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Blood, ISSN 0006-4971, 12/2012, Volume 120, Issue 24, pp. 4751 - 4760
Natural killer (NK) cells are lymphocytes that play an important role in the immune response to infection and malignancy. Recent studies in mice have shown... 
INNATE | NATURAL-KILLER-CELLS | INFECTION | HEMATOLOGY | EXPANSION | Receptors, Interleukin-12 - immunology | Antigens, CD - immunology | Interleukin-18 - immunology | Humans | Lectins, C-Type - immunology | Interferon-gamma - metabolism | Interleukin-15 - immunology | Antigens, CD - metabolism | NK Cell Lectin-Like Receptor Subfamily D - immunology | Lectins, C-Type - metabolism | NK Cell Lectin-Like Receptor Subfamily C - immunology | Lymphocyte Activation - immunology | Flow Cytometry | Time Factors | Killer Cells, Natural - immunology | Receptors, Interleukin-12 - genetics | Interferon-gamma - genetics | CD56 Antigen - immunology | Immunologic Memory - immunology | Cytokines - immunology | Interleukin-12 - pharmacology | Receptors, Interleukin-18 - metabolism | CD56 Antigen - metabolism | NK Cell Lectin-Like Receptor Subfamily C - metabolism | Antigens, Differentiation, T-Lymphocyte - immunology | Antigens, Differentiation, T-Lymphocyte - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Interleukin-15 - pharmacology | Receptors, Interleukin-12 - metabolism | Lymphocyte Activation - drug effects | Interferon-gamma - immunology | Interleukin-12 - immunology | K562 Cells | Receptors, Interleukin-18 - genetics | Receptors, Interleukin-18 - immunology | Cell Proliferation - drug effects | Interleukin-18 - pharmacology | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | NK Cell Lectin-Like Receptor Subfamily D - metabolism | Cytokines - pharmacology | Index Medicus | Abridged Index Medicus | Immunobiology
Journal Article
Nature Immunology, ISSN 1529-2908, 03/2015, Volume 16, Issue 4, pp. 354 - 365
Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan members of the IL-1 ligand family and IL-1 receptor family, respectively. Here... 
CELLS | FAMILY-MEMBER | INFLAMMATION | TIR8/SIGIRR | INFECTION | IMMUNOLOGY | TOLL | INHIBITOR | EXPRESSION | NEGATIVE REGULATOR | MOLECULES | Inflammation - pathology | Interleukin-1 - genetics | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Humans | Receptors, Interleukin-1 - genetics | NF-kappa B - immunology | Receptor Protein-Tyrosine Kinases - immunology | Proto-Oncogene Proteins c-fyn - genetics | Signal Transduction - immunology | TOR Serine-Threonine Kinases - genetics | PTEN Phosphohydrolase - immunology | RNA, Small Interfering - immunology | Receptors, Interleukin-1 - deficiency | Leukocytes, Mononuclear - immunology | c-Mer Tyrosine Kinase | Interleukin-1 - immunology | Interleukin-18 Receptor alpha Subunit - genetics | Proto-Oncogene Proteins - immunology | Proto-Oncogene Proteins c-fyn - immunology | STAT3 Transcription Factor - genetics | Cell Line | PTEN Phosphohydrolase - genetics | Interleukin-18 Receptor alpha Subunit - immunology | Leukocytes, Mononuclear - drug effects | MAP Kinase Kinase Kinases - genetics | Receptors, Interleukin-1 - immunology | RNA-Binding Proteins - immunology | Gene Expression Regulation | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Inflammation - immunology | Immunity, Innate | MAP Kinase Kinase Kinases - immunology | Interleukin-18 Receptor alpha Subunit - antagonists & inhibitors | Leukocytes, Mononuclear - pathology | TOR Serine-Threonine Kinases - immunology | Animals | NF-kappa B - genetics | Receptor Protein-Tyrosine Kinases - genetics | Lipopolysaccharides - pharmacology | Inflammation - genetics | Protein Binding | Mice | STAT3 Transcription Factor - immunology | Receptors, Interleukin-1 - antagonists & inhibitors | Index Medicus
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 07/2013, Volume 39, Issue 1, pp. 123 - 135
The NLRP3 inflammasome plays a major role in innate immune responses by activating caspase-1, resulting in secretion of interleukin-18 (IL-18) and IL-1β.... 
