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PloS one, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, pp. e0179431 - e0179431
Cytokines are potent immune modulating agents but are not ideal medicines in their natural form due to their short half-life and pleiotropic systemic effects.... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neoplasms - metabolism | T-Lymphocytes, Regulatory - metabolism | Immunotherapy - methods | Interleukin-2 Receptor beta Subunit - metabolism | Interleukin Receptor Common gamma Subunit - metabolism | Transplantation, Homologous | T-Lymphocytes, Regulatory - immunology | STAT5 Transcription Factor - metabolism | Neoplasms - therapy | Interleukin Receptor Common gamma Subunit - agonists | CD8-Positive T-Lymphocytes - metabolism | Female | Interleukin-2 - analogs & derivatives | Phosphorylation - drug effects | Polyethylene Glycols - pharmacology | Models, Theoretical | Tumor Microenvironment - drug effects | Interleukin-2 - pharmacokinetics | Interleukin-2 Receptor beta Subunit - agonists | Mice, Inbred C57BL | Polyethylene Glycols - pharmacokinetics | Receptors, Interleukin-2 - metabolism | Mice, Inbred C3H | Tumor Microenvironment - immunology | T-Lymphocytes, Regulatory - drug effects | Algorithms | Animals | Interleukin-2 Receptor alpha Subunit - agonists | Interleukin-2 Receptor alpha Subunit - metabolism | Prodrugs - pharmacokinetics | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Drug Liberation | Interleukin-2 - pharmacology | Mice, Inbred BALB C | Kinetics | CD8-Positive T-Lymphocytes - immunology | Prodrugs - pharmacology | Receptors, Interleukin-2 - agonists | Physiological aspects | Care and treatment | Interleukin-2 | Immunotherapy | Patient outcomes | Cancer | Polyethylenes | Conjugates | CD8 antigen | Interleukin | Lymphocytes T | Anticancer properties | Proteins | Biological effects | Cell activation | Immunology | Interleukin 2 | Lymphocytes | Polyethylene glycol | Modelling | Drug dosages | Immune system | Interleukin 2 receptors | Pharmacodynamics | Cytokines | Immunoregulation | Melanoma | Pharmacology | Affinity | Ligands | Mutation | Pharmacokinetics | In vitro methods and tests | Tumors | Index Medicus
Journal Article
Transplantation Proceedings, ISSN 0041-1345, 2012, Volume 44, Issue 9, pp. 2834 - 2839
Abstract Background Inevitable hepatitis C virus recurrence after liver transplantation, a major barrier to survival of the transplanted liver may be promoted... 
Surgery | Biomarkers - metabolism | Cyclosporine - pharmacology | Humans | Cells, Cultured | Adrenal Cortex Hormones - pharmacology | Lymphocyte Culture Test, Mixed | T-Lymphocytes, Regulatory - immunology | Dose-Response Relationship, Drug | Calcineurin Inhibitors | T-Lymphocytes, Regulatory - drug effects | Dexamethasone - pharmacology | Mycophenolic Acid - analogs & derivatives | Interleukin-2 Receptor alpha Subunit - metabolism | Lymphocyte Activation - drug effects | Mycophenolic Acid - pharmacology | Cell Proliferation - drug effects | Drug Therapy, Combination | Immunosuppressive Agents - pharmacology | Calcineurin - metabolism | Immune Tolerance - drug effects | Corticosteroids | Immunotherapy | Transplantation of organs, tissues, etc | Cyclosporine | Mycophenolate mofetil | Hepatitis C virus | Hepatitis C | T cells | Index Medicus | Lymphocyte Activation/drug effects | T-Lymphocytes, Regulatory/drug effects | Calcineurin/metabolism | T-Lymphocytes, Regulatory/immunology | Biomarkers/metabolism | Life Sciences | Dexamethasone/pharmacology | Mycophenolic Acid/pharmacology | Immune Tolerance/drug effects | Mycophenolic Acid/analogs & derivatives | Adrenal Cortex Hormones/pharmacology | Cyclosporine/pharmacology | Immunosuppressive Agents/pharmacology | Cell Proliferation/drug effects | Interleukin-2 Receptor alpha Subunit/metabolism
Journal Article
Blood, ISSN 1528-0020, 09/2006, Volume 109, Issue 1, pp. 228 - 234
The molecular mechanisms by which mesenchymal stem cells (MSCs) suppress T-cell proliferation are poorly understood, and whether a soluble factor plays a major... 
