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Nature Immunology, ISSN 1529-2908, 03/2015, Volume 16, Issue 4, pp. 354 - 365
Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan members of the IL-1 ligand family and IL-1 receptor family, respectively. Here... 
CELLS | FAMILY-MEMBER | INFLAMMATION | TIR8/SIGIRR | INFECTION | IMMUNOLOGY | TOLL | INHIBITOR | EXPRESSION | NEGATIVE REGULATOR | MOLECULES | Inflammation - pathology | Interleukin-1 - genetics | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Humans | Receptors, Interleukin-1 - genetics | NF-kappa B - immunology | Receptor Protein-Tyrosine Kinases - immunology | Proto-Oncogene Proteins c-fyn - genetics | Signal Transduction - immunology | TOR Serine-Threonine Kinases - genetics | PTEN Phosphohydrolase - immunology | RNA, Small Interfering - immunology | Receptors, Interleukin-1 - deficiency | Leukocytes, Mononuclear - immunology | c-Mer Tyrosine Kinase | Interleukin-1 - immunology | Interleukin-18 Receptor alpha Subunit - genetics | Proto-Oncogene Proteins - immunology | Proto-Oncogene Proteins c-fyn - immunology | STAT3 Transcription Factor - genetics | Cell Line | PTEN Phosphohydrolase - genetics | Interleukin-18 Receptor alpha Subunit - immunology | Leukocytes, Mononuclear - drug effects | MAP Kinase Kinase Kinases - genetics | Receptors, Interleukin-1 - immunology | RNA-Binding Proteins - immunology | Gene Expression Regulation | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Inflammation - immunology | Immunity, Innate | MAP Kinase Kinase Kinases - immunology | Interleukin-18 Receptor alpha Subunit - antagonists & inhibitors | Leukocytes, Mononuclear - pathology | TOR Serine-Threonine Kinases - immunology | Animals | NF-kappa B - genetics | Receptor Protein-Tyrosine Kinases - genetics | Lipopolysaccharides - pharmacology | Inflammation - genetics | Protein Binding | Mice | STAT3 Transcription Factor - immunology | Receptors, Interleukin-1 - antagonists & inhibitors
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, p. 6793
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2012, Volume 122, Issue 11, pp. 3965 - 3976
Psoriasis is a chronic inflammatory disorder of the skin affecting approximately 2% of the world's population. Accumulating evidence has revealed that the... 
GENERALIZED PUSTULAR PSORIASIS | MEDICINE, RESEARCH & EXPERIMENTAL | INFLAMMATORY SKIN-DISEASE | FAMILY-MEMBERS | MOUSE MODEL | DELTA-T-CELLS | NF-KAPPA-B | AUTOINFLAMMATORY DISEASE | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | CUTTING EDGE | TRANSGENIC MICE | Cell Communication - immunology | Interleukin-1 - genetics | Membrane Glycoproteins - metabolism | Dermatitis - immunology | Dendritic Cells - immunology | Receptors, Interleukin-1 - genetics | Interleukin-17 - immunology | Dendritic Cells - pathology | Interleukins - metabolism | Interleukin-23 - genetics | Interleukins - genetics | Psoriasis - genetics | Interleukin-23 - metabolism | Psoriasis - pathology | Interleukins - immunology | Toll-Like Receptor 7 - immunology | Interleukin-1 - immunology | Psoriasis - metabolism | Membrane Glycoproteins - immunology | Dendritic Cells - metabolism | Psoriasis - immunology | Toll-Like Receptor 7 - genetics | Interleukin-1 - metabolism | Toll-Like Receptor 7 - metabolism | Dermatitis - genetics | Receptors, Interleukin-1 - immunology | Interleukin-17 - genetics | Cell Communication - genetics | Interleukin-23 - immunology | Keratinocytes - immunology | Membrane Glycoproteins - genetics | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Dermatitis - pathology | Interleukin-17 - metabolism | Keratinocytes - pathology | Animals | Keratinocytes - metabolism | Mice | Dermatitis - metabolism | Psoriasis | Interleukins | Keratinocytes | Genetic aspects | Dosage and administration | Diagnosis | Drug therapy
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2017, Volume 13, Issue 1, p. e1006092
Toll/interleukin-1 receptor (TIR) domains in Toll-like receptors are essential for initiating and propagating the eukaryotic innate immune signaling cascade.... 
Laboratory of Phytopathology | EPS | Laboratorium voor Phytopathologie | Laboratorium voor Fytopathologie | STRAINS | SYSTEM | CONTAINING PROTEINS | MICROBIOLOGY | CASSETTE CHROMOSOME MEC | VECTOR | FAMILY | EVOLUTION | VIROLOGY | GENOMES | BTPB | CLONES | PARASITOLOGY | Virulence Factors - genetics | Humans | Receptors, Interleukin-1 - genetics | Penicillin-Binding Proteins - genetics | Virulence Factors - immunology | Signal Transduction - immunology | Staphylococcal Skin Infections - drug therapy | HEK293 Cells | Bacterial Proteins - immunology | Fusidic Acid - pharmacology | Membrane Glycoproteins - immunology | Macrophages - immunology | Disease Models, Animal | Staphylococcus aureus - genetics | Cell Line | Receptors, Interleukin-1 - immunology | Mice, Inbred C57BL | Bacterial Proteins - genetics | Myeloid Differentiation Factor 88 - genetics | Neutrophils - immunology | Staphylococcus aureus - pathogenicity | Membrane Glycoproteins - genetics | Mice, Knockout | Animals | Myeloid Differentiation Factor 88 - deficiency | Toll-Like Receptors - genetics | Staphylococcus aureus - immunology | Mice | Staphylococcal Skin Infections - microbiology | Bacterial infections | Disease transmission | Gene mutations | Analysis | Genetic aspects | Research | Bacterial genetics | Epidemiology | Risk factors | Studies | Pathogens | Medical research | Enzymes | Cytokines | Laboratories | Genes | Antimicrobial agents | Staphylococcus infections | Genetic engineering | Experiments | Life Sciences | Microbiology and Parasitology | Immunology | Bacteriology | Virology
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2010, Volume 207, Issue 8, pp. 1625 - 1636
Signaling through the adaptor protein myeloid differentiation factor 88 (MyD88) promotes carcinogenesis in several cancer models. In contrast, MyD88 signaling... 
