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Journal of Immunology, ISSN 0022-1767, 09/2015, Volume 195, Issue 5, pp. 2353 - 2364
IL-15 is currently undergoing clinical trials to assess its efficacy for treatment of advanced cancers. The combination of IL-15 with soluble IL-15R alpha... 
NATURAL-KILLER-CELLS | DENDRITIC CELLS | LYMPHOID HOMEOSTASIS | INTERLEUKIN-15 | IN-VIVO | TRANS-PRESENTATION | IMMUNOLOGY | MURINE MODELS | T-CELLS | ADOPTIVE IMMUNOTHERAPY | ESTABLISHED TUMORS | Antigens, CD - immunology | Body Temperature - drug effects | Granzymes - metabolism | Humans | Lectins, C-Type - immunology | Interferon-gamma - metabolism | Interleukin-15 Receptor alpha Subunit - metabolism | Interleukin-15 - immunology | Antigens, CD - metabolism | Dose-Response Relationship, Drug | Lectins, C-Type - metabolism | Multiprotein Complexes - metabolism | Lymphocyte Activation - immunology | Flow Cytometry | Killer Cells, Natural - immunology | Multiprotein Complexes - pharmacology | Female | Interleukin-15 Receptor alpha Subunit - immunology | Granzymes - immunology | Perforin - immunology | Interferon-gamma - genetics | Cytotoxicity, Immunologic - drug effects | Antigens, Differentiation, T-Lymphocyte - immunology | Mice, Inbred C57BL | Antigens, Differentiation, T-Lymphocyte - metabolism | Mice, Knockout | Animals | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Interferon-gamma - immunology | Interleukin-15 - metabolism | Cell Proliferation - drug effects | Killer Cells, Natural - drug effects | Perforin - metabolism | Killer Cells, Natural - metabolism | CD8-Positive T-Lymphocytes - immunology | Cytotoxicity, Immunologic - immunology | Body Temperature - immunology | Multiprotein Complexes - immunology | Index Medicus | Abridged Index Medicus | Innate Immunity and Inflammation
Journal Article
Blood, ISSN 0006-4971, 06/2018, Volume 131, Issue 23, pp. 2511 - 2512
In this issue of Blood, Romee et al report results of the first-in-human clinical trial of interleukin-15 (IL-15) superagonist ALT-803 in patients with... 
SURVIVAL | RELAPSE | NATURAL-KILLER-CELLS | INTERLEUKIN-15 | ACUTE MYELOGENOUS LEUKEMIA | HEMATOLOGY | CANCER | T-CELLS | TRANSPLANTATION | Proteins | Recurrence | Interleukin-15 | CD4-Positive T-Lymphocytes | Humans | Graft vs Host Disease
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, p. e0148452
Background Severely burned patients are highly susceptible to opportunistic infections and sepsis, owing to the loss of the protective skin barrier and... 
