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Journal of Immunology, ISSN 0022-1767, 06/2011, Volume 186, Issue 11, pp. 6553 - 6561
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0130624 - e0130624
Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or protein aggregates. The brain resident macrophages, microglia,... 
INTERLEUKIN-1 | ACTIVATION | MOLECULAR PLATFORM | INHIBITION | DISTINCT PATHWAYS | NEUROINFLAMMATION | MULTIDISCIPLINARY SCIENCES | IL-1-BETA | MECHANISMS | RECEPTORS | NALP3 INFLAMMASOME | Microglia - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Peptide Fragments - toxicity | Caspase 1 - metabolism | Interleukin-1alpha - metabolism | alpha-Synuclein - pharmacology | Interleukin-1beta - metabolism | Interleukin-1beta - secretion | Microglia - cytology | Brain - cytology | Interleukin-1beta - analysis | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Caspase 1 - deficiency | Receptors, Purinergic P2X7 - metabolism | Mice | Interleukin-18 - metabolism | Astrocytes - metabolism | Cytokines | Health aspects | Nervous system diseases | Brain | Cell culture | Traumatic brain injury | Peptides | Aluminum sulfate | Homeostasis | Nervous system | Activation | Macrophages | Synuclein | Proteins | Rodents | Amyloid | Life sciences | Communication | Neurodegenerative diseases | Secretion | Astrocytes | Inflammation | Trauma | Molecular chains | Microglia | Interleukin 18 | Mode of action | Neurological diseases | Immune systems | Nigericin | Brain research | Ligands | Alum | Laboratory animals | Alzheimers disease | Chemokines | Index Medicus
Journal Article
Cardiovascular Research, ISSN 0008-6363, 07/2013, Volume 99, Issue 1, pp. 164 - 174
Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) is considered necessary for initiating a profound sterile inflammatory... 
Heart | Myocardial infarction | Inflammasome | Ischaemia-reperfusion | IL-1β | Potassium - metabolism | Up-Regulation | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Male | NF-kappa B - metabolism | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Myocardial Reperfusion Injury - pathology | Time Factors | Interleukin-1beta - metabolism | Adenosine Triphosphate - metabolism | Myocardial Infarction - physiopathology | Toll-Like Receptors - metabolism | Myocardial Reperfusion Injury - genetics | Disease Models, Animal | Fibroblasts - metabolism | Myocardial Reperfusion Injury - immunology | Rats | Receptors, Cytoplasmic and Nuclear - genetics | Myocardial Infarction - metabolism | Myocardial Reperfusion Injury - physiopathology | Mice, Knockout | Fibroblasts - drug effects | Lipopolysaccharides - pharmacology | Fibroblasts - immunology | Heart Ventricles - metabolism | Mice | Interleukin-18 - genetics | Interleukin-18 - metabolism | Myocardial Reperfusion Injury - prevention & control | Heart Ventricles - drug effects | Receptors, Cytoplasmic and Nuclear - metabolism | Myocardial Infarction - genetics | Rats, Wistar | Ventricular Function, Left | Heart Ventricles - immunology | Myocardial Infarction - immunology | Cytoskeletal Proteins - deficiency | Myocardial Infarction - pathology | Heart Ventricles - pathology | Myocardial Contraction | Mice, Inbred C57BL | Cells, Cultured | Inflammasomes - genetics | Carrier Proteins - genetics | Myocardial Reperfusion Injury - metabolism | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Heart Ventricles - physiopathology | CARD Signaling Adaptor Proteins | Apoptosis | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 02/2009, Volume 113, Issue 7, pp. 1526 - 1534
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2013, Volume 190, Issue 7, pp. 3629 - 3638
Journal Article
Nature Immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 670 - 674
The inflammasome regulates the release of caspase activation-dependent cytokines, including interleukin (IL)-1 beta, IL-18 and high-mobility group box 1... 
