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BREAST CANCER RESEARCH AND TREATMENT, ISSN 0167-6806, 02/2016, Volume 155, Issue 3, pp. 419 - 421
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2010, Volume 184, Issue 7, pp. 3326 - 3330
To investigate the respective contributions of TLR versus lL-1R mediated signals in MyD88 dependent control of Mycobacterium tuberculosis, we compared the... 
ADAPTIVE IMMUNITY | RESPONSES | RECOGNITION | INTERLEUKIN-1-BETA | INFLAMMASOME | RECEPTOR | INFECTION | MICE | CYTOKINE | IMMUNOLOGY | INNATE IMMUNITY
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 06/2013, Volume 33, Issue 23, pp. 9592 - 9600
Accumulation of alpha-synuclein (alpha-syn) in the brain is a core feature of Parkinson disease (PD) and leads to microglial activation, production of... 
GAMMA | CHAIN | INTERLEUKIN-1-BETA | INFLAMMATION | MOUSE MODEL | CEREBROSPINAL-FLUID | SUBSTANTIA-NIGRA | EXPRESSION | NEUROSCIENCES | BRAIN | PARKINSONS-DISEASE
Journal Article
NATURE, ISSN 0028-0836, 04/2012, Volume 484, Issue 7395, pp. 514 - U139
IL-17-producing CD4(+) T helper cells (T(H)17) have been extensively investigated in mouse models of autoimmunity(1). However, the requirements for... 
HYPER-IGE SYNDROME | GROWTH-FACTOR-BETA | TGF-BETA | MEMORY | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | HELPER-CELLS | CD4(+) T-CELLS | DIFFERENTIATION | TH17 CELLS | PROSTAGLANDIN-E2
Journal Article
NATURE, ISSN 0028-0836, 06/2019, Volume 570, Issue 7761, pp. 316 - 317
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 06/2008, Volume 180, Issue 11, pp. 7147 - 7157
The proinflammatory IL-1 cytokines IL-1 alpha, IL-1 beta, and IL-18 are key mediators of the acute immune response to injury and infection. Mechanisms... 
P2X7 RECEPTOR | ACTIVATION | MICE DEFICIENT | CASPASE-1 | MURINE MACROPHAGES | INFLAMMASOME | INTERLEUKIN-1-BETA RELEASE | SECRETION | IMMUNOLOGY | ATP | MODULATION
Journal Article
by Kang, I
ARTHRITIS & RHEUMATOLOGY, ISSN 2326-5191, 02/2016, Volume 68, Issue 2, pp. 274 - 276
Journal Article
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, ISSN 1073-449X, 09/2010, Volume 182, Issue 6, pp. 774 - 783
Rationale: Pulmonary fibrosis is a devastating as yet untreatable disease. We previously investigated the endogenous mediators released on lung injury and... 
CASPASE-1 | pannexin-1 | P2X receptor | IDENTIFICATION | lung fibrosis | CRYOPYRIN/NALP3 | MOLECULES | TOLL-LIKE | EPITHELIAL-CELLS | inflammation | RESPIRATORY SYSTEM | HEMICHANNELS | INTERLEUKIN-1-BETA RELEASE | ATP | PULMONARY-FIBROSIS | CRITICAL CARE MEDICINE
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 04/2006, Volume 176, Issue 7, pp. 3877 - 3883
Human IL-1 family proteins are key mediators of the host response to infections, injury, and immunologic challenges. The mechanism by which IL-1 activates... 
EXTRACELLULAR ATP | RHEUMATOID-ARTHRITIS | IMMUNE-SYSTEM | IL-1-BETA RELEASE | NUCLEOTIDE RECEPTOR | INTERLEUKIN-1-BETA SECRETION | ATP-BINDING-SITE | GAMMA-INDUCING FACTOR | MICROGLIAL CELLS | IMMUNOLOGY | HUMAN MONOCYTES
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 08/2009, Volume 15, Issue 8, pp. 946 - U150
Lymphocyte recruitment and activation have been implicated in the progression of cerebral ischemia-reperfusion (I/R) injury, but the roles of specific... 
