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1. Full Text NLRP3 inflammasome is expressed and functional in mouse brain microglia but not in astrocytes
by Gustin, Audrey and Kirchmeyer, Mélanie and Koncina, Eric and Felten, Paul and Losciuto, Sophie and Heurtaux, Tony and Tardivel, Aubry and Heuschling, Paul and Dostert, Catherine
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0130624 - e0130624
Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or protein aggregates. The brain resident macrophages, microglia,... 
INTERLEUKIN-1 | ACTIVATION | MOLECULAR PLATFORM | INHIBITION | DISTINCT PATHWAYS | NEUROINFLAMMATION | MULTIDISCIPLINARY SCIENCES | IL-1-BETA | MECHANISMS | RECEPTORS | NALP3 INFLAMMASOME | Microglia - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Peptide Fragments - toxicity | Caspase 1 - metabolism | Interleukin-1alpha - metabolism | alpha-Synuclein - pharmacology | Interleukin-1beta - metabolism | Interleukin-1beta - secretion | Microglia - cytology | Brain - cytology | Interleukin-1beta - analysis | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Caspase 1 - deficiency | Receptors, Purinergic P2X7 - metabolism | Mice | Interleukin-18 - metabolism | Astrocytes - metabolism | Cytokines | Health aspects | Nervous system diseases | Brain | Cell culture | Traumatic brain injury | Peptides | Aluminum sulfate | Homeostasis | Nervous system | Activation | Macrophages | Synuclein | Proteins | Rodents | Amyloid | Life sciences | Communication | Immune system | Neurodegenerative diseases | Secretion | Astrocytes | Inflammation | Trauma | Molecular chains | Microglia | Interleukin 18 | Mode of action | Neurological diseases | Nigericin | Brain research | Ligands | Alum | Laboratory animals | Alzheimers disease | Chemokines | Index Medicus
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2. Full Text IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice
by Petrasek, Jan and Bala, Shashi and Csak, Timea and Lippai, Dora and Kodys, Karen and Menashy, Victoria and Barrieau, Matthew and Min, So-Yun and Kurt-Jones, Evelyn A and Szabo, Gyongyi
Journal of Clinical Investigation, ISSN 0021-9738, 10/2012, Volume 122, Issue 10, pp. 3476 - 3489
Alcoholic liver disease (ALD) is characterized by steatosis and upregulation of proinflammatory cytokines, including IL-1 beta. IL-1 beta, type I IL-1 receptor... 
MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | RAT | METABOLISM | DISEASE | DOUBLE-BLIND | KUPFFER CELLS | NECROSIS-FACTOR-ALPHA | HUMAN MONOCYTES | INDUCED LIVER-INJURY | CYTOKINE SYNTHESIS | Recombinant Proteins - therapeutic use | Kupffer Cells - pathology | Receptors, Interleukin-1 Type I - physiology | Ethanol - toxicity | NLR Family, Pyrin Domain-Containing 3 Protein | Hepatocytes - metabolism | Interleukin-1beta - blood | Fatty Liver, Alcoholic - drug therapy | Interleukin-1beta - toxicity | Female | Interleukin-1beta - biosynthesis | Caspase 1 - physiology | Drug Evaluation, Preclinical | Receptors, Interleukin-1 Type I - deficiency | Liver Cirrhosis - etiology | Interleukin-1beta - physiology | Liver Cirrhosis - prevention & control | Carrier Proteins - biosynthesis | Fatty Liver, Alcoholic - etiology | Mice, Inbred C57BL | Chemokine CCL2 - genetics | Interleukin-1alpha - blood | Mice, Knockout | Toll-Like Receptor 4 - physiology | Up-Regulation - drug effects | Carrier Proteins - genetics | Inflammasomes - physiology | Animals | Interleukin 1 Receptor Antagonist Protein - therapeutic use | Signal Transduction - drug effects | Chemokine CCL2 - biosynthesis | Interleukin-1alpha - biosynthesis | Mice | Physiological aspects | Interleukin-1 | Research