PATHWAYS | APOPTOSIS | ACID | PROTEIN-KINASE PKR | MULTIDISCIPLINARY SCIENCES | INFECTION | NLRP3 INFLAMMASOME | ELF2-ALPHA | STRESS | BINDING | SUBSTRATE RECOGNITION | Crystallins - metabolism | Interleukin-6 - analysis | Phosphorylation | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | eIF-2 Kinase - metabolism | Humans | Salmonella Infections - immunology | Male | Salmonella Infections - metabolism | HMGB1 Protein - secretion | Interleukin-1beta - blood | eIF-2 Kinase - deficiency | Adenosine Triphosphate - pharmacology | CARD Signaling Adaptor Proteins - metabolism | Transfection | Interleukin-6 - blood | Rotenone - pharmacology | Female | Membrane Proteins - metabolism | Escherichia coli - physiology | Macrophages, Peritoneal - drug effects | eIF-2 Kinase - genetics | Calcium-Binding Proteins - metabolism | Cell Line | Salmonella typhimurium - physiology | Interleukin-18 - blood | Salmonella typhimurium - immunology | Inflammasomes - agonists | Mice, Inbred C57BL | Peritonitis - metabolism | Cells, Cultured | Escherichia coli - immunology | Antigens, Bacterial - pharmacology | Escherichia coli Infections - metabolism | eIF-2 Kinase - antagonists & inhibitors | Apoptosis Regulatory Proteins - metabolism | Animals | Carrier Proteins - metabolism | Bacterial Toxins - pharmacology | Uric Acid - pharmacology | RNA, Double-Stranded - immunology | RNA, Double-Stranded - pharmacology | Escherichia coli Infections - immunology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | HMGB1 Protein - blood | Physiological aspects | Chromosomal proteins | Research | Cytokines | Aluminum | Health aspects | Proteins | E coli | Pathogenesis | Plasmids | Bone marrow | Bacteria | Kinases | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2012, Volume 490, Issue 7418, pp. 107 - 111
Detection of microbial products by host inflammasomes is an important mechanism of innate immune surveillance. Inflammasomes activate the caspase-1 (CASP1)... 
CYTOSOLIC PHOSPHOLIPASE A | FLAGELLIN | III SECRETION APPARATUS | MECHANISM | MICE DEFICIENT | MULTIDISCIPLINARY SCIENCES | NLRC4 INFLAMMASOME | INFECTION | PYROPTOSIS | CASPASE-1 ACTIVATION | IMMUNE RECOGNITION | Inflammation - pathology | Inflammasomes - metabolism | Hematocrit | Salmonella Infections - immunology | Eicosanoids - biosynthesis | Caspase 1 - metabolism | Male | Inflammation - metabolism | Time Factors | Flagellin - metabolism | Bacterial Toxins - genetics | Antigens, Bacterial - chemistry | Neuronal Apoptosis-Inhibitory Protein - deficiency | Macrophages, Peritoneal - immunology | Calcium-Binding Proteins - deficiency | Interleukin-1beta | Bacterial Toxins - chemistry | Apoptosis Regulatory Proteins - metabolism | Cyclooxygenase 1 - deficiency | Body Fluids - metabolism | Caspase 1 - deficiency | Recombinant Fusion Proteins - genetics | Cytosol - metabolism | Death | Mice | Antigens, Bacterial - metabolism | Capillary Permeability | Peritoneal Cavity | Legionella pneumophila | Intestines - metabolism | Antigens, Bacterial - genetics | Recombinant Fusion Proteins - metabolism | Peritoneal Lavage | Apoptosis Regulatory Proteins - deficiency | Flagellin - genetics | Female | Interleukin-18 | Calcium Signaling | Calcium-Binding Proteins - metabolism | Flagellin - immunology | Salmonella typhimurium - immunology | Mice, Inbred C57BL | Inflammation - immunology | Body Temperature | Neuronal Apoptosis-Inhibitory Protein - metabolism | Immunity, Innate - immunology | Bacterial Toxins - metabolism | Animals | Eicosanoids - metabolism | Fluid Shifts | Cellular signal transduction | Research | Properties | Bacterial proteins | Flagella (Microbiology) | Immune system | Proteins | Bone marrow | Pathology | Infections | Biosynthesis | Rodents | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 12/2012, Volume 120, Issue 24, pp. 4751 - 4760
Natural killer (NK) cells are lymphocytes that play an important role in the immune response to infection and malignancy. Recent studies in mice have shown... 
