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1. Full Text Distinct pathways of humoral and cellular immunity induced with the mucosal administration of a nanoemulsion adjuvant
by Bielinska, Anna U and Makidon, Paul E and Janczak, Katarzyna W and Blanco, Luz P and Swanson, Benjamin and Smith, Douglas M and Pham, Tiffany and Szabo, Zsuzsanna and Kukowska-Latallo, Jolanta F and Baker Jr, James R
Journal of Immunology, ISSN 0022-1767, 03/2014, Volume 192, Issue 6, pp. 2722 - 2733
Nasal administration of an oil-in-water nanoemulsion (NE) adjuvant W(80)5EC produces potent systemic and mucosal, Th-1- and Th-17-balanced cellular responses.... 
ADAPTIVE IMMUNITY | SIGNAL-TRANSDUCTION | MONOPHOSPHORYL-LIPID-A | CYTOKINE PRODUCTION | VACCINE ADJUVANT | DELIVERY-SYSTEMS | TOLL-LIKE RECEPTORS | NLRP3 INFLAMMASOME | IMMUNOLOGY | ANTIBODY-RESPONSES | T-CELLS | Adjuvants, Immunologic - administration & dosage | Adjuvants, Immunologic - pharmacology | Oligonucleotide Array Sequence Analysis | Immunity, Humoral - immunology | Interleukin-12 - genetics | Dendritic Cells - immunology | Humans | NF-kappa B - immunology | NF-kappa B - metabolism | Transcriptome - immunology | Emulsions - pharmacology | Signal Transduction - immunology | Immunity, Cellular - drug effects | Emulsions - administration & dosage | HEK293 Cells | Interleukin-12 Receptor beta 1 Subunit - genetics | Myeloid Differentiation Factor 88 - immunology | Dendritic Cells - drug effects | Female | Toll-Like Receptors - metabolism | Interleukin-12 Receptor beta 1 Subunit - metabolism | Dendritic Cells - metabolism | Cell Line | Immunity, Cellular - genetics | Immunity, Humoral - genetics | Mice, Inbred C57BL | Toll-Like Receptors - immunology | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Interleukin-12 - metabolism | Signal Transduction - genetics | Transcriptome - drug effects | Transcriptome - genetics | Reverse Transcriptase Polymerase Chain Reaction | Administration, Intranasal | Mice, Knockout | Immunity, Cellular - immunology | Animals | Signal Transduction - drug effects | Toll-Like Receptors - genetics | Interleukin-12 - immunology | Immunity, Humoral - drug effects | Mice | Interleukin-12 Receptor beta 1 Subunit - immunology | Myeloid Differentiation Factor 88 - metabolism | Index Medicus | Abridged Index Medicus | Immunotherapy and Vaccines
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2. Full Text Comparison of Ustekinumab and Etanercept for Moderate-to-Severe Psoriasis
by Griffiths, Christopher E.M and Strober, Bruce E and van de Kerkhof, Peter and Ho, Vincent and Fidelus-Gort, Roseanne and Yeilding, Newman and Guzzo, Cynthia and Xia, Yichuan and Zhou, Bei and Li, Shu and Dooley, Lisa T and Goldstein, Neil H and Menter, Alan and ACCEPT Study Grp and ACCEPT Study Group
The New England Journal of Medicine, ISSN 0028-4793, 01/2010, Volume 362, Issue 2, pp. 118 - 128
In this 12-week randomized trial comparing two biologic agents known to be effective for psoriasis, ustekinumab (an interleukin-12 and interleukin-23 blocker)... 
