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Nature Cell Biology, ISSN 1465-7392, 08/2015, Volume 17, Issue 8, pp. 1049 - 1061
The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates... 
EPITHELIAL-CELL LINE | GROWTH ARREST | DNA-DAMAGE | IN-VIVO | INFLAMMATORY CYTOKINE SECRETION | HUMAN FIBROBLASTS | TUMOR-CELLS | CANCER-THERAPY | REPLICATIVE SENESCENCE | P53 | CELL BIOLOGY | Up-Regulation | Fibroblasts - enzymology | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Humans | Gene Expression Regulation, Neoplastic | Interleukin-1alpha - metabolism | Male | NF-kappa B - metabolism | RNA, Messenger - metabolism | Prostatic Neoplasms - secretion | Prostatic Neoplasms - immunology | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Prostatic Neoplasms - genetics | TOR Serine-Threonine Kinases - genetics | Transfection | RNA Interference | Time Factors | Cellular Senescence | Inflammation Mediators - metabolism | Transcription, Genetic | Antineoplastic Agents - pharmacology | Interleukin-1alpha - genetics | Interleukin-6 - metabolism | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Anti-Inflammatory Agents - pharmacology | Interleukin-1alpha - secretion | Sirolimus - metabolism | Tumor Burden | Mice, SCID | Sirolimus - pharmacology | Xenograft Model Antitumor Assays | Phenotype | Animals | Fibroblasts - drug effects | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Mitoxantrone - pharmacology | Interleukins | Aging | Genetic aspects | Properties | Phosphotransferases | Carcinogenesis | Health aspects | Cells | Index Medicus
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 12/2014, Volume 745, pp. 223 - 233
We studied the effects of interleukin (IL)-1β on DNA synthesis and cell proliferation in primary cultures of adult rat hepatocytes in order to elucidate the... 
Signal transduction | DNA synthesis | Interleukin-1β | Proliferation (cultured hepatocytes) | Transforming growth factor-α | CELLS | ACTIVATED PROTEIN-KINASE | PRIMARY CULTURE | Transforming growth factor-alpha | Interleukin-1 beta | RECEPTOR ANTAGONIST | CAMP-ELEVATING AGENTS | TUMOR-NECROSIS-FACTOR | IN-VITRO | ADULT-RAT HEPATOCYTES | INDUCED DNA-SYNTHESIS | LIVER-REGENERATION | PHARMACOLOGY & PHARMACY | Interleukin-1beta - pharmacology | Rats, Wistar | Interleukin-1alpha - administration & dosage | Interleukin-1alpha - metabolism | Male | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Hepatocytes - cytology | Interleukin-1beta - metabolism | Interleukin 1 Receptor Antagonist Protein - metabolism | DNA - biosynthesis | Flavonoids - pharmacology | Interleukin 1 Receptor Antagonist Protein - pharmacology | Chromones - pharmacology | Transforming Growth Factor alpha - metabolism | Hepatocytes - drug effects | Transforming Growth Factor alpha - antagonists & inhibitors | Cell Proliferation - physiology | Cells, Cultured | Morpholines - pharmacology | Rats | Tyrphostins - pharmacology | Sirolimus - pharmacology | Animals | Interleukin-1beta - administration & dosage | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Cell Proliferation - drug effects | Cell Cycle - drug effects | Quinazolines - pharmacology | Interleukin-1alpha - pharmacology | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 09/2016, Volume 197, Issue 6, pp. 2421 - 2433
Journal Article
FASEB Journal, ISSN 0892-6638, 10/2015, Volume 29, Issue 10, pp. 4162 - 4173
Journal Article
Transplant International, ISSN 0934-0874, 04/2017, Volume 30, Issue 4, pp. 388 - 397
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, pp. e101937 - e101937
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2006, Volume 551, Issue 1, pp. 27 - 33
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 2410 - 9
Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells lose the ability to divide,... 