INNATE | NATURAL-KILLER-CELLS | INFECTION | HEMATOLOGY | EXPANSION | Receptors, Interleukin-12 - immunology | Antigens, CD - immunology | Interleukin-18 - immunology | Humans | Lectins, C-Type - immunology | Interferon-gamma - metabolism | Interleukin-15 - immunology | Antigens, CD - metabolism | NK Cell Lectin-Like Receptor Subfamily D - immunology | Lectins, C-Type - metabolism | NK Cell Lectin-Like Receptor Subfamily C - immunology | Lymphocyte Activation - immunology | Flow Cytometry | Time Factors | Killer Cells, Natural - immunology | Receptors, Interleukin-12 - genetics | Interferon-gamma - genetics | CD56 Antigen - immunology | Immunologic Memory - immunology | Cytokines - immunology | Interleukin-12 - pharmacology | Receptors, Interleukin-18 - metabolism | CD56 Antigen - metabolism | NK Cell Lectin-Like Receptor Subfamily C - metabolism | Antigens, Differentiation, T-Lymphocyte - immunology | Antigens, Differentiation, T-Lymphocyte - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Interleukin-15 - pharmacology | Receptors, Interleukin-12 - metabolism | Lymphocyte Activation - drug effects | Interferon-gamma - immunology | Interleukin-12 - immunology | K562 Cells | Receptors, Interleukin-18 - genetics | Receptors, Interleukin-18 - immunology | Cell Proliferation - drug effects | Interleukin-18 - pharmacology | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | NK Cell Lectin-Like Receptor Subfamily D - metabolism | Cytokines - pharmacology | Index Medicus | Abridged Index Medicus | Immunobiology
Journal Article
Immunity, ISSN 1074-7613, 07/2012, Volume 37, Issue 1, pp. 108 - 121
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2013, Volume 123, Issue 1, pp. 236 - 246
Nephrocalcinosis, acute calcium oxalate (CaOx) nephropathy, and renal stone disease can lead to inflammation and subsequent renal failure, but the underlying... 
KIDNEY-DISEASE | NEPHROLITHIASIS | MEDICINE, RESEARCH & EXPERIMENTAL | DANGER | ACTIVATION | DENDRITIC CELLS | NLRP3 INFLAMMASOME | STONE FORMATION | FAILURE | NEPHROPATHY | NALP3 INFLAMMASOME | Interleukin-18 - immunology | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Nephrocalcinosis - immunology | Receptors, Interleukin-1 - genetics | Interleukin-1beta - genetics | Inflammation - metabolism | Nephrocalcinosis - metabolism | Myeloid Differentiation Factor 88 - immunology | Cytoskeletal Proteins - metabolism | Kidney Tubules - pathology | Immunologic Deficiency Syndromes - immunology | Kidney Tubules - metabolism | Carrier Proteins - immunology | Dendritic Cells - metabolism | Interleukin-1beta - secretion | Kidney Tubules - immunology | Calcium Oxalate - immunology | Receptors, Interleukin-1 - immunology | Myeloid Differentiation Factor 88 - genetics | Interleukin-1beta - immunology | Inflammation - immunology | Calcium Oxalate - metabolism | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Carrier Proteins - genetics | Nephrocalcinosis - pathology | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | Nephrocalcinosis - genetics | CARD Signaling Adaptor Proteins | Immunologic Deficiency Syndromes - genetics | Immunologic Deficiency Syndromes - metabolism | Inflammation - genetics | Mice | Interleukin-18 - genetics | Myeloid Differentiation Factor 88 - metabolism | Interleukin-18 - metabolism | Phagocytosis | Index Medicus | Abridged Index Medicus
Journal Article