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Immunity (Cambridge, Mass.), ISSN 1074-7613, 2014, Volume 40, Issue 4, pp. 477 - 489
We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including... 
PATHWAYS | TARGET GENES | FOXP3 OCCUPANCY | T(H)17 | REGULATORY NETWORK | RECEPTOR | DIFFERENTIATION | IMMUNOLOGY | PSORIASIS | ANTI-INTERLEUKIN-17 MONOCLONAL-ANTIBODY | TH17 CELLS | Myelin-Oligodendrocyte Glycoprotein - immunology | T-Lymphocyte Subsets - immunology | Transcription, Genetic - drug effects | Nuclear Receptor Subfamily 1, Group F, Member 3 - antagonists & inhibitors | Humans | Transcriptional Activation - drug effects | Encephalomyelitis, Autoimmune, Experimental - immunology | Structure-Activity Relationship | Gene Regulatory Networks - drug effects | Cell Lineage - drug effects | Systems Biology | Benzhydryl Compounds - chemistry | Heterocyclic Compounds, 4 or More Rings - pharmacology | Th17 Cells - drug effects | T-Lymphocyte Subsets - drug effects | Peptide Fragments - immunology | Protein Binding - drug effects | Benzeneacetamides - chemistry | Benzeneacetamides - pharmacology | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Cytokines - metabolism | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Heterocyclic Compounds, 4 or More Rings - chemistry | Digoxin - chemistry | Digoxin - pharmacology | Mice, Knockout | Animals | Androstenols - chemistry | Cell Differentiation - drug effects | Cell Line, Tumor | Multiple Sclerosis - immunology | Th17 Cells - immunology | Benzhydryl Compounds - pharmacology | Mice | Multiple Sclerosis - drug therapy
Journal Article
Nature immunology, ISSN 1529-2916, 2012, Volume 13, Issue 5, pp. 465 - 473
Journal Article
Scientific reports, ISSN 2045-2322, 2016, Volume 6, Issue 1, p. 30859
Journal Article
The Journal of Immunology, ISSN 0022-1767, 05/2003, Volume 170, Issue 9, pp. 4665 - 4672
We have previously demonstrated that administration of the recently described cytokine IL-17 in rat airways in vivo recruits and activates neutrophils locally.... 
OBSTRUCTIVE PULMONARY-DISEASE | IN-VITRO | BRONCHIAL EPITHELIAL-CELLS | INFLAMMATORY RESPONSES | RESPIRATORY-DISTRESS SYNDROME | ELASTASE | ENDOTHELIAL-CELLS | ACUTE LUNG INJURY | CYSTIC-FIBROSIS | IMMUNOLOGY | T-LYMPHOCYTES | Dose-Response Relationship, Immunologic | Interleukin-6 - antagonists & inhibitors | Interleukin-17 - analysis | Lipopolysaccharides - administration & dosage | Interleukin-17 - immunology | Interleukin-17 - physiology | Bronchoalveolar Lavage Fluid - immunology | Male | Inflammation - blood | Inflammation Mediators - analysis | T-Lymphocytes - metabolism | Bronchoalveolar Lavage Fluid - cytology | Inflammation Mediators - antagonists & inhibitors | Inflammation Mediators - physiology | Interleukin-6 - metabolism | Neutrophils - metabolism | Neutrophil Infiltration - immunology | Neutrophils - pathology | Inflammation Mediators - immunology | Monokines - metabolism | Lung - pathology | Mice, Inbred C57BL | Injections, Intraperitoneal | Neutrophils - immunology | Solubility | Inflammation - immunology | Administration, Intranasal | Animals | Interleukin-17 - antagonists & inhibitors | Antibodies, Monoclonal - administration & dosage | Monokines - antagonists & inhibitors | Chemokine CXCL2 | T-Lymphocytes - immunology | Mice | Lung - immunology | inhibitors/immunology/physiology | Monoclonal/administration & dosage | Dermatologi och venereologi | Dermatology and Venereal Diseases | Neutrophil Infiltration/immunology | Antibodies | T-Lymphocytes/immunology/metabolism | Bronchoalveolar Lavage Fluid/cytology/immunology | Inflammation/blood/immunology | Intraperitoneal | Neutrophils/immunology/metabolism/pathology/secretion | Immunologic | Lung/immunology/pathology | Interleukin-17/analysis/antagonists & inhibitors/immunology/physiology | Inflammation Mediators/analysis/antagonists | Administration | Monokines/antagonists & inhibitors/metabolism/secretion | Intranasal | Inbred C57BL | Injections | Lipopolysaccharides/administration & dosage | Interleukin-6/antagonists & inhibitors/metabolism/secretion | Dose-Response Relationship
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 2013, Volume 127, Issue 21, pp. 2114 - 2124
.... Maraviroc, a CCR5 antagonist antiretroviral drug, might provide benefit for patients with M-tropic HIV infections at high risk for cardiovascular diseases... 