RANDOMIZED-CONTROLLED-TRIAL | MEDICINE, GENERAL & INTERNAL | PLACEBO | CHRONIC PLAQUE PSORIASIS | EFFICACY | SAFETY | DOUBLE-BLIND | METHOTREXATE | TNF INHIBITION | INDUCTION | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | Severity of Illness Index | Psoriasis - drug therapy | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Immunologic Factors - administration & dosage | Immunoglobulin G - therapeutic use | Ustekinumab | Antibodies, Monoclonal - therapeutic use | Male | Receptors, Tumor Necrosis Factor - administration & dosage | Immunoglobulin G - administration & dosage | Receptors, Tumor Necrosis Factor - therapeutic use | Antibodies, Monoclonal, Humanized | Etanercept | Antibodies, Monoclonal - administration & dosage | Interleukin-23 - antagonists & inhibitors | Interleukin-12 - antagonists & inhibitors | Adult | Female | Immunosuppressive Agents - administration & dosage | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Immunologic Factors - therapeutic use | Dosage and administration | Psoriasis | Comparative analysis | Drug therapy | Fees & charges | Cytokines | Stock options | Laboratories | Research & development--R&D | Equity | Interleukin 23 | Interleukin 12 | Tumor necrosis factor-α | Light therapy | Patients | Studies | Tumor necrosis factor-TNF | Index Medicus | Abridged Index Medicus
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3. Full Text Safety and Comparative Immunogenicity of an HIV-1 DNA Vaccine in Combination with Plasmid Interleukin 12 and Impact of Intramuscular Electroporation for Delivery
by Spyros A. Kalams and Scott D. Parker and Marnie Elizaga and Barbara Metch and Srilatha Edupuganti and John Hural and Stephen De Rosa and Donald K. Carter and Kyle Rybczyk and Ian Frank and Jonathan Fuchs and Beryl Koblin and Denny H. Kim and Patrice Joseph and Michael C. Keefer and Lindsey R. Baden and John Eldridge and Jean Boyer and Adam Sherwat and Massimo Cardinali and Mary Allen and Michael Pensiero and Chris Butler and Amir S. Khan and Jian Yan and Niranjan Y. Sardesai and James G. Kublin and David B. Weiner and NIAID HIV Vaccine Trials Network and the NIAID HIV Vaccine Trials Network
The Journal of Infectious Diseases, ISSN 0022-1899, 9/2013, Volume 208, Issue 5, pp. 818 - 829
Background. DNA vaccines have been very poorly immunogenic in humans but have been an effective priming modality in prime-boost regimens. Methods to increase... 
T lymphocytes | HIV/AIDS | Body mass index | Immune response | HIV | Interleukins | Plasmids | Vaccination | Electroporation | DNA vaccines | HIV 1 | plasmid cytokine adjuvant | electroporation | vaccination | INFECTIOUS DISEASES | PHASE-1 SAFETY | MICROBIOLOGY | CYTOKINE | IMMUNOLOGY | IL-12 | IN-VIVO ELECTROPORATION | VIREMIA | T-CELL RESPONSES | IMMUNE-RESPONSES | CANDIDATE VACCINE | GROWTH-FACTOR | RHESUS MACAQUES | Adjuvants, Immunologic - administration & dosage | Interleukin-12 - genetics | Humans | Middle Aged | AIDS Vaccines - immunology | Male | DNA - adverse effects | AIDS Vaccines - adverse effects | CD4-Positive T-Lymphocytes - immunology | Young Adult | Vaccination - methods | Adjuvants, Immunologic - genetics | Adult | Female | Drug Administration Routes | DNA - immunology | DNA - administration & dosage | HIV-1 - genetics | HIV-1 - immunology | Interleukin-12 - administration & dosage | Adolescent | AIDS Vaccines - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Cytokines - biosynthesis | Usage | AIDS vaccines | Interleukin-12 | Dosage and administration | Research | Human immunogenetics | Index Medicus | Abridged Index Medicus | Major and Brief Reports
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4. Full Text Identification of immune factors regulating antitumor immunity using polymeric vaccines with multiple adjuvants
by Ali, Omar A and Verbeke, Catia and Johnson, Chris and Sands, R. Warren and Lewin, Sarah A and White, Des and Doherty, Edward and Dranoff, Glenn and Mooney, David J
Cancer Research, ISSN 0008-5472, 03/2014, Volume 74, Issue 6, pp. 1670 - 1681
The innate cellular and molecular components required to mediate effective vaccination against weak tumor-associated antigens remain unclear. In this study, we... 
