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PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, pp. e0179431 - e0179431
Cytokines are potent immune modulating agents but are not ideal medicines in their natural form due to their short half-life and pleiotropic systemic effects.... 
LIGAND-BINDING | ALPHA-RECEPTOR | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | COMPLEXES | REGULATORY T-CELLS | MODULATION THERAPIES | IL-2 | CYTOKINE | HIGH-DOSE INTERLEUKIN-2 | RENAL-CELL CARCINOMA | Neoplasms - metabolism | T-Lymphocytes, Regulatory - metabolism | Immunotherapy - methods | Interleukin-2 Receptor beta Subunit - metabolism | Interleukin Receptor Common gamma Subunit - metabolism | Transplantation, Homologous | T-Lymphocytes, Regulatory - immunology | STAT5 Transcription Factor - metabolism | Neoplasms - therapy | Interleukin Receptor Common gamma Subunit - agonists | CD8-Positive T-Lymphocytes - metabolism | Female | Interleukin-2 - analogs & derivatives | Phosphorylation - drug effects | Polyethylene Glycols - pharmacology | Models, Theoretical | Tumor Microenvironment - drug effects | Interleukin-2 - pharmacokinetics | Interleukin-2 Receptor beta Subunit - agonists | Mice, Inbred C57BL | Polyethylene Glycols - pharmacokinetics | Receptors, Interleukin-2 - metabolism | Mice, Inbred C3H | Tumor Microenvironment - immunology | T-Lymphocytes, Regulatory - drug effects | Algorithms | Animals | Interleukin-2 Receptor alpha Subunit - agonists | Interleukin-2 Receptor alpha Subunit - metabolism | Prodrugs - pharmacokinetics | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Drug Liberation | Interleukin-2 - pharmacology | Mice, Inbred BALB C | Kinetics | CD8-Positive T-Lymphocytes - immunology | Prodrugs - pharmacology | Receptors, Interleukin-2 - agonists | Physiological aspects | Care and treatment | Interleukin-2 | Immunotherapy | Patient outcomes | Cancer | Polyethylenes | Conjugates | CD8 antigen | Interleukin | Lymphocytes T | Anticancer properties | Proteins | Biological effects | Cell activation | Immunology | Interleukin 2 | Lymphocytes | Polyethylene glycol | Modelling | Drug dosages | Immune system | Interleukin 2 receptors | Pharmacodynamics | Cytokines | Immunoregulation | Melanoma | Radioactive half-life | Pharmacology | Affinity | Ligands | Mutation | Pharmacokinetics | In vitro methods and tests | Tumors | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2016, Volume 113, Issue 35, pp. 9852 - 9857
Small-molecule inhibitors of the Janus kinase family (JAKis) are clinically efficacious in multiple autoimmune diseases, albeit with increased risk of certain... 
Tofacitinib | Jak inhibitor | Systems pharmacology | INTERLEUKIN-2 | ACTIVATION | MULTIDISCIPLINARY SCIENCES | DECERNOTINIB | JAK inhibitor | systems pharmacology | DISCOVERY | tofacitinib | Dosage and administration | Observations | Phosphotransferases | Health aspects | Drug interactions | Homeostasis | Chromatin | Inhibitor drugs | Immunology | Autoimmune diseases | Genomics | Index Medicus | Biological Sciences
Journal Article
European Journal of Immunology, ISSN 0014-2980, 06/2007, Volume 37, Issue 6, pp. 1600 - 1612
Zymosan is a particulate yeast preparation that elicits high levels of IL-2 and IL-10 from dendritic cells (DC) and engages multiple innate receptors,... 
