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nf-kappa-b (153) 153
interleukin 18 (152) 152
caspase 1 - metabolism (147) 147
enzyme-linked immunosorbent assay (147) 147
disease models, animal (146) 146
recombinant proteins - pharmacology (138) 138
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European Journal of Immunology, ISSN 0014-2980, 12/2012, Volume 42, Issue 12, pp. 3334 - 3345
Extracellular ATP, released upon microbial infection, cell damage, or inflammation, acts as an alert signal toward immune cells by activating P2 receptors. The... 
Extracellular ATP | IL‐18 | P2X7 | P2 receptors | Human macrophages | IL-18 | DENDRITIC CELLS | CASPASE-1 | IFN-GAMMA | GAMMA-INDUCING FACTOR | IMMUNOLOGY | POLYMYXIN-B | HUMAN BLOOD | IL-1-BETA | TNF-ALPHA | SECRETION | ATP | Polymyxin B - pharmacology | Interleukin-18 - immunology | Tetrazoles - pharmacology | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Acetamides - pharmacology | Purinergic P2X Receptor Antagonists - pharmacology | Quinolines - pharmacology | Adenosine Triphosphate - pharmacology | Calcium Ionophores - pharmacology | Cell-Derived Microparticles - metabolism | Receptors, Purinergic P2X7 - immunology | Macrophages - immunology | Receptors, Purinergic P2X4 - immunology | Protein Precursors - immunology | Toll-Like Receptor 4 - immunology | Sulfonamides - pharmacology | Calcimycin - pharmacology | Purinergic P2X Receptor Agonists - pharmacology | Toll-Like Receptor 4 - metabolism | Adenosine Triphosphate - analogs & derivatives | Protein Precursors - metabolism | Macrophages - metabolism | Cell-Derived Microparticles - immunology | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Lipopolysaccharides - pharmacology | Receptors, Purinergic P2X7 - metabolism | Anti-Bacterial Agents - pharmacology | Pyridines - pharmacology | Receptors, Purinergic P2X4 - metabolism | Interleukin-18 - metabolism | Macrophages | Ionophores | Rodents | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 670 - 674
The inflammasome regulates the release of caspase activation-dependent cytokines, including interleukin (IL)-1 beta, IL-18 and high-mobility group box 1... 
PATHWAYS | APOPTOSIS | ACID | PROTEIN-KINASE PKR | MULTIDISCIPLINARY SCIENCES | INFECTION | NLRP3 INFLAMMASOME | ELF2-ALPHA | STRESS | BINDING | SUBSTRATE RECOGNITION | Crystallins - metabolism | Interleukin-6 - analysis | Phosphorylation | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | eIF-2 Kinase - metabolism | Humans | Salmonella Infections - immunology | Male | Salmonella Infections - metabolism | HMGB1 Protein - secretion | Interleukin-1beta - blood | eIF-2 Kinase - deficiency | Adenosine Triphosphate - pharmacology | CARD Signaling Adaptor Proteins - metabolism | Transfection | Interleukin-6 - blood | Rotenone - pharmacology | Female | Membrane Proteins - metabolism | Escherichia coli - physiology | Macrophages, Peritoneal - drug effects | eIF-2 Kinase - genetics | Calcium-Binding Proteins - metabolism | Cell Line | Salmonella typhimurium - physiology | Interleukin-18 - blood | Salmonella typhimurium - immunology | Inflammasomes - agonists | Mice, Inbred C57BL | Peritonitis - metabolism | Cells, Cultured | Escherichia coli - immunology | Antigens, Bacterial - pharmacology | Escherichia coli Infections - metabolism | eIF-2 Kinase - antagonists & inhibitors | Apoptosis Regulatory Proteins - metabolism | Animals | Carrier Proteins - metabolism | Bacterial Toxins - pharmacology | Uric Acid - pharmacology | RNA, Double-Stranded - immunology | RNA, Double-Stranded - pharmacology | Escherichia coli Infections - immunology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Macrophages, Peritoneal - metabolism | HMGB1 Protein - blood | Physiological aspects | Chromosomal proteins | Research | Cytokines | Aluminum | Health aspects | Proteins | E coli | Pathogenesis | Plasmids | Bone marrow | Bacteria | Kinases | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 09/2016, Volume 197, Issue 6, pp. 2421 - 2433
Journal Article
Blood, ISSN 0006-4971, 12/2012, Volume 120, Issue 24, pp. 4751 - 4760
Natural killer (NK) cells are lymphocytes that play an important role in the immune response to infection and malignancy. Recent studies in mice have shown... 
