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Cell metabolism, ISSN 1550-4131, 2012, Volume 16, Issue 5, pp. 625 - 633
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 6, pp. e0130624 - e0130624
Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or protein aggregates. The brain resident macrophages, microglia,... 
INTERLEUKIN-1 | ACTIVATION | MOLECULAR PLATFORM | INHIBITION | DISTINCT PATHWAYS | NEUROINFLAMMATION | MULTIDISCIPLINARY SCIENCES | IL-1-BETA | MECHANISMS | RECEPTORS | NALP3 INFLAMMASOME | Microglia - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Peptide Fragments - toxicity | Caspase 1 - metabolism | Interleukin-1alpha - metabolism | alpha-Synuclein - pharmacology | Interleukin-1beta - metabolism | Interleukin-1beta - secretion | Microglia - cytology | Brain - cytology | Interleukin-1beta - analysis | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Caspase 1 - deficiency | Receptors, Purinergic P2X7 - metabolism | Mice | Interleukin-18 - metabolism | Astrocytes - metabolism | Cytokines | Health aspects | Nervous system diseases | Brain | Cell culture | Traumatic brain injury | Peptides | Aluminum sulfate | Homeostasis | Nervous system | Activation | Macrophages | Synuclein | Proteins | Rodents | Amyloid | Life sciences | Communication | Immune system | Neurodegenerative diseases | Astrocytes | Inflammation | Trauma | Molecular chains | Microglia | Interleukin 18 | Mode of action | Neurological diseases | Nigericin | Brain research | Ligands | Alum | Laboratory animals | Alzheimers disease | Chemokines | Index Medicus
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 5, p. e36949
Many molecular and cellular abnormalities detected in the diabetic retina support a role for IL-1 beta-driven neuroinflammation in the pathogenesis of diabetic... 
ADHESION MOLECULE-1 | PROTEIN-KINASE-C | MICROGLIAL ACTIVATION | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | GENE-EXPRESSION | RETINOPATHY | INDUCTION | INTERLEUKIN-1 INDUCES INTERLEUKIN-1 | MULLER CELLS | BRAIN | Microglia - metabolism | Up-Regulation | Retina - metabolism | Rats, Wistar | Diabetes Mellitus, Experimental - genetics | Male | Interleukin-1beta - genetics | Glial Fibrillary Acidic Protein - metabolism | Hyperglycemia - genetics | Glucose - administration & dosage | Interleukin-1beta - metabolism | Protein Kinase C - metabolism | Diabetes Mellitus, Experimental - metabolism | Interleukin-1beta - antagonists & inhibitors | Retinal Vessels - metabolism | Endothelial Cells - metabolism | Rats | Protein Kinase C - antagonists & inhibitors | Random Allocation | Rats, Sprague-Dawley | Diabetic Retinopathy - metabolism | Diabetic Retinopathy - genetics | Hyperglycemia - metabolism | alpha-Macroglobulins - metabolism | Animals | Endothelium - metabolism | Ceruloplasmin - metabolism | Glucose - metabolism | Neuroglia - metabolism | Astrocytes - metabolism | Ceruloplasmin | Diabetic retinopathy | Protein kinase C | Retinopathy | Pathogenesis | Streptozocin | Retina | Immunoblotting | Glucose | Hyperglycemia | Ischemia | Rodents | Enzyme-linked immunosorbent assay | Enzymes | Cytokines | Astrocytes | Abnormalities | Diabetes mellitus | Blood vessels | Inflammation | IL-1β | Endothelial cells | Endothelium | Microglia | Polymerase chain reaction | Brain research | Diabetes | Glia | Laboratory animals | Subcultures | Apoptosis
Journal Article
Diabetes care, ISSN 1935-5548, 2010, Volume 33, Issue 4, pp. 861 - 868
Journal Article
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2011, Volume 55, Issue 5, pp. 1086 - 1094
... liver diseases [3,4] . These cytokines are produced in the liver by Kupffer cells and hepatocytes, playing roles in lipid metabolism and hepatic inflammation [5–7... 