Zymosan | Dendritic cells | Syk | C-type lectins | Pattern recognition receptors | C-FOS | PROTEIN-KINASE | TOLL-LIKE RECEPTOR | LIPOPOLYSACCHARIDE ACTIVATION | INNATE IMMUNE-SYSTEM | IMMUNOLOGY | pattern recognition receptors | BETA-GLUCAN RECEPTOR | SIGNAL-TRANSDUCTION | TUMOR-NECROSIS-FACTOR | dendritic cells | zymosan | MESSENGER-RNA DECAY | Cysteine - analogs & derivatives | Interleukin-12 Subunit p40 - genetics | Gene Expression - drug effects | Nitriles - pharmacology | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Zymosan - pharmacology | Protein-Tyrosine Kinases - physiology | Signal Transduction - immunology | Protein-Tyrosine Kinases - genetics | Cysteine - pharmacology | Interleukin-10 - metabolism | Dendritic Cells - drug effects | Flavonoids - pharmacology | Phosphorylation - drug effects | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Dendritic Cells - metabolism | Interleukin-2 - metabolism | Cell Line | Butadienes - pharmacology | Membrane Proteins - genetics | Lectins, C-Type | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Myeloid Differentiation Factor 88 - genetics | Glucans - pharmacology | Nerve Tissue Proteins - genetics | Mice, Knockout | Interleukin-2 - genetics | Animals | Signal Transduction - drug effects | Lipoproteins - pharmacology | Interleukin-10 - genetics | Mice | Enzyme Activation | Intracellular Signaling Peptides and Proteins - physiology | Oligopeptides - pharmacology | Peptidoglycan - pharmacology | Lipopeptides | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2016, Volume 22, Issue 3, pp. 680 - 690
Purpose: Aldesleukin, recombinant human IL2, is an effective immunotherapy for metastatic melanoma and renal cancer, with durable responses in approximately... 
METASTATIC MELANOMA | CTLA-4 BLOCKADE | ONCOLOGY | ALPHA-RECEPTOR | IMMUNOTHERAPY | REGULATORY T-CELLS | RECOMBINANT INTERLEUKIN-2 | HIGH-DOSE INTERLEUKIN-2 | ANTITUMOR-ACTIVITY | PHASE-I | CANCER | Neoplasms - metabolism | T-Lymphocytes, Regulatory - metabolism | Recombinant Fusion Proteins - pharmacology | Humans | Molecular Conformation | Male | Polyethylene Glycols - chemistry | Receptors, Interleukin-2 - chemistry | T-Lymphocytes, Regulatory - immunology | Lymphocytes, Tumor-Infiltrating | Melanoma, Experimental | CD8-Positive T-Lymphocytes - metabolism | Female | Interleukin-2 - chemistry | Antineoplastic Agents - pharmacology | Interleukin-2 - analogs & derivatives | Disease Models, Animal | Polyethylene Glycols - pharmacology | Prodrugs | Models, Molecular | Receptors, Interleukin-2 - metabolism | Recombinant Fusion Proteins - chemistry | Recombinant Proteins - pharmacology | Antineoplastic Agents - chemistry | Neoplasms - drug therapy | Drug Synergism | T-Lymphocytes, Regulatory - drug effects | Animals | Tumor Burden - drug effects | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Interleukin-2 - pharmacology | Protein Binding | Immunologic Memory | Mice | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Neoplasms - pathology | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2016, Volume 197, Issue 10, pp. 3782 - 3791
The mechanisms contributing to persistent eosinophil activation and poor eosinopenic response to glucocorticoids in severe asthma are poorly defined. We... 
CELLS | SEVERE ASTHMA | A RECEPTOR | INHIBITION | INDUCED APOPTOSIS | GM-CSF | KINASE | MECHANISMS | IMMUNOLOGY | INTERLEUKIN-5 | EXPRESSION | Receptors, Glucocorticoid - deficiency | Phosphorylation | Eosinophils - drug effects | Apoptosis - drug effects | Humans | Phosphoprotein Phosphatases - metabolism | Lipoxins - pharmacology | Receptors, Glucocorticoid - metabolism | Eosinophils - immunology | Interleukin-3 - pharmacology | Interleukin-4 - pharmacology | Dexamethasone - pharmacology | Hypersensitivity - metabolism | Asthma - immunology | Nuclear Proteins - genetics | Cytokines - immunology | Interleukin-5 - pharmacology | Signal Transduction | RNA, Small Interfering - pharmacology | Metabolism, Inborn Errors - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Nuclear Proteins - metabolism | Receptors, Glucocorticoid - immunology | Phosphoprotein Phosphatases - antagonists & inhibitors | Eosinophils - physiology | Tumor Necrosis Factor-alpha - pharmacology | Metabolism, Inborn Errors - immunology | Phosphoprotein Phosphatases - genetics | Asthma - complications | Nuclear Proteins - antagonists & inhibitors | Proteomics | Interleukin-2 - pharmacology | Index Medicus | Abridged Index Medicus | Protein Phosphatase 5 | Glucocorticoid Receptor | Cytokines | Steroid Resistance and Asthma | Eosinophils
Journal Article
Blood, ISSN 0006-4971, 01/2007, Volume 109, Issue 1, pp. 228 - 234
The molecular mechanisms by which mesenchymal stem cells (MSCs) suppress T-cell proliferation are poorly understood, and whether a soluble factor plays a major... 
