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Arthritis Research and Therapy, ISSN 1478-6354, 10/2013, Volume 15, Issue 5, pp. R151 - R151
Introduction: T helper (Th)-17 cells are increased in systemic sclerosis (SSc). We therefore assessed whether Th17 cells could modulate the inflammatory and... 
RHEUMATOID-ARTHRITIS | MATRIX METALLOPROTEINASES | SYNOVIAL FIBROBLASTS | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | GENE-EXPRESSION | SKIN FIBROSIS | NECROSIS-FACTOR-ALPHA | RHEUMATOLOGY | NF-KAPPA-B | T-CELLS | PULMONARY-FIBROSIS | Interleukin-8 - genetics | Gene Expression - drug effects | Skin - metabolism | Humans | Scleroderma, Systemic - pathology | Culture Media, Conditioned - pharmacology | Male | Interleukin-17 - pharmacology | Dose-Response Relationship, Drug | Collagen Type I - genetics | Th17 Cells - metabolism | Radioimmunoassay | Inflammation Mediators - metabolism | Female | Chemokine CCL2 - metabolism | Interleukin-8 - metabolism | Matrix Metalloproteinase 1 - genetics | Skin - pathology | Fibroblasts - metabolism | Collagen Type I - metabolism | Enzyme-Linked Immunosorbent Assay | Scleroderma, Systemic - metabolism | Cells, Cultured | Scleroderma, Systemic - genetics | Chemokine CCL2 - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Tumor Necrosis Factor-alpha - pharmacology | Fibroblasts - drug effects | Matrix Metalloproteinase 1 - metabolism | Interferon-gamma - pharmacology | Culture Media, Conditioned - metabolism | Proteins | Medical equipment and supplies industry | Interleukins | Systemic scleroderma | Medical test kit industry | Scleroderma (Disease) | High-definition television | Skin | Biological response modifiers | Enzyme-linked immunosorbent assay | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2012, Volume 143, Issue 3, pp. 765 - 776.e3
Background & Aims Interleukin (IL)-17 signaling has been implicated in lung and skin fibrosis. We examined the role of IL-17 signaling in the pathogenesis of... 
Gastroenterology and Hepatology | Immune Response | Myofibroblast | Mouse Model | Bone Marrow-Derived Macrophages | RAT-LIVER | TARGET | IL-17 RECEPTOR | HEPATOCYTES | FAMILY-MEMBERS | STAT3 | TRANSDUCTION | PATHWAY | DISEASE | GENE-EXPRESSION | GASTROENTEROLOGY & HEPATOLOGY | Kupffer Cells - pathology | Liver - pathology | Carbon Tetrachloride | Humans | Transforming Growth Factor beta1 - metabolism | Hepatic Stellate Cells - metabolism | Receptors, Interleukin-17 - genetics | Interleukin-23 - genetics | Receptors, Interleukin-17 - deficiency | Interleukins - genetics | Liver Cirrhosis, Experimental - prevention & control | Liver - immunology | Time Factors | Bone Marrow Transplantation | Liver Cirrhosis, Alcoholic - immunology | Interleukin-6 - metabolism | STAT3 Transcription Factor - genetics | Interleukin-17 - administration & dosage | Liver Cirrhosis, Experimental - immunology | Signal Transduction | Liver Cirrhosis, Alcoholic - pathology | Liver - metabolism | Interleukin-17 - genetics | Genotype | Bile Ducts - surgery | Disease Progression | Mice, Knockout | Interleukin-17 - metabolism | Phenotype | Interleukins - deficiency | Mice | Liver Cirrhosis, Experimental - metabolism | Tumor Necrosis Factor-alpha - metabolism | Inflammation Mediators - administration & dosage | Liver Cirrhosis, Experimental - etiology | Interleukin-23 - deficiency | Ligation | Hepatic Stellate Cells - immunology | Inflammation Mediators - metabolism | STAT3 Transcription Factor - deficiency | Liver Cirrhosis, Experimental - pathology | Kupffer Cells - metabolism | Hepatic Stellate Cells - pathology | Cell Line | Interleukin-1 - metabolism | Collagen Type I - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Interleukin-17 - deficiency | Liver Cirrhosis, Experimental - genetics | Animals | Interleukins - administration & dosage | Kupffer Cells - immunology | Medical colleges | Liver diseases | Liver | Carbon tetrachloride | Transforming growth factors | Muscle proteins | Macrophages | Endothelium | Messenger RNA | Interleukins | Actin | Analysis | Collagen | Fibrosis | Liver cirrhosis | Index Medicus | Abridged Index Medicus
Journal Article
Mucosal Immunology, ISSN 1933-0219, 07/2015, Volume 8, Issue 4, pp. 943 - 958
Journal Article
Clinical and Experimental Immunology, ISSN 0009-9104, 10/2010, Volume 162, Issue 1, pp. 100 - 107
P>Pyoderma gangrenosum (PG) is a rare, immune-mediated inflammatory skin disease presenting with painful ulcers having undermined edges. Less commonly, bullous... 
