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PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 6, pp. e0130624 - e0130624
Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or protein aggregates. The brain resident macrophages, microglia,... 
INTERLEUKIN-1 | ACTIVATION | MOLECULAR PLATFORM | INHIBITION | DISTINCT PATHWAYS | NEUROINFLAMMATION | MULTIDISCIPLINARY SCIENCES | IL-1-BETA | MECHANISMS | RECEPTORS | NALP3 INFLAMMASOME | Microglia - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Peptide Fragments - toxicity | Caspase 1 - metabolism | Interleukin-1alpha - metabolism | alpha-Synuclein - pharmacology | Interleukin-1beta - metabolism | Interleukin-1beta - secretion | Microglia - cytology | Brain - cytology | Interleukin-1beta - analysis | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Caspase 1 - deficiency | Receptors, Purinergic P2X7 - metabolism | Mice | Interleukin-18 - metabolism | Astrocytes - metabolism | Cytokines | Health aspects | Nervous system diseases | Brain | Cell culture | Traumatic brain injury | Peptides | Aluminum sulfate | Homeostasis | Nervous system | Activation | Macrophages | Synuclein | Proteins | Rodents | Amyloid | Life sciences | Communication | Immune system | Neurodegenerative diseases | Astrocytes | Inflammation | Trauma | Molecular chains | Microglia | Interleukin 18 | Mode of action | Neurological diseases | Nigericin | Brain research | Ligands | Alum | Laboratory animals | Alzheimers disease | Chemokines | Index Medicus
Journal Article
Journal of hepatology, ISSN 0168-8278, 2011, Volume 55, Issue 5, pp. 1086 - 1094
... liver diseases [3,4] . These cytokines are produced in the liver by Kupffer cells and hepatocytes, playing roles in lipid metabolism and hepatic inflammation [5–7... 
Gastroenterology and Hepatology | Fatty liver | Cytokines | IL-1 | Steatohepatitis | Inflammation | Mouse model | Lipid metabolism | OXIDATIVE STRESS | PRECURSOR | IL-1-ALPHA | IL-1 RECEPTOR ANTAGONIST | TNF-ALPHA | GASTROENTEROLOGY & HEPATOLOGY | HEPATIC STEATOSIS | EXPRESSION | PROGRESSION | Tumor Necrosis Factor-alpha - metabolism | Interleukin-1 - genetics | Fatty Liver - pathology | P-Selectin - metabolism | Tumor Necrosis Factor-alpha - genetics | Interleukin-1alpha - metabolism | Male | Chemokine CXCL1 - genetics | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Interleukin-1beta - deficiency | Matrix Metalloproteinase 9 - metabolism | Interleukin-1beta - metabolism | Matrix Metalloproteinase 9 - genetics | Hepatitis - metabolism | Liver Cirrhosis - metabolism | Collagen - genetics | Interleukin-1alpha - genetics | Chemokine CXCL1 - metabolism | Interleukin-1 - metabolism | Gene Expression | Fatty Liver - metabolism | Serum Amyloid A Protein - metabolism | Mice, Inbred C57BL | Hepatitis - pathology | P-Selectin - genetics | Disease Progression | Mice, Knockout | Collagen - metabolism | Diet, Atherogenic | Animals | Transforming Growth Factor beta - genetics | Analysis of Variance | Interleukin-1alpha - deficiency | Liver Cirrhosis - pathology | Hypercholesterolemia - complications | Mice | Transforming Growth Factor beta - metabolism
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 12/2015, Volume 35, Issue 12, pp. 2605 - 2616
OBJECTIVE—Kawasaki disease (KD) is the most common cause of acute vasculitis and acquired cardiac disease among US children. We have previously shown that both... 
dendritic cells | interleukin-1 | mucocutaneous lymph node syndrome | MyD88 | Endothelial cells | protein | endothelial cells | ELEMENT-BINDING PROTEIN-2 | ACTIVATION | RECEPTOR | CORONARY-ARTERY ANEURYSMS | NLRP3 INFLAMMASOME | POLYMORPHISM | ACUTE-PHASE | INTRAVENOUS IMMUNOGLOBULIN | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | ASSOCIATION | Lactobacillus casei | Mucocutaneous Lymph Node Syndrome - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Stromal Cells - pathology | Caspase 1 - metabolism | Interleukin-1alpha - metabolism | Aortitis - chemically induced | Aorta - metabolism | Coronary Vessels - metabolism | Cell Wall | DNA-Binding Proteins - metabolism | Receptors, Interleukin-1 Type I - metabolism | Interleukin-1beta - metabolism | Bone Marrow Transplantation | Coronary Artery Disease - pathology | Aortitis - pathology | Dendritic Cells - metabolism | Disease Models, Animal | Mucocutaneous Lymph Node Syndrome - pathology | Coronary Vessels - pathology | Signal Transduction | Coronary Artery Disease - chemically induced | Endothelial Cells - metabolism | Mucocutaneous Lymph Node Syndrome - chemically induced | Coronary Artery Disease - metabolism | Mice, Inbred C57BL | Stromal Cells - metabolism | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Aortitis - genetics | DNA-Binding Proteins - genetics | Transplantation Chimera | Mice, Knockout | Aorta - pathology | Mucocutaneous Lymph Node Syndrome - genetics | Aortitis - metabolism | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Coronary Artery Disease - genetics | Receptors, Interleukin-1 Type I - genetics | Myeloid Differentiation Factor 88 - metabolism | Bone Marrow Cells - metabolism | coronary artery vasculitis | Kawasaki disease | IL-1
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2009, Volume 183, Issue 8, pp. 5208 - 5220
The role of proinflammatory cytokine production in the pathogenesis of malaria is well established, but the identification of the parasite products that... 