SYNTHASE | RESPONSES | ENGRAFTMENT | ACTIVATION | PATHWAY | IMMUNOSUPPRESSION | GROWTH | HEMATOLOGY | MARROW STROMAL CELLS | INHIBIT | TRANSPLANTATION | CD8-Positive T-Lymphocytes - cytology | Dinoprostone - physiology | Humans | B-Lymphocyte Subsets - cytology | T-Lymphocyte Subsets - drug effects | CD8-Positive T-Lymphocytes - metabolism | Phosphorylation - drug effects | Macrophages - physiology | B-Lymphocyte Subsets - drug effects | Nitric Oxide - biosynthesis | Signal Transduction | CD4-Positive T-Lymphocytes - metabolism | Cell Division - drug effects | Receptors, Antigen, T-Cell - physiology | Mice, Knockout | B-Lymphocyte Subsets - metabolism | Mice | Tryptophan - pharmacology | HeLa Cells | Interleukin-2 - biosynthesis | Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology | Nitric Oxide Synthase Type II - metabolism | Tetradecanoylphorbol Acetate - pharmacology | T-Lymphocyte Subsets - cytology | Concanavalin A - pharmacology | Nitric Oxide - pharmacology | STAT5 Transcription Factor - metabolism | Protein Processing, Post-Translational - drug effects | Nitric Oxide Synthase Type II - antagonists & inhibitors | Tryptophan - analogs & derivatives | Enzyme Induction - drug effects | Transforming Growth Factor beta - antagonists & inhibitors | Mesenchymal Stromal Cells - physiology | NG-Nitroarginine Methyl Ester - pharmacology | Transforming Growth Factor beta - immunology | Cell Line | Antigens, CD19 - analysis | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Nitric Oxide Synthase Type II - deficiency | Nitric Oxide - physiology | Cyclooxygenase Inhibitors - pharmacology | Animals | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Ionomycin - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Interferon-gamma - biosynthesis | Prostaglandin-Endoperoxide Synthases - physiology | Index Medicus | Abridged Index Medicus
Journal Article
International Immunology, ISSN 0953-8178, 4/2007, Volume 19, Issue 4, pp. 345 - 354
Forkhead box P3 (FOXP3) is currently thought to be the most specific marker for naturally occurring CD4+CD25+ T regulatory cells (nTregs). In mice, expression... 
INTERLEUKIN-2 | TGF-BETA | T cell activation | transcription factors | INDUCTION | IMMUNOLOGY | T cells | REGULATORY-CELLS | TRANSCRIPTION FACTOR FOXP3 | COSTIMULATION | GENERATION | FLOW-CYTOMETRY | DIFFERENTIATION | human | EXPRESSION | tolerance | T-Lymphocyte Subsets - immunology | Cysteine - analogs & derivatives | T-Lymphocytes, Regulatory - metabolism | Cell Proliferation | Coculture Techniques | Humans | Clonal Anergy | Receptors, Nerve Growth Factor - metabolism | Interferon-gamma - metabolism | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Flagellin - pharmacology | Lymphocyte Activation - immunology | Forkhead Transcription Factors - metabolism | T-Lymphocyte Subsets - drug effects | Cysteine - pharmacology | Antigens, Differentiation - metabolism | Interleukin-2 - metabolism | Receptors, Tumor Necrosis Factor - metabolism | Cell Line | Cytokines - metabolism | Lectins, C-Type | Toll-Like Receptors - immunology | CD4-Positive T-Lymphocytes - metabolism | Glucocorticoid-Induced TNFR-Related Protein | Antigens, Differentiation, T-Lymphocyte - metabolism | CD28 Antigens - immunology | Antibodies - pharmacology | CTLA-4 Antigen | T-Lymphocytes, Regulatory - drug effects | Interleukin-2 Receptor alpha Subunit - metabolism | Lipoproteins - pharmacology | T-Lymphocyte Subsets - metabolism | Interleukin-7 Receptor alpha Subunit - metabolism | CD3 Complex - immunology | Interleukin-2 - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/1997, Volume 185, Issue 1, pp. 171 - 175
Several inflammatory cytokines, most notably tumor necrosis factor (TNF) and IL-1, induce anorexia and loss of lean body mass, common manifestations of acute... 
