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Nature immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases... 
Life Sciences & Biomedicine | Immunology | Science & Technology | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases | Index Medicus
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 01/2014, Volume 40, Issue 1, pp. 128 - 139
Journal Article
The Journal of immunology (1950), ISSN 0022-1767, 06/2014, Volume 192, Issue 12, pp. 5924 - 5932
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 05/2013, Volume 110, Issue 24, pp. 9862 - 9867
The microbiota is pivotal in the pathogenesis of inflammatory bowel disease (IBD)-associated inflammation-induced colorectal cancer (CRC), yet mechanisms for... 
Microorganisms | Microbiota | Receptors | Epithelial cells | Colorectal cancer | Mice | Inflammation | Colitis | Tumors | Cancer | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neoplasms - metabolism | Interleukin-18 - immunology | Inflammasomes - metabolism | Colitis - genetics | Colorectal Neoplasms - genetics | Male | Chemokine CCL5 - deficiency | Epithelium - immunology | Signal Transduction - immunology | Inflammation - metabolism | Neoplasms - genetics | Colonoscopy | Epithelium - microbiology | Female | Colitis - immunology | Interleukin-6 - metabolism | Colorectal Neoplasms - metabolism | Epithelium - metabolism | Interleukin-6 - genetics | Mice, Inbred C57BL | Interleukin-18 - deficiency | Inflammation - immunology | Receptors, Cell Surface - immunology | Mice, Knockout | Animals | Colorectal Neoplasms - immunology | Neoplasms - immunology | Inflammasomes - immunology | Receptors, Cell Surface - deficiency | Chemokine CCL5 - genetics | Colitis - metabolism | Interleukin-6 - immunology | Inflammation - genetics | Metagenome - immunology | Interleukin-18 - genetics | Chemokine CCL5 - immunology | Receptors, Cell Surface - genetics | Physiological aspects | Development and progression | Health aspects | Interleukin-6 | Index Medicus | Biological Sciences | ASC | colon cancer | microflora
Journal Article