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Journal Article
The New England journal of medicine, ISSN 1533-4406, 2009, Volume 360, Issue 23, pp. 2426 - 2437
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 3/2013, Volume 110, Issue 10, pp. 3913 - 3918
.... Here we chimerized two IL-1 receptor ligands, IL-1β and IL-1Ra, to create an optimized receptor antagonist, EBI-005, for topical ocular administration... 
Molecules | Receptors | Nervous system diseases | Ligands | Agonists | Eye diseases | Chimeras | Mikulicz disease | Thermal stability | Crystal structure | DRY-EYE DISEASE | IL-1 RECEPTOR ANTAGONIST | PROTEIN | OCULAR-SURFACE | CRYSTAL-STRUCTURE | INFLAMMATION | STABILITY | MULTIDISCIPLINARY SCIENCES | I INTERLEUKIN-1 RECEPTOR | IL-1-BETA | BINDING | Humans | Molecular Sequence Data | Crystallography, X-Ray | Interleukin 1 Receptor Antagonist Protein - genetics | Interleukin-1beta - genetics | Cytokines - chemistry | Recombinant Fusion Proteins - antagonists & inhibitors | Receptors, Interleukin-1 Type I - antagonists & inhibitors | Drug Design | Interleukin-1beta - chemistry | Ophthalmic Solutions | Receptors, Interleukin-1 Type I - chemistry | Female | Interleukin-1beta - antagonists & inhibitors | Amino Acid Sequence | Drug Stability | Mice, Inbred C57BL | Models, Molecular | Recombinant Fusion Proteins - chemistry | Static Electricity | Sequence Homology, Amino Acid | Animals | Interleukin 1 Receptor Antagonist Protein - antagonists & inhibitors | Receptors, Interleukin-1 Type I - genetics | Recombinant Fusion Proteins - genetics | Protein Conformation | Mice | Cytokines - antagonists & inhibitors | Kinetics | Interleukin 1 Receptor Antagonist Protein - chemistry | Administration, Topical | Antagonists (Biochemistry) | Research | Cytokines | Biological Sciences
Journal Article
PloS one, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e80873
Numerous studies have reported that inflammatory cytokines are important mediators for osteoclastogenesis, thereby causing excessive bone resorption and... 
REHMANNIA-GLUTINOSA | ACTIVATION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | RECEPTOR | DIFFERENTIATION | MOLECULAR-BASIS | CELL | MICE LACKING | OSTEOPOROSIS | BONE-RESORPTION | Interleukin-6 - antagonists & inhibitors | RANK Ligand - metabolism | Reactive Oxygen Species - metabolism | NF-kappa B - metabolism | Osteoclasts - cytology | Bone Marrow Cells - drug effects | Female | Cell Differentiation | Interleukin-1beta - biosynthesis | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-1beta - antagonists & inhibitors | Phenols - pharmacology | Proto-Oncogene Proteins c-fos - antagonists & inhibitors | Cell Survival - drug effects | Glucosides - pharmacology | NF-kappa B - antagonists & inhibitors | Ovariectomy | Signal Transduction | Bone Marrow Cells - cytology | NFATC Transcription Factors - metabolism | Gene Expression Regulation | Proto-Oncogene Proteins c-fos - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | Antioxidants - pharmacology | Macrophages - cytology | Osteoclasts - metabolism | Mice, Inbred ICR | Bone Resorption - prevention & control | RANK Ligand - genetics | Macrophages - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Animals | NF-kappa B - genetics | RANK Ligand - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Interleukin-6 - biosynthesis | Macrophages - drug effects | Proto-Oncogene Proteins c-fos - genetics | Mice | NFATC Transcription Factors - antagonists & inhibitors | Tumor Necrosis Factor-alpha - biosynthesis | Bone Marrow Cells - metabolism | Osteoclasts - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | NFATC Transcription Factors - genetics | Osteoprogenitor cells | Transcription factors | Phosphorylation | Interleukin | Arthritis | Activation | Kinases | Macrophages | Interleukin 6 | Antioxidants | Bone resorption | Osteoporosis | Bone growth | Bone marrow | Tumor necrosis factor-TNF | Biocompatibility | Inhibition | Pretreatment | Bone loss | TRANCE protein | c-Fos protein | NF-κB protein | Cytokines | c-Jun protein | Pharmacology | Inflammation | Dentistry | Tumor necrosis factor-α | Orthodontics | Medicine | Osteoclastogenesis | Stem cells | Ligands | Osteoclasts | Laboratory animals | Differentiation
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 07/2013, Volume 98, Issue 7, pp. 2783 - 2790
.... Evidence suggests that orbital susceptibility to TAO may involve IL-1, which is modulated by IL-1 receptor antagonists, designated secreted (sIL-1RA) and intracellular (icIL-1RA). Objective... 
