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1. Full Text Structural biology of shared cytokine receptors
by Wang, Xinquan and Lupardus, Patrick and LaPorte, Sherry L and Garcia, K. Christopher
Annual Review of Immunology, ISSN 0732-0582, 2009, Volume 27, Issue 1, pp. 29 - 60
Recent structural information for complexes of cytokine receptor ectodomains bound to their ligands has significantly expanded our understanding of the... 
Structure | Signaling | Interleukin | signaling | COLONY-STIMULATING FACTOR | HUMAN INTERLEUKIN-2 RECEPTOR | SIGNAL-TRANSDUCING RECEPTOR | PSEUDO-HIGH AFFINITY | IMMUNOLOGY | structure | THYMIC STROMAL LYMPHOPOIETIN | PROTEIN-PROTEIN INTERFACE | HIGH-AFFINITY INTERACTION | COMMON GAMMA-CHAIN | AMINO-ACID-RESIDUES | GM-CSF RECEPTOR | interleukin | Cytokine Receptor gp130 - metabolism | Cytokines - metabolism | Signal Transduction | Interleukin Receptor Common gamma Subunit - chemistry | Cytokine Receptor gp130 - chemistry | Humans | Interleukin Receptor Common gamma Subunit - metabolism | Cytokine Receptor Common beta Subunit - chemistry | Cytokines - chemistry | Animals | Protein Binding | Ligands | Protein Conformation | Cytokine Receptor Common beta Subunit - metabolism | Binding Sites | Cytokines | Ligands (Biochemistry) | Cytokine receptors | Physiological aspects | Genetic aspects | Properties | Identification and classification | Immunological research
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2. Full Text The common γ-chain cytokine receptor: tricks-and-treats for T cells
by Waickman, Adam T and Waickman, Adam T and Park, Joo-Young and Park, Joo-Young and Park, Jung-Hyun and Park, Jung-Hyun
Cellular and Molecular Life Sciences, ISSN 1420-682X, 1/2016, Volume 73, Issue 2, pp. 253 - 269
Originally identified as the third subunit of the high-affinity IL-2 receptor complex, the common γ-chain (γc) also acts as a non-redundant receptor subunit... 
Life Sciences | Biochemistry, general | Alternative splicing | Signaling | Life Sciences, general | Homeostasis | JAK3 | Survival | Biomedicine general | Cell Biology | SEVERE COMBINED IMMUNODEFICIENCY | BIOCHEMISTRY & MOLECULAR BIOLOGY | JAK-3 JANUS KINASE | DEFECTIVE LYMPHOID DEVELOPMENT | THYMIC STROMAL LYMPHOPOIETIN | CELL BIOLOGY | FOLLICULAR-HELPER-CELLS | ACUTE LYMPHOBLASTIC-LEUKEMIA | INTERLEUKIN-2 RECEPTOR | IL-2 RECEPTOR | MEMBRANE-PROXIMAL REGION | MICE LACKING JAK3 | Janus Kinase 3 - immunology | Alternative Splicing | Signal Transduction | Interleukin Receptor Common gamma Subunit - chemistry | Lymphocyte Activation | Humans | Inflammation - immunology | Interleukin Receptor Common gamma Subunit - genetics | Interleukin Receptor Common gamma Subunit - immunology | Animals | T-Lymphocytes - cytology | T-Lymphocytes - metabolism | Th17 Cells - metabolism | Protein Isoforms - chemistry | Inflammation - genetics | Th17 Cells - immunology | Receptors, Cytokine - immunology | T-Lymphocytes - immunology | Th17 Cells - cytology | Protein Isoforms - immunology | Cytokines - immunology | Protein Isoforms - genetics
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3. Full Text Control of blood proteins by functional disulfide bonds
by Butera, Diego and Cook, Kristina M and Chiu, Joyce and Wong, Jason W. H and Hogg, Philip J
Blood, ISSN 0006-4971, 03/2014, Volume 123, Issue 13, pp. 2000 - 2007
Most proteins in nature are chemically modified after they are made to control how, when, and where they function. The 3 core features of proteins are... 