Receptors | Inflammation | Maraviroc | CCR5 | Acquired immunodeficiency syndrome | Atherosclerosis | atherosclerosis | maraviroc | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOTHELIAL DYSFUNCTION | MYOCARDIAL-INFARCTION | receptors, CCR5 | acquired immunodeficiency syndrome | HIV-INFECTED PATIENTS | inflammation | PPAR-GAMMA | PERIPHERAL VASCULAR DISEASE | CHEMOKINE RECEPTORS | PROTEASE INHIBITOR RITONAVIR | CORONARY-ARTERY-DISEASE | CARDIOVASCULAR RISK | Tumor Necrosis Factor-alpha - metabolism | Apolipoproteins E - deficiency | Male | Plaque, Atherosclerotic - chemically induced | Cyclohexanes - therapeutic use | Ritonavir - adverse effects | Chemokine CCL2 - metabolism | Chemokine CCL5 - metabolism | CCR5 Receptor Antagonists | Disease Models, Animal | Triazoles - therapeutic use | Macrophages - pathology | Plaque, Atherosclerotic - metabolism | Atherosclerosis - chemically induced | Mice, Inbred C57BL | Plaque, Atherosclerotic - prevention & control | Anti-Retroviral Agents - adverse effects | Treatment Outcome | Atherosclerosis - metabolism | Mice, Knockout | Interleukin-17 - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Animals | Apolipoproteins E - genetics | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Atherosclerosis - prevention & control | Cell Movement | Antagonists (Biochemistry) | Animal experimentation | Complications and side effects | Usage | Care and treatment | Atherosclerotic plaque | Ritonavir | Development and progression | Health aspects
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2012, Volume 109, Issue 8, pp. 3001 - 3005
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2009, Volume 183, Issue 10, pp. 6681 - 6688
The alpha 7 nicotinic acetylcholine receptor (nAChR) was recently described as an anti-inflammatory target in both macrophages and T cells. Its expression by... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | INFLAMMATORY-BOWEL-DISEASE | IMMUNE-SYSTEM | MULTIPLE-SCLEROSIS | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | ROR-GAMMA | ACTIVE ULCERATIVE-COLITIS | TRANSDERMAL NICOTINE | IMMUNOLOGY | T-CELLS | ACETYLCHOLINE-RECEPTOR | GATA3 Transcription Factor - agonists | T-Box Domain Proteins - antagonists & inhibitors | Encephalomyelitis, Autoimmune, Experimental - immunology | NF-kappa B - metabolism | Interferon-gamma - metabolism | Interleukin-4 - agonists | RNA, Messenger - metabolism | Interleukins - metabolism | CD4-Positive T-Lymphocytes - immunology | Peptide Fragments - immunology | Tumor Necrosis Factor-alpha - immunology | GATA3 Transcription Factor - metabolism | Th1 Cells - drug effects | Antigen-Presenting Cells - metabolism | NF-kappa B - antagonists & inhibitors | Antigen-Presenting Cells - drug effects | Myelin-Oligodendrocyte Glycoprotein | T-Box Domain Proteins - metabolism | Interleukins - antagonists & inhibitors | Mice, Knockout | Spinal Cord - immunology | Interleukin-4 - immunology | Receptors, Nicotinic - immunology | Glycoproteins - immunology | Mice | alpha7 Nicotinic Acetylcholine Receptor | Tumor Necrosis Factor-alpha - metabolism | RNA, Messenger - immunology | Spinal Cord - drug effects | Encephalomyelitis, Autoimmune, Experimental - metabolism | GATA3 Transcription Factor - immunology | Interleukin-17 - immunology | NF-kappa B - immunology | T-Box Domain Proteins - immunology | Th1 Cells - immunology | Nicotine - pharmacology | Spinal Cord - pathology | Interleukins - immunology | Interferon-gamma - antagonists & inhibitors | Female | RNA, Messenger - drug effects | Receptors, Nicotinic - drug effects | Interleukin-4 - metabolism | Mice, Inbred C57BL | Antigen-Presenting Cells - immunology | Animals | Interleukin-17 - antagonists & inhibitors | Interferon-gamma - immunology | Cell Proliferation - drug effects | Receptors, Nicotinic - genetics | CD4-Positive T-Lymphocytes - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Journal of allergy and clinical immunology, ISSN 0091-6749, 2009, Volume 124, Issue 5, pp. 1022 - 1030.e395
... inflammatory diseases. The initial rationale for testing TNF antagonists in rheumatoid arthritis was based on demonstrated increases in all sepsis cascade cytokines... 
Allergy and Immunology | T H1 | gene | TNF | T H17 | psoriasis | etanercept | T-CELL-CLONES | DENDRITIC CELLS | MACROPHAGES | IMMUNOLOGY | ARTHRITIS | T(H)1 | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | SKIN-LESIONS | TUMOR-NECROSIS-FACTOR | KERATINOCYTE | ALLERGY | INFLAMMATION | T(H)17 | DOUBLE-BLIND | Gene Expression - drug effects | Oligonucleotide Array Sequence Analysis | Dendritic Cells - immunology | Humans | Interleukin-17 - immunology | Gene Expression Profiling | Interferon-gamma - metabolism | Receptors, Tumor Necrosis Factor - therapeutic use | T-Lymphocytes, Helper-Inducer - drug effects | Psoriasis - genetics | Etanercept | Interleukin-1beta - metabolism | Myeloid Cells - immunology | T-Lymphocytes, Helper-Inducer - immunology | Interferon-gamma - antagonists & inhibitors | Dendritic Cells - drug effects | Myeloid Cells - drug effects | Interleukin-8 - metabolism | Dendritic Cells - metabolism | Skin - pathology | Interleukin-1beta - antagonists & inhibitors | Skin - immunology | Psoriasis - immunology | Psoriasis - drug therapy | T-Lymphocytes, Helper-Inducer - metabolism | Signal Transduction | Immunoglobulin G - therapeutic use | Interleukin-1beta - immunology | Receptors, Tumor Necrosis Factor - administration & dosage | Up-Regulation - genetics | Interleukin-8 - antagonists & inhibitors | Down-Regulation - drug effects | Immunoglobulin G - administration & dosage | Down-Regulation - genetics | Up-Regulation - drug effects | Interleukin-17 - metabolism | Interleukin-17 - antagonists & inhibitors | Up-Regulation - immunology | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Down-Regulation - immunology | Interferon-gamma - immunology | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Myeloid Cells - metabolism | Interleukin-8 - immunology | Skin - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Rheumatoid factor | Dendritic cells | Psoriasis | Tumor necrosis factor | Dermatology | Rheumatoid arthritis | Analysis | Formulae, receipts, prescriptions | Genetic research | Dermatologic agents | Crohn's disease | Drug therapy | Drugs | Helper cells | Clinical trials | Lymphocytes T | Interleukin 17 | CD1c antigen | Signal transduction | psoriasis vulgaris | Interleukin 1 | Sepsis | Skin diseases | genomics | Interleukin 8 | Th1 | Th17
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 05/2001, Volume 133, Issue 1, pp. 200 - 206
Recent data indicate that interleukin (IL)‐17 may contribute to neutrophilic airway inflammation by inducing the release of neutrophil‐mobilizing cytokines... 