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3. Full Text Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
by Ridker, Paul M and Everett, Brendan M and Thuren, Tom and MacFadyen, Jean G and Chang, William H and Ballantyne, Christie and Fonseca, Francisco and Nicolau, Jose and Koenig, Wolfgang and Anker, Stefan D and Kastelein, John J.P and Cornel, Jan H and Pais, Prem and Pella, Daniel and Genest, Jacques and Cifkova, Renata and Lorenzatti, Alberto and Forster, Tamas and Kobalava, Zhanna and Vida-Simiti, Luminita and Flather, Marcus and Shimokawa, Hiroaki and Ogawa, Hisao and Dellborg, Mikael and Rossi, Paulo R.F and Troquay, Roland P.T and Libby, Peter and Glynn, Robert J and CANTOS Trial Grp and CANTOS Trial Group and Sahlgrenska akademin and Institute of Medicine and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Institutionen för medicin
The New England Journal of Medicine, ISSN 0028-4793, 09/2017, Volume 377, Issue 12, pp. 1119 - 1131
Patients with myocardial infarction and a high-sensitivity CRP level of 2 mg or more per liter were assigned to one of three canakinumab doses or placebo. The... 
C-REACTIVE PROTEIN | MEDICINE, GENERAL & INTERNAL | HEART-DISEASE | MYOCARDIAL-INFARCTION | STATIN THERAPY | CLONAL HEMATOPOIESIS | INFLAMMATION | CARDIOVASCULAR-DISEASE | INTERLEUKIN-1-BETA INHIBITION | RISK | CORONARY-ARTERY-DISEASE | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Secondary Prevention | Infection - etiology | Incidence | Dose-Response Relationship, Drug | Anti-Inflammatory Agents - adverse effects | C-Reactive Protein - metabolism | Lipids - blood | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Anti-Inflammatory Agents - administration & dosage | Female | Neutropenia - chemically induced | Interleukin-1beta - antagonists & inhibitors | Stroke - prevention & control | Atherosclerosis - drug therapy | Double-Blind Method | Interleukin-1beta - immunology | Atherosclerosis - blood | Myocardial Infarction - drug therapy | Antibodies, Monoclonal - administration & dosage | Aged | Myocardial Infarction - prevention & control | Myocardial infarction | Cerebral infarction | Stroke | Heart attacks | C-reactive protein | Cytokines | Clinical trials | Cardiovascular disease | Innate immunity | Inflammation | Angina | Angina pectoris | Thrombosis | Cholesterol | Disease prevention | Proteins | Arteriosclerosis | Atherosclerosis | Cardiovascular diseases | Health risk assessment | Drug therapy | Drug dosages | Klinisk medicin | Clinical Medicine
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4. Full Text Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats
by Pan, Ying and Chen, Xu-Yang and Zhang, Qing-Yu and Kong, Ling-Dong
Brain, Behavior, and Immunity, ISSN 0889-1591, 2014, Volume 41, Issue 1, pp. 90 - 100
Abstract Depression is an inflammatory disorder. Pro-inflammatory cytokine interleukin-1 beta (IL-1β) may play a pivotal role in the central nervous system... 
