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Diabetologia, ISSN 0012-186X, 8/2005, Volume 48, Issue 8, pp. 1523 - 1533
Journal Article
Life Sciences, ISSN 0024-3205, 2003, Volume 73, Issue 4, pp. 471 - 485
Antinociceptive profiles of decursinol were examined in ICR mice. Decursinol administered orally (from 5 to 200 mg/kg) showed an antinociceptive effect in a... 
Serotonin receptor | α 2 adrenoceptor | Antinociception | Decursinol | Histamine receptor | Adenosine receptor | Inflammatory pain | adrenoceptor | MEDICINE, RESEARCH & EXPERIMENTAL | antinociception | histamine receptor | MORPHINE | ADENOSINE | STIMULI | SPINAL-CORD | RECEPTOR | serotonin receptor | RESPONSES | alpha adrenoceptor | PAIN | adenosine receptor | inflammatory pain | PHARMACOLOGY & PHARMACY | MICE | FORMALIN TEST | SUBSTANCE-P | decursinol | Analgesics - pharmacology | Models, Chemical | Histamine H2 Antagonists - pharmacology | Butyrates - pharmacology | Male | Substance P - pharmacology | Adrenergic alpha-Antagonists - pharmacology | Methysergide - pharmacology | Xanthines - pharmacology | Yohimbine - pharmacology | Dose-Response Relationship, Drug | Theobromine - analogs & derivatives | Cyproheptadine - pharmacology | Piperidines - pharmacology | Pain - drug therapy | Butyrates - administration & dosage | Theobromine - pharmacology | Benzopyrans - pharmacology | Ranitidine - pharmacology | Glutamic Acid - pharmacology | Administration, Oral | Receptors, Adrenergic - metabolism | Protein Kinase C - antagonists & inhibitors | Serotonin Antagonists - pharmacology | Mice, Inbred ICR | Receptors, Serotonin - metabolism | Interleukin-1 - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Benzopyrans - administration & dosage | Receptors, Histamine - metabolism | Animals | Naloxone - pharmacology | Narcotic Antagonists - pharmacology | Mice | Receptors, Purinergic P1 - metabolism | Interferon-gamma - pharmacology | Index Medicus
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2000, Volume 130, Issue 6, pp. 1418 - 1424
The effect of IL‐1ra on response to intraplantar (i.pl.) injection of LPS, carrageenin, bradykinin, TNFα, IL‐1β, IL‐8, PGE 2 and dopamine was investigated in a... 
interleukin‐8 | interleukin‐1 receptor antagonist | prostaglandin E | Inflammatory hyperalgesia | bradykinin | interleukin‐1β | tumour necrosis factor alpha | Tumour necrosis factor alpha | Interleukin-8 | Bradykinin | Interleukin-1β | Interleukin-1 receptor antagonist | inflammatory hyperalgesia | RAT | IL-1 | ALPHA TNF-ALPHA | ENDOTOXEMIA | interleukin-8 | prostaglandin E-2 | NERVE GROWTH-FACTOR | TUMOR-NECROSIS-FACTOR | interleukin-1 beta | INHIBITION | PHARMACOLOGY & PHARMACY | IL-1-BETA | EXPRESSION | interleukin-1 receptor antagonist | PENTOXIFYLLINE | Tumor Necrosis Factor-alpha - metabolism | Hindlimb | Rats, Wistar | Skin - metabolism | Sialoglycoproteins - metabolism | Male | Dose-Response Relationship, Drug | Inflammation - metabolism | Sialoglycoproteins - pharmacology | Carrageenan - pharmacology | Antibodies - immunology | Interleukin-8 - pharmacology | Sialoglycoproteins - immunology | Bradykinin - pharmacology | Dinoprostone - pharmacology | Immune Sera - pharmacology | Interleukin-1 - metabolism | Cytokines - metabolism | Hyperalgesia - metabolism | Dopamine - pharmacology | Hyperalgesia - prevention & control | Rats | Acetic Acid - pharmacology | Interleukin-1 - pharmacology | Antibodies - pharmacology | Interleukin-4 - immunology | Tumor Necrosis Factor-alpha - pharmacology | Animals | Lipopolysaccharides - pharmacology | Interleukin 1 Receptor Antagonist Protein | Sheep | Inflammation - prevention & control | Mice | Pain Measurement | Interleukin-10 - immunology | Cytokines - pharmacology | Skin - drug effects | Index Medicus | prostaglandin E2 | Papers | interleukin-1β
Journal Article
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 6/2012, Volume 385, Issue 6, pp. 605 - 619
The present study has been designed to investigate the effect of selective inhibitors of histone deacetylase and/or N-acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO),... 