TUMOR-NECROSIS-FACTOR | INTERFERON | ONCOLOGY | IN-VIVO | INTERLEUKIN-12 | T-CELL | CANCER-IMMUNOTHERAPY | DIFFERENTIATION | DENDRITIC-CELL SUBSETS | INNATE IMMUNITY | ANTIGEN | Neoplasm Transplantation | Oligodeoxyribonucleotides - administration & dosage | Adjuvants, Immunologic - administration & dosage | Poly I-C - administration & dosage | Dendritic Cells - immunology | Lipid A - analogs & derivatives | Drug Carriers - administration & dosage | Mice, 129 Strain | Drug Carriers - chemistry | Adjuvants, Immunologic - pharmacokinetics | Melanoma, Experimental - immunology | Female | Toll-Like Receptors - metabolism | Polyglactin 910 - administration & dosage | T-Lymphocytes, Cytotoxic - immunology | Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage | Lipid A - administration & dosage | Cancer Vaccines - administration & dosage | Melanoma, Experimental - therapy | Mice, Inbred C57BL | Interleukin-12 - metabolism | Toll-Like Receptors - agonists | Mice, Knockout | Animals | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacokinetics | Cell Line, Tumor | Mice | Delayed-Action Preparations | Index Medicus
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5. Full Text IFN-γ induced by IL-12 administration prevents diabetes by inhibiting pathogenic IL-17 production in NOD mice
by Zhang, Jun and Huang, Zhan and Sun, Rui and Tian, Zhigang and Wei, Haiming
Journal of Autoimmunity, ISSN 0896-8411, 2011, Volume 38, Issue 1, pp. 20 - 28
Abstract Interleukin 12 (IL-12) is a pivotal Th1-associated cytokine and a potent immunoregulatory molecule. However, the role of IL-12 in inducing immune... 
Allergy and Immunology | Interleukin 12 | IFN-γ | Dendritic cells | Type 1 diabetes | Interleukin 17 | IMMUNITY | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | CD4 T-CELLS | INTERLEUKIN-12 | IMMUNOLOGY | TH1 RESPONSE | IFN-gamma | INFLAMMATION | IN-VIVO | ANTIGEN-PRESENTING CELLS | TRANSGENIC MICE | Interleukin-12 Subunit p35 - metabolism | Interleukin-12 Subunit p40 - genetics | Islets of Langerhans - drug effects | Diabetes Mellitus, Type 1 - prevention & control | Gene Expression - drug effects | Diabetes Mellitus, Type 1 - metabolism | Interferon-gamma - metabolism | Dose-Response Relationship, Drug | Interleukin-23 - genetics | Flow Cytometry | Interleukin-23 - metabolism | Islets of Langerhans - metabolism | Dendritic Cells - drug effects | Female | Interferon-gamma - genetics | Interleukin-6 - metabolism | Dendritic Cells - metabolism | Interleukin-12 - pharmacology | Interleukin-12 Subunit p40 - metabolism | Drug Administration Schedule | Enzyme-Linked Immunosorbent Assay | Interleukin-6 - genetics | Mice, Inbred C57BL | Cells, Cultured | Injections, Intraperitoneal | Diabetes Mellitus, Type 1 - genetics | Interleukin-12 Subunit p35 - genetics | Reverse Transcriptase Polymerase Chain Reaction | Interleukin-17 - metabolism | Animals | Interleukin-12 - administration & dosage | Survival Analysis | Mice, Inbred NOD | Mice | Mice, Inbred BALB C | Index Medicus
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6. Full Text IFN-γ-inducing factor/IL-18 administration mediates IFN-γ- and IL-12- independent antitumor effects
by Osaki, Tadashi and Péron, Jean-Marie and Cai, Quan and Okamura, Haruki and Robbins, Paul D and Kurimoto, Masashi and Lotze, Michael T and Tahara, Hideaki
Journal of Immunology, ISSN 0022-1767, 02/1998, Volume 160, Issue 4, pp. 1742 - 1749
We evaluated the mechanism of the antitumor effects of mouse rIFN-gamma-inducing factor/IL-18 protein on the growth of mouse tumor cell lines in vivo. Mice... 
INTERFERON-GAMMA | ANGIOGENESIS IN-VIVO | METASTASES | INTERLEUKIN-12 | ALPHA | CYTOKINE | MICE | IMMUNOLOGY | TYPE-1 | TUMORS | T-CELLS | Neoplasm Transplantation | CD8-Positive T-Lymphocytes - pathology | Interleukin-12 - genetics | Interferon Inducers - antagonists & inhibitors | Interleukin-12 - physiology | Interleukin-10 - blood | Fibrosarcoma - immunology | Antineoplastic Agents - administration & dosage | Lymphocyte Depletion | Sarcoma, Experimental - immunology | Melanoma, Experimental - prevention & control | G(M1) Ganglioside - immunology | Melanoma, Experimental - immunology | Gene Deletion | Killer Cells, Natural - immunology | Interferon-gamma - genetics | Tumor Cells, Cultured | Interleukin-18 | Immune Sera - pharmacology | Sarcoma, Experimental - prevention & control | Adjuvants, Immunologic - physiology | Antineoplastic Agents - antagonists & inhibitors | Mice, Inbred C57BL | Injections, Intraperitoneal | Interferon-gamma - physiology | Melanoma, Experimental - pathology | Cytokines - administration & dosage | Mice, Knockout | Animals | Growth Inhibitors - administration & dosage | Interleukin-12 - administration & dosage | CD8-Positive T-Lymphocytes - drug effects | Mice | CD4-CD8 Ratio - drug effects | Cytokines - antagonists & inhibitors | Interferon Inducers - administration & dosage | Growth Inhibitors - antagonists & inhibitors | Interferon-gamma - blood | Cytotoxicity, Immunologic | Fibrosarcoma - prevention & control | Index Medicus | Abridged Index Medicus | AIDS/HIV
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7. Full Text Improving survival rates in two models of spontaneous postoperative metastasis in mice by combined administration of a β-adrenergic antagonist and a cyclooxygenase-2 inhibitor
by Glasner, Ariella and Avraham, Roi and Rosenne, Ella and Benish, Marganit and Zmora, Oded and Shemer, Shaily and Meiboom, Hadas and Ben-Eliyahu, Shamgar
Journal of Immunology, ISSN 0022-1767, 03/2010, Volume 184, Issue 5, pp. 2449 - 2457
Clinical practice does not consider perioperative paracrine and neuroendocrine stress responses as risk factors for cancer recurrence, although recent animal... 