Life Sciences & Biomedicine | Hematology | Science & Technology | CD8-Positive T-Lymphocytes - cytology | Dinoprostone - physiology | Humans | B-Lymphocyte Subsets - cytology | T-Lymphocyte Subsets - drug effects | CD8-Positive T-Lymphocytes - metabolism | Phosphorylation - drug effects | Macrophages - physiology | B-Lymphocyte Subsets - drug effects | Nitric Oxide - biosynthesis | Signal Transduction | CD4-Positive T-Lymphocytes - metabolism | Cell Division - drug effects | Receptors, Antigen, T-Cell - physiology | Mice, Knockout | B-Lymphocyte Subsets - metabolism | Mice | Tryptophan - pharmacology | HeLa Cells | Interleukin-2 - biosynthesis | Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology | Nitric Oxide Synthase Type II - metabolism | Tetradecanoylphorbol Acetate - pharmacology | T-Lymphocyte Subsets - cytology | Concanavalin A - pharmacology | Nitric Oxide - pharmacology | STAT5 Transcription Factor - metabolism | Protein Processing, Post-Translational - drug effects | Nitric Oxide Synthase Type II - antagonists & inhibitors | Tryptophan - analogs & derivatives | Enzyme Induction - drug effects | Transforming Growth Factor beta - antagonists & inhibitors | Mesenchymal Stromal Cells - physiology | NG-Nitroarginine Methyl Ester - pharmacology | Transforming Growth Factor beta - immunology | Cell Line | Antigens, CD19 - analysis | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Nitric Oxide Synthase Type II - deficiency | Nitric Oxide - physiology | Cyclooxygenase Inhibitors - pharmacology | Animals | Lymphocyte Activation - drug effects | CD8-Positive T-Lymphocytes - drug effects | Ionomycin - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Interferon-gamma - biosynthesis | Prostaglandin-Endoperoxide Synthases - physiology | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Treatment Reviews, ISSN 0305-7372, 2014, Volume 40, Issue 9, pp. 1080 - 1088
Highlights • PTCL has a poor prognosis; existing therapies are insufficient. • We summarize current evidence on novel therapies for relapsed/refractory PTCL. •... 
Hematology, Oncology and Palliative Medicine | Antifolate | Nucleoside analog | Histone deacetylase inhibitor | Fusion protein | Peripheral T-cell lymphoma | Immunomodulatory agent | Life Sciences & Biomedicine | Oncology | Science & Technology | Doxorubicin - therapeutic use | Humans | Recombinant Fusion Proteins - therapeutic use | Interleukin-2 - therapeutic use | Neoplasm Recurrence, Local - drug therapy | Antineoplastic Agents - therapeutic use | Cyclophosphamide - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Folic Acid Antagonists - therapeutic use | Stem Cell Transplantation | Topoisomerase Inhibitors - pharmacology | Thalidomide - analogs & derivatives | Diphtheria Toxin - therapeutic use | Topoisomerase Inhibitors - therapeutic use | Immunoconjugates - therapeutic use | Antineoplastic Agents - pharmacology | Depsipeptides - therapeutic use | Prednisolone - therapeutic use | Lymphoma, T-Cell, Peripheral - drug therapy | Antibodies, Monoclonal, Humanized - therapeutic use | Alemtuzumab | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Lymphoma, T-Cell, Peripheral - pathology | Vincristine - therapeutic use | Histone Deacetylase Inhibitors - therapeutic use | Lymphoma, T-Cell, Peripheral - therapy | Thalidomide - therapeutic use | Folic Acid Antagonists - pharmacology | Care and treatment | Lymphomas | T cells | Health aspects | Index Medicus
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 04/2012, Volume 188, Issue 8, pp. 3745 - 3756
Journal Article
International immunology, ISSN 1460-2377, 02/2007, Volume 19, Issue 4, pp. 345 - 354
Forkhead box P3 (FOXP3) is currently thought to be the most specific marker for naturally occurring CD4+CD25+ T regulatory cells (nTregs). In mice, expression... 
