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Journal of Cellular Physiology, ISSN 0021-9541, 09/2007, Volume 212, Issue 3, pp. 702 - 709
Adipose tissue serves as a source of adipokines and cytokines with both local and systemic actions in health and disease. In this study, we examine the... 
BREAST-CANCER | TUMOR-NECROSIS-FACTOR | IN-VITRO | PHYSIOLOGY | TEMPORAL-CHANGES | MURINE BONE-MARROW | INSULIN-RESISTANCE | HEPATOCYTE GROWTH-FACTOR | ENDOTHELIAL-CELLS | TISSUE | STROMAL CELLS | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | Angiogenic Proteins - genetics | Cell Proliferation | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Coculture Techniques | Humans | Middle Aged | Multipotent Stem Cells - metabolism | Adipose Tissue - cytology | RNA, Messenger - metabolism | Hematopoiesis - drug effects | Adipose Tissue - metabolism | Multipotent Stem Cells - drug effects | Time Factors | Inflammation Mediators - metabolism | Fibroblast Growth Factor 2 - metabolism | Adult | Female | Cell Differentiation | Interleukin-8 - metabolism | Cytokines - genetics | Interleukin-6 - metabolism | Granulocyte Colony-Stimulating Factor - metabolism | Interleukin-7 - metabolism | Adult Stem Cells - drug effects | Adult Stem Cells - cytology | Cytokines - metabolism | Paracrine Communication | Endothelial Cells - metabolism | Ascorbic Acid - analogs & derivatives | Cells, Cultured | Epidermal Growth Factor - metabolism | Interleukin-11 - metabolism | Hematopoietic Stem Cells - metabolism | Hepatocyte Growth Factor - metabolism | Adult Stem Cells - metabolism | Adipocytes - metabolism | Ascorbic Acid - pharmacology | Lipopolysaccharides - pharmacology | Adipose Tissue - drug effects | Angiogenic Proteins - metabolism | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 10/2002, Volume 8, Issue 10, pp. 1089 - 1097
The intracellular signaling mechanisms that specify tissue-specific responses to the interleukin-6 (IL-6) family of cytokines are not well understood. Here, we... 
MEDICINE, RESEARCH & EXPERIMENTAL | HEPATIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | INTESTINAL INFLAMMATION | RESPONSES | INTERLEUKIN-6 FAMILY | COLITIS | IN-VIVO | DISEASE | CYTOKINE RECEPTORS | TRANSGENIC MICE | SIGNAL TRANSDUCER | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | Membrane Glycoproteins - metabolism | Transcriptional Activation | Peptides - genetics | Neuropeptides | Protein Tyrosine Phosphatases - metabolism | Wound Healing | Antigens, CD - genetics | Antigens, CD - metabolism | Growth Substances - genetics | Peptides - metabolism | Digestive System Physiological Phenomena | Protein Phosphatase 2 | Interleukin-6 - metabolism | Cytokine Receptor gp130 | Colon - pathology | Interleukin-11 - metabolism | Mice, Transgenic | Spleen - cytology | Colon - metabolism | STAT1 Transcription Factor | Mice | Intestinal Mucosa - pathology | Intestinal Mucosa - metabolism | Homeostasis | Stomach Neoplasms - metabolism | Stomach Neoplasms - pathology | Stomach - metabolism | Adenoma - metabolism | DNA-Binding Proteins - metabolism | Muscle Proteins | Trefoil Factor-3 | Trefoil Factor-2 | Cell Line | Stomach - pathology | Gene Expression Regulation | Intracellular Signaling Peptides and Proteins | Membrane Glycoproteins - genetics | Proteins - genetics | Animals | Proteins - metabolism | Spleen - metabolism | Mucins | Stomach - cytology | Adenoma - pathology | Signal Transduction - physiology | Trans-Activators - metabolism | Growth Substances - metabolism | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2013, Volume 210, Issue 10, pp. 2041 - 2056
Unresolved endoplasmic reticulum (ER) stress in the epithelium can provoke intestinal inflammation. Hypomorphic variants of ER stress response mediators, such... 
MEDICINE, RESEARCH & EXPERIMENTAL | UNFOLDED PROTEIN RESPONSE | INFLAMMATORY-BOWEL-DISEASE | EPITHELIAL-CELLS | COLORECTAL-CANCER | ULCERATIVE-COLITIS | IN-VIVO | COLITIS-ASSOCIATED CANCER | ENDOPLASMIC-RETICULUM STRESS | IMMUNOLOGY | NF-KAPPA-B | TUMOR-GROWTH | Index Medicus
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 12/2012, Volume 26, Issue 12, pp. 2016 - 2030
During each menstrual cycle, the human uterus undergoes a unique transformation, known as decidualization, which involves endometrial stromal proliferation and... 