Psychiatry | Allergy and Immunology | Depression | IL-1β-related CNS inflammation | Chronic unpredictable mild stress | Prefrontal cortex | NLRP3 inflammasome | ANTIDEPRESSANT | CHRONIC MILD STRESS | CYTOKINE LEVELS | MAJOR DEPRESSION | IMMUNOLOGY | IL-1 beta-related CNS inflammation | FLUOXETINE | NEUROSCIENCES | TOLL-LIKE | DISORDER | ALTERED EXPRESSION | PITUITARY-ADRENAL AXIS | BRAIN | Microglia - metabolism | Rats, Wistar | Sucrose | Depressive Disorder - pathology | NLR Family, Pyrin Domain-Containing 3 Protein | Nerve Tissue Proteins - analysis | Stress, Physiological | Depressive Disorder - drug therapy | Male | NF-kappa B - metabolism | Receptors, Cytoplasmic and Nuclear - biosynthesis | Interleukin-1beta - blood | Prefrontal Cortex - pathology | Nerve Tissue Proteins - biosynthesis | Microglia - pathology | Interleukin-1beta - biosynthesis | Fluoxetine - therapeutic use | Carrier Proteins | Interleukin-1beta - physiology | Nerve Tissue Proteins - physiology | Calcium-Binding Proteins - analysis | Gene Expression Regulation | Interleukin-1beta - cerebrospinal fluid | Microfilament Proteins - analysis | Rats | Anhedonia | Receptors, Cytoplasmic and Nuclear - physiology | Inflammation | Random Allocation | Depressive Disorder - metabolism | Drinking Behavior | Antidepressive Agents - therapeutic use | Inflammasomes - physiology | Animals | Receptors, Cytoplasmic and Nuclear - analysis | Prefrontal Cortex - metabolism | Enzyme Activation | Chronic Disease
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5. Full Text Th17 micro-milieu regulates NLRP1-dependent caspase-5 activity in skin autoinflammation
by Zwicker, Stephanie and Hattinger, Eva and Bureik, Daniela and Batycka-Baran, Aleksandra and Schmidt, Andreas and Gerber, Peter-Arne and Rothenfusser, Simon and Gilliet, Michel and Ruzicka, Thomas and Wolf, Ronald
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0175153
IL-1 beta is a potent player in cutaneous inflammation and central for the development of a Th17 micro-milieu in autoinflammatory diseases including psoriasis.... 
VITAMIN-D | SYSTEMIC-LUPUS-ERYTHEMATOSUS | INTERFERON-GAMMA | MULTIDISCIPLINARY SCIENCES | PSORIASIN S100A7 | INFLAMMATORY CASPASES | KERATINOCYTES | 1,25-DIHYDROXYVITAMIN D-3 | MOLECULAR-CLONING | EXPRESSION | T-CELLS | Caspases - immunology | Humans | Interleukin-17 - immunology | Interleukin-17 - pharmacology | Interleukin-1beta - genetics | S100 Proteins - immunology | Psoriasis - genetics | S100 Proteins - genetics | Th17 Cells - drug effects | Transfection | Inflammasomes - drug effects | Psoriasis - pathology | Adaptor Proteins, Signal Transducing - immunology | Apoptosis Regulatory Proteins - genetics | Skin - pathology | Skin - immunology | Th17 Cells - pathology | Interleukin-1beta - secretion | Psoriasis - immunology | S100 Calcium Binding Protein A7 | Apoptosis Regulatory Proteins - immunology | DNA - immunology | Signal Transduction | Caspases - genetics | Cells, Cultured | Gene Expression Regulation | Interleukin-17 - genetics | Interleukin-1beta - immunology | Vitamin D - pharmacology | Keratinocytes - cytology | Keratinocytes - immunology | DNA - genetics | Interleukin-17 - antagonists & inhibitors | Keratinocytes - drug effects | Inflammasomes - immunology | Adaptor Proteins, Signal Transducing - genetics | Th17 Cells - immunology | Interferon-gamma - pharmacology | Interleukins | Physiological aspects | Development and progression | Skin diseases | Genetic aspects | Inflammation | Research | Cell culture | Transcription | Interleukin | Helper cells | Lymphocytes T | Inflammatory diseases | Vitamin D | Lymphocytes | Interleukin 1 | Lesions | Deoxyribonucleic acid--DNA | Psoriasis | Cytokines | Dermatology | Keratinocytes | Caspase | Epidermis | Hazards | Gene expression | Caspase-5 | Hospitals | Biopsy | Interferon | Autoimmune diseases | Apoptosis | Deoxyribonucleic acid | DNA
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