CIGARETTE-SMOKING | PROTEIN | THYROTROPIN RECEPTOR | IFN-GAMMA | DISEASE | TISSUE | ENDOCRINOLOGY & METABOLISM | ENDOPEROXIDE H SYNTHASE-2 | IL-1-BETA | INDUCTION | GRAVES OPHTHALMOPATHY | Leukocytes - pathology | Fibroblasts - secretion | Antigens, CD34 - metabolism | Orbit - immunology | Graves Ophthalmopathy - surgery | Humans | Interleukin 1 Receptor Antagonist Protein - genetics | Interleukin-1alpha - metabolism | Orbit - surgery | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Cyclooxygenase 2 - biosynthesis | Leukocytes - immunology | Graves Ophthalmopathy - metabolism | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Interleukin 1 Receptor Antagonist Protein - metabolism | Cell Transdifferentiation | Interleukin 1 Receptor Antagonist Protein - secretion | Interleukin-1alpha - genetics | Interleukin-1beta - biosynthesis | Orbit - pathology | Fibroblasts - metabolism | Recombinant Proteins - metabolism | Promoter Regions, Genetic | Disease Susceptibility | Cells, Cultured | Gene Expression Regulation | Fibroblasts - pathology | RNA Stability | Graves Ophthalmopathy - immunology | Orbit - metabolism | Cyclooxygenase 2 - metabolism | Fibroblasts - immunology | Interleukin-1alpha - biosynthesis | Leukocytes - secretion | Graves Ophthalmopathy - pathology | Leukocytes - metabolism | Endocrine Research
Journal Article
British journal of nutrition, ISSN 0007-1145, 02/2014, Volume 111, Issue 3, pp. 415 - 423
Dietary redox-active/antioxidant phytochemicals may help control or mitigate the inflammatory response in chronic inflammatory bowel disease (IBD). In the... 
Full Papers | Molecular Nutrition | Indicaxanthin | Inflammatory bowel disease | Redox-active phytochemicals | Inflammation | In vitro models | NADPH Oxidases - chemistry | Betaxanthins - isolation & purification | Interleukin-6 - antagonists & inhibitors | Reactive Oxygen Species - metabolism | Enterocytes - metabolism | Antioxidants - metabolism | Humans | Inflammatory Bowel Diseases - immunology | NADPH Oxidases - metabolism | Cell Membrane Permeability | NF-kappa B - metabolism | Inflammatory Bowel Diseases - metabolism | Intestinal Absorption | Interleukin-1beta - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Inflammation Mediators - metabolism | Opuntia - chemistry | Inflammation Mediators - antagonists & inhibitors | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Interleukin-1beta - antagonists & inhibitors | NF-kappa B - agonists | Pyridines - isolation & purification | Pyridines - therapeutic use | Caco-2 Cells | NF-kappa B - antagonists & inhibitors | Fruit - chemistry | Cyclooxygenase 2 - chemistry | NADPH Oxidases - antagonists & inhibitors | Betaxanthins - metabolism | Interleukin-8 - antagonists & inhibitors | Inflammatory Bowel Diseases - diet therapy | Betaxanthins - therapeutic use | NADPH Oxidase 1 | Enterocytes - immunology | Antioxidants - therapeutic use | Reactive Oxygen Species - antagonists & inhibitors | Pyridines - metabolism | Antioxidants - isolation & purification | Cyclooxygenase 2 - metabolism | Enzyme Activation | Nitric Oxide Synthase Type II - metabolism
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 07/2013, Volume 98, Issue 7, pp. E1163 - E1172
...+1000 U/mL interferon-γ, or 50 μM H2O2) with or without 500 ng/mL IL-1 receptor antagonist (IL-1Ra) or 30–50 nM linagliptin. Results... 