bronchial epithelial cell | MAP kinase | neutrophil | Interleukin‐17 | Bronchial epithelial cell | Interleukin-17 | Neutrophil | PATHWAYS | PHOSPHATIDYLINOSITOL 3-KINASE | MAST-CELLS | NEUTROPHIL RECRUITMENT | INTERLEUKIN-8 | SIGNAL-TRANSDUCTION | interleukin-17 | IN-VITRO | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | CYSTIC-FIBROSIS | NF-KAPPA-B | Bronchi - enzymology | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Humans | Phosphatidylinositol 3-Kinases - metabolism | Interleukin-17 - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | MAP Kinase Kinase 1 | Bronchi - drug effects | Mitogen-Activated Protein Kinase Kinases - metabolism | Protein Kinase C - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Bronchi - metabolism | Interleukin-8 - secretion | Interleukin-8 - metabolism | Epithelial Cells - cytology | Bronchi - cytology | Interleukin-6 - metabolism | p38 Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Cytokines - metabolism | Cytokines - secretion | Enzyme Inhibitors - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Protein Kinase C - antagonists & inhibitors | Interleukin-6 - secretion | Cell Division - drug effects | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Epithelial Cells - enzymology | Cell Line, Transformed | Mitogen-Activated Protein Kinases - metabolism | Papers | Cell Line | Interleukin-8/metabolism/secretion | Cytokines/metabolism/secretion | Epithelial Cells/cytology/drug effects/enzymology/metabolism | Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism | Bronchi/cytology/drug effects/enzymology/metabolism | Cell Division/drug effects | Enzyme Inhibitors/pharmacology | MAP Kinase Signaling System/drug effects | Transformed | Interleukin-17/pharmacology | inhibitors/metabolism | Interleukin-6/metabolism/secretion | Mitogen-Activated Protein Kinase Kinases/antagonists | Protein Kinase C/antagonists & inhibitors/metabolism | Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism | Lungmedicin och allergi | Respiratory Medicine and Allergy | 1-Phosphatidylinositol 3-Kinase/antagonists & inhibitors/metabolism
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2009, Volume 183, Issue 1, pp. 97 - 105
TGF-beta, together with IL-6 and IL-21, promotes Th17 cell development. IL-6 and IL-21 induce activation of STAT3, which is crucial for Th17 cell... 
T(H)17 CELLS | ROR-GAMMA-T | IN-VIVO | STAT3 | HOST-DEFENSE | GENERATION | CYTOKINE | DIFFERENTIATION | IMMUNOLOGY | LINEAGE | FOXP3 | Protein-Serine-Threonine Kinases - deficiency | Intestinal Mucosa - metabolism | Receptors, Transforming Growth Factor beta - genetics | Interleukin-6 - antagonists & inhibitors | Transforming Growth Factor beta1 - antagonists & inhibitors | Interleukin-17 - physiology | Receptors, Transforming Growth Factor beta - physiology | Intestinal Mucosa - cytology | Cell Differentiation - genetics | Signal Transduction - immunology | Mucous Membrane - cytology | STAT3 Transcription Factor - physiology | Interleukins - physiology | Intestinal Mucosa - immunology | T-Lymphocytes, Helper-Inducer - immunology | Interleukin-6 - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | T-Lymphocytes, Helper-Inducer - cytology | STAT3 Transcription Factor - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Protein-Serine-Threonine Kinases - physiology | Mice, Inbred C57BL | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Suppressor of Cytokine Signaling Proteins - genetics | Mice, Transgenic | Up-Regulation - genetics | Signal Transduction - genetics | Transforming Growth Factor beta1 - genetics | Interleukin-17 - biosynthesis | Transforming Growth Factor beta1 - physiology | Down-Regulation - genetics | Interleukins - antagonists & inhibitors | Mice, Knockout | Mucous Membrane - metabolism | Cell Differentiation - immunology | Suppressor of Cytokine Signaling 3 Protein | Animals | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Mucous Membrane - immunology | Up-Regulation - immunology | Down-Regulation - immunology | Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors | Mice | Suppressor of Cytokine Signaling Proteins - biosynthesis | Receptors, Transforming Growth Factor beta - deficiency
Journal Article