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European Journal of Pharmacology, ISSN 0014-2999, 2003, Volume 462, Issue 1, pp. 193 - 198
The cytokine interleukin-17 may play a role in the recruitment of airway neutrophils, and interleukin-17 protein is increased in the airways of patients with... 
C-X-C chemokine | Interleukin-17 | Bronchial epithelial cell | human | Human | ACTIVATION | PROTEIN | MECHANISMS | CYTOKINE | NEUTROPHIL RECRUITMENT | bronchial epithelial cell, human | interleukin-17 | IN-VITRO | IL-17 | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | AIRWAYS | CYCLOSPORINE | Epithelial Cells - metabolism | Albuterol - pharmacology | Cyclosporine - pharmacology | Epithelial Cells - drug effects | Humans | Receptors, Glucocorticoid - metabolism | Interleukin-17 - pharmacology | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Bronchi - drug effects | Dose-Response Relationship, Drug | Calcineurin Inhibitors | Bronchi - metabolism | Interleukin-8 - secretion | Flavonoids - pharmacology | Intercellular Signaling Peptides and Proteins - secretion | Receptors, Adrenergic, beta - drug effects | Receptors, Adrenergic, beta - metabolism | Receptors, Glucocorticoid - drug effects | Bronchi - cytology | Chemotactic Factors - secretion | p38 Mitogen-Activated Protein Kinases | Chemokines - secretion | Enzyme Inhibitors - pharmacology | Adrenergic beta-Agonists - pharmacology | Imidazoles - pharmacology | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Chemokines, CXC - secretion | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Chemokine CXCL1 | Hydrocortisone - pharmacology | Pyridines - pharmacology | Chemokine CXCL6 | Cell Line, Transformed | Index Medicus | Chemokines/secretion | Albuterol/pharmacology | Flavonoids/pharmacology | Adrenergic | beta/drug effects/metabolism | Epithelial Cells/drug effects/metabolism | Enzyme Inhibitors/pharmacology | Transformed | Adrenergic beta-Agonists/pharmacology | Ca(2+)-Calmodulin Dependent Protein Kinase/antagonists & inhibitors | Receptors | Imidazoles/pharmacology | Chemotactic Factors/secretion | Cyclosporine/pharmacology | Lungmedicin och allergi | Respiratory Medicine and Allergy | Bronchi/cytology/drug effects/metabolism | Drug | Intercellular Signaling Peptides and Proteins/secretion | Cell Line | P-Glycoprotein/antagonists & inhibitors | Interleukin-8/secretion | Hydrocortisone/pharmacology | Glucocorticoid/drug effects/metabolism | CXC/secretion | Interleukin-17/pharmacology | Mitogen-Activated Protein Kinases/antagonists & inhibitors | Calcineurin/antagonists & inhibitors | Dose-Response Relationship | Chemokines | Pyridines/pharmacology
Journal Article
Rheumatology, ISSN 1462-0324, 11/2008, Volume 47, Issue 11, pp. 1635 - 1640
Objectives. We investigated the influence of cytokines on the expression of RANK ligand (RANKL) in fibroblast-like synoviocytes from RA patients (RA-FLS).... 
Interleukin-1 | Soluble IL-6 receptor | Tumour necrosis factor-α | Receptor activator of nuclear factor-αB ligand | Tocilizumab | Janus kinase/signal transducer and activator of transcription | Mitogen-activated protein kinase | Fibroblast-like synoviocytes | Interleukin-17 | Interleukin-6 | RHEUMATOID-ARTHRITIS | ACTIVATION | NECROSIS-FACTOR-ALPHA | CYTOKINE | T-CELL | RHEUMATOLOGY | OSTEOBLASTIC CELLS | Receptor activator of nuclear factor-kappa B ligand | SOLUBLE INTERLEUKIN-6 RECEPTORS | OSTEOPROTEGERIN LIGAND | OSTEOCLAST DIFFERENTIATION | EXPRESSION | Tumour necrosis factor-alpha | Immunohistochemistry | Interleukin-1beta - pharmacology | RANK Ligand - metabolism | Humans | RNA, Messenger - analysis | Receptors, Interleukin-6 - antagonists & inhibitors | Synovial Membrane - drug effects | Interleukin-17 - pharmacology | Antibodies, Monoclonal, Humanized | Arthritis, Rheumatoid - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Reverse Transcriptase Polymerase Chain Reaction - methods | Fibroblasts | Flavonoids - pharmacology | Phosphorylation - drug effects | Receptor Activator of Nuclear Factor-kappa B - metabolism | Interleukin-6 - metabolism | STAT3 Transcription Factor - metabolism | Blotting, Western - methods | Antibodies, Monoclonal - pharmacology | Cells, Cultured | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | RANK Ligand - analysis | Recombinant Proteins - pharmacology | Stimulation, Chemical | Synovial Membrane - metabolism | RANK Ligand - genetics | Tumor Necrosis Factor-alpha - pharmacology | Interleukin-6 - pharmacology | Signal Transduction - physiology | Cell Proliferation - drug effects | Sesquiterpenes - pharmacology | Receptors, Interleukin-6 - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2015, Volume 112, Issue 34, pp. 10768 - 10773
Th17 responses are critical to a variety of human autoimmune diseases, and therapeutic targeting with monoclonal antibodies against IL-17 and IL-23 has shown... 