CROSS-TALK | FORKHEAD TRANSCRIPTION FACTOR | IMPLANTATION FAILURE | KINASE-A | ENDOCRINOLOGY & METABOLISM | LEUKEMIA INHIBITORY FACTOR | CELL-CYCLE | PROGESTERONE-RECEPTOR | MICE LACKING | BINDING-PROTEIN-BETA | MAMMARY-GLAND | Phosphorylation | Cell Proliferation | Humans | Menstrual Cycle - metabolism | Uterus - metabolism | Embryo Implantation - genetics | Gene Expression Profiling | RNA, Messenger - metabolism | Receptors, Interleukin-11 - genetics | Retinoblastoma Protein - biosynthesis | Chromatin Immunoprecipitation | RNA Interference | Female | Transcription, Genetic | Cell Differentiation | Endometrium - cytology | Estrogens - metabolism | Cyclic AMP - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Endometrium - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Embryo Implantation - physiology | CCAAT-Enhancer-Binding Protein-beta - genetics | RNA, Messenger - genetics | Retinoblastoma Protein - metabolism | Stromal Cells - metabolism | Cells, Cultured | Signal Transduction - genetics | E2F1 Transcription Factor - metabolism | CCAAT-Enhancer-Binding Protein-beta - metabolism | Cell Cycle | Receptors, Interleukin-11 - metabolism | Progesterone - metabolism | E2F1 Transcription Factor - biosynthesis | RNA, Small Interfering | Cyclin E - metabolism | Stromal Cells - cytology | Index Medicus | Original Research
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 11/2004, Volume 19, Issue 11, pp. 1873 - 1881
We determined that sFRP‐1 mRNA was differentially expressed by osteoblast/stromal cell lines and that sFRP‐1 neutralizing antibodies and siRNA complementary to... 
secreted Frizzled‐related protein | RANKL | osteoclast | Wnt | Secreted Frizzled-related protein | Osteoclast | BONE-DENSITY | secreted frizzled-related protein | COLONY-STIMULATING FACTOR | MOUSE | DIFFERENTIATION FACTOR | RECEPTOR | OSTEOPROTEGERIN | CELL-LINES | ENDOCRINOLOGY & METABOLISM | LIGAND | CHONDROGENESIS | SPEMANN ORGANIZER | Receptor Activator of Nuclear Factor-kappa B | Membrane Glycoproteins - metabolism | Male | RANK Ligand | Gene Expression Profiling | Wnt Proteins | RNA, Messenger - metabolism | Recombinant Fusion Proteins - metabolism | Intercellular Signaling Peptides and Proteins - physiology | Dose-Response Relationship, Drug | Intercellular Signaling Peptides and Proteins - metabolism | In Situ Hybridization | Membrane Glycoproteins - antagonists & inhibitors | Membrane Proteins - physiology | Parathyroid Hormone - metabolism | Bone and Bones - metabolism | Escherichia coli - metabolism | Polymerase Chain Reaction | Calcitriol - metabolism | Membrane Proteins - metabolism | Interleukin-6 - metabolism | Chondrocytes - metabolism | Recombinant Proteins - metabolism | Cell Line | Enzyme-Linked Immunosorbent Assay | Signal Transduction | Mice, Inbred C57BL | Carrier Proteins - antagonists & inhibitors | Gene Expression Regulation | Glutathione Transferase - metabolism | Recombinant Proteins - chemistry | Interleukin-11 - metabolism | Macrophage Colony-Stimulating Factor - metabolism | Osteoclasts - metabolism | Animals | Carrier Proteins - metabolism | Mice | Osteoblasts - metabolism | Bone Marrow Cells - metabolism | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 05/2014, Volume 25, Issue 5, pp. 666 - 681
Journal Article
Nature, ISSN 0028-0836, 2017, Volume 552, Issue 7683, pp. 110 - 115
Fibrosis is a common pathology in cardiovascular disease(1). In the heart, fibrosis causes mechanical and electrical dysfunction(1,2) and in the kidney, it... 
MYOCARDIAL-INFARCTION | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | MUTATION | MYOFIBROBLASTS | INTERLEUKIN-11 | MECHANISMS | CYTOKINE | CARDIAC FIBROSIS | FAILURE | FIBROBLASTS | Heart | Protein Biosynthesis | Kidney - pathology | Humans | Middle Aged | Transforming Growth Factor beta1 - metabolism | Male | Fibrosis - metabolism | Myocardium - metabolism | Female | Interleukin-11 Receptor alpha Subunit - genetics | Transforming Growth Factor beta1 - pharmacology | Fibroblasts - metabolism | Interleukin-11 - antagonists & inhibitors | Autocrine Communication | Fibrosis - chemically induced | Interleukin-11 Receptor alpha Subunit - deficiency | Transgenes - genetics | Cells, Cultured | Interleukin-11 - genetics | Interleukin-11 - metabolism | Myocardium - pathology | Fibroblasts - pathology | Mice, Knockout | Cardiovascular System - pathology | Animals | Cardiovascular System - metabolism | Fibroblasts - drug effects | Organ Dysfunction Scores | Mice | Fibrosis - pathology | Physiological aspects | Interleukins | Cardiovascular diseases | Health aspects | Fibrosis | Transcription | Toxicity | Syngeneic grafts | Downstream effects | Transforming growth factor | Genomics | Interleukin | Cardiovascular disease | Proteins | Clonal deletion | Interleukin 1 | Fibroblasts | Deletion | Inhibition | Autocrine signalling | Heart diseases | Immunoglobulins | Kidneys | Cytokines | Organs | Extracellular signal-regulated kinase | Interleukin 11 | Protein biosynthesis | Gene expression | Coronary artery disease | Studies | Side effects | Protein synthesis | Renal failure | Ligands | Kidney transplantation | Index Medicus
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 06/2003, Volume 111, Issue 6, pp. 1293 - 1298
Journal Article
Journal Article
Journal Article