PROMOTES TUMOR-GROWTH | SURGICAL STRESS | ANESTHETIC TECHNIQUE | KILLER-CELL ACTIVITY | OVARIAN-CANCER | SUPPRESSOR-CELLS | IMMUNOLOGY | PROPHYLACTIC MEASURES | ANTITUMOR-ACTIVITY | PROSTAGLANDIN E-2 | INNATE IMMUNITY | Fas Ligand Protein - metabolism | Postoperative Complications - etiology | Poly I-C - administration & dosage | Postoperative Complications - prevention & control | Male | Postoperative Complications - mortality | Carcinoma, Lewis Lung - surgery | Melanoma, Experimental - surgery | Etodolac - administration & dosage | Neoplasm Metastasis | Propranolol - administration & dosage | Killer Cells, Natural - immunology | Female | Laparotomy - adverse effects | Adrenergic beta-Antagonists - administration & dosage | CD11a Antigen - metabolism | Amputation - adverse effects | Cyclooxygenase 2 Inhibitors - administration & dosage | Mice, Inbred C57BL | Melanoma, Experimental - pathology | Survival Rate | Animals | Interleukin-12 - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Carcinoma, Lewis Lung - pathology | Cell Line, Tumor | Killer Cells, Natural - drug effects | Mice | Killer Cells, Natural - metabolism | Index Medicus | Abridged Index Medicus
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8. Full Text Oral Administration of Poly-γ-Glutamate Ameliorates Atopic Dermatitis in Nc/Nga Mice by Suppressing Th2-Biased Immune Response and Production of IL-17A
by Lee, Il-Han and Lee, Tae-Young and Kim, Doo-Jin and Won, Ji-Na and Sung, Moon-Hee and Poo, Haryoung
Journal of Investigative Dermatology, ISSN 0022-202X, 03/2014, Volume 134, Issue 3, pp. 704 - 711
Atopic dermatitis (AD) is a chronic inflammatory skin disease that is closely related to dysregulation of the T helper type 1 and 2 (Th1)/Th2 balance. A... 
IGE HYPERPRODUCTION | SKIN-LESIONS | ATONIC DERMATITIS | DENDRITIC CELLS | IN-VIVO | MOUSE | FLAKY TAIL | M-CELLS | MODEL | EXPRESSION | DERMATOLOGY | Dermatitis, Atopic - genetics | Immunoglobulin G - blood | Dendritic Cells - immunology | Dermatologic Agents - administration & dosage | Interleukin-17 - immunology | Male | Polyglutamic Acid - administration & dosage | Th2 Cells - immunology | Th2 Cells - drug effects | Immunoglobulin E - blood | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - pharmacology | Mice, Mutant Strains | Dermatitis, Atopic - immunology | Dendritic Cells - drug effects | Dermatologic Agents - pharmacology | Disease Models, Animal | Mast Cells - immunology | Administration, Oral | Mice, Inbred C57BL | Interleukin-12 - metabolism | Mast Cells - drug effects | Interleukin-17 - metabolism | Animals | Dermatitis, Atopic - drug therapy | Interleukin-12 - immunology | Mice | Index Medicus
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9. Full Text Oral administration of Euglena gracilis Z and its carbohydrate storage substance provides survival protection against influenza virus infection in mice
by Nakashima, Ayaka and Suzuki, Kengo and Asayama, Yuta and Konno, Makoto and Saito, Keita and Yamazaki, Noriyuki and Takimoto, Hiroaki
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 12/2017, Volume 494, Issue 1-2, pp. 379 - 383
Z is a micro-algae that is used as a food or nutritional supplement. Paramylon, the carbohydrate storage substance of Z has β-1, 3-glucan structure. Z and... 