Epigenetic inhibitors | Bromodomain | Th17 | CBP/p300 | Ankylosing spondylitis | RHEUMATOID-ARTHRITIS | CELLS | epigenetic inhibitors | EFFICACY | P300 | MULTIDISCIPLINARY SCIENCES | ankylosing spondylitis | CRYSTALLOGRAPHY | ANKYLOSING-SPONDYLITIS | BINDING PROTEIN | bromodomain | LIGANDS | DOUBLE-BLIND | BET BROMODOMAINS | p300-CBP Transcription Factors - antagonists & inhibitors | Humans | Middle Aged | Crystallography, X-Ray | Male | Structure-Activity Relationship | Benzimidazoles - chemistry | Th17 Cells - drug effects | Arthritis, Psoriatic - pathology | Adult | Female | Molecular Structure | Drug Evaluation, Preclinical | Immunosuppressive Agents - pharmacology | Arthritis, Psoriatic - metabolism | Recombinant Proteins - metabolism | Interleukin-17 - secretion | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Interleukin-17 - genetics | Models, Molecular | Interleukin-17 - biosynthesis | Isoxazoles - chemistry | Spondylitis, Ankylosing - metabolism | Azepines - pharmacology | Gene Expression Regulation - drug effects | Isoxazoles - pharmacology | Triazoles - pharmacology | Th17 Cells - immunology | Benzimidazoles - pharmacology | Calorimetry | Protein Conformation | Aged | Kinetics | Spondylitis, Ankylosing - pathology | CD4-Positive T-Lymphocytes - drug effects | Immunosuppressive Agents - chemistry | Protein Structure, Tertiary - drug effects | Immune response | Development and progression | Genetic aspects | Genetic transcription | Binding proteins | Properties | Autoimmune diseases | Health aspects | Cytokines | Medical treatment | Monoclonal antibodies | Clinical trials | T cell receptors | Gene expression | Index Medicus | CBP | p300 | Biological Sciences
Journal Article
FASEB Journal, ISSN 0892-6638, 04/2010, Volume 24, Issue 4, pp. 1023 - 1034
Recently T-helper 17 (Th17) cells were demonstrated to disrupt the blood-brain barrier (BBB) by the action of IL-17A. The aim of the present study was to... 
Neuroinflammation | Multiple sclerosis | Reactive oxygen species | LIGHT-CHAIN KINASE | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MULTIPLE-SCLEROSIS LESIONS | multiple sclerosis | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICROVESSEL ENDOTHELIAL-CELLS | T-CELL | SPHINGOSINE 1-PHOSPHATE | FREE-RADICALS | CELL BIOLOGY | MEDICAL PROGRESS | neuroinflammation | reactive oxygen species | IL-17 | BIOLOGY | CENTRAL-NERVOUS-SYSTEM | Reactive Oxygen Species - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Interleukin-17 - immunology | NADPH Oxidases - metabolism | Oxidative Stress - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | NADPH Oxidases - immunology | Interleukin-17 - pharmacology | Occludin | Antibodies, Neutralizing - immunology | Reactive Oxygen Species - immunology | T-Lymphocytes, Helper-Inducer - immunology | Membrane Proteins - metabolism | T-Lymphocytes, Helper-Inducer - pathology | Xanthine Oxidase - metabolism | Blood-Brain Barrier - immunology | Myosin-Light-Chain Kinase | Encephalomyelitis, Autoimmune, Experimental - pathology | T-Lymphocytes, Helper-Inducer - metabolism | Endothelial Cells - metabolism | Enzyme Inhibitors - pharmacology | Antibodies, Neutralizing - pharmacology | Membrane Proteins - immunology | Xanthine Oxidase - immunology | Down-Regulation - drug effects | Blood-Brain Barrier - metabolism | Naphthalenes - pharmacology | Azepines - pharmacology | Endothelial Cells - immunology | Blood-Brain Barrier - pathology | Interleukin-17 - metabolism | Animals | Interleukin-17 - antagonists & inhibitors | Down-Regulation - immunology | Mice | Mice, Inbred BALB C | Oxidative Stress - drug effects | Endothelial Cells - pathology | Cell Line, Transformed | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0175153 - e0175153
IL-1 beta is a potent player in cutaneous inflammation and central for the development of a Th17 micro-milieu in autoinflammatory diseases including psoriasis.... 