DOUBLE-STRANDED-RNA | ANTIVIRAL RESPONSES | INTRACELLULAR DNA | DENDRITIC CELLS | RECOGNITION | BACTERIAL RNA | CASPASE-1 | INDUCIBLE GENE-I | RIG-I | IMMUNOLOGY | CYTOPLASMIC DNA | Interleukin-18 - immunology | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Cytosol - immunology | Humans | Caspase 1 - metabolism | Immunoblotting | Caspase 1 - immunology | RNA - genetics | RNA Interference | Interleukin-1beta - metabolism | Gene Expression - immunology | HEK293 Cells | Poly I-C - immunology | RNA, Double-Stranded - metabolism | DEAD-box RNA Helicases - metabolism | Carrier Proteins - immunology | Macrophages - immunology | RNA - metabolism | Cell Line | RNA - immunology | Macrophage Activation - immunology | Interleukin-1beta - immunology | Protein Binding - immunology | Reverse Transcriptase Polymerase Chain Reaction | Inflammasomes - genetics | Carrier Proteins - genetics | DEAD-box RNA Helicases - genetics | Microscopy, Confocal | Macrophages - metabolism | Carrier Proteins - metabolism | Inflammasomes - immunology | RNA, Double-Stranded - genetics | RNA, Double-Stranded - immunology | DEAD-box RNA Helicases - immunology | RNA, Bacterial - immunology | Cytosol - metabolism | RNA, Viral - immunology | Interleukin-18 - metabolism | RNA | Biological response modifiers | Proteins | Immunology | Laboratories | Glycerol | Infections | Sensors | Viral infections | Deoxyribonucleic acid--DNA | Immune system | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 09/2012, Volume 37, Issue 3, pp. 549 - 562
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2015, Volume 195, Issue 2, pp. 587 - 601
Mucosal-associated invariant T (MAIT) cells have a semi-invariant TCR V alpha-chain, and their optimal development is dependent upon commensal flora and... 
MYCOBACTERIUM-TUBERCULOSIS | ANTIGEN RECEPTOR RECOGNITION | IMMUNE-RESPONSE | NATURAL-KILLER-CELLS | MAIT CELLS | NK CELLS | MULTIPLE-SCLEROSIS | VITAMIN-B METABOLITES | TCR ALPHA-CHAIN | BACTERIAL-INFECTION | IMMUNOLOGY | Lung - microbiology | Interleukin-18 - immunology | Mycobacterium bovis - immunology | Immunity, Mucosal | Receptors, Antigen, T-Cell, alpha-beta - immunology | Antigens, CD - genetics | Riboflavin - analogs & derivatives | CD4-Positive T-Lymphocytes - immunology | Tuberculosis - pathology | CD4-Positive T-Lymphocytes - microbiology | Signal Transduction | Riboflavin - immunology | Genetic Heterogeneity | Mice, Knockout | Integrin alpha4beta1 - immunology | Lung - drug effects | Receptors, CXCR3 - genetics | Interleukin-12 - immunology | Receptors, CXCR3 - immunology | Hyaluronan Receptors - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | Interleukin-18 - genetics | Antigens, CD - immunology | CD8-Positive T-Lymphocytes - pathology | Interleukin-12 - genetics | Minor Histocompatibility Antigens | Protein Multimerization | Antigens, Ly - genetics | Lectins, C-Type - immunology | Tuberculosis - microbiology | Riboflavin - pharmacology | CD4-Positive T-Lymphocytes - pathology | Lectins, C-Type - genetics | Gene Expression Regulation, Developmental | CD8-Positive T-Lymphocytes - microbiology | Antigens, Differentiation, T-Lymphocyte - immunology | Mice, Inbred C57BL | Cells, Cultured | Histocompatibility Antigens Class I - immunology | Integrin alpha4beta1 - genetics | Histocompatibility Antigens Class I - genetics | Tuberculosis - veterinary | Hyaluronan Receptors - genetics | NK Cell Lectin-Like Receptor Subfamily B - immunology | Receptors, Antigen, T-Cell, alpha-beta - genetics | Tuberculosis - immunology | Animals | Antigens, Ly - immunology | NK Cell Lectin-Like Receptor Subfamily B - genetics | CD8-Positive T-Lymphocytes - drug effects | Antigens, Differentiation, T-Lymphocyte - genetics | Immunologic Memory | CD4-Positive T-Lymphocytes - drug effects | Lung - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 02/2015, Volume 42, Issue 2, pp. 321 - 331
T helper 1 (Th1) cell-associated immunity exacerbates ileitis induced by oral infection. We show here that attenuated ileitis observed in interleukin-22... 