SELF-ASSOCIATION | THIOL ISOMERASE ACTIVITY | FORMATION IN-VIVO | INTEGRIN ACTIVATION | THROMBUS FORMATION | ENDOTHELIAL-CELLS | PLATELET-FUNCTION | HEMATOLOGY | VON-WILLEBRAND-FACTOR | TISSUE FACTOR | ANTIPHOSPHOLIPID SYNDROME | Disulfides - metabolism | beta 2-Glycoprotein I - chemistry | Interleukin Receptor Common gamma Subunit - chemistry | Humans | Angiotensinogen - metabolism | Plasminogen - metabolism | Interleukin Receptor Common gamma Subunit - metabolism | Blood Proteins - chemistry | Blood Proteins - metabolism | beta 2-Glycoprotein I - metabolism | Animals | Allosteric Regulation - physiology | Hydrogen Bonding | Disulfides - chemistry | Plasminogen - chemistry | Angiotensinogen - chemistry | Review
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4. Full Text IL-7 Induces an Epitope Masking of γ c Protein in IL-7 Receptor Signaling Complex
by Goh, Tae Sik and Jo, Yuna and Lee, Byunghyuk and Kim, Geona and Hwang, Hyunju and Ko, Eunhee and Kang, Seung Wan and Oh, Sae-Ock and Baek, Sun-Yong and Yoon, Sik and Lee, Jung Sub and Hong, Changwan
Mediators of Inflammation, ISSN 0962-9351, 2017, Volume 2017, pp. 9096829 - 14
IL-7 signaling via IL-7R alpha and common gamma-chain (gamma c) is necessary for the development and homeostasis of T cells. Although the delicate mechanism in... 
ACTIVATION | HOMEOSTASIS | ALPHA-CHAIN | CYTOKINE | MICE | OF-FUNCTION MUTATIONS | IMMUNOLOGY | BINDING | EXPRESSION | T-CELLS | INTERLEUKIN-7 | CELL BIOLOGY | Receptors, Interleukin-7 - chemistry | Phosphorylation | Cytokines - metabolism | Signal Transduction | Interleukin Receptor Common gamma Subunit - chemistry | Humans | Mice, Inbred C57BL | Animals | Protein Binding | Protein Domains | Epitopes - chemistry | Mice | Kinetics | Antibodies, Monoclonal - chemistry | Interleukin-7 - metabolism
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5. Full Text The extracellular and transmembrane domains of the γC and interleukin (IL)-13 receptor α1 chains, not their cytoplasmic domains, dictate the nature of signaling responses to IL-4 and IL-13
by Heller, Nicola M and Qi, Xiulan and Gesbert, Franck and Keegan, Achsah D
Journal of Biological Chemistry, ISSN 0021-9258, 09/2012, Volume 287, Issue 38, pp. 31948 - 31961
Previously, we demonstrated that the γC subunit of type I IL-4 receptor was required for robust tyrosine phosphorylation of the downstream adapter protein,... 
Protein Structure, Tertiary | Cell Line | Cricetinae | Phosphorylation | Cricetulus | Cytokines - metabolism | Signal Transduction | Interleukin Receptor Common gamma Subunit - chemistry | Receptors, Interleukin-4 - metabolism | Cytoplasm - metabolism | Interleukin-13 - chemistry | STAT6 Transcription Factor - metabolism | Interleukin-4 - chemistry | Interleukin-13 Receptor alpha1 Subunit - chemistry | Animals | Flow Cytometry | Receptors, IgE - metabolism | Models, Biological | Mice | Mutation | CHO Cells | Allergy | Signal transduction | Immunology | IRS-2 | Interleukin | Cytokine | Cytokine Action | STAT6 | Inflammation | IL-13 Receptor | IL-4 Receptor
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6. Full Text Identification of the functional interleukin-2 binding domain of the chicken common cytokine receptor gamma chain
by Gu, Jianyou and Teng, Qiaoyang and Huang, Zhenyu and Ruan, Xizhen and Zhou, Jiyong
Developmental and Comparative Immunology, ISSN 0145-305X, 2010, Volume 34, Issue 3, pp. 258 - 263
CD132 is the common gamma chain to a number of cytokine receptor complexes including that for IL-2. To identify the functional domain of chicken CD132... 