cytokines | pyoderma gangrenosum | matrix metalloproteinases | neutrophilic dermatoses | Sweet's syndrome | VEGF | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | BOWEL-DISEASE | FAMILY | INTERLEUKIN-17 | PYODERMA-GANGRENOSUM | SWEETS-SYNDROME | DERMATOSIS | EXPRESSION | LYMPHOCYTES | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Humans | Middle Aged | Male | Vascular Endothelial Growth Factor A - metabolism | Antigens, CD - metabolism | Young Adult | Matrix Metalloproteinase 9 - metabolism | Sweet Syndrome - metabolism | Inflammation Mediators - metabolism | Adult | Female | Interleukin-8 - metabolism | Neutrophils - metabolism | Neutrophils - pathology | Pyoderma Gangrenosum - metabolism | Cytokines - metabolism | Matrix Metalloproteinase 2 - metabolism | Receptors, Cell Surface - metabolism | Sweet Syndrome - pathology | CD3 Complex - metabolism | Pyoderma Gangrenosum - pathology | Interleukin-17 - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Adolescent | Aged | Matrix Metalloproteinases - metabolism | Peroxidase - metabolism | Skin diseases | Cytokines | T cells | Macrophages | Vascular endothelial growth factor | Index Medicus | Wounds | CD3 antigen | Inflammation | Leukocytes (neutrophilic) | Lymphocytes T | Matrix metalloproteinase | Gelatinase B | Inflammatory diseases | Interleukin 17 | Gelatinase A | CD163 antigen | Ulcers | Peroxidase | Immunoreactivity | Chemokines | Interleukin 8 | Tumor necrosis factor- alpha | Translational Studies
Journal Article
Scandinavian Journal of Immunology, ISSN 0300-9475, 09/2014, Volume 80, Issue 3, pp. 180 - 190
Experimental autoimmune neuritis ( EAN ), an animal model of human Guillain–Barré syndrome, has long been considered as a T helper (Th) 1 cell–mediated... 
PHASE | INTERLEUKIN-17 | ROLES | GUILLAIN-BARRE-SYNDROME | IL-17 | REGULATORY T-CELLS | TNF-ALPHA | IMMUNOLOGY | LEWIS RATS | DEFICIENCY | BETA | Forkhead Transcription Factors - immunology | T-Lymphocytes, Regulatory - metabolism | Spleen - immunology | Humans | Receptors, Interleukin-17 - immunology | Interleukin-17 - immunology | Male | Th2 Cells - immunology | Interferon-gamma - metabolism | Th1 Cells - immunology | Cauda Equina - metabolism | Interleukins - metabolism | T-Lymphocytes, Regulatory - immunology | Th1 Cells - metabolism | Flow Cytometry | Th17 Cells - metabolism | Time Factors | Forkhead Transcription Factors - metabolism | Interleukins - immunology | Interleukin-10 - metabolism | Neuritis, Autoimmune, Experimental - immunology | Receptors, Interleukin-17 - metabolism | Interleukin-6 - metabolism | Cytokines - immunology | Disease Models, Animal | Guillain-Barre Syndrome - metabolism | Interleukin-17 - blood | Severity of Illness Index | Cytokines - metabolism | Interleukins - blood | Mice, Inbred C57BL | Cauda Equina - immunology | Interleukin-12 - metabolism | Th2 Cells - metabolism | Interleukin-17 - metabolism | Animals | Guillain-Barre Syndrome - immunology | Spleen - metabolism | Interferon-gamma - immunology | Neuritis, Autoimmune, Experimental - metabolism | Interleukin-12 - immunology | Interleukin-6 - immunology | Th17 Cells - immunology | Guillain-Barre Syndrome - pathology | Interleukin-10 - immunology | Neuritis, Autoimmune, Experimental - pathology | Cytokines | Inflammation | Nerves | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 08/2014, Volume 4, Issue 1, pp. 5865 - 5865
In a murine model of allergic asthma, we found that Tyk-2((-/-)) asthmatic mice have induced peribronchial collagen deposition, mucosal type mast cells in the... 