VITAMIN-D | SYSTEMIC-LUPUS-ERYTHEMATOSUS | INTERFERON-GAMMA | MULTIDISCIPLINARY SCIENCES | PSORIASIN S100A7 | INFLAMMATORY CASPASES | KERATINOCYTES | 1,25-DIHYDROXYVITAMIN D-3 | MOLECULAR-CLONING | EXPRESSION | T-CELLS | Caspases - immunology | Humans | Interleukin-17 - immunology | Interleukin-17 - pharmacology | Interleukin-1beta - genetics | S100 Proteins - immunology | Psoriasis - genetics | S100 Proteins - genetics | Th17 Cells - drug effects | Transfection | Inflammasomes - drug effects | Psoriasis - pathology | Adaptor Proteins, Signal Transducing - immunology | Apoptosis Regulatory Proteins - genetics | Skin - pathology | Skin - immunology | Th17 Cells - pathology | Interleukin-1beta - secretion | Psoriasis - immunology | S100 Calcium Binding Protein A7 | Apoptosis Regulatory Proteins - immunology | DNA - immunology | Signal Transduction | Caspases - genetics | Cells, Cultured | Gene Expression Regulation | Interleukin-17 - genetics | Interleukin-1beta - immunology | Vitamin D - pharmacology | Keratinocytes - cytology | Keratinocytes - immunology | DNA - genetics | Interleukin-17 - antagonists & inhibitors | Keratinocytes - drug effects | Inflammasomes - immunology | Adaptor Proteins, Signal Transducing - genetics | Th17 Cells - immunology | Interferon-gamma - pharmacology | Interleukins | Physiological aspects | Development and progression | Skin diseases | Genetic aspects | Inflammation | Research | Cell culture | Transcription | Interleukin | Helper cells | Lymphocytes T | Inflammatory diseases | Vitamin D | Lymphocytes | Interleukin 1 | Lesions | Deoxyribonucleic acid--DNA | Psoriasis | Cytokines | Dermatology | Keratinocytes | Caspase | Epidermis | Hazards | Gene expression | Caspase-5 | Hospitals | Biopsy | Interferon | Autoimmune diseases | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 10/2013, Volume 15, Issue 5, pp. R151 - R151
Introduction: T helper (Th)-17 cells are increased in systemic sclerosis (SSc). We therefore assessed whether Th17 cells could modulate the inflammatory and... 
RHEUMATOID-ARTHRITIS | MATRIX METALLOPROTEINASES | SYNOVIAL FIBROBLASTS | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | GENE-EXPRESSION | SKIN FIBROSIS | NECROSIS-FACTOR-ALPHA | RHEUMATOLOGY | NF-KAPPA-B | T-CELLS | PULMONARY-FIBROSIS | Interleukin-8 - genetics | Gene Expression - drug effects | Skin - metabolism | Humans | Scleroderma, Systemic - pathology | Culture Media, Conditioned - pharmacology | Male | Interleukin-17 - pharmacology | Dose-Response Relationship, Drug | Collagen Type I - genetics | Th17 Cells - metabolism | Radioimmunoassay | Inflammation Mediators - metabolism | Female | Chemokine CCL2 - metabolism | Interleukin-8 - metabolism | Matrix Metalloproteinase 1 - genetics | Skin - pathology | Fibroblasts - metabolism | Collagen Type I - metabolism | Enzyme-Linked Immunosorbent Assay | Scleroderma, Systemic - metabolism | Cells, Cultured | Scleroderma, Systemic - genetics | Chemokine CCL2 - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Tumor Necrosis Factor-alpha - pharmacology | Fibroblasts - drug effects | Matrix Metalloproteinase 1 - metabolism | Interferon-gamma - pharmacology | Culture Media, Conditioned - metabolism | Proteins | Medical equipment and supplies industry | Interleukins | Systemic scleroderma | Medical test kit industry | Scleroderma (Disease) | High-definition television | Skin | Biological response modifiers | Enzyme-linked immunosorbent assay | Index Medicus
Journal Article
Nature Neuroscience, ISSN 1097-6256, 02/2018, Volume 21, Issue 2, pp. 240 - 249
A diet rich in salt is linked to an increased risk of cerebrovascular diseases and dementia, but it remains unclear how dietary salt harms the brain. We report... 