SURVIVAL | TYROSINE KINASE-3 LIGAND | DENDRITIC CELLS | INDUCED APOPTOSIS | INTERLEUKIN-15 | MULTIDISCIPLINARY SCIENCES | IN-VIVO | RECEPTOR | TRANS-PRESENTATION | ORGAN DYSFUNCTION | SEPSIS | Liver - pathology | Pseudomonas Infections - etiology | CD8-Positive T-Lymphocytes - pathology | Spleen - immunology | Humans | Recombinant Fusion Proteins - therapeutic use | Male | Killer Cells, Natural - pathology | Lymphocyte Subsets - immunology | Liver - immunology | Natural Killer T-Cells - pathology | Killer Cells, Natural - immunology | Pseudomonas aeruginosa | Spleen - pathology | Wound Infection - therapy | Burns - complications | Lymphocyte Subsets - pathology | Receptors, Interleukin-15 - therapeutic use | Cytokines - blood | Disease Models, Animal | Adaptive Immunity | Wound Infection - etiology | Lymphocyte Activation | Pseudomonas Infections - therapy | Pseudomonas Infections - immunology | Animals | Interleukin-15 - agonists | Wound Infection - immunology | Lymphocyte Count | Burns - therapy | Mice | Mice, Inbred BALB C | Burns - immunology | CD8-Positive T-Lymphocytes - immunology | Cytokines - biosynthesis | Natural Killer T-Cells - immunology | Pediatrics | CD8 antigen | Liver | Immune clearance | Leukocytes | Cell activation | Cell growth | Natural killer cells | Nosocomial infections | Growth factors | Spleen | Cytokines | Mortality | Cecum | T cell receptors | Interleukin 15 | Survival | Trauma | Studies | Pathology | Injury prevention | Sepsis | Ligands | Skin | Anesthesiology | Burns | Cell proliferation | Burn resistance | Flow cytometry | Adaptive systems | Interleukin | Lymphocytes T | Infections | Activation | CD69 antigen | Immunology | Interleukin 2 | Lymphocytes | Rodents | Bacteria | Injuries | Immune system | Heparan sulfate | Wound infection | Cell survival | Bacterial infections | Dendritic cells | Blood cells | Neutrophils | Morbidity | CD4 antigen | Cytometry | Lymphocytes B | Surface area | Peritoneum | Apoptosis
Journal Article
International Journal of Cancer, ISSN 0020-7136, 01/2016, Volume 138, Issue 1, pp. 187 - 194
Glioblastoma is the most aggressive primary central nervous system malignancy with a poor prognosis in patients. Despite the need for better treatments against... 
anti‐PD‐1 | glioblastoma | IL‐15 superagonist | ALT‐803 | IL-15 superagonist | ALT-803 | anti-PD-1 | GLIOMAS | CANCER | RADIATION | CD8(+) T-CELLS | TEMOZOLOMIDE | ONCOLOGY | IMMUNOTHERAPY | IMMUNOSUPPRESSION | INTERLEUKIN-15 | BLOCKADE | EXPRESSION | T-Lymphocyte Subsets - immunology | Humans | Radiosurgery | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Central Nervous System Neoplasms - immunology | T-Lymphocyte Subsets - drug effects | Immunotherapy | Female | Glioblastoma - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Antineoplastic Agents - pharmacology | Disease Models, Animal | Central Nervous System Neoplasms - metabolism | Antibodies, Monoclonal - pharmacology | Programmed Cell Death 1 Receptor - metabolism | Central Nervous System Neoplasms - therapy | Glioblastoma - therapy | Xenograft Model Antitumor Assays | Central Nervous System Neoplasms - pathology | Animals | Interleukin-15 - agonists | Glioblastoma - immunology | T-Lymphocyte Subsets - metabolism | Glioblastoma - pathology | Cell Line, Tumor | Immunologic Memory | Mice | Proteins - pharmacology | Glioblastoma - mortality | Central Nervous System Neoplasms - mortality | Lymphocytes, Tumor-Infiltrating - immunology | Killer cells | Immune response | Interleukins | Analysis | Health aspects | Glioblastoma multiforme | Cytokines | Medical prognosis | Immune system
Journal Article
OncoImmunology, ISSN 2162-4011, 2013, Volume 2, Issue 11, p. e26442
ALT-803, an interleukin-15-based superagonist, induces memory CD8(+) T cells to proliferate, upregulate receptors involved in innate immunity, secrete... 
Interferon γ | NKG2D | Memory CD8 | Immunotherapy | Innate immunity | Interleukin-15 | Tumor | Adaptive immunity | T cells | Myeloma | COMPLEX | interferon gamma | memory CD8(+) T cells | CANCER-IMMUNOTHERAPY | IMMUNOLOGY | adaptive immunity | interleukin-15 | RESPONSES | myeloma | innate immunity | ONCOLOGY | tumor | immunotherapy | LYMPHOCYTES | Author's View | interferon γ | memory CD8+ T cells
Journal Article
International Journal of Cancer, ISSN 0020-7136, 08/2013, Volume 133, Issue 3, pp. 757 - 765
Immunocytokines (ICKs) targeting cytokines to the tumor environment using antibodies directed against a tumor‐associated antigen often have a higher... 