Functional domain | Tertiary structure | Chicken CD132 | COMPLEX | ZOOLOGY | CLONING | COMPONENT | IMMUNOLOGY | IL-2 RECEPTOR | Protein Structure, Tertiary | Amino Acid Sequence | Epitope Mapping | Gene Expression | Enzyme-Linked Immunosorbent Assay | Cell Separation | Interleukin Receptor Common gamma Subunit - chemistry | Molecular Sequence Data | Recombinant Proteins - chemistry | Gene Expression Profiling | Recombinant Proteins - genetics | Peptide Library | Reverse Transcriptase Polymerase Chain Reaction | Chickens - immunology | Interleukin Receptor Common gamma Subunit - genetics | Interleukin Receptor Common gamma Subunit - immunology | Interleukin-2 - genetics | Animals | Flow Cytometry | Interleukin-2 - immunology | Recombinant Proteins - immunology | Leukocytes, Mononuclear - immunology | Chickens - genetics | Cytokines | Interleukins | Questions and answers | Analysis | Monoclonal antibodies | Development and progression | Cross infection | Chemical properties | Nosocomial infections | T cells | Enzyme-linked immunosorbent assay
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7. Full Text Keratinocyte antiviral response to poly(dA:dT) stimulation and papillomavirus infection in a canine model of X-linked severe combined immunodeficiency
by Luff, Jennifer A and Yuan, Hang and Kennedy, Douglas and Schlegel, Richard and Felsburg, Peter and Moore, Peter F
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, p. e102033
X-linked severe combined immunodeficiency (XSCID) is caused by a genetic mutation within the common gamma chain (cc), an essential component of the cytokine... 
BONE-MARROW-TRANSPLANTATION | INTERLEUKIN-15 | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DISEASE | IL-15 | RETROVIRAL GENE-THERAPY | DIFFERENTIATION | STEM-CELL TRANSPLANTATION | EXPRESSION | PSORIASIS | Keratinocytes - virology | Interferon Regulatory Factors - metabolism | X-Linked Combined Immunodeficiency Diseases - genetics | Molecular Sequence Data | X-Linked Combined Immunodeficiency Diseases - immunology | Poly dA-dT - pharmacology | Base Sequence | Bone Marrow Transplantation | Female | Papillomavirus Infections - etiology | Cytokines - genetics | Disease Models, Animal | Gene Expression | Cytokines - metabolism | Interleukin Receptor Common gamma Subunit - chemistry | RNA, Messenger - genetics | Interferon Regulatory Factors - genetics | X-Linked Combined Immunodeficiency Diseases - therapy | X-Linked Combined Immunodeficiency Diseases - complications | Interleukin Receptor Common gamma Subunit - genetics | Gene Expression Regulation - drug effects | Animals | Keratinocytes - drug effects | Keratinocytes - metabolism | Dogs | Papillomavirus Infections - drug therapy | Papillomaviridae | Poly dA-dT - administration & dosage | Mutation | Primary Cell Culture | Papillomaviruses | Infection | Cytokines | Severe combined immunodeficiency | Biological response modifiers | Papillomavirus infections | Veterinary colleges | Transplants & implants | Disease | Interleukin | Bone marrow transplantation | Recovery of function | Cytokine receptors | Infections | Veterinary medicine | Neoplasms | Defects | Proteins | Interleukin 7 | Receptors | Human papillomavirus | Interleukin 4 | Immunology | Photovoltaic cells | Cell cycle | Interleukin 21 | Bone marrow | Interleukin 9 | Immune system | Solar cells | Immune response | Psoriasis | Dermatology | Keratinocytes | Transplants | Interleukin 15 | Patients | Virology | Studies | Polymerase chain reaction | Pathology | Biopsy | Interferon | Laboratory animals | Viral infections
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8. Full Text Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation
by Olsen, Shaun K and Ota, Naruhisa and Kishishita, Seiichiro and Kukimoto-Niino, Mutsuko and Murayama, Kazutaka and Uchiyama, Hidemi and Toyama, Mitsutoshi and Terada, Takaho and Shirouzu, Mikako and Kanagawa, Osami and Yokoyama, Shigeyuki
The Journal of biological chemistry, ISSN 0021-9258, 12/2007, Volume 282, Issue 51, p. 37191
Interleukin (IL)-15 is a pleiotropic cytokine that plays a pivotal role in both innate and adaptive immunity. IL-15 is unique among cytokines due to its... 
Epitopes - metabolism | Interleukin Receptor Common gamma Subunit - chemistry | Interleukin-2 Receptor beta Subunit - metabolism | Models, Molecular | Crystallography, X-Ray | Receptors, Interleukin-15 - metabolism | Interleukin Receptor Common gamma Subunit - metabolism | Receptors, Interleukin-15 - chemistry | Multiprotein Complexes - metabolism | Interleukin-15 - chemistry | Multiprotein Complexes - chemistry | Animals | Interleukin-2 Receptor beta Subunit - chemistry | Interleukin-15 - metabolism | Binding Sites - physiology | Protein Structure, Quaternary | Signal Transduction - physiology | Epitopes - chemistry | Mice
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9. Full Text A new in-silico method for determination of helical transmembrane domains based on the PepLook scan: application to IL-2R beta and IL-2R gamma c receptor chains
by Charlois, Y and Lins, L and Brasseur, R
BMC STRUCTURAL BIOLOGY, ISSN 1472-6807, 05/2011, Volume 11, Issue 1, pp. 26 - 26
Background: Modeling of transmembrane domains (TMDs) requires correct prediction of interfacial residues for in-silico modeling and membrane insertion studies.... 