EXPRESSION PATTERNS | MEDICINE, RESEARCH & EXPERIMENTAL | CHRONIC INTESTINAL INFLAMMATION | MUTANT MICE | SODIUM-SULFATE COLITIS | CELL LINES | COLITIS-ASSOCIATED CANCER | IMMUNOLOGY | BETA-CATENIN | TUMORIGENESIS | INNATE IMMUNITY | BOWEL-DISEASE | Colonic Neoplasms - genetics | Intestinal Mucosa - metabolism | Adenocarcinoma - pathology | Azoxymethane - pharmacology | Epithelial Cells - metabolism | Gene Expression - drug effects | Apoptosis - drug effects | Gene Expression - genetics | Adenocarcinoma - chemically induced | Colonic Polyps - pathology | Epithelial Cells - drug effects | Colon - drug effects | DNA Repair Enzymes - genetics | Apoptosis - genetics | Colonic Neoplasms - chemically induced | Gene Expression Profiling | Inflammatory Bowel Diseases - metabolism | Colonic Neoplasms - metabolism | Intestinal Mucosa - drug effects | Adenocarcinoma - metabolism | Cyclooxygenase 2 - genetics | Inflammatory Bowel Diseases - pathology | Inflammatory Bowel Diseases - genetics | Interleukin-18 Receptor alpha Subunit - genetics | Inflammatory Bowel Diseases - chemically induced | Adenocarcinoma - genetics | Phosphorylation - drug effects | STAT3 Transcription Factor - genetics | Dextran Sulfate - pharmacology | Genetic Predisposition to Disease - genetics | Specific Pathogen-Free Organisms | Colon - pathology | Mice, Inbred C57BL | Epithelial Cells - pathology | Mutation - genetics | Colon - metabolism | beta Catenin - genetics | Mice, Knockout | Animals | Colonic Neoplasms - pathology | Receptors, Interleukin-1 Type I - genetics | Signal Transduction - physiology | Cell Proliferation - drug effects | Mice | Interleukin-18 - genetics | Myeloid Differentiation Factor 88 - metabolism | Interleukin-18 - metabolism | Intestinal Mucosa - pathology | Index Medicus
Journal Article
Nature Genetics, ISSN 1061-4036, 01/2014, Volume 46, Issue 1, pp. 51 - +
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 04/2016, Volume 68, Issue 4, pp. 932 - 943
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 05/2006, Volume 1067, Issue 1, pp. 252 - 263
:  Aging is due to a complex interaction of genetic, epigenetic, and environmental factors, but a strong genetic component appears to have an impact on... 
CETP | TLR-4 | apolipoproteins | insulin/IGF-1 | PON1 | longevity genes | IL-6 | IL-10 | PPARγ | IL-1 cluster | p53, p66shc | TNF-α | TGF-β | insulin/IGF‐1 | TNF‐α | IL‐6 | TGF‐β | IL‐10 | TLR‐4 | IL‐1 cluster | Apolipoproteins | Longevity genes | p53, p66 | LIFE-SPAN | RISK-FACTORS | AGED PEOPLE | TNF-alpha | MULTIDISCIPLINARY SCIENCES | SPORADIC ALZHEIMERS-DISEASE | PROMOTER POLYMORPHISM | NECROSIS-FACTOR-ALPHA | PPAR gamma | p53, p66(shc) | OLDER PERSONS | TGF-beta | HEALTHY CENTENARIANS | ITALIAN CENTENARIANS | GROWTH-FACTOR-I | Interleukin-1 - genetics | Multigene Family | Oxidative Stress | Humans | Tumor Necrosis Factor-alpha - genetics | Insulin-Like Growth Factor I - genetics | Tumor Suppressor Protein p53 - genetics | Aging - genetics | Apolipoproteins - genetics | Aged, 80 and over | Lipid Metabolism - genetics | Insulin - genetics | PPAR gamma - genetics | Shc Signaling Adaptor Proteins | Glycoproteins - genetics | Interleukin-6 - genetics | Signal Transduction | Toll-Like Receptor 4 - genetics | Longevity - genetics | Aryldialkylphosphatase - genetics | Polymorphism, Genetic | Carrier Proteins - genetics | Src Homology 2 Domain-Containing, Transforming Protein 1 | Aging - physiology | Interleukin-10 - genetics | Adaptor Proteins, Signal Transducing - genetics | Inflammation - genetics | Cholesterol Ester Transfer Proteins | Longevity - physiology
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2008, Volume 205, Issue 7, pp. 1543 - 1550
Journal Article