cancer therapy | GD2 disialoganglioside | interleukin‐15 | immunocytokine | interleukin-15 | NATURAL-KILLER | CELL GROWTH-FACTOR | CANCER | CD8(+) T-CELLS | ONCOLOGY | IN-VIVO | RECEPTOR-ALPHA-CHAIN | TRANS-PRESENTATION | PHASE-I | FUSION PROTEINS | Recombinant Fusion Proteins - immunology | Cell Proliferation | Recombinant Fusion Proteins - pharmacology | Mice, Inbred A | Humans | Recombinant Fusion Proteins - therapeutic use | Antibody-Dependent Cell Cytotoxicity - immunology | Male | Interleukin-15 - immunology | Antibodies, Neoplasm - metabolism | Antibodies, Neoplasm - pharmacology | Neoplasm Metastasis - drug therapy | Gangliosides - metabolism | Immunotherapy | Female | Interleukin-15 - therapeutic use | Liver Neoplasms - secondary | Antibodies, Monoclonal - immunology | Antibodies, Neoplasm - immunology | Antigens, Neoplasm - immunology | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Liver Neoplasms - drug therapy | Protein Binding - immunology | Gangliosides - immunology | Lymphoma, T-Cell - drug therapy | Animals | Interleukin-15 - agonists | Interleukin-15 Receptor alpha Subunit | Neuroblastoma - drug therapy | Cell Line, Tumor | Mice | Antibodies, Monoclonal - metabolism | Viral antibodies | Antibodies | Interleukins | Gangliosides | Analysis | Tumors | Clinical trials | Cytotoxicity | Immunoglobulins | Cytokines | Index Medicus
Journal Article
Molecular Therapy, ISSN 1525-0016, 10/2018, Volume 26, Issue 10, pp. 2476 - 2486
Oncolytic immunotherapy is a promising novel therapeutic for cancer, and further preclinical studies may maximize its therapeutic efficacy. In this study, we... 
superagonist | oncolytic vicotherapy | oncolytic virus | immunotherapy | IL-15 | vaccinia virus | antitumor immunity | efficacy | immune checkpoint blockade | MEDICINE, RESEARCH & EXPERIMENTAL | MEMORY | MICROENVIRONMENT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | POXVIRUS | GENETICS & HEREDITY | VACCINIA VIRUS | COMBINATION | CANCER | CD8(+) T-CELLS | ESTABLISHED TUMORS | Recombinant Fusion Proteins - immunology | Interleukin-15 - administration & dosage | Immunotherapy - methods | Humans | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Interleukin-15 Receptor alpha Subunit - administration & dosage | Neoplasms - therapy | Neoplasms - genetics | Killer Cells, Natural - immunology | Female | Interferon-gamma - genetics | Recombinant Fusion Proteins - administration & dosage | Immunity, Innate - drug effects | Combined Modality Therapy | Interleukin-15 Receptor alpha Subunit - genetics | Xenograft Model Antitumor Assays | Immunity, Innate - immunology | Oncolytic Virotherapy - methods | Animals | Interleukin-15 - genetics | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Killer Cells, Natural - drug effects | Mice | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Programmed Cell Death 1 Receptor - genetics | PD-1 protein | CD8 antigen | Genomics | Genes | Colorectal cancer | Viruses | Lymphocytes T | Kinases | Ovarian cancer | Proteins | Colon cancer | Efficiency | Lymphocytes | Immunotherapy | Interleukin 1 | Oncolysis | Colon | Fusion protein | Enzyme-linked immunosorbent assay | Antigens | Cytokines | Melanoma | Interleukin 15 | Biological activity | CD4 antigen | Studies | γ-Interferon | Antitumor activity | Chemokines | Apoptosis | Tumors | Original
Journal Article
Journal Article
The Lancet Oncology, ISSN 1470-2045, 05/2018, Volume 19, Issue 5, pp. 694 - 704
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 27, pp. 44366 - 44378
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2016, Volume 197, Issue 1, pp. 168 - 178
Journal Article