PDB FILES | INTERLEUKIN-2 | METASTATIC CANCER | PROTEIN | BIOPHYSICS | ANALYTICAL TOOLS | MEMBRANE | STABILITY | RESTRAINT FIELD | PREDICTION METHODS | T-CELLS | Protein Structure, Tertiary | Amino Acid Sequence | Interleukin Receptor Common gamma Subunit - chemistry | Humans | Molecular Sequence Data | Rats | Macaca mulatta | Pan troglodytes | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Interleukin-2 Receptor beta Subunit - chemistry | Cattle | Dogs | Hydrophobic and Hydrophilic Interactions | Mice | Software
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10. Full Text Identification and Biochemical Characterization of Human Plasma Soluble IL-7R: Lower Concentrations in HIV-1-Infected Patients
by Rose, Thierry and Lambotte, Olivier and Pallier, Coralie and Delfraissy, Jean-Francois and Colle, Jean-Herve
The Journal of Immunology, ISSN 0022-1767, 06/2009, Volume 182, Issue 12, pp. 7389 - 7397
The IL-7R alpha-chain and the common gamma-chain (gamma(c)) are both components of IL-7R. Human plasma harbors soluble forms of IL-7R (sIL-7R alpha and s... 
MULTIPLE-SCLEROSIS | CD127 EXPRESSION | RT-PCR | IN-VIVO | ANTIRETROVIRAL THERAPY | IMMUNOLOGY | CD8(+) T-CELLS | INTERLEUKIN-7 RECEPTOR | HIV-INFECTED PATIENTS | THYMIC STROMAL LYMPHOPOIETIN | GAMMA-CHAIN | Humans | Middle Aged | Molecular Sequence Data | Interleukin-7 Receptor alpha Subunit - immunology | Interleukin Receptor Common gamma Subunit - immunology | Interleukin-7 Receptor alpha Subunit - blood | Interleukin-7 Receptor alpha Subunit - chemistry | HIV Infections - immunology | Base Sequence | Mass Spectrometry | Adult | Interleukin-7 Receptor alpha Subunit - genetics | Protein Biosynthesis - genetics | Interleukin-7 - metabolism | HIV Infections - blood | Amino Acid Sequence | Alternative Splicing - genetics | RNA, Messenger - genetics | Cells, Cultured | Solubility | Interleukin Receptor Common gamma Subunit - genetics | HIV-1 - immunology | Interleukin-7 - immunology | Interleukin Receptor Common gamma Subunit - blood | Protein Binding | HIV Infections | HIV-1 | Protein Biosynthesis | Alternative Splicing | Interleukin-7 | Life Sciences | Immunology | Interleukin-7 Receptor alpha Subunit | Interleukin Receptor Common gamma Subunit | RNA, Messenger
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11. Full Text Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy
by Charych, Deborah and Khalili, Samira and Dixit, Vidula and Kirk, Peter and Chang, Thomas and Langowski, John and Rubas, Werner and Doberstein, Stephen K and Eldon, Michael and Hoch, Ute and Zalevsky, Jonathan
PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0179431
Cytokines are potent immune modulating agents but are not ideal medicines in their natural form due to their short half-life and pleiotropic systemic effects.... 