INNATE | NATURAL-KILLER-CELLS | INFECTION | HEMATOLOGY | EXPANSION | Receptors, Interleukin-12 - immunology | Antigens, CD - immunology | Interleukin-18 - immunology | Humans | Lectins, C-Type - immunology | Interferon-gamma - metabolism | Interleukin-15 - immunology | Antigens, CD - metabolism | NK Cell Lectin-Like Receptor Subfamily D - immunology | Lectins, C-Type - metabolism | NK Cell Lectin-Like Receptor Subfamily C - immunology | Lymphocyte Activation - immunology | Flow Cytometry | Time Factors | Killer Cells, Natural - immunology | Receptors, Interleukin-12 - genetics | Interferon-gamma - genetics | CD56 Antigen - immunology | Immunologic Memory - immunology | Cytokines - immunology | Interleukin-12 - pharmacology | Receptors, Interleukin-18 - metabolism | CD56 Antigen - metabolism | NK Cell Lectin-Like Receptor Subfamily C - metabolism | Antigens, Differentiation, T-Lymphocyte - immunology | Antigens, Differentiation, T-Lymphocyte - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Interleukin-15 - pharmacology | Receptors, Interleukin-12 - metabolism | Lymphocyte Activation - drug effects | Interferon-gamma - immunology | Interleukin-12 - immunology | K562 Cells | Receptors, Interleukin-18 - genetics | Receptors, Interleukin-18 - immunology | Cell Proliferation - drug effects | Interleukin-18 - pharmacology | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | NK Cell Lectin-Like Receptor Subfamily D - metabolism | Cytokines - pharmacology | Index Medicus | Abridged Index Medicus | Immunobiology
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2015, Volume 459, Issue 3, pp. 379 - 386
Interleukin-18 (IL-18) was recently reported to have a pro-tumor effect in various cancers. Increased IL-18 levels in the serum of cancer patients correlated... 
Tight junction | Breast cancer | Claudin-12 | Migration | Interleukin-18 (IL-18) | METASTASIS | SERUM INTERLEUKIN-18 | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNE ESCAPE | HUMAN GASTRIC-CANCER | BIOPHYSICS | MESSENGER-RNA | MURINE MELANOMA-CELLS | TIGHT JUNCTION PROTEINS | EXPRESSION | CARCINOMA | N-CADHERIN | Claudin-1 - antagonists & inhibitors | RNA, Small Interfering - genetics | Interleukin-18 - physiology | Claudin-4 - genetics | Humans | Interleukin-18 - antagonists & inhibitors | Claudin-3 - physiology | Breast Neoplasms - physiopathology | Cell Movement - genetics | Cell Movement - physiology | Claudin-4 - physiology | Gene Knockdown Techniques | Tight Junctions - physiology | MCF-7 Cells | Claudin-3 - genetics | Claudin-1 - physiology | Female | Flavonoids - pharmacology | Tight Junctions - drug effects | Claudins - genetics | Claudins - physiology | Imidazoles - pharmacology | Recombinant Proteins - pharmacology | Down-Regulation - drug effects | Claudin-4 - antagonists & inhibitors | Cell Movement - drug effects | Breast Neoplasms - genetics | MAP Kinase Signaling System - drug effects | Breast Neoplasms - pathology | Claudin-1 - genetics | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Claudins - antagonists & inhibitors | Claudin-3 - antagonists & inhibitors | Interleukin-18 - genetics | Proteins | Development and progression | Metastasis | Interleukins | Melanoma | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 01/2013, Volume 121, Issue 1, pp. 95 - 106
Persistent high fever is one of the most typical clinical symptoms in dengue virus (DV)-infected patients. However, the source of endogenous pyrogen (eg, IL-1... 