TUMOR-NECROSIS-FACTOR | DENDRITIC CELLS | INTERFERON-GAMMA | TOLL-LIKE RECEPTOR-9 | PLASMODIUM-FALCIPARUM | EXPERIMENTAL CEREBRAL MALARIA | ENDOTHELIAL-CELLS | IMMUNOLOGY | NF-KAPPA-B | INNATE IMMUNE ACTIVATION | INTRACELLULAR COMPARTMENTS | Interleukin-1alpha - immunology | Chemokine CCL2 - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | NF-kappa B - metabolism | Inflammation - parasitology | Endothelial Cells - parasitology | Extracellular Signal-Regulated MAP Kinases - immunology | Plasmodium falciparum | Interleukin-1beta - metabolism | Tumor Necrosis Factor-alpha - immunology | Interleukin-8 - metabolism | Toll-Like Receptors - metabolism | Chemokine CXCL1 - metabolism | Interleukin-6 - metabolism | Carrier Proteins - immunology | Toll-Like Receptors - immunology | Chemokine CXCL1 - immunology | Signal Transduction - drug effects | Interleukin-6 - immunology | Malaria, Falciparum - immunology | Uric Acid - antagonists & inhibitors | Mice | Interleukin-8 - immunology | Inflammation - chemically induced | Tumor Necrosis Factor-alpha - metabolism | NF-kappa B - immunology | Interleukin-1alpha - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Hemeproteins - immunology | Macrophages - parasitology | Signal Transduction - immunology | Myeloid Differentiation Factor 88 - immunology | Cytoskeletal Proteins - metabolism | Chemokine CCL2 - metabolism | Macrophages - immunology | Uric Acid - metabolism | Interleukin-1beta - immunology | Hemeproteins - pharmacology | Inflammation - immunology | Endothelial Cells - immunology | Malaria, Falciparum - parasitology | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Allopurinol - pharmacology | Macrophages - drug effects | Myeloid Differentiation Factor 88 - metabolism | Interferon-gamma - pharmacology | Endothelial Cells - drug effects | Chemokine | TLR9 | Plasmodium | Inflammasome | NALP3 | Cytokine
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 5, p. e20245
Immune adaptation is a critical component of successful pregnancy. Of primary importance is the modification of cytokine production upon immune activation.... 
NORMAL-PREGNANCY | COLONY-STIMULATING FACTOR | HUMAN PLACENTA | ANGIOGENESIS | CIRCULATION | ALKALINE-PHOSPHATASE | MULTIDISCIPLINARY SCIENCES | RECEPTOR EXPRESSION | EXOSOMES | PREECLAMPSIA | MICROPARTICLES | Exosomes - metabolism | Tumor Necrosis Factor-alpha - metabolism | Leukocytes, Mononuclear - metabolism | Interleukin-1alpha - immunology | Chemokine CCL3 - immunology | Humans | Interleukin-1alpha - metabolism | Monocytes - metabolism | Monocytes - immunology | Cytoplasmic Vesicles - immunology | Interleukin-1beta - metabolism | Leukocytes, Mononuclear - immunology | Cytoplasmic Vesicles - metabolism | Exosomes - immunology | Tumor Necrosis Factor-alpha - immunology | Adult | Chemokine CCL3 - metabolism | Female | Interleukin-8 - metabolism | Binding, Competitive - immunology | Interleukin-6 - metabolism | B-Lymphocytes - metabolism | Trophoblasts - metabolism | Enzyme-Linked Immunosorbent Assay | Placenta - immunology | Immunologic Factors - immunology | Interleukin-1beta - immunology | Placenta - metabolism | Pregnancy | Trophoblasts - immunology | B-Lymphocytes - immunology | Interleukin-6 - immunology | Interleukin-8 - immunology | Viral antibodies | Cytokines | Pregnant women | Antibodies | Hostages | B cells | Lymphocytes T | Immunity | Interleukin 6 | Proteins | Angiogenesis | Granulocytes | Lymphocytes | Peripheral blood mononuclear cells | IP-10 protein | Tumor necrosis factor-TNF | Interleukin 8 | Immune system | Antigens | Immunomodulation | Fetuses | Gynecology | Inflammation | T cell receptors | Tumor necrosis factor-α | Obstetrics | Graft rejection | Monocytes | Placenta | Lymphocytes B | Preeclampsia | Ligands | Interferon | Miscarriage | Chemokines | Apoptosis
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 3, p. e58639
miR-181a has been presumed to target the 3'-untranslated regions (3'-UTR) of IL1a based on software predictions. miR-181a and IL1a have opposite expression... 
