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Immunity, ISSN 1074-7613, 05/2013, Volume 38, Issue 5, pp. 1038 - 1049
Journal Article
Cell Metabolism, ISSN 1550-4131, 12/2013, Volume 18, Issue 6, pp. 844 - 859
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0130624 - e0130624
Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or protein aggregates. The brain resident macrophages, microglia,... 
INTERLEUKIN-1 | ACTIVATION | MOLECULAR PLATFORM | INHIBITION | DISTINCT PATHWAYS | NEUROINFLAMMATION | MULTIDISCIPLINARY SCIENCES | IL-1-BETA | MECHANISMS | RECEPTORS | NALP3 INFLAMMASOME | Microglia - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Peptide Fragments - toxicity | Caspase 1 - metabolism | Interleukin-1alpha - metabolism | alpha-Synuclein - pharmacology | Interleukin-1beta - metabolism | Interleukin-1beta - secretion | Microglia - cytology | Brain - cytology | Interleukin-1beta - analysis | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Caspase 1 - deficiency | Receptors, Purinergic P2X7 - metabolism | Mice | Interleukin-18 - metabolism | Astrocytes - metabolism | Cytokines | Health aspects | Nervous system diseases | Brain | Cell culture | Traumatic brain injury | Peptides | Aluminum sulfate | Homeostasis | Nervous system | Activation | Macrophages | Synuclein | Proteins | Rodents | Amyloid | Life sciences | Communication | Neurodegenerative diseases | Secretion | Astrocytes | Inflammation | Trauma | Molecular chains | Microglia | Interleukin 18 | Mode of action | Neurological diseases | Immune systems | Nigericin | Brain research | Ligands | Alum | Laboratory animals | Alzheimers disease | Chemokines | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 11/2012, Volume 16, Issue 5, pp. 625 - 633
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2011, Volume 186, Issue 11, pp. 6553 - 6561
Journal Article
Diabetes Care, ISSN 0149-5992, 04/2010, Volume 33, Issue 4, pp. 861 - 868
Journal Article
Nature, ISSN 0028-0836, 12/2012, Volume 491, Issue 7427, pp. 123 - 127
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2011, Volume 55, Issue 5, pp. 1086 - 1094
Journal Article
Cardiovascular Research, ISSN 0008-6363, 07/2013, Volume 99, Issue 1, pp. 164 - 174
Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) is considered necessary for initiating a profound sterile inflammatory... 
Heart | Myocardial infarction | Inflammasome | Ischaemia-reperfusion | IL-1β | Potassium - metabolism | Up-Regulation | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Male | NF-kappa B - metabolism | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Myocardial Reperfusion Injury - pathology | Time Factors | Interleukin-1beta - metabolism | Adenosine Triphosphate - metabolism | Myocardial Infarction - physiopathology | Toll-Like Receptors - metabolism | Myocardial Reperfusion Injury - genetics | Disease Models, Animal | Fibroblasts - metabolism | Myocardial Reperfusion Injury - immunology | Rats | Receptors, Cytoplasmic and Nuclear - genetics | Myocardial Infarction - metabolism | Myocardial Reperfusion Injury - physiopathology | Mice, Knockout | Fibroblasts - drug effects | Lipopolysaccharides - pharmacology | Fibroblasts - immunology | Heart Ventricles - metabolism | Mice | Interleukin-18 - genetics | Interleukin-18 - metabolism | Myocardial Reperfusion Injury - prevention & control | Heart Ventricles - drug effects | Receptors, Cytoplasmic and Nuclear - metabolism | Myocardial Infarction - genetics | Rats, Wistar | Ventricular Function, Left | Heart Ventricles - immunology | Myocardial Infarction - immunology | Cytoskeletal Proteins - deficiency | Myocardial Infarction - pathology | Heart Ventricles - pathology | Myocardial Contraction | Mice, Inbred C57BL | Cells, Cultured | Inflammasomes - genetics | Carrier Proteins - genetics | Myocardial Reperfusion Injury - metabolism | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Heart Ventricles - physiopathology | CARD Signaling Adaptor Proteins | Apoptosis | Index Medicus
Journal Article
Laboratory Investigation, ISSN 0023-6837, 05/2012, Volume 92, Issue 5, pp. 713 - 723
Non-alcoholic steatohepatitis (NASH) is typically associated with pro-apoptotic caspase activation. A potential role for pro-inflammatory caspases remains... 