Euglena gracilis Z | Influenza virus | Interferon-γ | Paramylon | β-1, 3-D-glucan | Interleukin-12 | Interferon-gamma | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | ALPHA | MODEL | IL-12 | beta-1, 3-D-glucan | PATHOGENESIS | BIOPHYSICS | INFLAMMATION | Adjuvants, Immunologic - administration & dosage | Influenza A Virus, H1N1 Subtype - growth & development | Glucans - administration & dosage | Lung - virology | Female | Interleukin-1beta - biosynthesis | Euglena gracilis - chemistry | Interleukin-12 - biosynthesis | Administration, Oral | Euglena gracilis - immunology | Interleukin-1beta - immunology | Influenza A Virus, H1N1 Subtype - pathogenicity | Orthomyxoviridae Infections - diet therapy | Influenza A Virus, H1N1 Subtype - drug effects | Animals | Orthomyxoviridae Infections - mortality | Interferon-gamma - immunology | Lung - drug effects | Interleukin-12 - immunology | Interleukin-6 - immunology | Survival Analysis | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Mice | Mice, Inbred BALB C | Dietary Supplements | Interleukin-10 - immunology | Orthomyxoviridae Infections - virology | Interferon-gamma - biosynthesis | Lung - immunology | Orthomyxoviridae Infections - immunology | Influenza viruses | Interleukins | Influenza | Dietary supplements | Interferon | Biological response modifiers | Health aspects | Index Medicus
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10. Full Text The protective effects of intranasal administration of IL‐12 given before influenza virus infection and the negative effects of IL‐12 treatment given after viral infection
by Ishikawa, Hiroki and Ino, Satoshi and Sasaki, Hiraku and Fukui, Toshie and Kohda, Chikara and Tanaka, Kazuo
Journal of Medical Virology, ISSN 0146-6615, 09/2016, Volume 88, Issue 9, pp. 1487 - 1496
To investigate whether the administration of IL-12 is effective against influenza virus infection, mice were intranasally administered IL-12 for three... 
IL‐12 | myeloid‐derived suppressor cell (MDSC) | influenza virus infection | NK cell | Myeloid-derived suppressor cell (MDSC) | IL-12 | Influenza virus infection | myeloid-derived suppressor cell (MDSC) | IMMUNE-RESPONSE | RESPIRATORY-TRACT | RECOGNITION | INTERLEUKIN-12 | CANCER | VIROLOGY | NK CELLS | MICE | ABSENCE | SUPPRESSOR-CELLS | T-CELLS | Influenza A Virus, H1N1 Subtype - immunology | Orthomyxoviridae Infections - prevention & control | Humans | Lung - virology | Inflammation - drug therapy | Killer Cells, Natural - immunology | Influenza, Human - virology | Interleukin-12 - therapeutic use | Influenza, Human - drug therapy | Orthomyxoviridae Infections - drug therapy | Cytokines - immunology | Interleukin-12 - adverse effects | Myeloid-Derived Suppressor Cells - immunology | Drug Administration Schedule | Inflammation - immunology | Administration, Intranasal | Animals | Interleukin-12 - administration & dosage | Mice | Mice, Inbred BALB C | Influenza, Human - prevention & control | Orthomyxoviridae Infections - virology | Cytokines - biosynthesis | Orthomyxoviridae Infections - immunology | Influenza, Human - immunology | Influenza viruses | Health aspects | Analysis | Influenza | Cytokines | Antiviral drugs | Viral infections | Index Medicus
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11. Full Text Immunotherapeutic Synergy Between Anti-CD137 mAb and Intratumoral Administration of a Cytopathic Semliki Forest Virus Encoding IL-12
by Quetglas, José I and Dubrot, Juan and Bezunartea, Jaione and Sanmamed, Miguel F and Hervas-Stubbs, Sandra and Smerdou, Cristian and Melero, Ignacio
Molecular Therapy, ISSN 1525-0016, 09/2012, Volume 20, Issue 9, pp. 1664 - 1675
Intratumoral injection of Semliki Forest virus encoding interleukin-12 (SFV-IL-12) combines acute expression of IL-12 and stressful apoptosis of infected... 
