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The Journal of immunology (1950), ISSN 1550-6606, 2007, Volume 179, Issue 6, pp. 3463 - 3471
Dectin-1 is a fungal pattern recognition receptor that binds to beta-glucans and triggers cytokine production by facilitating interaction with TLR2 or by... 
BETA-GLUCAN RECEPTOR | ADAPTIVE IMMUNITY | RESPONSES | C-TYPE LECTINS | MACROPHAGE RECEPTORS | INFECTION | INDUCTION | IMMUNOLOGY | IMMUNE RECOGNITION | PATHOGEN RECOGNITION | INNATE IMMUNITY | Receptors, Immunologic - physiology | Spleen - immunology | Toll-Like Receptor 2 - genetics | Hypolipidemic Agents - metabolism | Dendritic Cells - immunology | Mycobacterium tuberculosis - immunology | Male | Stilbenes - pharmacology | Mycobacterium tuberculosis - drug effects | Interleukin-12 Subunit p40 - antagonists & inhibitors | Receptors, Immunologic - antagonists & inhibitors | Toll-Like Receptor 2 - deficiency | Membrane Proteins - physiology | Interleukin-12 - antagonists & inhibitors | Adjuvants, Immunologic - metabolism | Dendritic Cells - drug effects | Female | Membrane Proteins - metabolism | Interleukin-12 Subunit p40 - biosynthesis | Mycobacterium tuberculosis - metabolism | Syk Kinase | Dendritic Cells - metabolism | Interleukin-12 - biosynthesis | Adjuvants, Immunologic - antagonists & inhibitors | Nerve Tissue Proteins - antagonists & inhibitors | Adjuvants, Immunologic - physiology | Nerve Tissue Proteins - physiology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Lectins, C-Type | Mice, Inbred C57BL | Spleen - cytology | Hypolipidemic Agents - pharmacology | Polysaccharides - pharmacology | Mice, Knockout | Polysaccharides - metabolism | Nerve Tissue Proteins - metabolism | Animals | Membrane Proteins - antagonists & inhibitors | Spleen - metabolism | Glucans | CD11b Antigen - physiology | Mice | Protein Kinase Inhibitors - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2010, Volume 184, Issue 5, pp. 2449 - 2457
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2004, Volume 172, Issue 7, pp. 4425 - 4434
Lipoarabinomannans (LAM) and lipomannans (LM) are integral parts of the mycobacterial cell wall recognized by cells involved in the innate immune response and... 
DENDRITIC CELL-FUNCTION | MACROPHAGE RESPONSES | TUMOR-NECROSIS-FACTOR | BACILLUS-CALMETTE-GUERIN | LIPOTEICHOIC ACID | SURFACTANT PROTEIN-A | NITRIC-OXIDE SYNTHASE | TUBERCULOSIS INFECTION | IMMUNOLOGY | 2-DEFICIENT MICE | CUTTING EDGE | Tumor Necrosis Factor-alpha - metabolism | Toll-Like Receptor 2 | Mycobacterium bovis - immunology | Receptors, Immunologic - physiology | Toll-Like Receptor 4 | Lipopolysaccharides - antagonists & inhibitors | Protein Subunits - metabolism | Toll-Like Receptors | Membrane Glycoproteins - physiology | Interleukin-12 - antagonists & inhibitors | Inflammation Mediators - metabolism | Inflammation Mediators - antagonists & inhibitors | Receptors, Cell Surface - physiology | Macrophages - immunology | Cytokines - metabolism | Nitric Oxide - antagonists & inhibitors | Cells, Cultured | Receptors, Immunologic - deficiency | Mycobacterium kansasii - immunology | Interleukin-12 - metabolism | Myeloid Differentiation Factor 88 | Antigens, Differentiation - physiology | Macrophage Activation | Membrane Glycoproteins - genetics | Mice, Knockout | Adaptor Proteins, Signal Transducing | Macrophages - metabolism | Animals | Mycobacterium chelonae - immunology | Up-Regulation - immunology | Down-Regulation - immunology | Receptors, Cell Surface - deficiency | Lipopolysaccharides - pharmacology | Antigens, Differentiation - genetics | Mice | Protein Subunits - antagonists & inhibitors | Cytokines - antagonists & inhibitors | Nitric Oxide - metabolism | Receptors, Immunologic - genetics | Cytokines - biosynthesis | Interleukin-12 Subunit p40 | Membrane Glycoproteins - deficiency | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Receptors, Cell Surface - genetics
Journal Article
Pharmacological reviews, ISSN 1521-0081, 2015, Volume 67, Issue 2, pp. 280 - 309
The human immune system involves highly complex and coordinated processes in which small proteins named cytokines play a key role. Cytokines have been... 