INFLAMMATION IN-VIVO | TGF-BETA | INTERLEUKIN-17 | TYK2-DEFICIENT MICE | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | AIRWAY INFLAMMATION | PHENOTYPE | EXPRESSION | HYPERRESPONSIVENESS | IL-21 | Asthma - metabolism | Cell Proliferation | Ovalbumin - immunology | TYK2 Kinase - metabolism | Th2 Cells - immunology | Interleukin-17 - pharmacology | Recombinant Proteins - biosynthesis | CD4-Positive T-Lymphocytes - immunology | T-Lymphocytes, Helper-Inducer - drug effects | Th17 Cells - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Asthma - immunology | Th17 Cells - cytology | Cell Differentiation | Lung - metabolism | Disease Models, Animal | T-Lymphocytes, Helper-Inducer - metabolism | Cytokines - metabolism | CD4-Positive T-Lymphocytes - cytology | Interleukin-17 - genetics | Th2 Cells - cytology | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Th2 Cells - metabolism | Mice, Knockout | Interleukin-17 - metabolism | Suppressor of Cytokine Signaling 3 Protein | Phenotype | Animals | Th17 Cells - immunology | Mice | Mice, Inbred BALB C | Suppressor of Cytokine Signaling Proteins - metabolism | TYK2 Kinase - genetics | Asthma - pathology | Animal models | Mucosa | Lung | Helper cells | Effector cells | Lymphocytes T | Interleukin 6 | Interleukin 4 | Interleukin 5 | Interleukin 3 | Rodents | Interleukin 21 | CD25 antigen | Foxp3 protein | Interleukin 9 | Immunoregulation | Interleukin 13 | Asthma | CD4 antigen | Interferon regulatory factor 4 | Collagen | Interleukin 10 | Mast cells | Autoimmune diseases | Cancer | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2005, Volume 175, Issue 1, pp. 404 - 412
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 11/2008, Volume 128, Issue 11, pp. 2625 - 2630
The critical role of IL-17 has recently been reported in a variety of conditions. Since IL-17 deeply participates in the pathogenesis of psoriasis and... 
INTERFERON-GAMMA | CHEMOKINE PRODUCTION | T(H)17 | IL-17 | GENE-EXPRESSION | GROWTH-FACTOR | DIFFERENTIATION | HUMAN KERATINOCYTES | T-LYMPHOCYTES | SKIN INFLAMMATION | DERMATOLOGY | Th1 Cells - pathology | Tumor Necrosis Factor-alpha - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Humans | Middle Aged | Male | Vascular Endothelial Growth Factor A - metabolism | Interleukin-17 - pharmacology | CD4-Positive T-Lymphocytes - pathology | Case-Control Studies | Interleukins - metabolism | Th1 Cells - metabolism | Psoriasis - pathology | Dermatitis, Atopic - etiology | Psoriasis - metabolism | Adult | Female | T-Lymphocytes, Helper-Inducer - pathology | Interleukin-8 - metabolism | Child | Th2 Cells - pathology | Dermis - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | CD4-Positive T-Lymphocytes - metabolism | Dermatitis, Atopic - pathology | Th2 Cells - metabolism | Interleukin-17 - metabolism | Adolescent | Dermis - pathology | Aged | Dermatitis, Atopic - metabolism | Cell Movement | Flow cytometry | Psoriasis | Dermatology | Granulocyte-macrophage colony-stimulating factor | Helper cells | Dermis | Interleukin 22 | Keratinocytes | Lymphocytes T | Interleukin 17 | Atopic dermatitis | CXCL10 protein | Eczema | Peripheral blood | gamma -Interferon | Skin diseases | Internet | Vascular endothelial growth factor | Interleukin 8 | Tumor necrosis factor- alpha | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2014, Volume 289, Issue 24, pp. 16773 - 16789
Lipocalin-2 (LCN2) plays an important role in cellular processes as diverse as cell growth, migration/invasion, differentiation, and death/survival.... 
PATHOGENESIS | MULTIPLE-SCLEROSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | NEURON DEATH | REACTIVE ASTROCYTES | CENTRAL-NERVOUS-SYSTEM | GELATINASE-ASSOCIATED LIPOCALIN | CHEMOKINE RECEPTORS | EXPRESSION | CD8(+) T-CELLS | Oncogene Proteins - genetics | Spinal Cord - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Acute-Phase Proteins - genetics | Interferon-gamma - metabolism | Myelin Sheath - metabolism | Matrix Metalloproteinase 9 - metabolism | T-Lymphocytes - metabolism | Lipocalins - genetics | Matrix Metalloproteinase 9 - genetics | Spinal Cord - pathology | Gene Deletion | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Interferon-gamma - genetics | Neutrophils - metabolism | Dendritic Cells - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Lipocalins - metabolism | Acute-Phase Proteins - metabolism | Mice, Inbred C57BL | Cells, Cultured | Oncogene Proteins - metabolism | Interleukin-17 - genetics | Lymphoid Tissue - metabolism | Receptors, Cell Surface - metabolism | Interleukin-17 - metabolism | Lymphoid Tissue - pathology | Animals | Lipocalin-2 | Myelin Sheath - genetics | Mice | Astrocytes - metabolism | Receptors, Cell Surface - genetics | Index Medicus | Multiple Sclerosis | Autoimmune Disease | Central Nervous System | Neurobiology | EAE | LCN2 | Neuroinflammation | Astrocyte | Microglia
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2012, Volume 122, Issue 11, pp. 3965 - 3976
Psoriasis is a chronic inflammatory disorder of the skin affecting approximately 2% of the world's population. Accumulating evidence has revealed that the... 