Gastroenterology and Hepatology | Fatty liver | Cytokines | IL-1 | Steatohepatitis | Inflammation | Mouse model | Lipid metabolism | OXIDATIVE STRESS | PRECURSOR | IL-1-ALPHA | IL-1 RECEPTOR ANTAGONIST | TNF-ALPHA | GASTROENTEROLOGY & HEPATOLOGY | HEPATIC STEATOSIS | EXPRESSION | PROGRESSION | Tumor Necrosis Factor-alpha - metabolism | Interleukin-1 - genetics | Fatty Liver - pathology | P-Selectin - metabolism | Tumor Necrosis Factor-alpha - genetics | Interleukin-1alpha - metabolism | Male | Chemokine CXCL1 - genetics | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Interleukin-1beta - deficiency | Matrix Metalloproteinase 9 - metabolism | Interleukin-1beta - metabolism | Matrix Metalloproteinase 9 - genetics | Hepatitis - metabolism | Liver Cirrhosis - metabolism | Collagen - genetics | Interleukin-1alpha - genetics | Chemokine CXCL1 - metabolism | Interleukin-1 - metabolism | Gene Expression | Fatty Liver - metabolism | Serum Amyloid A Protein - metabolism | Mice, Inbred C57BL | Hepatitis - pathology | P-Selectin - genetics | Disease Progression | Mice, Knockout | Collagen - metabolism | Diet, Atherogenic | Animals | Transforming Growth Factor beta - genetics | Analysis of Variance | Interleukin-1alpha - deficiency | Liver Cirrhosis - pathology | Hypercholesterolemia - complications | Mice | Transforming Growth Factor beta - metabolism
Journal Article
Gastroenterology, ISSN 0016-5085, 2012, Volume 143, Issue 5, pp. 1158 - 1172
Journal Article
Laboratory investigation, ISSN 1530-0307, 2012, Volume 92, Issue 5, pp. 713 - 723
Non-alcoholic steatohepatitis (NASH) is typically associated with pro-apoptotic caspase activation. A potential role for pro-inflammatory caspases remains... 
Inflammasome | Inflammation | Caspases | Non-alcoholic fatty liver disease | Non-alcoholic steatohepatitis | Fibrosis | MEDICINE, RESEARCH & EXPERIMENTAL | POPULATION | APOPTOSIS | non-alcoholic fatty liver disease | MICE DEFICIENT | FATTY LIVER-DISEASE | INJURY | NONALCOHOLIC STEATOHEPATITIS | MODEL | PATHOLOGY | inflammation | inflammasome | fibrosis | caspases | HEPATIC STEATOSIS | non-alcoholic steatohepatitis | Tumor Necrosis Factor-alpha - metabolism | Liver - pathology | Clodronic Acid - pharmacology | Fatty Liver - pathology | Actins - metabolism | Caspase 3 - metabolism | Hepatic Stellate Cells - metabolism | Caspase 1 - metabolism | Choline Deficiency - complications | Hepatocytes - pathology | Hepatocytes - metabolism | Fatty Liver - chemically induced | LIM Domain Proteins - metabolism | Liver Cirrhosis - chemically induced | Inflammation - metabolism | Caspase 3 - blood | Interleukin-1beta - metabolism | Choline Deficiency - metabolism | Liver Cirrhosis - metabolism | Muscle Proteins - metabolism | Antigens, Differentiation - metabolism | Kupffer Cells - metabolism | Hepatic Stellate Cells - pathology | Methionine - deficiency | Collagen Type I - metabolism | Fatty Liver - metabolism | Liver - metabolism | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Choline Deficiency - pathology | Kupffer Cells - drug effects | Mice, Knockout | Animals | Caspase 1 - genetics | Caspase 1 - deficiency | Liver Cirrhosis - pathology | Mice | Transforming Growth Factor beta - metabolism | Nonalcoholic fatty liver disease (NAFLD) | nonalcoholic steatohepatitis (NASH)
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 469, Issue 7329, pp. 221 - 225
Journal Article