TUMOR-NECROSIS-FACTOR | MODIFYING ANTIRHEUMATIC DRUGS | COLONY-STIMULATING FACTOR | JUVENILE IDIOPATHIC ARTHRITIS | SEVERE PLAQUE PSORIASIS | ANTI-TNF THERAPY | PHARMACOLOGY & PHARMACY | PLACEBO-CONTROLLED TRIAL | LONG-TERM TREATMENT | ACTIVE ANKYLOSING-SPONDYLITIS | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | Drugs, Investigational - adverse effects | Interleukin-6 - antagonists & inhibitors | Humans | Crohn Disease - metabolism | Drugs, Investigational - therapeutic use | Spondylitis, Ankylosing - immunology | Arthritis, Rheumatoid - metabolism | Anti-Inflammatory Agents - adverse effects | Arthritis, Rheumatoid - drug therapy | Arthritis, Psoriatic - drug therapy | Psoriasis - metabolism | Anti-Inflammatory Agents - therapeutic use | Antirheumatic Agents - adverse effects | Interleukin-1 - antagonists & inhibitors | Interleukin-6 - metabolism | Arthritis, Psoriatic - metabolism | Antirheumatic Agents - therapeutic use | Psoriasis - immunology | Interleukin-1 - metabolism | Molecular Targeted Therapy - adverse effects | Psoriasis - drug therapy | Cytokines - metabolism | Spondylitis, Ankylosing - drug therapy | Tumor Necrosis Factors - metabolism | Spondylitis, Ankylosing - metabolism | Crohn Disease - immunology | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Arthritis, Psoriatic - immunology | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Models, Biological | Crohn Disease - drug therapy | Cytokines - antagonists & inhibitors | Arthritis, Rheumatoid - immunology | Tumor Necrosis Factors - antagonists & inhibitors
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2009, Volume 124, Issue 5, pp. 1022 - 1030.e395
... inflammatory diseases. The initial rationale for testing TNF antagonists in rheumatoid arthritis was based on demonstrated increases in all sepsis cascade cytokines... 
Allergy and Immunology | T H1 | gene | TNF | T H17 | psoriasis | etanercept | T-CELL-CLONES | DENDRITIC CELLS | MACROPHAGES | IMMUNOLOGY | ARTHRITIS | T(H)1 | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | SKIN-LESIONS | TUMOR-NECROSIS-FACTOR | KERATINOCYTE | ALLERGY | INFLAMMATION | T(H)17 | DOUBLE-BLIND | Gene Expression - drug effects | Oligonucleotide Array Sequence Analysis | Dendritic Cells - immunology | Humans | Interleukin-17 - immunology | Gene Expression Profiling | Interferon-gamma - metabolism | Receptors, Tumor Necrosis Factor - therapeutic use | T-Lymphocytes, Helper-Inducer - drug effects | Psoriasis - genetics | Etanercept | Interleukin-1beta - metabolism | Myeloid Cells - immunology | T-Lymphocytes, Helper-Inducer - immunology | Interferon-gamma - antagonists & inhibitors | Dendritic Cells - drug effects | Myeloid Cells - drug effects | Interleukin-8 - metabolism | Dendritic Cells - metabolism | Skin - pathology | Interleukin-1beta - antagonists & inhibitors | Skin - immunology | Psoriasis - immunology | Psoriasis - drug therapy | T-Lymphocytes, Helper-Inducer - metabolism | Signal Transduction | Immunoglobulin G - therapeutic use | Interleukin-1beta - immunology | Receptors, Tumor Necrosis Factor - administration & dosage | Up-Regulation - genetics | Interleukin-8 - antagonists & inhibitors | Down-Regulation - drug effects | Immunoglobulin G - administration & dosage | Down-Regulation - genetics | Up-Regulation - drug effects | Interleukin-17 - metabolism | Interleukin-17 - antagonists & inhibitors | Up-Regulation - immunology | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Down-Regulation - immunology | Interferon-gamma - immunology | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Myeloid Cells - metabolism | Interleukin-8 - immunology | Skin - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Rheumatoid factor | Dendritic cells | Psoriasis | Tumor necrosis factor | Dermatology | Rheumatoid arthritis | Analysis | Formulae, receipts, prescriptions | Genetic research | Dermatologic agents | Crohn's disease | Drug therapy | Drugs | Helper cells | Clinical trials | Lymphocytes T | Interleukin 17 | CD1c antigen | Signal transduction | psoriasis vulgaris | Interleukin 1 | Sepsis | Skin diseases | genomics | Interleukin 8 | Th1 | Th17
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 12/2004, Volume 173, Issue 12, pp. 7548 - 7555
Recognition of microbial products through TLRs triggers the expression of several cytokines that regulate innate and adaptive immunity. Signaling by various... 