MEDICINE, RESEARCH & EXPERIMENTAL | CANCER CACHEXIA | NUDE-MICE | FOOD-INTAKE | CACHECTIN | K NI IMMUNOLOGY | IMMUNOLOGY | INTERLEUKIN-6 | LEUKEMIA-INHIBITORY FACTOR | FACTOR-ALPHA | BODY-WEIGHT | TUMOR-NECROSIS-FACTOR | K QA MEDICINE, RESEARCH & EXPERIMENTAL | OBESE GENE | Index Medicus
Journal Article
Journal Article
International Immunology, ISSN 0953-8178, 12/2004, Volume 16, Issue 12, pp. 1769 - 1780
Naturally occurring CD4(+)CD25(+) regulatory T (T-R) cells play crucial roles in normal immunohomeostasis. CD4(+)CD25(+) T-R cells exhibit a number of... 
CD4 | Regulation | CD25 | Anergy | LPS | SUPPRESSOR | IMMUNITY | RECEPTOR | ALPHA | INDUCTION | IMMUNOLOGY | GENE-EXPRESSION ANALYSIS | anergy | IL-2 PRODUCTION | regulation | CD25+CD4+T-R | IMMUNOREGULATORY T-CELLS | IN-VIVO | IMMUNOLOGICAL SELF-TOLERANCE | Interleukin-15 - physiology | T-Lymphocyte Subsets - immunology | Dendritic Cells - immunology | Bone Marrow Cells - physiology | DNA-Binding Proteins - analysis | Lipopolysaccharides - immunology | Clonal Anergy - physiology | T-Lymphocytes, Regulatory - immunology | DNA-Binding Proteins - metabolism | B7-2 Antigen | Lymphocyte Activation - immunology | Membrane Glycoproteins - physiology | T-Lymphocyte Subsets - drug effects | Interleukin-6 - physiology | Bone Marrow Cells - drug effects | Dendritic Cells - drug effects | Polysaccharides, Bacterial - pharmacology | CD4 Antigens - immunology | Membrane Glycoproteins - pharmacology | Homeostasis - immunology | Polysaccharides, Bacterial - immunology | DNA-Binding Proteins - genetics | Receptors, Interleukin-2 - immunology | Mice, Knockout | Salmonella enteritidis - immunology | Interleukin-15 - pharmacology | Interleukin-2 - genetics | T-Lymphocytes, Regulatory - drug effects | Animals | Interleukin-6 - pharmacology | Lipopolysaccharides - pharmacology | Clonal Anergy - immunology | Interleukin-2 - pharmacology | Antigens, CD - pharmacology | Antigens, CD - physiology | Mice | Interleukin-2 - biosynthesis | Forkhead Transcription Factors | Lymphocyte Activation - physiology | Receptors, Interleukin-2 - analysis | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2012, Volume 188, Issue 8, pp. 3745 - 3756
Journal Article
Circulation, ISSN 0009-7322, 09/2012, Volume 126, Issue 10, pp. 1256 - 1266
Background-CD4+CD25+Foxp3+ regulatory T cells (Tregs) attenuate atherosclerosis, but their therapeutic application by adoptive transfer is limited by the need... 
atherosclerosis | inflammation | cytokines | CARDIAC & CARDIOVASCULAR SYSTEMS | DENDRITIC CELLS | SUBSETS | E KNOCKOUT MICE | LESIONS | AGGRAVATES ATHEROSCLEROSIS | SMOOTH-MUSCLE | INTERFERON-GAMMA | MEDIATED SUPPRESSION | PERIPHERAL VASCULAR DISEASE | IN-VIVO EXPANSION | HEMATOLOGY | E-DEFICIENT MICE | T-Lymphocytes, Regulatory - metabolism | Dose-Response Relationship, Immunologic | Antigen-Antibody Complex - pharmacology | Male | T-Lymphocytes, Regulatory - immunology | Antibodies, Neutralizing - immunology | Interleukin-2 - immunology | Cell Division - immunology | Dietary Fats - pharmacology | Forkhead Transcription Factors - metabolism | Mice, Mutant Strains | Antibodies, Monoclonal - immunology | Disease Models, Animal | Biomarkers - metabolism | Atherosclerosis - drug therapy | Atherosclerosis - immunology | Antibodies, Monoclonal - pharmacology | Antibodies, Neutralizing - pharmacology | Cell Division - drug effects | Disease Progression | T-Lymphocytes, Regulatory - drug effects | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Apolipoproteins E - genetics | Interleukin-2 - pharmacology | Mice | Antigen-Antibody Complex - immunology | CD4 Antigens - metabolism | Development and progression | Interleukin-2 | Research | T cells | Analysis | Atherosclerosis | Index Medicus | Abridged Index Medicus
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