Histone deacetylase | Neurosciences | Biomedicine | Morphine dependence | Interleukin-1β converting enzyme | Isolated rat ileum | Pharmacology/Toxicology | Withdrawal syndrome | Interleukin-1βconverting enzyme | I DIABETIC-NEPHROPATHY | TOLERANCE | RATS | MORPHINE-WITHDRAWAL | DEPENDENCE | MOUSE MODEL | PHARMACOLOGY & PHARMACY | INHIBITORS | Interleukin-1 beta converting enzyme | EXPRESSION | MOLECULAR-MECHANISMS | CONVERTING-ENZYME | Analgesics, Opioid - pharmacology | Motor Activity - drug effects | Male | Behavior, Animal | Brain - metabolism | Ileum - drug effects | Female | Viral Proteins - pharmacology | Triglycerides - pharmacology | Hydroxamic Acids - pharmacology | Memantine - pharmacology | Morphine - pharmacology | Rats | Serpins - pharmacology | Brain - drug effects | Animals | Naloxone - pharmacology | Cysteine Proteinase Inhibitors - pharmacology | Narcotic Antagonists - pharmacology | Histone Deacetylase Inhibitors - pharmacology | Ileum - physiology | Mice | Histone Deacetylases - physiology | Histones - metabolism | Opioid-Related Disorders - physiopathology | In Vitro Techniques | Oligopeptides - pharmacology | Substance Withdrawal Syndrome - physiopathology | Animal experimentation | Drug abuse | Enzymes | Chemical inhibitors | Enzyme inhibitors | Interleukins | Analysis | Morphine | Precipitation (Meteorology) | Index Medicus
Journal Article
Journal of Neurophysiology, ISSN 0022-3077, 06/2016, Volume 115, Issue 6, pp. 2964 - 2975
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 12/2000, Volume 68, Issue 6, pp. 909 - 915
During inflammation the balance between cell activation and cell death is determined by the tight regulation of multiple intracellular enzyme cascades. Key... 
intracellular signaling | interleukin‐1 | transforming growth factor β‐activated kinase‐1 | Intracellular signaling | Interleukin-1 | Transforming growth factor β-activated kinase-1 | CELLS | interleukin-1 | MECHANISM | PHOSPHATIDYLINOSITOL 3-KINASE | AKT | IMMUNOLOGY | CELL BIOLOGY | SIGNAL-TRANSDUCTION | INSULIN | PATHWAY | transforming growth factor beta-activated kinase-1 | CD14 | TAB1 | HEMATOLOGY | I-KAPPA-B | Protein Kinases - metabolism | Okadaic Acid - pharmacology | Insulin-Like Growth Factor I - pharmacology | MAP Kinase Signaling System - physiology | Apoptosis - drug effects | Humans | Recombinant Fusion Proteins - physiology | NF-kappa B - metabolism | Hypertonic Solutions - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Cell Line - drug effects | Transfection | JNK Mitogen-Activated Protein Kinases | Flavonoids - pharmacology | Chromones - pharmacology | p38 Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Tumor Cells, Cultured - drug effects | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Morpholines - pharmacology | Imidazoles - pharmacology | Enzyme Activation - drug effects | I-kappa B Kinase | Stress, Physiological - enzymology | Interleukin-1 - pharmacology | Proto-Oncogene Proteins c-akt | Animals | MAP Kinase Signaling System - drug effects | Prostaglandins A - pharmacology | Androstadienes - pharmacology | Signal Transduction - drug effects | Cysteine Proteinase Inhibitors - pharmacology | Lipopolysaccharides - pharmacology | MAP Kinase Kinase Kinases - physiology | Signal Transduction - physiology | Mice | Pyridines - pharmacology | Inflammation - enzymology | Mitogen-Activated Protein Kinases - metabolism | TAK1 protein | lipopolysaccharides | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0122752 - e0122752
Background Infection is a common cause of acute lung injury (ALI). This study was aimed to explore whether Toll-like receptors 4 (TLR4) of airway smooth muscle... 
ISCHEMIA/REPERFUSION INJURY | OXIDATIVE STRESS | TLR4 PATHWAY | ISOFLURANE | MULTIDISCIPLINARY SCIENCES | ALVEOLAR MACROPHAGES | MICE | EXPRESSION | BINDING | LPS | Tumor Necrosis Factor-alpha - metabolism | Interleukin-1 - genetics | Nitriles - pharmacology | Tumor Necrosis Factor-alpha - genetics | Myocytes, Smooth Muscle - pathology | Acute Lung Injury - genetics | NF-kappa B - metabolism | Sulfones - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Lipopolysaccharides | Acute Lung Injury - prevention & control | Muscle Relaxants, Central - pharmacology | Female | Lung - metabolism | Toll-Like Receptor 4 - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Interleukin-6 - metabolism | Myocytes, Smooth Muscle - metabolism | Interleukin-1 - metabolism | Lung - pathology | NF-kappa B - antagonists & inhibitors | Vasodilator Agents - pharmacology | Interleukin-6 - genetics | Signal Transduction | Acetylcholine - pharmacology | Mice, Inbred C57BL | Gene Expression Regulation | Toll-Like Receptor 4 - genetics | Bronchodilator Agents - pharmacology | Methyl Ethers - pharmacology | Acute Lung Injury - pathology | Toll-Like Receptor 4 - metabolism | Sevoflurane | Animals | Acute Lung Injury - chemically induced | NF-kappa B - genetics | Isoproterenol - pharmacology | Lung - drug effects | Mice | Bronchoalveolar Lavage Fluid - chemistry | Primary Cell Culture | Lung | Smooth muscle | Segments | Activation | Isoproterenol | Interleukin 6 | Proteins | Respiratory tract | Receptors | Bronchoalveolar lavage | Rodents | Methacholine | Interleukin 1 | Toll-like receptors | Anesthesia | Chronic obstructive pulmonary disease | Alveoli | Trachea | Sensitizing | Antigens | NF-κB protein | Cytokines | Contractility | Muscles | Bronchus | Inflammation | Pharmacology | TLR4 protein | Tumor necrosis factor-α | Gene expression | Muscle contraction | Asthma | Immune systems | Phenobarbital | Hospitals | In vivo methods and tests | Acetylcholine | Infiltration | Anesthesiology | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2002, Volume 277, Issue 25, pp. 22131 - 22139
Journal Article
Circulation, ISSN 0009-7322, 12/2002, Volume 106, Issue 23, pp. 2961 - 2966
Background-We identified an interleukin-1 receptor family member, ST2, as a gene markedly induced by mechanical strain in cardiac myocytes and hypothesized... 