CELLS | ACTIVATION | NUTLIN-3A | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GENE-EXPRESSION | P53 PATHWAY | CELLULAR SENESCENCE | CANCER-THERAPY | FIBROBLASTS | Gamma Rays | Proto-Oncogene Proteins c-mdm2 - genetics | Epithelial Cells - metabolism | Interleukin-6 - antagonists & inhibitors | Epithelial Cells - drug effects | Humans | Cellular Senescence - drug effects | Interleukin-1alpha - metabolism | Male | Lung - cytology | Tumor Suppressor Protein p53 - genetics | Tumor Suppressor Protein p53 - agonists | Cellular Senescence - radiation effects | Cell Cycle Checkpoints - genetics | Indoles - pharmacology | Interleukin-1alpha - genetics | Epithelial Cells - cytology | Interleukin-6 - metabolism | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Fibroblasts - metabolism | Cell Line | Cellular Senescence - genetics | Epithelial Cells - radiation effects | Interleukin-6 - genetics | Enzyme Inhibitors - pharmacology | Tumor Suppressor Protein p53 - metabolism | Interleukin-1alpha - antagonists & inhibitors | Imidazoles - pharmacology | Piperazines - pharmacology | Fibroblasts - radiation effects | Foreskin - cytology | Cell Cycle Checkpoints - drug effects | Fibroblasts - drug effects | Fibroblasts - cytology | Spiro Compounds - pharmacology | Biodegradation | MDM2 protein | Phenotypes | Senescence | p53 Protein | Genotoxicity | Antagonists | Breast cancer | Inflammation | Interleukin 6 | Fibroblasts | Aging | Tumor suppressor genes | Growth factors | Cancer | Index Medicus
Journal Article
Stem Cell Research and Therapy, ISSN 1757-6512, 04/2017, Volume 8, Issue 1, pp. 79 - 79
Background: Inflammation is a key contributor to central nervous system (CNS) injury such as stroke, and is a major target for therapeutic intervention.... 
Priming | Interleukin-1 | Stroke | Human mesenchymal stem cells | Cytokines | Bone marrow-derived stromal cells | MEDICINE, RESEARCH & EXPERIMENTAL | NERVOUS-SYSTEM | COLONY-STIMULATING FACTOR | DONOR VARIATION | FOCAL CEREBRAL-ISCHEMIA | STROKE PATIENTS | RECEPTOR ANTAGONIST | BRAIN REPAIR | CELL BIOLOGY | INTRACEREBRAL HEMORRHAGE | FACTOR G-CSF | MARROW STROMAL CELLS | Biomarkers - metabolism | Microglia - cytology | Tumor Necrosis Factor-alpha - metabolism | Mesenchymal Stromal Cells - drug effects | Interleukin-1beta - pharmacology | Microglia - drug effects | Anti-Inflammatory Agents - pharmacology | Humans | Mesenchymal Stromal Cells - metabolism | Culture Media, Conditioned - pharmacology | Male | Nerve Growth Factors - pharmacology | Young Adult | Granulocyte Colony-Stimulating Factor - pharmacology | Mesenchymal Stromal Cells - cytology | Phenotype | Animals | Lipopolysaccharides - pharmacology | Adult | Female | Mice | Interleukin-1alpha - pharmacology | Interleukin-6 - metabolism | Flow cytometry | Animal models | Senescence | Media (culture) | Adipose tissue | Disease | Central nervous system | Bone marrow transplantation | Nervous system | Transplantation | Cerebrospinal fluid | Adipocytes | Neurogenesis | Hemorrhage | Interleukin 6 | Genotype & phenotype | Bone growth | Granulocytes | Blood-brain barrier | Interleukin 1 | Bone marrow | Tumor necrosis factor-TNF | Trends | Growth factors | Astrocytes | Fetuses | Amyotrophic lateral sclerosis | Inflammation | Gene expression | Microglia | Stem cells | Tumors | Index Medicus
Journal Article