CELLS | MICRORNA MIR-181A | IL-1-ALPHA | INTERLEUKIN-1-ALPHA | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TRANSCRIPTION | SURFACE EXPRESSION | NF-KAPPA-B | CANCER | Tumor Necrosis Factor-alpha - metabolism | RNA, Small Interfering - genetics | Reactive Oxygen Species - metabolism | Tetradecanoylphorbol Acetate - pharmacology | Humans | Tumor Necrosis Factor-alpha - genetics | 3' Untranslated Regions - genetics | Interleukin-1alpha - metabolism | MicroRNAs - metabolism | Monocytes - metabolism | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Inflammation - metabolism | Interleukin-1beta - metabolism | Base Sequence | Interleukin-1alpha - genetics | Binding Sites | Interleukin-6 - metabolism | Interleukin-6 - genetics | RNA, Messenger - genetics | Gene Expression Regulation - drug effects | Monocytes - drug effects | Macrophages - metabolism | Animals | Interleukin-1alpha - deficiency | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Inflammation - genetics | Macrophages - drug effects | Mice | MicroRNAs - genetics | Cell culture | Reactive oxygen species | Fluorescence | Inflammatory response | Cardiovascular disease | Kinases | Macrophages | Lipopolysaccharides | Interleukin 6 | Proteins | Signal transduction | Interleukin 1 | Tumor necrosis factor-TNF | Physiology | Life sciences | Inhibition | Oxygen | Cytokines | Inflammation | Tumor necrosis factor-α | Gene expression | Monocytes | Inhibitors | 3' Untranslated regions | MicroRNAs | Stem cells | Acetic acid | Phorbol 12-myristate 13-acetate
Journal Article
Arthritis research & therapy, ISSN 1478-6354, 08/2011, Volume 13, Issue 4, pp. R136 - R136
Introduction: In addition to its direct proinflammatory activity, extracellular high mobility group box protein 1 (HMGB1) can strongly enhance the cytokine... 
RHEUMATOID-ARTHRITIS | PATHOGENESIS | COLLAGEN-INDUCED ARTHRITIS | ACTIVATION | NECROTIC CELLS | DENDRITIC CELLS | CYTOKINE | HMGB1 | RHEUMATOLOGY | HUMAN MONOCYTES | GLYCATION END-PRODUCTS | Immunohistochemistry | Interleukin-1beta - pharmacology | Interleukin-1alpha - immunology | Humans | Lipopolysaccharides - metabolism | Synovial Membrane - immunology | Interleukin-1alpha - metabolism | HMGB1 Protein - immunology | Synovial Membrane - drug effects | Lipopolysaccharides - immunology | Arthritis, Rheumatoid - metabolism | Inflammation - metabolism | HMGB1 Protein - pharmacology | Interleukin-1beta - metabolism | HMGB1 Protein - metabolism | Inflammation Mediators - metabolism | Tumor Necrosis Factor-alpha - immunology | Osteoarthritis - pathology | Cytokines - immunology | Fibroblasts - metabolism | Inflammation Mediators - immunology | Enzyme-Linked Immunosorbent Assay | Osteoarthritis - immunology | Cells, Cultured | Interleukin-1beta - immunology | Osteoarthritis - metabolism | Inflammation - immunology | Synovial Membrane - metabolism | Arthritis, Rheumatoid - pathology | Phenotype | Fibroblasts - drug effects | Lipopolysaccharides - pharmacology | Fibroblasts - immunology | Arthritis, Rheumatoid - immunology | Interleukin-1alpha - pharmacology | Tumor Necrosis Factor-alpha - biosynthesis | Cytokines - biosynthesis | Complications and side effects | Care and treatment | Rheumatoid arthritis | Fibroblasts | Physiological aspects | Research | Diagnosis
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 541, Issue 7638, pp. 481 - 487
Journal Article
Journal Article
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