DENDRITIC CELLS | RECOGNITION | HEMORRHAGIC-FEVER | TYROSINE KINASE | IFN-GAMMA | INFECTION | MICE | IL-1-BETA | NLRP3 INFLAMMASOME | HEMATOLOGY | NALP3 INFLAMMASOME | Caspase Inhibitors - pharmacology | Capillary Permeability | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Tumor Necrosis Factor-alpha - genetics | Lectins, C-Type - physiology | Interleukin-1beta - genetics | Receptors, Cell Surface - antagonists & inhibitors | Fever - physiopathology | Endothelium, Vascular - physiology | Macrophage Colony-Stimulating Factor - pharmacology | Interleukin-1beta - biosynthesis | Receptors, Cell Surface - physiology | Dengue - immunology | Carrier Proteins - immunology | Dengue - genetics | Macrophages - immunology | Cells, Cultured - drug effects | Macrophages - classification | RNA, Small Interfering - pharmacology | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Macrophage Activation | Gene Expression Regulation - drug effects | Interleukin-18 - biosynthesis | Virus Replication | Inflammasomes - immunology | Fever - etiology | Lipopolysaccharides - pharmacology | Dengue Virus - physiology | Macrophages - drug effects | Cells, Cultured - metabolism | Interleukin-18 - genetics | Tumor Necrosis Factor-alpha - biosynthesis | Lectins, C-Type - antagonists & inhibitors | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
Cellular Signalling, ISSN 0898-6568, 06/2013, Volume 25, Issue 6, pp. 1447 - 1456
We investigated the role of TRAF3 interacting protein 2 (TRAF3IP2), a redox-sensitive adapter protein and an upstream regulator of IKK and JNK in interleukin... 
Oxidative stress | Vascular diseases | TRAF3IP2 | Interleukin-18 | Nox1 | SMC migration | Reactive Oxygen Species - metabolism | Humans | NADPH Oxidases - metabolism | NF-kappa B - metabolism | Recombinant Proteins - biosynthesis | Simvastatin - pharmacology | Transcription Factor AP-1 - metabolism | RNA Interference | Protein Binding - drug effects | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - cytology | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics | Receptors, Interleukin-18 - metabolism | Mevalonic Acid - pharmacology | Cells, Cultured | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - antagonists & inhibitors | NADPH Oxidase 1 | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism | Cell Movement - drug effects | rac1 GTP-Binding Protein - antagonists & inhibitors | Interleukin-18 - pharmacology | Polyisoprenyl Phosphates - pharmacology | Sesquiterpenes - pharmacology | Interleukin-18 - genetics | Anticholesteremic Agents - pharmacology | Interleukin-18 - metabolism | rac1 GTP-Binding Protein - metabolism | RNA, Small Interfering - metabolism | Smooth muscle | Interleukins | Simvastatin | Antilipemic agents | Index Medicus | Proteins | Binding | Inhibitors | Migration | Interleukin | Muscles | Activation | Inhibition | oxidative stress | vascular diseases
Journal Article
Clinical Science, ISSN 0143-5221, 2014, Volume 126, Issue 3, pp. 233 - 241
Journal Article
Nature, ISSN 0028-0836, 03/2006, Volume 440, Issue 7081, pp. 233 - 236
Missense mutations in the CIAS1 gene cause three autoinflammatory disorders: familial cold autoinflammatory syndrome, Muckle-Wells syndrome and neonatal-onset... 
CELLS | RECOGNITION | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | INFLAMMASOME | DISEASE | TOLL-LIKE RECEPTORS | INNATE | SECRETION | CUTTING EDGE | IMIQUIMOD | Interleukin-18 - immunology | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Male | NF-kappa B - metabolism | Legionella pneumophila - genetics | Toll-Like Receptors - deficiency | Multiprotein Complexes - metabolism | Inflammation - metabolism | Antiviral Agents - chemistry | Interleukin-1 - immunology | Macrophages, Peritoneal - drug effects | Antiviral Agents - pharmacology | Toll-Like Receptors - immunology | Imidazoles - pharmacology | Multiprotein Complexes - chemistry | Adaptor Proteins, Signal Transducing - deficiency | Toll-Like Receptors - genetics | Mice | Macrophages, Peritoneal - metabolism | Interleukin-1 - secretion | Interleukin-18 - metabolism | Inflammation - chemically induced | Listeria monocytogenes - immunology | Cytoskeletal Proteins - deficiency | RNA, Bacterial - genetics | Cytoskeletal Proteins - metabolism | Female | Aminoquinolines - pharmacology | Interleukin-1 - metabolism | Legionella pneumophila - immunology | Cells, Cultured | Inflammation - immunology | Myeloid Differentiation Factor 88 | Enzyme Activation - drug effects | Toll-Like Receptors - agonists | Carrier Proteins - genetics | RNA, Bacterial - pharmacology | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Macrophages, Peritoneal - microbiology | CARD Signaling Adaptor Proteins | Adaptor Proteins, Signal Transducing - genetics | Listeria monocytogenes - genetics | RNA, Bacterial - immunology | Interleukin-18 - secretion | Adaptor Proteins, Signal Transducing - metabolism | Mitogen-Activated Protein Kinases - metabolism | Immunology | Ribonucleic acid | Bacteria | Mutation | Autoimmune diseases | Gene expression | Ribonucleic acid--RNA | Index Medicus | Life Sciences
Journal Article
The Journal of Immunology, ISSN 0022-1767, 11/2009, Volume 183, Issue 10, pp. 6639 - 6645
We determined whether human NK cells could contribute to immune defenses against Mycobacterium tuberculosis through production of IL-22. CD3(-)CD56(+) NK cells... 
