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Journal of Neurochemistry, ISSN 0022-3042, 09/2011, Volume 118, Issue 5, pp. 826 - 840
Inflammation contributes to neurodegeneration in post-ischemic brain, diabetes, and Alzheimer's disease. Participants in this inflammatory response include... 
gap junctions | Alzheimer’s disease | amyloid β‐peptide | cytokines | diabetes mellitus | pannexin | stroke | connexin | amyloid β-peptide | Alzheimer's disease | BRAIN-INJURY | GAP JUNCTIONAL COMMUNICATION | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYLOID PLAQUES | ASTROCYTES | NEUROTOXICITY | NEUROSCIENCES | BETA | IN-VIVO | CHANNELS | RECEPTORS | amyloid beta-peptide | Tumor Necrosis Factor-alpha - metabolism | Oxygen - pharmacology | Cell Hypoxia - physiology | Amyloid beta-Peptides - pharmacology | Microtubule-Associated Proteins - pharmacology | Culture Media, Conditioned - pharmacology | Lanthanum - pharmacology | Peptide Fragments - pharmacology | Cerebral Cortex - cytology | Adenosine Triphosphate - pharmacology | Time Factors | Interleukin-1beta - metabolism | Adenosine Triphosphate - metabolism | Neuropeptides - pharmacology | Nerve Tissue Proteins - pharmacology | Neurons - physiology | Astrocytes - chemistry | Female | Cell Death - drug effects | Connexins - pharmacology | Neurons - drug effects | Animals, Newborn | Astrocytes - drug effects | Cell Hypoxia - drug effects | Connexin 43 - metabolism | Glutamic Acid - pharmacology | Cells, Cultured | Fluoresceins | Coculture Techniques - methods | Connexin 43 - deficiency | Connexins - metabolism | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Biotinylation - methods | Glutamic Acid - metabolism | Mice | Astrocytes - metabolism | Methyl aspartate | Neurosciences | Peptides | Neurons | Diabetes | Glucose | Glutamate | Dextrose | Index Medicus
Journal Article
International Journal of Oncology, ISSN 1019-6439, 12/2013, Volume 43, Issue 6, pp. 1787 - 1798
The highly aggressive adult sarcomas are characterized by high levels of matrix metalloproteinase (MMP)-2 and -9, which play crucial roles in tumor invasion... 
synovial sarcoma | inhibitors | inducers | chondrosarcoma | cytokines | matrix metalloproteinases | liposarcoma | fibrosarcoma | Chondrosarcoma | Inhibitors | Matrix metalloproteinases | Cytokines | Synovial sarcoma | Liposarcoma | Fibrosarcoma | Inducers | CANCER-CELLS | VITAMIN-C | TUMOR INVASION | ASCORBIC-ACID | GREEN TEA | ONCOLOGY | NUTRIENT MIXTURE | SERUM-LEVELS | SOFT-TISSUE SARCOMA | ENDOTHELIAL GROWTH-FACTOR | Interleukin-1beta - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Humans | Fibrosarcoma - metabolism | Liposarcoma - metabolism | Matrix Metalloproteinase 9 - metabolism | Carcinogens - pharmacology | Dexamethasone - pharmacology | Antineoplastic Agents - pharmacology | Catechin - pharmacology | Matrix Metalloproteinase 2 - biosynthesis | Tretinoin - pharmacology | Matrix Metalloproteinase 9 - biosynthesis | Anti-Inflammatory Agents - pharmacology | Matrix Metalloproteinase 2 - metabolism | Sarcoma, Synovial - metabolism | Antioxidants - pharmacology | Sarcoma - metabolism | Matrix Metalloproteinase Inhibitors - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Chondrosarcoma - metabolism | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Doxycycline - pharmacology | Anti-Bacterial Agents - pharmacology | Catechin - analogs & derivatives | Dactinomycin - pharmacology | Studies | Tea | Cell growth | Medical prognosis | Collagen | Penicillin | Tumor necrosis factor-TNF | Physiology | Metastasis | Growth factors | Cancer
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 08/2011, Volume 163, Issue 7, pp. 1533 - 1549
BACKGROUND AND PURPOSE Endocannabinoids have both anti‐inflammatory and neuroprotective properties against harmful stimuli. We previously demonstrated that the... 