LIGAND-BINDING | ALPHA-RECEPTOR | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | COMPLEXES | REGULATORY T-CELLS | MODULATION THERAPIES | IL-2 | CYTOKINE | HIGH-DOSE INTERLEUKIN-2 | RENAL-CELL CARCINOMA | Neoplasms - metabolism | T-Lymphocytes, Regulatory - metabolism | Immunotherapy - methods | Interleukin-2 Receptor beta Subunit - metabolism | Interleukin Receptor Common gamma Subunit - metabolism | Transplantation, Homologous | T-Lymphocytes, Regulatory - immunology | STAT5 Transcription Factor - metabolism | Neoplasms - therapy | Interleukin Receptor Common gamma Subunit - agonists | CD8-Positive T-Lymphocytes - metabolism | Female | Interleukin-2 - analogs & derivatives | Phosphorylation - drug effects | Polyethylene Glycols - pharmacology | Models, Theoretical | Tumor Microenvironment - drug effects | Interleukin-2 - pharmacokinetics | Interleukin-2 Receptor beta Subunit - agonists | Mice, Inbred C57BL | Polyethylene Glycols - pharmacokinetics | Receptors, Interleukin-2 - metabolism | Mice, Inbred C3H | Tumor Microenvironment - immunology | T-Lymphocytes, Regulatory - drug effects | Algorithms | Animals | Interleukin-2 Receptor alpha Subunit - agonists | Interleukin-2 Receptor alpha Subunit - metabolism | Prodrugs - pharmacokinetics | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Drug Liberation | Interleukin-2 - pharmacology | Mice, Inbred BALB C | Kinetics | CD8-Positive T-Lymphocytes - immunology | Prodrugs - pharmacology | Receptors, Interleukin-2 - agonists | Physiological aspects | Care and treatment | Interleukin-2 | Immunotherapy | Patient outcomes | Cancer | Polyethylenes | Conjugates | CD8 antigen | Interleukin | Lymphocytes T | Anticancer properties | Proteins | Biological effects | Cell activation | Immunology | Interleukin 2 | Lymphocytes | Polyethylene glycol | Modelling | Drug dosages | Immune system | Interleukin 2 receptors | Pharmacodynamics | Cytokines | Immunoregulation | Melanoma | Radioactive half-life | Pharmacology | Affinity | Ligands | Mutation | Pharmacokinetics | In vitro methods and tests | Tumors
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12. Full Text Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum
by Nata, Toshie and Basheer, Asjad and Cocchi, Fiorenza and Van Besien, Richard and Massoud, Raya and Jacobson, Steven and Azimi, Nazli and Tagaya, Yutaka
Journal of Biological Chemistry, ISSN 0021-9258, 09/2015, Volume 290, Issue 37, pp. 22338 - 22351
The common gamma molecule (gamma c) is a shared signaling receptor subunit used by six gamma c-cytokines. These cytokines play crucial roles in the... 
RHEUMATOID-ARTHRITIS | BETA-CHAIN | NATURAL-KILLER | LYMPHOID DEVELOPMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | ULCERATIVE-COLITIS | ACTIVATED KILLER-CELLS | T-CELLS | INTRAEPITHELIAL LYMPHOCYTES | CELIAC-DISEASE | TRANSGENIC MICE | Cytokines - metabolism | Peptides - chemistry | Humans | Cells, Cultured | Peptides - genetics | Interleukin Receptor Common gamma Subunit - antagonists & inhibitors | Male | Interleukin Receptor Common gamma Subunit - metabolism | Interleukin Receptor Common gamma Subunit - genetics | Peptides - pharmacology | Female | Cytokines - antagonists & inhibitors | Cytokines - genetics | cell proliferation | interleukin | drug design | peptide interaction | Cell Biology | cytokine action
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13. Full Text Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3-mutation-positive leukemia
by Agarwal, A and Mackenzie, R.J and Eide, C.A and Davare, M.A and Watanabe-Smith, K and Tognon, C.E and Mongoue-Tchokote, S and Park, B and Braziel, R.M and Tyner, J.W and Druker, B.J
Oncogene, ISSN 0950-9232, 06/2015, Volume 34, Issue 23, pp. 2991 - 2999
To understand the role of cytokine and growth factor receptor-mediated signaling in leukemia pathogenesis, we designed a functional RNA interference (RNAi)... 
FERM DOMAIN | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | SOMATIC MUTATIONS | CELL BIOLOGY | JAK3 MUTATIONS | JAK/STAT PATHWAY | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | DOWN-SYNDROME | GENETICS & HEREDITY | ACUTE MEGAKARYOBLASTIC LEUKEMIA | EXPRESSION | Phosphorylation | Leukemia - pathology | Signal Transduction | Humans | RNA, Small Interfering - pharmacology | Molecular Sequence Data | Interleukin Receptor Common gamma Subunit - antagonists & inhibitors | Interleukin Receptor Common gamma Subunit - metabolism | Leukemia - metabolism | Interleukin Receptor Common gamma Subunit - genetics | Animals | Cell Transformation, Neoplastic - genetics | Janus Kinase 3 - genetics | Cell Line, Tumor | Mice | Mutation | Janus Kinase 3 - metabolism | Binding Sites | Leukemia - genetics | Development and progression | Cell receptors | Genetic aspects | Properties | Identification and classification | Leukemia | Signal transduction | Oncology | Cytokines | Pathogenesis | Growth factors | AML | IL2Rγ | leukemia | RNAi | receptors | JAK3
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