Inflammasome | Inflammation | Caspases | Non-alcoholic fatty liver disease | Non-alcoholic steatohepatitis | Fibrosis | MEDICINE, RESEARCH & EXPERIMENTAL | POPULATION | APOPTOSIS | non-alcoholic fatty liver disease | MICE DEFICIENT | FATTY LIVER-DISEASE | INJURY | NONALCOHOLIC STEATOHEPATITIS | MODEL | PATHOLOGY | inflammation | inflammasome | fibrosis | caspases | HEPATIC STEATOSIS | non-alcoholic steatohepatitis | Tumor Necrosis Factor-alpha - metabolism | Liver - pathology | Clodronic Acid - pharmacology | Fatty Liver - pathology | Actins - metabolism | Caspase 3 - metabolism | Hepatic Stellate Cells - metabolism | Caspase 1 - metabolism | Choline Deficiency - complications | Hepatocytes - pathology | Hepatocytes - metabolism | Fatty Liver - chemically induced | LIM Domain Proteins - metabolism | Liver Cirrhosis - chemically induced | Inflammation - metabolism | Caspase 3 - blood | Interleukin-1beta - metabolism | Choline Deficiency - metabolism | Liver Cirrhosis - metabolism | Muscle Proteins - metabolism | Antigens, Differentiation - metabolism | Kupffer Cells - metabolism | Hepatic Stellate Cells - pathology | Methionine - deficiency | Collagen Type I - metabolism | Fatty Liver - metabolism | Liver - metabolism | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Choline Deficiency - pathology | Kupffer Cells - drug effects | Mice, Knockout | Animals | Caspase 1 - genetics | Caspase 1 - deficiency | Liver Cirrhosis - pathology | Mice | Transforming Growth Factor beta - metabolism | Index Medicus | Nonalcoholic fatty liver disease (NAFLD) | nonalcoholic steatohepatitis (NASH)
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 08/2009, Volume 5, Issue 8, pp. e1000559 - e1000559
The intraerythrocytic parasite Plasmodium-the causative agent of malaria-produces an inorganic crystal called hemozoin (Hz) during the heme detoxification... 
APOPTOSIS | INNATE IMMUNE RECEPTORS | INTERLEUKIN-1-BETA | MACROPHAGES | CASPASE-1 INFLAMMASOME | MICROBIOLOGY | KAPPA-B | NALP3 INFLAMMASOME | RESPONSES | VIROLOGY | IN-VIVO | MICE | PARASITOLOGY | Potassium - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Humans | Caspase 1 - metabolism | Male | Caspase 1 - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Hemeproteins - immunology | Signal Transduction - immunology | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | src-Family Kinases - metabolism | Cytoskeletal Proteins - metabolism | Female | Interleukin-1beta - biosynthesis | Phosphorylation - immunology | Malaria - metabolism | Syk Kinase | Carrier Proteins - immunology | Disease Models, Animal | Neutrophil Infiltration - immunology | Calcium-Binding Proteins - metabolism | Carrier Proteins - physiology | Apoptosis Regulatory Proteins - immunology | Plasmodium chabaudi - chemistry | Hemeproteins - metabolism | Malaria - immunology | Mice, Inbred C57BL | Cathepsin B - metabolism | Inflammation - immunology | Plasmodium chabaudi - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Malaria - parasitology | Proteomics | HSP90 Heat-Shock Proteins - metabolism | Hemeproteins - physiology | Mice | Phagocytosis | Hostages | Inflammation | Malaria | Phosphotransferases | Index Medicus | Medical research | Salmonella | Phosphorylation | Lipids | Parasites | Experiments | Fever | Tropical diseases
Journal Article