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1. Full Text Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg‐like metabolism?
by Escoll, Pedro and Buchrieser, Carmen
The FEBS journal, ISSN 1742-464X, 06/2018, Volume 285, Issue 12, pp. 2146 - 2160
OXPHOS | Warburg‐like metabolism | bacterial infection | mitochondria | glycolysis | Warburg-like metabolism | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Proliferation | Humans | Mitochondria - immunology | Glycolysis - genetics | Oxidative Phosphorylation - drug effects | Bacteria - growth & development | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Cell Differentiation | Interleukin-1beta - biosynthesis | Macrophages - immunology | Macrophages - microbiology | T-Lymphocytes - microbiology | Interleukin-1beta - immunology | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - microbiology | Cellular Reprogramming - drug effects | Host-Pathogen Interactions | Macrophages - metabolism | Animals | Lipopolysaccharides - pharmacology | Macrophages - drug effects | T-Lymphocytes - immunology | Bacteria - pathogenicity | Physiological aspects | Glucose metabolism | Bacterial infections | Health aspects | Cells | Immune response | Bacteria | Infections | Intracellular | Metabolism | Cancer | Mammalian cells | Immune system | Index Medicus | Bacteria/growth & development | Macrophages/microbiology | Mitochondria/metabolism | Interleukin-1beta/biosynthesis | Macrophages/metabolism | Glycolysis/genetics | Macrophages/immunology | Cellular Biology | Bacteria/pathogenicity | Life Sciences | Cellular Reprogramming/drug effects | Mitochondria/drug effects | T-Lymphocytes/metabolism | T-Lymphocytes/drug effects | Oxidative Phosphorylation/drug effects | T-Lymphocytes/microbiology | Interleukin-1beta/immunology | T-Lymphocytes/immunology | Lipopolysaccharides/pharmacology | Mitochondria/microbiology | Mitochondria/immunology | Macrophages/drug effects
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2. Full Text IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice
by Petrasek, Jan and Bala, Shashi and Csak, Timea and Lippai, Dora and Kodys, Karen and Menashy, Victoria and Barrieau, Matthew and Min, So-Yun and Kurt-Jones, Evelyn A and Szabo, Gyongyi
The Journal of clinical investigation, ISSN 0021-9738, 10/2012, Volume 122, Issue 10, pp. 3476 - 3489
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Recombinant Proteins - therapeutic use | Kupffer Cells - pathology | Receptors, Interleukin-1 Type I - physiology | Ethanol - toxicity | NLR Family, Pyrin Domain-Containing 3 Protein | Hepatocytes - metabolism | Interleukin-1beta - blood | Fatty Liver, Alcoholic - drug therapy | Interleukin-1beta - toxicity | Female | Interleukin-1beta - biosynthesis | Caspase 1 - physiology | Drug Evaluation, Preclinical | Receptors, Interleukin-1 Type I - deficiency | Liver Cirrhosis - etiology | Interleukin-1beta - physiology | Liver Cirrhosis - prevention & control | Carrier Proteins - biosynthesis | Fatty Liver, Alcoholic - etiology | Mice, Inbred C57BL | Chemokine CCL2 - genetics | Interleukin-1alpha - blood | Mice, Knockout | Toll-Like Receptor 4 - physiology | Up-Regulation - drug effects | Carrier Proteins - genetics | Inflammasomes - physiology | Animals | Interleukin 1 Receptor Antagonist Protein - therapeutic use | Signal Transduction - drug effects | Chemokine CCL2 - biosynthesis | Interleukin-1alpha - biosynthesis | Mice | Physiological aspects | Interleukin-1 | Research | Index Medicus | Abridged Index Medicus
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3. Full Text Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats
by Pan, Ying and Chen, Xu-Yang and Zhang, Qing-Yu and Kong, Ling-Dong
Brain, behavior, and immunity, ISSN 0889-1591, 2014, Volume 41, Issue 1, pp. 90 - 100