T(H)17 CYTOKINE | NATURAL-KILLER-CELLS | ROR-GAMMA-T | INTERFERON-GAMMA | HUMAN MACROPHAGES | MUCOSAL HOST-DEFENSE | NECROSIS-FACTOR-ALPHA | INTRACELLULAR BACTERIUM | IMMUNOLOGY | HUMAN MONOCYTES | INNATE IMMUNITY | Phagosomes - microbiology | RNA, Messenger - immunology | Humans | Mycobacterium tuberculosis - immunology | Tuberculosis - microbiology | RNA, Messenger - metabolism | Mycobacterium tuberculosis - drug effects | Interleukins - metabolism | Phagosomes - immunology | RNA, Small Interfering - immunology | Receptors, Immunologic - agonists | Interleukins - immunology | Killer Cells, Natural - immunology | Interleukins - pharmacology | Receptors, Immunologic - immunology | Macrophages - immunology | Macrophages - microbiology | Interleukin-12 - pharmacology | Killer Cells, Natural - microbiology | Phagosomes - drug effects | Phagosomes - metabolism | Recombinant Proteins - pharmacology | RNA, Messenger - agonists | Tuberculosis - immunology | Interleukin-15 - pharmacology | Macrophages - metabolism | Interleukin-23 - pharmacology | Macrophages - drug effects | Interleukin-18 - pharmacology | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Mycobacterium tuberculosis - growth & development | RNA, Small Interfering - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 11/2011, Volume 119, Issue 4, pp. 736 - 748
Microglia are important innate immune effectors against invading CNS pathogens, such as Staphylococcus aureus (S. aureus), a common etiological agent of brain... 
IL‐1β | NLRP3 | IL‐18 | microglia | inflammasome | P2X | R | IL-18 | IL-1β | NERVOUS-SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | IL-1 beta | NLRP3 INFLAMMASOME | RESISTANT STAPHYLOCOCCUS-AUREUS | NEUROSCIENCES | NALP3 INFLAMMASOME | TOLL-LIKE | DIFFERENTIAL REQUIREMENT | HOST IMMUNE-RESPONSE | EXPERIMENTAL BRAIN-ABSCESS | P2XR | GENETIC-HETEROGENEITY | ATP RELEASE | Enzyme-Linked Immunosorbent Assay - methods | Microglia - metabolism | Hemolysin Proteins - pharmacology | NLR Family, Pyrin Domain-Containing 3 Protein | Staphylococcus aureus - physiology | Cell Survival - genetics | Cerebral Cortex - cytology | Cytoskeletal Proteins - deficiency | Dose-Response Relationship, Drug | Drug Interactions | Microglia - immunology | Time Factors | Interleukin-1beta - metabolism | Adenosine Triphosphate - metabolism | Purinergic P2 Receptor Antagonists - pharmacology | Cytoskeletal Proteins - metabolism | Microglia - microbiology | Animals, Newborn | Cell Survival - drug effects | Microglia - drug effects | Mice, Inbred C57BL | Cells, Cultured | Enzyme Inhibitors - pharmacology | Signal Transduction - genetics | Staphylococcus aureus - pathogenicity | Mice, Knockout | Carrier Proteins - genetics | Bacterial Proteins - pharmacology | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Signal Transduction - drug effects | Bacterial Toxins - pharmacology | Models, Biological | CARD Signaling Adaptor Proteins | Mice | Thiazoles - pharmacology | Interleukin-18 - metabolism | Index Medicus | ASC | hemolysins | cathepsin B | P2X7R
Journal Article