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American journal of respiratory cell and molecular biology, ISSN 1044-1549, 11/2015, Volume 53, Issue 5, pp. 676 - 688
Macrophages are dynamic cells that mature under the influence of signals from the local microenvironment into either classically (M1) or alternatively (M2)... 
classically activated macrophages (CAM/M1) | Phagocytosis/ endocytosis | phagocytosis/endocytosis | phenotypic stability | alternatively activated macrophages (AAM/M2) | reprogramming of polarization | PHAGOCYTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONOCYTES | DIFFERENTIAL REGULATION | MURINE | CELL BIOLOGY | GM-CSF | RESPIRATORY SYSTEM | THP-1 CELLS | MANNOSE | RECEPTOR-ACTIVITY | POLARIZATION | EXPRESSION | Chemokines, CC - secretion | Gene Expression - drug effects | Monocytes - cytology | Humans | Monocytes - immunology | Chemokine CCL5 - secretion | Chemokine CCL17 - secretion | Chemokine CXCL10 - biosynthesis | Interleukin-4 - pharmacology | Chemokine CCL17 - biosynthesis | Gene Expression - immunology | Chemokines, CC - biosynthesis | Interleukin-8 - secretion | Cell Differentiation | Interleukin-1beta - biosynthesis | Macrophages - immunology | Endocytosis - immunology | Interleukin-1beta - secretion | Interleukin-8 - biosynthesis | Endocytosis - drug effects | Tumor Necrosis Factor-alpha - secretion | Immunophenotyping | Macrophages - cytology | Interleukin-13 - pharmacology | Monocytes - drug effects | Chemokine CCL5 - biosynthesis | Chemokine CXCL10 - secretion | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Primary Cell Culture | Macrophage Activation - drug effects | Tumor Necrosis Factor-alpha - biosynthesis | Interferon-gamma - pharmacology | Studies | Biology | Immunology | Blood & organ donations | Cytokines | Gene expression
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 12, p. e116142
Rationale: Replication deficient adenoviruses (Ad) vectors are common tools in gene therapy. Since Ad vectors are known to activate innate and adaptive... 
PATHOGENESIS | MATRIX | ACTIVATION | HIPPEL-LINDAU-PROTEIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DISEASE | ANIMAL-MODELS | MEDIATED GENE-TRANSFER | IDIOPATHIC PULMONARY-FIBROSIS | EXPRESSION | Male | Interleukin-13 - biosynthesis | Lung Injury - virology | Proliferating Cell Nuclear Antigen - biosynthesis | Pulmonary Fibrosis - virology | Interleukin-16 - biosynthesis | Bronchoalveolar Lavage Fluid - cytology | Interleukin-1beta - biosynthesis | Adenoviridae - immunology | Integrins - biosynthesis | Matrix Metalloproteinase 2 - biosynthesis | Transforming Growth Factor beta1 - biosynthesis | Disease Models, Animal | Matrix Metalloproteinase 9 - biosynthesis | Actins - biosynthesis | Mice, Inbred C57BL | Inflammation - virology | Pulmonary Fibrosis - immunology | Inflammation - immunology | Bleomycin - administration & dosage | Collagen Type I - biosynthesis | Animals | Interleukin-1alpha - biosynthesis | Mice | Bronchoalveolar Lavage Fluid - chemistry | Wnt Proteins - biosynthesis | Lung Injury - immunology | RNA | Collagen | Adenoviruses | Fibrosis | Bone morphogenetic proteins | Transforming growth factors | Gene therapy | Health aspects | Integrins | Pediatrics | Collagen (type I) | Disease | Pathogenesis | Immunity | Proteins | Bleomycin | Proliferating cell nuclear antigen | Physiology | Chronic obstructive pulmonary disease | Drug dosages | Deoxyribonucleic acid--DNA | Cytokines | Bronchus | Interleukin 13 | Tumor necrosis factor-α | Gene expression | Interleukin 16 | DNA viruses | Vectors (Biology) | Pulmonary fibrosis | Interleukin 10 | Wnt protein | Laboratories | Staining | Critical care | Inflammatory response | Viruses | mRNA | Infections | Kinases | Tissues | Bronchoalveolar lavage | Rodents | Alveoli | Trachea | Injuries | Expression vectors | Lung diseases | Inflammation | Adaptive immunity | Gelatinase B | Gelatinase A | Signaling | Lungs | Molecular biology | Immunofluorescence | Deoxyribonucleic acid | DNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2002, Volume 99, Issue 9, pp. 6198 - 6203
Endothelial cells (EC) play a central role in inflammatory immune responses and efficiently induce effector functions in T cells, despite lacking the classical... 