Psychiatry | Allergy and Immunology | Depression | IL-1β-related CNS inflammation | Chronic unpredictable mild stress | Prefrontal cortex | NLRP3 inflammasome | Neurosciences | Immunology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Microglia - metabolism | Rats, Wistar | Sucrose | Depressive Disorder - pathology | NLR Family, Pyrin Domain-Containing 3 Protein | Nerve Tissue Proteins - analysis | Stress, Physiological | Depressive Disorder - drug therapy | Male | NF-kappa B - metabolism | Receptors, Cytoplasmic and Nuclear - biosynthesis | Interleukin-1beta - blood | Prefrontal Cortex - pathology | Nerve Tissue Proteins - biosynthesis | Microglia - pathology | Interleukin-1beta - biosynthesis | Fluoxetine - therapeutic use | Carrier Proteins | Interleukin-1beta - physiology | Nerve Tissue Proteins - physiology | Calcium-Binding Proteins - analysis | Gene Expression Regulation | Interleukin-1beta - cerebrospinal fluid | Microfilament Proteins - analysis | Rats | Anhedonia | Receptors, Cytoplasmic and Nuclear - physiology | Inflammation | Random Allocation | Depressive Disorder - metabolism | Drinking Behavior | Antidepressive Agents - therapeutic use | Inflammasomes - physiology | Animals | Receptors, Cytoplasmic and Nuclear - analysis | Prefrontal Cortex - metabolism | Enzyme Activation | Chronic Disease | Index Medicus
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4. Full Text Molecular Profiling Reveals a Tumor-Promoting Phenotype of Monocytes and Macrophages in Human Cancer Progression
by Chittezhath, Manesh and Dhillon, Manprit Kaur and Lim, Jyue Yuan and Laoui, Damya and Shalova, Irina N and Teo, Yi Ling and Chen, Jinmiao and Kamaraj, Revathy and Raman, Lata and Lum, Josephine and Thamboo, Thomas Paulraj and Chiong, Edmund and Zolezzi, Francesca and Yang, Henry and Van Ginderachter, Jo A and Poidinger, Michael and Wong, Alvin S.C and Biswas, Subhra K
Immunity (Cambridge, Mass.), ISSN 1074-7613, 11/2014, Volume 41, Issue 5, pp. 815 - 829
Life Sciences & Biomedicine | Immunology | Science & Technology | Neoplasm Transplantation | Humans | Receptors, Interleukin-1 - genetics | Neovascularization, Pathologic | Transplantation, Heterologous | Gene Expression Profiling | Monocytes - immunology | Interleukin-1beta - genetics | Transcription Factor RelA - genetics | Carcinoma, Renal Cell - immunology | Interleukin-1beta - biosynthesis | Interleukin 1 Receptor Antagonist Protein - pharmacology | Tumor Cells, Cultured | Macrophages - immunology | Cytokines - immunology | Interleukin-1beta - antagonists & inhibitors | Cell Proliferation - genetics | Receptors, Interleukin-1 - immunology | Interleukin-1beta - immunology | Inflammation - immunology | Myeloid Differentiation Factor 88 | Mice, SCID | Mice, Knockout | Animals | Mice | Receptors, Interleukin-1 - antagonists & inhibitors | Cytokines - biosynthesis | Yuan (China) | Analysis | Development and progression | Genetic aspects | Macrophages | Gene expression | Cancer | Medical research | Genotype & phenotype | Medical prognosis | Ligands | Principal components analysis | Metastasis | Kinases | Cancer therapies | Chemokines | Index Medicus
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5. Full Text Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
by Ridker, Paul M and Everett, Brendan M and Thuren, Tom and MacFadyen, Jean G and Chang, William H and Ballantyne, Christie and Fonseca, Francisco and Nicolau, Jose and Koenig, Wolfgang and Anker, Stefan D and Kastelein, John J.P and Cornel, Jan H and Pais, Prem and Pella, Daniel and Genest, Jacques and Cifkova, Renata and Lorenzatti, Alberto and Forster, Tamas and Kobalava, Zhanna and Vida-Simiti, Luminita and Flather, Marcus and Shimokawa, Hiroaki and Ogawa, Hisao and Dellborg, Mikael and Rossi, Paulo R.F and Troquay, Roland P.T and Libby, Peter and Glynn, Robert J and CANTOS Trial Grp and CANTOS Trial Group and Sahlgrenska akademin and Institute of Medicine and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Institutionen för medicin
The New England journal of medicine, ISSN 0028-4793, 09/2017, Volume 377, Issue 12, pp. 1119 - 1131
no | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Secondary Prevention | Infection - etiology | Incidence | Dose-Response Relationship, Drug | Anti-Inflammatory Agents - adverse effects | C-Reactive Protein - metabolism | Lipids - blood | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Anti-Inflammatory Agents - administration & dosage | Female | Neutropenia - chemically induced | Interleukin-1beta - antagonists & inhibitors | Stroke - prevention & control | Atherosclerosis - drug therapy | Double-Blind Method | Interleukin-1beta - immunology | Atherosclerosis - blood | Myocardial Infarction - drug therapy | Antibodies, Monoclonal - administration & dosage | Aged | Myocardial Infarction - prevention & control | Myocardial infarction | Cerebral infarction | Stroke | Heart attacks | C-reactive protein | Cytokines | Clinical trials | Cardiovascular disease | Innate immunity | Inflammation | Angina | Angina pectoris | Thrombosis | Cholesterol | Disease prevention | Proteins | Arteriosclerosis | Atherosclerosis | Cardiovascular diseases | Health risk assessment | Drug therapy | Drug dosages | Index Medicus | Abridged Index Medicus | Klinisk medicin | Clinical Medicine
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6. Full Text BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity
by Arts, Rob J.W and Moorlag, Simone J.C.F.M and Novakovic, Boris and Li, Yang and Wang, Shuang-Yin and Oosting, Marije and Kumar, Vinod and Xavier, Ramnik J and Wijmenga, Cisca and Joosten, Leo A.B and Reusken, Chantal B.E.M and Benn, Christine S and Aaby, Peter and Koopmans, Marion P and Stunnenberg, Hendrik G and van Crevel, Reinout and Netea, Mihai G
Cell host & microbe, ISSN 1931-3128, 01/2018, Volume 23, Issue 1, pp. 89 - 100.e5
monocytes | IL-1 | BCG | innate immune memory | yellow fever vaccine | trained immunity | epigenetics | non-specific effects of vaccines | Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Yellow Fever - prevention & control | Mycobacterium bovis - immunology | Virus Diseases - immunology | Humans | Vaccination | Interleukin-1beta - immunology | Male | Monocytes - immunology | Yellow fever virus - immunology | Interleukin-1beta - genetics | Interleukin-1beta - blood | Young Adult | Yellow Fever - virology | Epigenesis, Genetic - genetics | Viremia - prevention & control | BCG Vaccine - immunology | Polymorphism, Single Nucleotide - genetics | Adult | Cellular Reprogramming - genetics | Interferon-gamma - blood | Virus Diseases - prevention & control | Yellow Fever - immunology | Epigenetic inheritance | Tuberculosis vaccines | Cytokines | Genomics | BCG vaccines | Health aspects | Index Medicus
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7. Full Text Novel Role of IL (Interleukin)-1β in Neutrophil Extracellular Trap Formation and Abdominal Aortic Aneurysms
by Meher, Akshaya K and Spinosa, Michael and Davis, John P and Pope, Nicolas and Laubach, Victor E and Su, Gang and Serbulea, Vlad and Leitinger, Norbert and Ailawadi, Gorav and Upchurch, Gilbert R
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 02/2018, Volume 38, Issue 4, pp. 843 - 853
extracellular traps | aortic aneurysm | interleukin-1beta | neutrophils | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Aortic Aneurysm, Abdominal - prevention & control | Extracellular Traps - metabolism | Humans | Ornithine - analogs & derivatives | Interleukin-1beta - genetics | Aorta, Abdominal - drug effects | Interleukin-1beta - deficiency | Aortic Aneurysm, Abdominal - metabolism | Interleukin-1beta - metabolism | Extracellular Traps - drug effects | Membrane Proteins - metabolism | Aorta, Abdominal - pathology | Aorta, Abdominal - metabolism | Neutrophils - metabolism | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Neutrophils - pathology | Sphingosine N-Acyltransferase - metabolism | Ceramides - metabolism | Signal Transduction | Neutrophils - drug effects | Ornithine - pharmacology | Aortic Aneurysm, Abdominal - genetics | Image Processing, Computer-Assisted - methods | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Animals | Microscopy, Fluorescence - methods | Neutrophils - transplantation | Mice | Index Medicus
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