GENERALIZED PUSTULAR PSORIASIS | MEDICINE, RESEARCH & EXPERIMENTAL | INFLAMMATORY SKIN-DISEASE | FAMILY-MEMBERS | MOUSE MODEL | DELTA-T-CELLS | NF-KAPPA-B | AUTOINFLAMMATORY DISEASE | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | CUTTING EDGE | TRANSGENIC MICE | Cell Communication - immunology | Interleukin-1 - genetics | Membrane Glycoproteins - metabolism | Dermatitis - immunology | Dendritic Cells - immunology | Receptors, Interleukin-1 - genetics | Interleukin-17 - immunology | Dendritic Cells - pathology | Interleukins - metabolism | Interleukin-23 - genetics | Interleukins - genetics | Psoriasis - genetics | Interleukin-23 - metabolism | Psoriasis - pathology | Interleukins - immunology | Toll-Like Receptor 7 - immunology | Interleukin-1 - immunology | Psoriasis - metabolism | Membrane Glycoproteins - immunology | Dendritic Cells - metabolism | Psoriasis - immunology | Toll-Like Receptor 7 - genetics | Interleukin-1 - metabolism | Toll-Like Receptor 7 - metabolism | Dermatitis - genetics | Receptors, Interleukin-1 - immunology | Interleukin-17 - genetics | Cell Communication - genetics | Interleukin-23 - immunology | Keratinocytes - immunology | Membrane Glycoproteins - genetics | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Dermatitis - pathology | Interleukin-17 - metabolism | Keratinocytes - pathology | Animals | Keratinocytes - metabolism | Mice | Dermatitis - metabolism | Psoriasis | Interleukins | Keratinocytes | Genetic aspects | Dosage and administration | Diagnosis | Drug therapy | Index Medicus | Abridged Index Medicus | TLR7 protein | Dendritic cells | Mesenchyme | Interleukin 22 | Interleukin 23 | Leukocytes (neutrophilic) | Interleukin 1 receptors | Dermatitis | Inflammatory diseases | Interleukin 17 | Toll-like receptors | Skin
Journal Article
International Journal of Cancer, ISSN 0020-7136, 12/2012, Volume 131, Issue 11, pp. 2553 - 2561
Estrogen receptor‐beta (ERβ) has been suggested to exert anti‐inflammatory and anti‐tumorigenic effects in the colon, providing a translational potential to... 
dextran sodium sulfate | estrogen receptor‐beta | colon cancer | azoxymethane | inflammatory bowel disease | estrogen receptor-beta | Estradiol - blood | Mucin-2 - genetics | Neoplasms - metabolism | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Colitis - genetics | Colorectal Neoplasms - genetics | Tumor Necrosis Factor-alpha - genetics | Colitis - pathology | NF-kappa B - metabolism | Interferon-gamma - metabolism | Inflammatory Bowel Diseases - metabolism | Estrogen Receptor beta - metabolism | Cell Differentiation - genetics | Inflammation - metabolism | Estrogen Receptor beta - genetics | Proliferating Cell Nuclear Antigen - genetics | Neoplasms - genetics | Inflammatory Bowel Diseases - pathology | Inflammatory Bowel Diseases - genetics | Female | Interferon-gamma - genetics | Interleukin-6 - metabolism | Colorectal Neoplasms - metabolism | Mucin-2 - metabolism | Mucin-1 - metabolism | Interleukin-6 - genetics | Colon - pathology | Mice, Inbred C57BL | Caveolin 1 - genetics | Interleukin-17 - genetics | beta Catenin - metabolism | Colon - metabolism | beta Catenin - genetics | Mice, Knockout | Caveolin 1 - metabolism | Interleukin-17 - metabolism | Animals | NF-kappa B - genetics | Nitric Oxide Synthase Type II - genetics | Colitis - metabolism | Inflammation - genetics | Mice | Colorectal Neoplasms - pathology | Neoplasms - pathology | Proliferating Cell Nuclear Antigen - metabolism | Mucin-1 - genetics | Nitric Oxide Synthase Type II - metabolism | Index Medicus | Estrogen receptor-beta
Journal Article