T lymphocytes | Cytometry | Molecules | Biological Sciences | Human umbilical vein endothelial cells | Isotypes | Cytokines | Secretion | Coculture techniques | Ligands | Cultured cells | RESPONSES | HELPER | PROTEIN | SPECIFICITY | MULTIDISCIPLINARY SCIENCES | CO-STIMULATION | RECEPTOR | ANTIGEN-PRESENTING CELLS | MONOCLONAL-ANTIBODY | IDENTIFICATION | MOLECULE ICOS | Endothelium, Vascular - cytology | Inducible T-Cell Co-Stimulator Protein | Tumor Necrosis Factor-alpha - metabolism | Up-Regulation | Protein Biosynthesis | Alternative Splicing | Antigens, CD - biosynthesis | Humans | Membrane Glycoproteins - biosynthesis | Lipopolysaccharides - metabolism | Interleukin-13 - biosynthesis | Th1 Cells - metabolism | B7-2 Antigen | Interleukin-4 - biosynthesis | Flow Cytometry | T-Lymphocytes - metabolism | Time Factors | Antigens, Differentiation, T-Lymphocyte - physiology | Cell Division | B7-1 Antigen - biosynthesis | Interleukin-1 - metabolism | Proteins - physiology | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Reverse Transcriptase Polymerase Chain Reaction | Th2 Cells - metabolism | Precipitin Tests | Animals | Inducible T-Cell Co-Stimulator Ligand | Protein Binding | Interleukin-10 - biosynthesis | Mice | Mice, Inbred BALB C | Antibodies, Monoclonal - metabolism | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Interleukin-2 - biosynthesis | Cytokines - biosynthesis | Interferon-gamma - biosynthesis
Journal Article
Journal Article
Journal of Immunotherapy, ISSN 1524-9557, 07/2012, Volume 35, Issue 6, pp. 502 - 512
Angiogenesis and inflammation are important therapeutic targets in non-small cell lung cancer (NSCLC). It is well known that proteolysis mediated by matrix... 
VEGF-R1 | angiogenesis | tumor immunotherapy | tissue inhibitor of metalloproteases | tumor immunosuppression | tumor inflammation | myeloid-derived suppressor cells (MDSC) | VEGF-A | matrix metalloproteinases | non-small cell lung cancer (NSCLC) | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | METASTASIS | MEDIATED UP-REGULATION | ANNEXIN A1 | IMMUNOLOGY | ONCOLOGY | MARROW-DERIVED CELLS | ENDOTHELIAL-CELLS | GROWTH | INHIBITOR | NF-KAPPA-B | Humans | Lung Neoplasms - metabolism | Neovascularization, Pathologic | Lung Neoplasms - pathology | Tissue Inhibitor of Metalloproteinase-2 - genetics | Interleukin-13 - biosynthesis | CD40 Antigens - biosynthesis | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Annexin A1 - biosynthesis | Interleukin-6 - blood | Female | Tissue Inhibitor of Metalloproteinase-2 - deficiency | Carcinoma, Lewis Lung | Carcinoma, Non-Small-Cell Lung - pathology | Mice, Inbred C57BL | Carcinoma, Non-Small-Cell Lung - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Interleukin-11 - biosynthesis | Mice, Knockout | Carcinoma, Non-Small-Cell Lung - immunology | Lung Neoplasms - immunology | Animals | Chemokine CCL5 - biosynthesis | Mice, Nude | NF-kappa B - biosynthesis | Myeloid Cells - metabolism | Interleukin-10 - biosynthesis | Metalloproteases - biosynthesis | Mice | Interferon-gamma - biosynthesis
Journal Article
European Journal of Immunology, ISSN 0014-2980, 09/2006, Volume 36, Issue 9, pp. 2336 - 2346
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2013, Volume 191, Issue 10, pp. 5220 - 5229
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2018, Volume 200, Issue 3, pp. 915 - 927
Cysteinyl leukotrienes (cysLTs) facilitate mucosal type 2 immunopathology by incompletely understood mechanisms. Aspirin-exacerbated respiratory disease, a... 
BRONCHIAL BIOPSIES | GENE DISRUPTION REVEALS | PULMONARY INFLAMMATION | INNATE LYMPHOID-CELLS | EXACERBATED RESPIRATORY-DISEASE | ALLERGIC AIRWAY INFLAMMATION | VASCULAR-PERMEABILITY | ASTHMATIC SUBJECTS | IMMUNOLOGY | C-4 SYNTHASE | CHRONIC RHINOSINUSITIS | Interleukin-33 - biosynthesis | Mast Cells - immunology | Lung - pathology | Epithelial Cells - metabolism | Asthma, Aspirin-Induced - pathology | Mice, Inbred C57BL | Leukotrienes - biosynthesis | Receptors, Leukotriene - immunology | Male | Interleukin-5 - biosynthesis | Receptors, Leukotriene - genetics | Interleukin-33 - immunology | Leukotriene E4 - biosynthesis | Mice, Knockout | Eosinophilia - pathology | Interleukin-13 - biosynthesis | Asthma, Aspirin-Induced - immunology | Animals | Glutathione Transferase - genetics | Eosinophilia - immunology | Prostaglandin-E Synthases - genetics | Cysteine - biosynthesis | Aspirin - immunology | Mice | Drugs | Allergens | Animal models | Respiratory function | Epithelial cells | Mucosa | Activation | Respiratory tract | Leukotriene-C4 synthase | Receptors | Cell activation | Interleukin 5 | Clonal deletion | Rodents | Deletion | Respiratory tract diseases | Alveoli | Expansion | Aspirin | Lymphoid cells | Leukocytes (eosinophilic) | Pharmacology | Interleukin 13 | Eosinophilia | Asthma | Inhalation | Signaling | Sensitivity | Lungs | Leukotrienes | Respiratory diseases | Respiration | type 2 immunity | asthma
Journal Article
Journal of Immunology, ISSN 0022-1767, 09/2014, Volume 193, Issue 6, pp. 2801 - 2811
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 04/2006, Volume 203, Issue 4, pp. 1105 - 1116
Journal Article