monoacylglycerol lipase | peroxisome proliferator‐activated receptor‐γ | nuclear factor κ‐B | endocannabinoids | neuroinflammation | cyclooxygenase‐2 | nuclear factor κ-B | peroxisome proliferator-activated receptor-γ | cyclooxygenase-2 | CB1 CANNABINOID RECEPTORS | 2-ARACHIDONYL GLYCEROL | NUCLEAR RECEPTORS | SYNAPTIC-TRANSMISSION | MICROGLIAL CELLS | KAPPA-B | OXIDATIVE-METABOLISM | peroxisome proliferator-activated receptor-gamma | PROTECTS NEURONS | nuclear factor kappa-B | ACTIVATED-RECEPTOR-GAMMA | PHARMACOLOGY & PHARMACY | Cannabinoid Receptor Modulators - pharmacology | Interleukin-1beta - pharmacology | Monoacylglycerol Lipases - antagonists & inhibitors | NF-kappa B - metabolism | Hippocampus - drug effects | PPAR gamma - metabolism | Excitatory Postsynaptic Potentials - drug effects | Cyclooxygenase 2 - biosynthesis | Inflammation - metabolism | Biphenyl Compounds - pharmacology | Piperidines - pharmacology | Cyclooxygenase 2 - genetics | Prostaglandin D2 - analogs & derivatives | Synaptic Transmission - drug effects | Neurons - metabolism | Phosphorylation - drug effects | Neurons - drug effects | Thiazolidinediones - pharmacology | Endocannabinoids | PPAR gamma - genetics | NF-kappa B - antagonists & inhibitors | Cyclooxygenase 2 Inhibitors - pharmacology | Cells, Cultured | Arachidonic Acids - pharmacology | Hippocampus - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Glycerides - pharmacology | Animals | PPAR gamma - antagonists & inhibitors | Signal Transduction - drug effects | Anilides - pharmacology | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | PPAR gamma - agonists | Mice | Prostaglandin D2 - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Benzodioxoles - pharmacology | Research Papers
Journal Article
Oncology Reports, ISSN 1021-335X, 03/2017, Volume 37, Issue 3, pp. 1907 - 1913
Brain tumors are highly aggressive, characterized by the secretion of high levels of matrix metalloproteinase (MMP)-2 and MMP-9 that degrade the extracellular... 
Inhibitors | Matrix metalloproteinases | Cytokines | Glioblastoma T-98G | Inducers | VITAMIN-C | GLIOMA-CELLS | inhibitors | CANCER-RELATED INFLAMMATION | glioblastoma T-98G | N-ACETYLCYSTEINE | LINES | GREEN TEA | BRAIN-TUMOR | IN-VITRO | ONCOLOGY | inducers | GROWTH | cytokines | matrix metalloproteinases | TUMOR MICROENVIRONMENT | Enzyme Activators - pharmacology | Gene Expression Regulation, Enzymologic - drug effects | Glioblastoma - enzymology | Interleukin-1beta - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Humans | Carcinogens - pharmacology | Cattle | Matrix Metalloproteinase 9 - secretion | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Catechin - pharmacology | Tretinoin - pharmacology | Antioxidants - pharmacology | Matrix Metalloproteinase Inhibitors - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Animals | Glioblastoma - pathology | Lipopolysaccharides - pharmacology | Doxycycline - pharmacology | Matrix Metalloproteinase 2 - secretion | Anti-Bacterial Agents - pharmacology | Catechin - analogs & derivatives | Glioblastoma - drug therapy | Cytokines - pharmacology | Enzymes | Care and treatment | Proteases | Development and progression | Genetic aspects | Regulation | Health aspects | Glioblastoma multiforme | Angiogenesis | Acids | Collagen | Brain cancer | Penicillin | Tumor necrosis factor-TNF | Nervous system | Metastasis | Cancer therapies | Tumors | Apoptosis | Index Medicus
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 07/2013, Volume 98, Issue 7, pp. E1163 - E1172
Context: Inhibition of dipeptidyl peptidase-4 (DPP-4) is a potent strategy to increase glucose-dependent insulinotropic polypeptide and glucagon like peptide 1... 