ORAL INFECTION | INTERFERON-GAMMA | IFN-GAMMA | IL-18 | INFLAMMATION | HOST-DEFENSE | TOXOPLASMA-GONDII | MICE | TNF-ALPHA | IMMUNOLOGY | T-CELLS | Toxoplasma - immunology | Up-Regulation | Interleukin-18 - immunology | Toxoplasmosis - immunology | Ileum - parasitology | Ileum - immunology | Th1 Cells - immunology | Toxoplasmosis - parasitology | Enterobacteriaceae Infections - immunology | Interleukins - genetics | RNA, Messenger - biosynthesis | Intestinal Mucosa - immunology | Interleukins - immunology | Organ Culture Techniques | Neutrophil Infiltration - immunology | Citrobacter rodentium - immunology | Enterobacteriaceae Infections - microbiology | Mice, Inbred C57BL | Cells, Cultured | Neutrophils - immunology | Inflammation - immunology | Intestinal Mucosa - microbiology | Mice, Knockout | Interleukin-18 - biosynthesis | Animals | Ileitis - parasitology | Ileitis - immunology | Epithelial Cells - immunology | Ileitis - microbiology | Mice | Ileum - microbiology | Interferon-gamma - biosynthesis | Intestinal Mucosa - parasitology | RNA | Interleukins | Health aspects | Gastrointestinal diseases | Medical research | Microbiology | Medicine, Experimental | Automation | Data analysis | Cytokines | Cysts | Rodents | Gangrene | Infections | Gene expression | Small intestine | Experiments | Immune system | Index Medicus
Journal Article
Infection and Immunity, ISSN 0019-9567, 12/2015, Volume 83, Issue 12, pp. 4740 - 4749
Interferon (IFN)-inducible guanylate binding proteins (GBPs) mediate cell-autonomous host resistance to bacterial pathogens and promote inflammasome... 
IFN | AIM2 INFLAMMASOME | IMMUNITY | INFECTIOUS DISEASES | CASPASE-1 | SUSCEPTIBILITY | TRACHOMATIS | INNATE | PYROPTOSIS | IMMUNOLOGY | HOST-RESISTANCE | PROTECTS | Interleukin-18 - immunology | Caspases - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | Chlamydia trachomatis - immunology | Interleukin-1beta - genetics | GTP-Binding Proteins - genetics | Chlamydia muridarum - immunology | Chlamydia Infections - immunology | Chlamydia Infections - pathology | Vacuoles - immunology | Chlamydia Infections - genetics | Inclusion Bodies - microbiology | Fibroblasts - microbiology | Interferon-gamma - genetics | Carrier Proteins - immunology | Macrophages - immunology | Macrophages - microbiology | Chlamydia trachomatis - genetics | Inclusion Bodies - immunology | Vacuoles - microbiology | DNA-Binding Proteins - immunology | GTP-Binding Proteins - immunology | Signal Transduction | Caspases - genetics | Mice, Inbred C57BL | Chlamydia muridarum - genetics | Gene Expression Regulation | Interleukin-1beta - immunology | DNA-Binding Proteins - genetics | Inflammasomes - genetics | Mice, Knockout | Host-Pathogen Interactions | Carrier Proteins - genetics | Animals | Chlamydia Infections - microbiology | Chlamydia muridarum - pathogenicity | Inflammasomes - immunology | Interferon-gamma - immunology | Chlamydia trachomatis - pathogenicity | Fibroblasts - immunology | Mice | Primary Cell Culture | Interleukin-18 - genetics | Index Medicus | Cellular Microbiology | Pathogen-Host Cell Molecular Interactions | Spotlight
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2014, Volume 192, Issue 7, pp. 3259 - 3268
Adjuvants are an essential component of modern vaccines and used for their ability to elicit immunity to coadministered Ags. Many adjuvants in clinical... 