Receptors | Infarction | Interleukins | Creatine kinase | Stress | stress | AFTERLOAD REDUCING THERAPY | CARDIAC & CARDIOVASCULAR SYSTEMS | receptors | TRANSCRIPTION | infarction | IDENTIFICATION | interleukins | PROMOTER USAGE | GENE | IMMUNE-RESPONSES | SUPERFAMILY | PERIPHERAL VASCULAR DISEASE | creatine kinase | PROTEINS | HEMATOLOGY | T-CELLS | T1/ST2 | Interleukin-1 Receptor-Like 1 Protein | Receptor, Angiotensin, Type 1 | Myocardial Infarction - blood | Angiotensin Receptor Antagonists | Humans | Receptors, Interleukin-1 - genetics | Stress, Mechanical | Receptors, Cell Surface | Receptors, Interleukin | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | Interleukin-4 - pharmacology | Myocardium - metabolism | Phorbol Esters - pharmacology | Membrane Proteins - metabolism | Membrane Proteins - blood | Disease Models, Animal | Animals, Newborn | Angiotensin II - pharmacology | Receptors, Interleukin-1 - blood | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation - physiology | Rats | Imidazoles - pharmacology | Biomarkers - blood | Myocardial Infarction - metabolism | Rats, Sprague-Dawley | Interleukin-1 - pharmacology | Myocardium - cytology | Receptors, Interleukin-1 - metabolism | Gene Expression Regulation - drug effects | Stroke Volume | Animals | Nuclease Protection Assays | Promoter Regions, Genetic - physiology | Lipopolysaccharides - pharmacology | Mice | Pyridines - pharmacology | Index Medicus | Abridged Index Medicus | Space life sciences
Journal Article
Rheumatology, ISSN 1462-0324, 11/2008, Volume 47, Issue 11, pp. 1635 - 1640
Objectives. We investigated the influence of cytokines on the expression of RANK ligand (RANKL) in fibroblast-like synoviocytes from RA patients (RA-FLS).... 
Interleukin-1 | Soluble IL-6 receptor | Tumour necrosis factor-α | Receptor activator of nuclear factor-αB ligand | Tocilizumab | Janus kinase/signal transducer and activator of transcription | Mitogen-activated protein kinase | Fibroblast-like synoviocytes | Interleukin-17 | Interleukin-6 | RHEUMATOID-ARTHRITIS | ACTIVATION | NECROSIS-FACTOR-ALPHA | CYTOKINE | T-CELL | RHEUMATOLOGY | OSTEOBLASTIC CELLS | Receptor activator of nuclear factor-kappa B ligand | SOLUBLE INTERLEUKIN-6 RECEPTORS | OSTEOPROTEGERIN LIGAND | OSTEOCLAST DIFFERENTIATION | EXPRESSION | Tumour necrosis factor-alpha | Immunohistochemistry | Interleukin-1beta - pharmacology | RANK Ligand - metabolism | Humans | RNA, Messenger - analysis | Receptors, Interleukin-6 - antagonists & inhibitors | Synovial Membrane - drug effects | Interleukin-17 - pharmacology | Antibodies, Monoclonal, Humanized | Arthritis, Rheumatoid - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Reverse Transcriptase Polymerase Chain Reaction - methods | Fibroblasts | Flavonoids - pharmacology | Phosphorylation - drug effects | Receptor Activator of Nuclear Factor-kappa B - metabolism | Interleukin-6 - metabolism | STAT3 Transcription Factor - metabolism | Blotting, Western - methods | Antibodies, Monoclonal - pharmacology | Cells, Cultured | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | RANK Ligand - analysis | Recombinant Proteins - pharmacology | Stimulation, Chemical | Synovial Membrane - metabolism | RANK Ligand - genetics | Tumor Necrosis Factor-alpha - pharmacology | Interleukin-6 - pharmacology | Signal Transduction - physiology | Cell Proliferation - drug effects | Sesquiterpenes - pharmacology | Receptors, Interleukin-6 - metabolism | Index Medicus | Abridged Index Medicus
Journal Article