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Journal Article
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2015, Volume 459, Issue 3, pp. 379 - 386
Interleukin-18 (IL-18) was recently reported to have a pro-tumor effect in various cancers. Increased IL-18 levels in the serum of cancer patients correlated... 
Tight junction | Breast cancer | Claudin-12 | Migration | Interleukin-18 (IL-18) | SERUM INTERLEUKIN-18 | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNE ESCAPE | CYTOKINE | HUMAN GASTRIC-CANCER | BIOPHYSICS | MESSENGER-RNA | MURINE MELANOMA-CELLS | TIGHT JUNCTION PROTEINS | EXPRESSION | N-CADHERIN | Claudin-1 - antagonists & inhibitors | RNA, Small Interfering - genetics | Interleukin-18 - physiology | Claudin-4 - genetics | Humans | Interleukin-18 - antagonists & inhibitors | Claudin-3 - physiology | Breast Neoplasms - physiopathology | Cell Movement - genetics | Cell Movement - physiology | Claudin-4 - physiology | Gene Knockdown Techniques | Tight Junctions - physiology | MCF-7 Cells | Claudin-3 - genetics | Claudin-1 - physiology | Female | Flavonoids - pharmacology | Tight Junctions - drug effects | Claudins - genetics | Claudins - physiology | Imidazoles - pharmacology | Recombinant Proteins - pharmacology | Down-Regulation - drug effects | Claudin-4 - antagonists & inhibitors | Cell Movement - drug effects | Breast Neoplasms - genetics | MAP Kinase Signaling System - drug effects | Breast Neoplasms - pathology | Claudin-1 - genetics | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Claudins - antagonists & inhibitors | Claudin-3 - antagonists & inhibitors | Interleukin-18 - genetics | Proteins | Development and progression | Metastasis | Interleukins | Melanoma
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 10/2015, Volume 43, Issue 4, pp. 751 - 763
The crosstalk between inflammation and tumorigenesis is now clearly established. However, how inflammation is elicited in the metastatic environment and the... 
colorectal cancer | cell death | innate immunity | metastasis | interleukin-18 | inflammasome | NLRP3 | Fas | natural killer (NK) cells | caspase-1 | immunosurveillance | Cell death | Natural killer (NK) cells | Colorectal cancer | Immunosurveillance | Innate immunity | Inflammasome | Metastasis | Interleukin-18 | Caspase-1 | COLON-CANCER | APOPTOSIS | ACTIVATION | NK CELLS | CASPASE-1 | INTERLEUKIN-1-BETA | HUMAN-MELANOMA | KUPFFER CELLS | RECEPTOR | CYTOKINE | IMMUNOLOGY | Immunologic Surveillance | Interleukin-18 - physiology | NLR Family, Pyrin Domain-Containing 3 Protein | Neoplasm Proteins - physiology | Radiation Tolerance | Tumor Microenvironment | DNA-Binding Proteins - deficiency | Apoptosis Regulatory Proteins - deficiency | Killer Cells, Natural - immunology | Liver Neoplasms - secondary | Inflammasomes - deficiency | Carrier Proteins - physiology | Interleukin-1beta - physiology | Adenocarcinoma - immunology | Mice, Inbred C57BL | Gastrointestinal Microbiome | Calcium-Binding Proteins - deficiency | Liver Neoplasms - immunology | Radiation Chimera | Immunity, Innate | Adenocarcinoma - secondary | Mice, Knockout | Fas Ligand Protein - physiology | Inflammasomes - physiology | Animals | Colorectal Neoplasms - immunology | Caspase 1 - deficiency | Cell Line, Tumor | Mice | Neoplasm Proteins - deficiency | Colorectal Neoplasms - pathology | Cytotoxicity, Immunologic | Lymphocytes, Tumor-Infiltrating - immunology | Killer cells | Microbiota (Symbiotic organisms) | Growth | Cytokines | Liver | Inflammation | Gene expression | Inflammatory bowel disease | Scholarships & fellowships | Rodents | Tumorigenesis | Immune system | Tumors | Apoptosis
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2010, Volume 30, Issue 47, pp. 15811 - 15820
Journal Article
Journal Article
Cell Metabolism, ISSN 1550-4131, 2010, Volume 12, Issue 6, pp. 593 - 605
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 04/2015, Volume 97, Issue 4, pp. 665 - 675
Review of the dual role of IL‐18 and IL‐18BP in cancer therapy based on specific tumor characteristics. IL‐18 is a proinflammatory and immune regulatory... 
Th1 response | immune regulation | cancer immunotherapy | Cancer immunotherapy | Immune regulation | NATURAL-KILLER-CELLS | BINDING-PROTEIN | OVARIAN-CANCER | IMMUNOLOGY | HUMAN GASTRIC-CANCER | CELL BIOLOGY | IL-18-BINDING PROTEIN | SERUM-LEVELS | RECOMBINANT HUMAN INTERLEUKIN-18 | HEPATIC MELANOMA METASTASIS | GENE-EXPRESSION | HEMATOLOGY | T-CELLS | Neoplasms - metabolism | Interleukin-18 - physiology | Humans | Promoter Regions, Genetic - genetics | Lymphocyte Subsets - immunology | Intercellular Signaling Peptides and Proteins - physiology | Inflammation - metabolism | Neoplasms - therapy | Neoplasms, Experimental - microbiology | Receptors, Interleukin-18 - physiology | Immunotherapy | Neoplasms, Experimental - immunology | Neoplasms, Experimental - genetics | Killer Cells, Natural - immunology | Caspase 1 - physiology | Interleukin-18 - therapeutic use | Killer Cells, Natural - transplantation | Virus Diseases - immunology | Immunotherapy, Adoptive | Interleukin-18 - deficiency | Virus Diseases - metabolism | Inflammation - immunology | Phagocytes - immunology | Disease Progression | Mice, Knockout | Protein Precursors - metabolism | Randomized Controlled Trials as Topic | Cocarcinogenesis | Inflammasomes - physiology | Models, Immunological | Animals | Neoplasms - immunology | Intercellular Signaling Peptides and Proteins - therapeutic use | Mice | Enzyme Activation | Neoplasms, Experimental - metabolism | Clinical Trials, Phase I as Topic | Drug Screening Assays, Antitumor
Journal Article