APOPTOSIS | HUMAN PANCREATIC-ISLETS | METABOLIC SYNDROME | HYPERGLYCEMIA | ALPHA-CELLS | GLUCOSE | ENDOCRINOLOGY & METABOLISM | RECEPTOR EXPRESSION | RANDOMIZED CONTROLLED-TRIAL | BI 1356 | DIPEPTIDYL PEPTIDASE-IV | Palmitic Acid - metabolism | Dipeptidyl Peptidase 4 - metabolism | Antioxidants - chemistry | Dipeptidyl Peptidase 4 - chemistry | Humans | Interleukin 1 Receptor Antagonist Protein - genetics | Peptide Fragments - pharmacology | Interleukin-1beta - genetics | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Insulin-Secreting Cells - metabolism | Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors | Glucagon-Like Peptide 1 - agonists | Interleukin-1beta - metabolism | Interleukin 1 Receptor Antagonist Protein - metabolism | Purines - antagonists & inhibitors | Linagliptin | Interleukin 1 Receptor Antagonist Protein - pharmacology | Sitagliptin Phosphate | Insulin Secretion | Interleukin-1beta - antagonists & inhibitors | Recombinant Proteins - metabolism | Cell Survival - drug effects | Recombinant Proteins - antagonists & inhibitors | Cytokines - metabolism | Glucagon-Like Peptide 1 - metabolism | Purines - pharmacology | Tissue Culture Techniques | Dipeptidyl-Peptidase IV Inhibitors - chemistry | Glucagon-Like Peptide 1 - chemistry | Antioxidants - pharmacology | Recombinant Proteins - pharmacology | Insulin-Secreting Cells - immunology | Triazoles - pharmacology | Insulin - metabolism | Insulin-Secreting Cells - drug effects | Drug Inverse Agonism | Protein Stability - drug effects | Pyrazines - pharmacology | Quinazolines - pharmacology | Quinazolines - antagonists & inhibitors
Journal Article
Scientific reports, ISSN 2045-2322, 2016, Volume 6, Issue 1, p. 21931
.... Here we showed that the transient increase of interleukin-1 beta (IL-1 beta) after prolonged FS promoted adult seizure susceptibility, which was blocked by interleukin-1 receptor antagonist (IL-1Ra... 
CYTOKINES | HIPPOCAMPAL EXCITABILITY | STIMULATION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | THERAPEUTIC TIME WINDOW | CONVULSIONS | MODEL | BLOCKADE | CANNABINOIDS | PLASTICITY | RNA, Small Interfering - genetics | Lipoprotein Lipase - antagonists & inhibitors | Seizures - genetics | Humans | Interleukin 1 Receptor Antagonist Protein - genetics | Seizures - metabolism | Interleukin-1beta - genetics | Seizures, Febrile - pathology | Seizures - physiopathology | Seizures, Febrile - physiopathology | Seizures - pathology | Aging - genetics | Piperidines - pharmacology | Interleukin-1beta - metabolism | Interleukin 1 Receptor Antagonist Protein - metabolism | Seizures, Febrile - genetics | Cannabinoid Receptor Antagonists - pharmacology | Lipoprotein Lipase - metabolism | Interleukin-1beta - antagonists & inhibitors | Pyrazoles - pharmacology | Seizures, Febrile - metabolism | Signal Transduction | Lipoprotein Lipase - genetics | Tissue Culture Techniques | Gene Expression Regulation | Morpholines - pharmacology | Hippocampus - pathology | Cyclohexanones - pharmacology | Rats, Sprague-Dawley | Mice, Knockout | Naphthalenes - pharmacology | Hippocampus - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Interleukin 1 Receptor Antagonist Protein - antagonists & inhibitors | Benzoxazines - pharmacology | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | RNA, Small Interfering - metabolism
Journal Article
Journal Article