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Immunity, ISSN 1074-7613, 10/2018, Volume 49, Issue 4, pp. 725 - 739.e6
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 10/2010, Volume 202, Issue 8, pp. 1254 - 1264
Journal Article
JOURNAL OF RHEUMATOLOGY, ISSN 0315-162X, 04/2012, Volume 39, Issue 4, pp. 720 - 727
Objective. To evaluate efficacy and safety of CE-224,535, a selective P2X(7) receptor antagonist, versus placebo, in patients with active rheumatoid arthritis... 
INTERLEUKIN 18 | INTERLEUKIN-1 | MODIFYING ANTIRHEUMATIC DRUGS | PLACEBO | AMERICAN-COLLEGE | ANAKINRA | RELEASE | RHEUMATOLOGY | PATHOGENESIS | INTERLEUKIN 1 | RECOMMENDATIONS | PURINERGIC P2X RECEPTOR | RHEUMATOID ARTHRITIS | DOUBLE-BLIND | QUALITY-OF-LIFE
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, pp. e84634 - e84634
Psoriasis is a complex inflammatory disease resulting from the activation of T helper (Th) 1 and Th17 cells. Recent evidence suggests that abnormal activation... 
SIGNALING PATHWAYS | IN-VITRO | MULTIDISCIPLINARY SCIENCES | KERATINOCYTES | EPIDERMAL HYPERPLASIA | ANTIMICROBIAL PEPTIDES | PLASMACYTOID DENDRITIC CELL | EXPRESSION | T-CELLS | PSORIASIS-VULGARIS | INNATE IMMUNITY | RNA, Messenger - immunology | Interleukin-23 - toxicity | Toll-Like Receptor 7 - antagonists & inhibitors | Toll-Like Receptor 9 - antagonists & inhibitors | Dermatitis - immunology | Gene Expression Regulation - immunology | Dermatitis - prevention & control | Gene Expression Regulation - drug effects | Toll-Like Receptor 9 - immunology | Dermatitis - pathology | Signal Transduction - immunology | Toll-Like Receptor 8 - immunology | Animals | Membrane Glycoproteins - antagonists & inhibitors | Toll-Like Receptor 8 - antagonists & inhibitors | Signal Transduction - drug effects | Toll-Like Receptor 7 - immunology | Th17 Cells - immunology | Female | Mice | Membrane Glycoproteins - immunology | Th17 Cells - pathology | Keratin | Psoriasis | Genes | Skin | Inflammation | B cells | Comparative analysis | Gene expression | Dermatitis | Laboratories | Pathogenesis | Hyperplasia | Helper cells | Interleukin 23 | Activation | Antagonists | Lymphocytes T | Kinases | Proteins | Genotype & phenotype | Receptors | Psoriasis vulgaris | Pathways | Lymphocytes | Rodents | Modulation | Toll-like receptors | Skin diseases | Lesions | Growth factors | Antigens | Cytokines | Dendritic cells | Dermatology | Injection | Interleukin 17 | Immune systems | Signaling | Aberration | Pharmaceuticals | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2015, Volume 290, Issue 44, pp. 26688 - 26698
We have recently reported that extracellular RNA (exRNA) released from necrotic cells induces cytokine production in cardiomyocytes and immune cells and... 