Intramolecular Oxidoreductases - immunology | Immunotherapy - methods | Semliki forest virus - immunology | Injections, Intravenous | Gene Expression - drug effects | Apoptosis - drug effects | Interleukin-12 - genetics | Lung Neoplasms - mortality | Carcinoma - mortality | Immunologic Memory - drug effects | T-Lymphocytes, Cytotoxic - drug effects | Immunity, Cellular - drug effects | Melanoma, Experimental - immunology | Injections, Intralesional | Skin Neoplasms - mortality | Tumor Necrosis Factor Receptor Superfamily, Member 9 - agonists | Antibodies, Monoclonal - immunology | T-Lymphocytes, Cytotoxic - immunology | Cricetinae | Melanoma, Experimental - mortality | Skin Neoplasms - immunology | Skin Neoplasms - therapy | Carcinoma - immunology | Melanoma, Experimental - therapy | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Survival Rate | Lung Neoplasms - therapy | Lung Neoplasms - immunology | Animals | Interleukin-12 - administration & dosage | Intramolecular Oxidoreductases - genetics | Semliki forest virus - genetics | Antibodies, Monoclonal - administration & dosage | CD8-Positive T-Lymphocytes - drug effects | Interleukin-12 - immunology | Cell Line, Tumor | Carcinoma - therapy | Mice | CD8-Positive T-Lymphocytes - immunology | Index Medicus | Original
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12. Full Text Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer
by Gao, Shujun and Ye, Wen-Hui and Yang, Yi-Yan and Yoon, Ho Sup and Wang, Yong
Nature Materials, ISSN 1476-1122, 10/2006, Volume 5, Issue 10, pp. 791 - 796
Non-viral gene-delivery systems are safer to use and easier to produce than viral vectors, but their comparatively low transfection efficiency has limited... 
PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | MATERIALS SCIENCE, MULTIDISCIPLINARY | ENHANCEMENT | CHEMISTRY, PHYSICAL | GENE-THERAPY | COMBINATION | EXPRESSION | CANCER | Interleukin-12 - genetics | Humans | Coated Materials, Biocompatible - chemistry | Antineoplastic Agents - administration & dosage | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Absorbable Implants | Paclitaxel - chemistry | Breast Neoplasms - genetics | Interleukin-12 - administration & dosage | Transfection - methods | Pharmaceutical Vehicles - chemistry | Breast Neoplasms - pathology | Plasmids - genetics | Cell Line, Tumor | Interleukin-12 - chemistry | Nanostructures - chemistry | Polymers - chemistry | Cations | Paclitaxel - administration & dosage | Drug Delivery Systems - methods | Crystallization - methods | Drug Combinations | Plasmids - administration & dosage | Medical research | Deoxyribonucleic acid | DNA | Rodents | Materials science | Breast cancer | Gene expression | Drug therapy | Nanotechnology | Index Medicus
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13. Full Text Tofacitinib withdrawal and retreatment in moderate‐to‐severe chronic plaque psoriasis: a randomized controlled trial
by Bissonnette, R and Iversen, L and Sofen, H and Griffiths, C.E.M and Foley, P and Romiti, R and Bachinsky, M and Rottinghaus, S.T and Tan, H and Proulx, J and Valdez, H and Gupta, P and Mallbris, L and Wolk, R
British Journal of Dermatology, ISSN 0007-0963, 05/2015, Volume 172, Issue 5, pp. 1395 - 1406
What's already known about this topic? Tofacitinib inhibits Janus kinase (JAK)1/JAK3 implicated in psoriasis pathogenesis. Oral tofacitinib was effective in... 
THERAPY | ADALIMUMAB | SAFETY | USTEKINUMAB | DOUBLE-BLIND | LONG-TERM EFFICACY | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | DERMATOLOGY | Dermatologic Agents - administration & dosage | Humans | Middle Aged | Male | Protein Kinase Inhibitors - adverse effects | Dermatologic Agents - adverse effects | Young Adult | Pyrroles - administration & dosage | Pyrroles - adverse effects | Adult | Female | Piperidines - administration & dosage | Psoriasis - drug therapy | Double-Blind Method | Drug Administration Schedule | Pyrimidines - administration & dosage | Treatment Outcome | Patient Outcome Assessment | Protein Kinase Inhibitors - administration & dosage | Retreatment | Piperidines - adverse effects | Adolescent | Pyrimidines - adverse effects | Quality of Life | Aged | Chronic Disease | Index Medicus
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