APOPTOSIS | HUMAN PANCREATIC-ISLETS | METABOLIC SYNDROME | HYPERGLYCEMIA | ALPHA-CELLS | GLUCOSE | ENDOCRINOLOGY & METABOLISM | RECEPTOR EXPRESSION | RANDOMIZED CONTROLLED-TRIAL | BI 1356 | DIPEPTIDYL PEPTIDASE-IV | Palmitic Acid - metabolism | Dipeptidyl Peptidase 4 - metabolism | Antioxidants - chemistry | Dipeptidyl Peptidase 4 - chemistry | Humans | Interleukin 1 Receptor Antagonist Protein - genetics | Peptide Fragments - pharmacology | Interleukin-1beta - genetics | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Insulin-Secreting Cells - metabolism | Anti-Inflammatory Agents, Non-Steroidal - antagonists & inhibitors | Glucagon-Like Peptide 1 - agonists | Interleukin-1beta - metabolism | Interleukin 1 Receptor Antagonist Protein - metabolism | Purines - antagonists & inhibitors | Linagliptin | Interleukin 1 Receptor Antagonist Protein - pharmacology | Sitagliptin Phosphate | Insulin Secretion | Interleukin-1beta - antagonists & inhibitors | Recombinant Proteins - metabolism | Cell Survival - drug effects | Recombinant Proteins - antagonists & inhibitors | Cytokines - metabolism | Glucagon-Like Peptide 1 - metabolism | Purines - pharmacology | Tissue Culture Techniques | Dipeptidyl-Peptidase IV Inhibitors - chemistry | Glucagon-Like Peptide 1 - chemistry | Antioxidants - pharmacology | Recombinant Proteins - pharmacology | Insulin-Secreting Cells - immunology | Triazoles - pharmacology | Insulin - metabolism | Insulin-Secreting Cells - drug effects | Drug Inverse Agonism | Protein Stability - drug effects | Pyrazines - pharmacology | Quinazolines - pharmacology | Quinazolines - antagonists & inhibitors
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 03/2016, Volume 75, Issue 3, pp. 593 - 600
Journal Article
Nature Communications, ISSN 2041-1723, 02/2016, Volume 7, Issue 1, pp. 10760 - 10760
Tityus serrulatus sting causes thousands of deaths annually worldwide. T. serrulatus-envenomed victims exhibit local or systemic reaction that culminates in... 
Interleukin-1beta - drug effects | Receptors, Prostaglandin E, EP4 Subtype - immunology | Arachidonate 5-Lipoxygenase - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | NF-kappa B - immunology | Xanthones - pharmacology | Dinoprostone - immunology | Scorpion Stings - immunology | Receptors, Prostaglandin E, EP2 Subtype - drug effects | Scorpion Stings - mortality | Scorpions | Phosphoproteins | Indoles - pharmacology | Prostaglandin Antagonists - pharmacology | Macrophages, Peritoneal - drug effects | Carrier Proteins - immunology | Cyclic AMP-Dependent Protein Kinases - drug effects | Macrophages - immunology | Receptors, Prostaglandin E, EP4 Subtype - drug effects | Dinoprostone - pharmacology | Interleukin-1beta - immunology | Macrophages, Peritoneal - immunology | Celecoxib - pharmacology | Leukotriene B4 - immunology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Mice, Knockout | Leukotriene B4 - pharmacology | Scorpion Venoms - pharmacology | Carrier Proteins - genetics | Animals | Receptors, Prostaglandin E, EP2 Subtype - immunology | Cyclic AMP-Dependent Protein Kinases - immunology | Cyclic AMP - immunology | Inflammasomes - immunology | Macrophages - drug effects | Mice | In Vitro Techniques | Lipoxygenase Inhibitors - pharmacology | NF-kappa B - drug effects | Index Medicus
Journal Article
Oncology Reports, ISSN 1021-335X, 03/2017, Volume 37, Issue 3, pp. 1842 - 1848
Acute myeloid leukemia and head and neck squamous cell carcinomas are the major causes of mortality and morbidity in Fanconi anemia (FA) patients. Matrix... 
Fanconi anemia fibroblasts | Inhibitors | Matrix metalloproteinases | Cytokines | Inducers | VITAMIN-C | inhibitors | TUMOR INVASION | STRAND BREAK REPAIR | METASTASIS | CARCINOMA CELLS | N-ACETYLCYSTEINE | GREEN TEA | IN-VITRO | ONCOLOGY | inducers | CANCER-CELL LINES | cytokines | matrix metalloproteinases | EXPRESSION | Enzyme Activators - pharmacology | Gene Expression Regulation, Enzymologic - drug effects | Fibroblasts - enzymology | Interleukin-1beta - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Humans | Carcinogens - pharmacology | Cattle | Fanconi Anemia - enzymology | Fanconi Anemia - pathology | Matrix Metalloproteinase 9 - secretion | Antineoplastic Agents - pharmacology | Catechin - pharmacology | Tretinoin - pharmacology | Cells, Cultured | Antioxidants - pharmacology | Fibroblasts - pathology | Matrix Metalloproteinase Inhibitors - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Animals | Fibroblasts - drug effects | Lipopolysaccharides - pharmacology | Doxycycline - pharmacology | Matrix Metalloproteinase 2 - secretion | Anti-Bacterial Agents - pharmacology | Catechin - analogs & derivatives | Fanconi Anemia - drug therapy | Cytokines - pharmacology | Care and treatment | Proteases | Development and progression | Genetic aspects | Health aspects | Fanconi's anemia | Tea | Acids | Anemia | Penicillin | Fibroblasts | Tumor necrosis factor-TNF | Metastasis | Cancer | Index Medicus
Journal Article
Journal of Neuroimmunology, ISSN 0165-5728, 2012, Volume 254, Issue 1, pp. 10 - 18
Journal Article
Immunology, ISSN 0019-2805, 07/2010, Volume 130, Issue 3, pp. 399 - 409
Calcitonin gene‐related peptide (CGRP) is widely distributed and plays important roles in a wide array of biological functions. It is enriched in primary... 