T-CELL RESPONSES | HUMAN NEUTROPHILS | DENDRITIC CELLS | NLRP3 INFLAMMASOME | IMMUNOLOGY | THERAPEUTIC VACCINES | PARTICULATE VACCINE ADJUVANTS | NALP3 INFLAMMASOME | ANTIGEN DELIVERY | INNATE IMMUNITY | TUMOR-ANTIGEN | Interleukin-18 - immunology | Inflammasomes - metabolism | Dendritic Cells - immunology | Humans | Tumor Necrosis Factor-alpha - genetics | Lymphocyte Activation - immunology | Interleukin-1beta - metabolism | Adenosine Triphosphate - metabolism | Tumor Necrosis Factor-alpha - immunology | Macrophages, Peritoneal - drug effects | Cell Survival - drug effects | Antigen-Presenting Cells - metabolism | Antigen-Presenting Cells - drug effects | Phospholipids - immunology | Immunity - immunology | Macrophages, Peritoneal - immunology | Saponins - immunology | Phospholipids - pharmacology | Blotting, Western | Mice, Knockout | Microscopy, Confocal | Macrophages - metabolism | Signal Transduction - drug effects | Cholesterol - pharmacology | Killer Cells, Natural - drug effects | Mice | Killer Cells, Natural - metabolism | Macrophages, Peritoneal - metabolism | Lysosomes - immunology | Interleukin-18 - metabolism | Saponins - pharmacology | Adjuvants, Immunologic - pharmacology | Cholesterol - immunology | Tumor Necrosis Factor-alpha - deficiency | Immunity - drug effects | Signal Transduction - immunology | Lysosomes - metabolism | Inflammasomes - drug effects | Killer Cells, Natural - immunology | Dendritic Cells - drug effects | Receptors, Tumor Necrosis Factor - deficiency | Dendritic Cells - metabolism | Macrophages - immunology | Receptors, Tumor Necrosis Factor - genetics | Lysosomes - drug effects | Mice, Inbred C57BL | Interleukin-1beta - immunology | Adenosine Triphosphate - immunology | Cell Survival - immunology | Antigen-Presenting Cells - immunology | Animals | Lymphocyte Activation - drug effects | Inflammasomes - immunology | Macrophages - drug effects | Receptors, Tumor Necrosis Factor - immunology | Drug Combinations | Index Medicus | Abridged Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2017, Volume 23, Issue 2, pp. 174 - 184
Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear.... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | INTERLEUKIN-18 LEVELS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIOVASCULAR-DISEASE | RECEPTOR | ESSENTIAL-HYPERTENSION | PROTEINS | T-CELLS | AGE | CELL BIOLOGY | Toll-Like Receptor 5 - genetics | Humans | Middle Aged | Oxidative Stress - immunology | Transcriptome | Immunoblotting | Male | Purinergic P1 Receptor Antagonists - pharmacology | Young Adult | Toll-Like Receptor 8 - immunology | Aging - immunology | Toll-Like Receptor 6 - immunology | Aging - genetics | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | Aged, 80 and over | Caffeine - pharmacology | Hypertension - genetics | Intracellular Signaling Peptides and Proteins - genetics | Interleukin 1 Receptor Antagonist Protein - immunology | Carotid Intima-Media Thickness | Mortality | Neutrophils - drug effects | Hypertension - immunology | Nucleotides - metabolism | Toll-Like Receptor 5 - immunology | Monocytes - drug effects | Regression Analysis | Phenotype | Mice | Calcium-Binding Proteins - genetics | Metabolomics | Pulse Wave Analysis | Neutrophil Activation - drug effects | Cytidine - pharmacology | Interleukin 1 Receptor Antagonist Protein - genetics | Intracellular Signaling Peptides and Proteins - immunology | Cytidine - analogs & derivatives | CARD Signaling Adaptor Proteins - genetics | Toll-Like Receptor 6 - genetics | Adult | Female | Blood Pressure - drug effects | Blood Platelets - drug effects | Macrophages - immunology | Cytokines - immunology | CARD Signaling Adaptor Proteins - immunology | Cell Line | Vascular Stiffness - genetics | Cytokines - metabolism | Oxidative Stress - genetics | Interleukin-1beta - immunology | Adenine - pharmacology | Inflammation - immunology | Inflammasomes - genetics | Vascular Stiffness - immunology | Animals | Inflammasomes - immunology | Toll-Like Receptor 8 - genetics | Inflammation - genetics | Aged | Platelet Activation - drug effects | Genetic aspects | Immune response | Gene expression | Health aspects | Aging | Inflammation | Immune system | Index Medicus
Journal Article