CIRCULATING MICRORNAS | POTENTIAL BIOMARKER | STRANDED-RNA | PATTERN-RECOGNITION | NECROTIC CELLS | MESSENGER-RNA | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYOCARDIAL INJURY | NUCLEIC-ACIDS | CUTTING EDGE | Myocytes, Cardiac - immunology | Humans | Peritonitis - pathology | Peritonitis - genetics | Myocardium - metabolism | Interleukins - biosynthesis | Animals, Newborn | Gene Expression | Macrophages - pathology | Signal Transduction | Neutrophils - drug effects | Tumor Necrosis Factor-alpha - secretion | Myeloid Differentiation Factor 88 - genetics | Rats | Toll-Like Receptor 3 - immunology | Myocytes, Cardiac - chemistry | Mice, Knockout | Myocytes, Cardiac - pathology | Myeloid Differentiation Factor 88 - deficiency | Myocytes, Cardiac - drug effects | Mice | Necrosis - genetics | Tumor Necrosis Factor-alpha - biosynthesis | Necrosis - pathology | RNA - isolation & purification | Toll-Like Receptor 3 - deficiency | Toll-Like Receptor 7 - immunology | Myeloid Differentiation Factor 88 - immunology | Toll-Like Receptor 3 - genetics | Membrane Glycoproteins - immunology | Macrophages - immunology | Neutrophils - pathology | Toll-Like Receptor 7 - genetics | Chemokine CXCL2 - secretion | Mice, Inbred C57BL | Neutrophils - immunology | Toll-Like Receptor 7 - deficiency | Myocardium - pathology | Necrosis - metabolism | Peritonitis - chemically induced | Peritonitis - immunology | Membrane Glycoproteins - genetics | Animals | RNA - pharmacology | Macrophages - drug effects | Chemokine CXCL2 - biosynthesis | Primary Cell Culture | Membrane Glycoproteins - deficiency | Interleukins - secretion | Index Medicus | Molecular Bases of Disease | innate immunity | RNA | inflammation | signal transduction | extracellular RNA | toll-like receptor (TLR)
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 09/2000, Volume 192, Issue 5, pp. 659 - 669
Journal Article
Diabetologia, ISSN 0012-186X, 09/2015, Volume 58, Issue 9, p. 2201
Journal Article
Journal Article
Journal Article
by Cai, SJ and Chen, Y and Shang, Y and Cui, JL and Li, ZJ and Li, YH
CELL DEATH & DISEASE, ISSN 2041-4889, 02/2018, Volume 9, Issue 3, pp. 273 - 11
Interleukin 7 receptor (il7r), a transmembrane receptor, belongs to the type I cytokine receptor family. Il7r is involved in the pathogenesis of... 
BACTERIA | ENDONUCLEASE | MUTATION | GENE-EXPRESSION | RHODOPSIN | MECHANISMS | T-CELL DEVELOPMENT | RETINITIS-PIGMENTOSA | IL-7 | NUCLEASES | CELL BIOLOGY | CRISPR | Multiple sclerosis | Cytokines | Neurodegenerative diseases | Zebrafish | Retina | Nervous system | Neurogenesis | Visual perception | Interleukin 7 receptors | Interleukin 7 | Signal transduction | Phototransduction | Myelination | DNA microarrays
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 04/2017, Volume 130, p. 433
Here we report adamantyl cyanoguanidine compounds based on hybrids of the adamantyl amide scaffold reported by AstraZeneca and cyanoguanidine scaffold reported... 
Interleukins | Antidepressants | Analysis | Alzheimer's disease
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, pp. e0159491 - e0159491
Bovine viral diarrhea virus (BVDV) is a member of the Flaviviridae family. BVDV isolates are classified into two biotypes based on the development of... 
IN-VITRO | HEPATITIS-C VIRUS | MESSENGER-RNA EXPRESSION | PROTEASOMAL DEGRADATION | MULTIDISCIPLINARY SCIENCES | INTERFERON REGULATORY FACTOR-3 | BVDV | MUCOSAL DISEASE | BLOOD MONONUCLEAR-CELLS | T-CELLS | ACUTE INFECTION | Bovine Virus Diarrhea-Mucosal Disease - immunology | Diarrhea Virus 2, Bovine Viral - immunology | Diarrhea Virus 2, Bovine Viral - physiology | Interleukin-6 - genetics | Macrophages - pathology | RNA, Messenger - genetics | Toll-Like Receptors - immunology | Cells, Cultured | Gene Expression Regulation | Cytopathogenic Effect, Viral | Diarrhea Virus 2, Bovine Viral - pathogenicity | Animals | Macrophages - virology | Cattle | Bovine Virus Diarrhea-Mucosal Disease - genetics | Toll-Like Receptor 7 - immunology | Interleukin-6 - immunology | Bovine Virus Diarrhea-Mucosal Disease - pathology | Cytokines - genetics | Macrophages - immunology | Cytokines - immunology | Diarrhea | Causes of | Physiological aspects | Development and progression | Genetic aspects | Research | Virulence (Microbiology) | Macrophages | Diseases | Cell culture | Epithelial cells | Virulence | Animal diseases | Viruses | Innate immunity | Infections | mRNA | Immunity | Biotypes | Interleukin 6 | Proteins | Hepatitis | Receptors | Immunology | Toll-like receptors | TLR7 protein | Cytokines | Blood & organ donations | Secretion | Inflammation | Gene expression | TLR3 protein | Immune systems | Signaling | Monocytes | Immunosuppression | TLR2 protein | Interferon | Viral infections | Index Medicus
Journal Article