MEDICINE, RESEARCH & EXPERIMENTAL | NERVOUS-SYSTEM | ARTERY OCCLUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | FOCAL ISCHEMIA | AUTOIMMUNE ENCEPHALOMYELITIS | INTERLEUKIN-1-BETA CONVERTING-ENZYME | CELL BIOLOGY | BARRIER DISRUPTION | INTERFERON-GAMMA | INFLAMMATION | IL-17 PRODUCTION
Journal Article
Journal of Neuroinflammation, ISSN 1742-2094, 04/2012, Volume 9, Issue 1, pp. 83 - 83
Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7575, pp. 666 - 671
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 12/2007, Volume 72, Issue 6, pp. 1447 - 1456
The cytolytic ionotropic ATP receptor P2X(7) has several important roles in immune cell regulation, such as cytokine release, apoptosis, and microbial killing.... 
NEUROPATHIC PAIN | CELLS | NUCLEOTIDES | MICROGLIA | P2X RECEPTOR | INTERLEUKIN-1-BETA | MACROPHAGES | PHARMACOLOGY & PHARMACY | PORE FORMATION | SUBUNITS | RELEASE
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 04/2009, Volume 182, Issue 7, pp. 4378 - 4385
Extracellular ATP is a mediator of intercellular communication and a danger signal. Release of this and other nucleotides modulates microglia responses via P2Y... 
EXTRACELLULAR ATP | NERVOUS-SYSTEM | CELLS | IN-VITRO | INFLAMMATORY PROCESSES | ALZHEIMERS-DISEASE | INTERLEUKIN-1-BETA RELEASE | IMMUNOLOGY | CYSTEINYL-LEUKOTRIENES | ASTROCYTES | PEPTIDE
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 08/2019, Volume 139, Issue 8, pp. 1788 - 1797.e6
The inflammasome protein NLRP1 is an important innate immune sensor in human keratinocytes, and, together with ASC and caspase-1, it mediates the activation... 
APOPTOSIS | ACTIVATION | DNA METHYLATION | CASPASE-1 | ASC/TMS1 | INTERLEUKIN-1-BETA | SKIN | MUTATIONS | GENETIC-VARIATIONS | CANCER | DERMATOLOGY
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 12/2018, Volume 138, Issue 12, pp. 2644 - 2652
By forming a protective barrier, epidermal keratinocytes represent the first line of defense against environmental insults. UVB radiation of the sun is a major... 
ACTIVATION | GASDERMIN D | VITILIGO | INTERLEUKIN-1-BETA | LENTIVIRAL VECTOR | SUSCEPTIBILITY | EPIDERMAL-KERATINOCYTES | SKIN | GENETIC-VARIATIONS | CULTIVATION | DERMATOLOGY
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 06/2019, Volume 139, Issue 6, pp. 1373 - 1384
Chronic wounds represent a major and growing health and economic burden worldwide. A better understanding of molecular mechanisms of normal as well as impaired... 
MATRIX METALLOPROTEINASES | GENE | IMMUNE-RESPONSES | CELL-MIGRATION | INTERLEUKIN-1-BETA | INNATE | DIFFERENTIATION | IDENTIFICATION | EXPRESSION | EPITHELIALIZATION | DERMATOLOGY
Journal Article
Blood, ISSN 0006-4971, 05/2007, Volume 109, Issue 9, pp. 3856 - 3864
Dendritic cells (DCs) are professional antigen-presenting cells that initiate the immune response by activating T lymphocytes. DCs express plasma membrane... 
EXTRACELLULAR ATP | ACTIVATION | CYTOKINE PRODUCTION | P2X RECEPTOR | SOLUBLE-ANTIGEN | MEMBRANE | INTERLEUKIN-1-BETA | ROCK-I | SECRETION | HEMATOLOGY | EXPRESSION
Journal Article