATION | CARCINOMA | IL27 GENE | SINGLE NUCLEOTIDE POLYMORPHISMS | Genetic Predisposition to Disease | Gene Frequency | Humans | Middle Aged | Colitis, Ulcerative - genetics | Genotype | Male | Risk | Interleukin-27 - genetics | Young Adult | Interleukins - genetics | Minor Histocompatibility Antigens - genetics | Adult | Female | Mexico | Polymorphism, Single Nucleotide | Care and treatment | Interleukins | Analysis | Genes | Genetic aspects | Genetic polymorphisms
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8. Full Text A folding switch regulates interleukin 27 biogenesis and secretion of its α-subunit as a cytokine
by Müller, Stephanie I and Friedl, Antonie and Aschenbrenner, Isabel and Bieren, Julia Esser-von and Zacharias, Martin and Devergne, Odile and Feige, Matthias J
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2019, Volume 116, Issue 5, pp. 1585 - 1590
A common design principle of heteromeric signaling proteins is the use of shared subunits. This allows encoding of complex messages while maintaining... 
Protein assembly | Protein quality control | Interleukins | Protein folding | Immune engineering | immune engineering | IL-12P40 | PROTEIN | FORM | MULTIDISCIPLINARY SCIENCES | DISTINCT | P40 SUBUNIT | IL-27 | RECEPTOR | QUALITY-CONTROL | protein assembly | interleukins | PERITONITIS | P35 SUBUNIT | protein quality control | protein folding | Cytokines | Computer simulation | Immunoregulation | Immunomodulation | Secretion | Interleukin | Amino acids | Interleukin 12 | Biosynthesis | Interleukin 27 | Modulators | Complexity | Proteins | Signaling | Molecular modelling | Mice | Mathematical models | Assembly | Folding | Immune system | Biological Sciences
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9. Full Text Polymorphisms of -174G>C and -572G>C in the interleukin 6 (IL-6) gene and coronary heart disease risk: A meta-analysis of 27 research studies
by Zheng, Guo-hua and Chen, Hai-ying and Xiong, Shang-Quan
PLoS ONE, ISSN 1932-6203, 2012, Volume 7, Issue 4, p. e34839
Objective: Elevated serum IL-6 level is a risk factor for coronary heart disease (CHD). The -174G>C and -572G>C polymorphisms in the IL-6 gene have previously... 
C-REACTIVE PROTEIN | NO ASSOCIATION | MYOCARDIAL-INFARCTION | SERUM INTERLEUKIN-6 | PLASMA-LEVELS | MULTIDISCIPLINARY SCIENCES | ADHESION MOLECULES | G/C PROMOTER POLYMORPHISM | BLOOD-PRESSURE | ARTERY-DISEASE | INFLAMMATORY MARKERS | Coronary Disease - genetics | Genetic Association Studies | Interleukin-6 - genetics | Interleukin-6 - blood | Gene Frequency | Humans | Databases, Genetic | Coronary Disease - epidemiology | Risk | Mutation | PubMed | Polymorphism, Genetic | Medical research | Interleukins | Genes | Medicine, Experimental | Development and progression | Genetic aspects | Coronary heart disease | Risk factors | Genetic polymorphisms | Interleukin | Health risks | Cardiovascular disease | Population studies | Risk analysis | Gene polymorphism | Coronary artery disease | Subgroups | Interleukin 6 | Chinese medicine | Genetic analysis | Alleles | Cardiovascular diseases | Health risk assessment | Heart diseases | Genotypes | Polymorphism
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10. Full Text Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses
by Moro, Kazuyo and Kabata, Hiroki and Tanabe, Masanobu and Koga, Satoshi and Takeno, Natsuki and Mochizuki, Miho and Fukunaga, Koichi and Asano, Koichiro and Betsuyaku, Tomoko and Koyasu, Shigeo
Nature Immunology, ISSN 1529-2908, 01/2016, Volume 17, Issue 1, pp. 76 - 86
Group 2 innate lymphoid cells (ILC2 cells) are type 2 cytokine-producing cells of the innate immune system with important roles in helminth infection and... 
HELMINTH INFECTION | ALLERGIC INFLAMMATION | ACTIVATION | CYTOKINES | HOMEOSTASIS | DENDRITIC CELLS | AIRWAY INFLAMMATION | IMMUNOLOGY | NATURAL HELPER-CELLS | LUNG INFLAMMATION | THYMIC STROMAL LYMPHOPOIETIN | Mice, Inbred C57BL | Adoptive Transfer | Interferons - immunology | Mice, Knockout | Immunity, Innate - immunology | Animals | Flow Cytometry | Lymphocytes - immunology | Helminthiasis, Animal - immunology | Interleukins - immunology | Pneumonia - immunology | Mice | Real-Time Polymerase Chain Reaction | Disease Models, Animal | Interferon | Regulation | Genetic aspects | Immune response | Interleukins | Properties
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11. Full Text An Interspecies Analysis Reveals Molecular Construction Principles of Interleukin 27
by Müller, Stephanie I and Aschenbrenner, Isabel and Zacharias, Martin and Feige, Matthias J
Journal of Molecular Biology, ISSN 0022-2836, 05/2019, Volume 431, Issue 12, pp. 2383 - 2393
Interleukin 27 (IL-27) is a cytokine that regulates inflammatory responses. It is composed of an α subunit (IL-27α) and a β subunit (EBI3), which together form... 
Protein evolution | Protein assembly | Protein docking | Interleukins | IL-12 FAMILY | BIOCHEMISTRY & MOLECULAR BIOLOGY | IL-27 | RECEPTOR | CYTOKINE | PROTEIN-PROTEIN DOCKING | MODEL | IDENTIFICATION | BINDING-SITE | CILIARY NEUROTROPHIC FACTOR | SUBUNIT | Proteins | Inflammation | Analysis
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