Life Sciences & Biomedicine | Immunology | Science & Technology | T-Lymphocyte Subsets - immunology | Cysteine - analogs & derivatives | T-Lymphocytes, Regulatory - metabolism | Cell Proliferation | Coculture Techniques | Humans | Clonal Anergy | Receptors, Nerve Growth Factor - metabolism | Interferon-gamma - metabolism | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Flagellin - pharmacology | Lymphocyte Activation - immunology | Forkhead Transcription Factors - metabolism | T-Lymphocyte Subsets - drug effects | Cysteine - pharmacology | Antigens, Differentiation - metabolism | Interleukin-2 - metabolism | Receptors, Tumor Necrosis Factor - metabolism | Cell Line | Cytokines - metabolism | Lectins, C-Type | Toll-Like Receptors - immunology | CD4-Positive T-Lymphocytes - metabolism | Glucocorticoid-Induced TNFR-Related Protein | Antigens, Differentiation, T-Lymphocyte - metabolism | CD28 Antigens - immunology | Antibodies - pharmacology | CTLA-4 Antigen | T-Lymphocytes, Regulatory - drug effects | Interleukin-2 Receptor alpha Subunit - metabolism | Lipoproteins - pharmacology | T-Lymphocyte Subsets - metabolism | Interleukin-7 Receptor alpha Subunit - metabolism | CD3 Complex - immunology | Interleukin-2 - pharmacology | CD4-Positive T-Lymphocytes - drug effects | Index Medicus
Journal Article
International immunology, ISSN 0953-8178, 12/2004, Volume 16, Issue 12, pp. 1769 - 1780
Naturally occurring CD4(+)CD25(+) regulatory T (T-R) cells play crucial roles in normal immunohomeostasis. CD4(+)CD25(+) T-R cells exhibit a number of... 
CD4 | Regulation | CD25 | Anergy | LPS | Life Sciences & Biomedicine | Immunology | Science & Technology | Interleukin-15 - physiology | T-Lymphocyte Subsets - immunology | Dendritic Cells - immunology | Bone Marrow Cells - physiology | DNA-Binding Proteins - analysis | Lipopolysaccharides - immunology | Clonal Anergy - physiology | T-Lymphocytes, Regulatory - immunology | DNA-Binding Proteins - metabolism | B7-2 Antigen | Lymphocyte Activation - immunology | Membrane Glycoproteins - physiology | T-Lymphocyte Subsets - drug effects | Interleukin-6 - physiology | Bone Marrow Cells - drug effects | Dendritic Cells - drug effects | Polysaccharides, Bacterial - pharmacology | CD4 Antigens - immunology | Membrane Glycoproteins - pharmacology | Homeostasis - immunology | Polysaccharides, Bacterial - immunology | DNA-Binding Proteins - genetics | Receptors, Interleukin-2 - immunology | Mice, Knockout | Salmonella enteritidis - immunology | Interleukin-15 - pharmacology | Interleukin-2 - genetics | T-Lymphocytes, Regulatory - drug effects | Animals | Interleukin-6 - pharmacology | Lipopolysaccharides - pharmacology | Clonal Anergy - immunology | Interleukin-2 - pharmacology | Antigens, CD - pharmacology | Antigens, CD - physiology | Mice | Interleukin-2 - biosynthesis | Forkhead Transcription Factors | Lymphocyte Activation - physiology | Receptors, Interleukin-2 - analysis | Index Medicus
Journal Article
Drugs (New York, N.Y.), ISSN 0012-6667, 11/2015, Volume 75, Issue 17, pp. 1993 - 2016
Journal Article