OXIDATIVE STRESS | SODIUM | PHOSPHORYLATION | NITRIC-OXIDE SYNTHASE | PATHOGENIC T(H)17 CELLS | DISEASE | CENTRAL-NERVOUS-SYSTEM | MICE | HEALTH | HYPERTENSION | NEUROSCIENCES | Antihypertensive Agents - pharmacology | Cerebrovascular Disorders - drug therapy | Intestine, Small - pathology | Cognition Disorders - chemically induced | Homeodomain Proteins - metabolism | Male | Th17 Cells - drug effects | Cell Polarity - drug effects | Phosphorylation - drug effects | Neurovascular Coupling - drug effects | Disease Models, Animal | Amides - pharmacology | Interleukin-17 - blood | Interleukin-17 - administration & dosage | Cerebrovascular Disorders - chemically induced | Acetylcholine - pharmacology | Cerebrovascular Circulation - drug effects | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Interleukin-17 - genetics | Mice, Transgenic | Homeodomain Proteins - genetics | Gene Expression Regulation - drug effects | Interleukin-17 - metabolism | Animals | Cell Differentiation - drug effects | Sodium Chloride, Dietary - toxicity | Mice | Pyridines - pharmacology | Salt | Gastrointestinal system | Neurovascular diseases | Cognition disorders | T cells | Health aspects | Risk factors | Brain | Phosphorylation | Salts | Interleukin | Cognitive ability | Helper cells | Impairment | Lymphocytes T | Small intestine | Vascular diseases | Cerebral blood flow | Rodents | Dementia disorders | Digestive tract | Cerebrovascular diseases | Immune response | Digestive system | Health risks | Interleukin 17 | Nitric-oxide synthase | Endothelial cells | Rho-associated kinase | Blood flow | Immune systems | Diet | Nitric oxide | Habits | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 06/2012, Volume 36, Issue 6, pp. 1017 - 1030
Interleukin-27 (IL-27) is a key immunosuppressive cytokine that counters T helper 17 (Th17) cell-mediated pathology. To identify mechanisms by which IL-27... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | INFLAMMATION | GRAVES-DISEASE | IL-27 | RECEPTOR | IMMUNOLOGY | PROINFLAMMATORY CYTOKINE PRODUCTION | C-MAF | EXPRESSION | TH1 DIFFERENTIATION | CUTTING EDGE | T-Lymphocyte Subsets - immunology | Interleukin-1beta - pharmacology | T-Lymphocyte Subsets - cytology | B7-H1 Antigen - deficiency | Minor Histocompatibility Antigens | Encephalomyelitis, Autoimmune, Experimental - etiology | Interleukin-17 - physiology | Encephalomyelitis, Autoimmune, Experimental - immunology | Th17 Cells - transplantation | Bystander Effect | CD4-Positive T-Lymphocytes - immunology | Receptors, Cytokine - deficiency | Th17 Cells - drug effects | Myelin Proteins - toxicity | Th17 Cells - metabolism | Myelin Proteins - immunology | Th17 Cells - cytology | Cell Differentiation | Interferon-gamma - genetics | Interleukins - pharmacology | Forkhead Transcription Factors - deficiency | B7-H1 Antigen - physiology | Encephalomyelitis, Autoimmune, Experimental - pathology | Gene Expression Regulation - immunology | Mice, Inbred C57BL | Interleukin-17 - genetics | Myelin-Oligodendrocyte Glycoprotein | Mice, Transgenic | Interleukin-17 - biosynthesis | B7-H1 Antigen - genetics | Mice, Knockout | Transforming Growth Factor beta - pharmacology | Animals | Interleukin-23 - pharmacology | Interleukin-6 - pharmacology | B7-H1 Antigen - biosynthesis | Encephalomyelitis, Autoimmune, Experimental - prevention & control | Mice | Interferon-gamma - biosynthesis | Interleukins | Analysis | Genes | Skin diseases | Arthritis | Skin | T cells | Design | Pathology | Flow cytometry | Scholarships & fellowships | Phosphorylation | Cytokines | Cysts | Rodents | T cell receptors | Software | Gene expression | Experiments | Index Medicus | Apoptosis
Journal Article