cytokine | macrophage | chemokine | enzyme‐linked immunosorbent assay | neuropeptide | Chemokine | Neuropeptide | Enzyme-linked immunosorbent assay | Cytokine | Macrophage | TRIGEMINAL GANGLION | ALVEOLAR EPITHELIAL-CELLS | NECROSIS-FACTOR-ALPHA | ADRENOMEDULLIN RECEPTORS | IMMUNOLOGY | RAT SENSORY NEURONS | HUMAN MONOCYTES | CYTOKINE PRODUCTION | enzyme-linked immunosorbent assay | RECEPTOR-LIKE RECEPTOR | NF-KAPPA-B | ACTIVITY-MODIFYING PROTEIN-1 | Interleukin-6 - antagonists & inhibitors | Nitriles - pharmacology | Receptor, trkA - antagonists & inhibitors | Receptor, trkA - immunology | Intracellular Signaling Peptides and Proteins - immunology | Peptide Fragments - pharmacology | Calcitonin Receptor-Like Protein | Nitrobenzenes - pharmacology | Sulfones - pharmacology | Nerve Growth Factor - antagonists & inhibitors | I-kappa B Proteins - antagonists & inhibitors | Receptors, Calcitonin - antagonists & inhibitors | Antibodies - immunology | Toll-Like Receptor 4 - agonists | Calcitonin Gene-Related Peptide - metabolism | Interleukin-1beta - antagonists & inhibitors | Cell Line | Dinoprostone - pharmacology | Cyclooxygenase 2 Inhibitors - pharmacology | Cytokines - metabolism | Calcitonin Gene-Related Peptide - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Interleukin-1beta - immunology | Membrane Proteins - immunology | Sulfonamides - pharmacology | Piperazines - pharmacology | Cycloheximide - pharmacology | Antibodies - pharmacology | Macrophages - metabolism | Animals | Receptors, Calcitonin - immunology | Membrane Proteins - antagonists & inhibitors | Interleukin-6 - immunology | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Receptor Activity-Modifying Proteins | Chemokines - metabolism | Mice | Kinetics | Quinazolines - pharmacology | Dactinomycin - pharmacology | Peptides | Immunotherapy | Prostaglandins E | Nerve growth factor | Inflammation | Macrophages | Mitogens | Cytokines | Rodents | Immune system | Original
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 03/2015, Volume 750, pp. 141 - 150
Osteoarthritis is a progressive joint disease and a major cause of disability for which no curative therapies are yet available. To identify compounds with... 
NF-κB | MAPK | Chronic inflammation | Natural products | Osteoarthritis | CYTOKINES | ESSENTIAL OILS | CHONDROCYTES | KAPPA-B | AP-1 | CARTILAGE | NF-kappa B | GENE-EXPRESSION | NITRIC-OXIDE | DEGRADATION | PHARMACOLOGY & PHARMACY | EXTRACT | Gene Expression Regulation, Enzymologic - drug effects | Interleukin-1beta - pharmacology | Humans | Middle Aged | Extracellular Matrix - metabolism | NF-kappa B - metabolism | Terpenes - pharmacology | Young Adult | Chondrocytes - drug effects | Monoterpenes - pharmacology | Anabolic Agents - pharmacology | Collagen Type I - genetics | Adult | Osteoarthritis - pathology | Chondrocytes - metabolism | Matrix Metalloproteinase 1 - genetics | Interleukin-1beta - antagonists & inhibitors | Tissue Inhibitor of Metalloproteinase-3 - genetics | Nitric Oxide - biosynthesis | Anti-Inflammatory Agents - pharmacology | Extracellular Matrix - drug effects | Matrix Metalloproteinase 13 - genetics | Enzyme Activation - drug effects | Aggrecans - genetics | Collagen Type II - genetics | Chondrocytes - enzymology | Tissue Inhibitor of Metalloproteinase-1 - genetics | Nitric Oxide Synthase Type II - genetics | Cyclohexenes - pharmacology | Aged | Sesquiterpenes - pharmacology | Alkenes - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Neurosciences | Anti-inflammatory drugs | Collagen | Analysis | Nitric oxide | Pharmacy | Drugstores | Cells
Journal Article