TOLL-LIKE RECEPTOR-2 | RESPONSES | IN-VITRO | INTERFERON-GAMMA | SIGNALING PATHWAY | MACROPHAGES | GENE-EXPRESSION | MICE | IMMUNOLOGY | T-CELLS | CUTTING EDGE | Cysteine - analogs & derivatives | Leukocytes, Mononuclear - metabolism | Toll-Like Receptor 2 | Toll-Like Receptor 3 | Toll-Like Receptor 4 | Dendritic Cells - immunology | Humans | Receptors, Cell Surface - antagonists & inhibitors | Th1 Cells - immunology | Toll-Like Receptor 5 | Interleukin-10 - physiology | Toll-Like Receptor 7 | Th1 Cells - metabolism | Toll-Like Receptors | Membrane Glycoproteins - antagonists & inhibitors | Autocrine Communication - immunology | Protein Isoforms - agonists | Interleukin-12 - antagonists & inhibitors | Leukocytes, Mononuclear - immunology | Cysteine - pharmacology | Interleukin-10 - metabolism | Chemokines, CXC - biosynthesis | Cytokines - genetics | Dendritic Cells - metabolism | Interleukin-12 - biosynthesis | Chemokines, CXC - antagonists & inhibitors | Poly I-C - pharmacology | Membrane Glycoproteins - pharmacology | Membrane Glycoproteins - agonists | Receptors, Cell Surface - agonists | Down-Regulation - genetics | Autocrine Communication - genetics | Chemokine CXCL10 | Protein Isoforms - pharmacology | Down-Regulation - immunology | Lipoproteins - pharmacology | Lipopolysaccharides - pharmacology | Cytokines - antagonists & inhibitors | Peptidoglycan - pharmacology | Cytokines - biosynthesis | Drug Combinations | Protein Isoforms - antagonists & inhibitors
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 04/2007, Volume 127, Issue 4, pp. 835 - 845
A mixture of different fumaric acid esters (FAE) is established for systemic therapy of psoriasis, a frequent inflammatory skin disease. The main active... 
FUMARIC-ACID ESTERS | IN-VITRO | OXIDATIVE STRESS | HYPERPROLIFERATIVE KERATINOCYTES | CELLULAR GLUTATHIONE | SEVERE PSORIASIS | DOUBLE-BLIND | ANTIGEN-PRESENTING CELLS | SYSTEMIC THERAPY | HUMAN ENDOTHELIAL-CELLS | DERMATOLOGY | Tumor Necrosis Factor-alpha - metabolism | Humans | Fumarates - administration & dosage | Interferon-gamma - metabolism | Dose-Response Relationship, Drug | Heme Oxygenase-1 - genetics | Glutathione - pharmacology | Interleukin-12 - antagonists & inhibitors | Interferon-gamma - antagonists & inhibitors | Enzyme Induction - drug effects | Inflammation Mediators - antagonists & inhibitors | Dimethyl Fumarate | Immunosuppressive Agents - pharmacology | Immunosuppressive Agents - administration & dosage | Heme Oxygenase-1 - biosynthesis | Glutathione - analogs & derivatives | RNA, Small Interfering - pharmacology | Cells, Cultured | Glutathione - antagonists & inhibitors | Interleukin-12 - metabolism | Lymphocytes - cytology | Heme Oxygenase-1 - antagonists & inhibitors | Fumarates - pharmacology | Cell Proliferation - drug effects | Cytokines - antagonists & inhibitors | Immune response | Psoriasis | Dermatology | Immunomodulation | Dietary supplements | Heme oxygenase (decyclizing) | Depression | Esters | Interleukin 12 | Inflammation | Lymphocytes T | Mixed leukocyte reaction | Inflammatory diseases | stress proteins | Immunosuppression | Fumaric acid | Peripheral blood mononuclear cells | Skin diseases | Internet | Glutathione
Journal Article