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PloS one, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0179431
Cytokines are potent immune modulating agents but are not ideal medicines in their natural form due to their short half-life and pleiotropic systemic effects.... 
LIGAND-BINDING | ALPHA-RECEPTOR | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | COMPLEXES | REGULATORY T-CELLS | MODULATION THERAPIES | IL-2 | CYTOKINE | HIGH-DOSE INTERLEUKIN-2 | RENAL-CELL CARCINOMA | Neoplasms - metabolism | T-Lymphocytes, Regulatory - metabolism | Immunotherapy - methods | Interleukin-2 Receptor beta Subunit - metabolism | Interleukin Receptor Common gamma Subunit - metabolism | Transplantation, Homologous | T-Lymphocytes, Regulatory - immunology | STAT5 Transcription Factor - metabolism | Neoplasms - therapy | Interleukin Receptor Common gamma Subunit - agonists | CD8-Positive T-Lymphocytes - metabolism | Female | Interleukin-2 - analogs & derivatives | Phosphorylation - drug effects | Polyethylene Glycols - pharmacology | Models, Theoretical | Tumor Microenvironment - drug effects | Interleukin-2 - pharmacokinetics | Interleukin-2 Receptor beta Subunit - agonists | Mice, Inbred C57BL | Polyethylene Glycols - pharmacokinetics | Receptors, Interleukin-2 - metabolism | Mice, Inbred C3H | Tumor Microenvironment - immunology | T-Lymphocytes, Regulatory - drug effects | Algorithms | Animals | Interleukin-2 Receptor alpha Subunit - agonists | Interleukin-2 Receptor alpha Subunit - metabolism | Prodrugs - pharmacokinetics | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Drug Liberation | Interleukin-2 - pharmacology | Mice, Inbred BALB C | Kinetics | CD8-Positive T-Lymphocytes - immunology | Prodrugs - pharmacology | Receptors, Interleukin-2 - agonists | Physiological aspects | Care and treatment | Interleukin-2 | Immunotherapy | Patient outcomes | Cancer | Polyethylenes | Conjugates | CD8 antigen | Interleukin | Lymphocytes T | Anticancer properties | Proteins | Biological effects | Cell activation | Immunology | Interleukin 2 | Lymphocytes | Polyethylene glycol | Modelling | Drug dosages | Immune system | Interleukin 2 receptors | Pharmacodynamics | Cytokines | Immunoregulation | Melanoma | Pharmacology | Affinity | Ligands | Mutation | Pharmacokinetics | In vitro methods and tests | Tumors
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 484, Issue 7395, pp. 529 - 533
.... However, adverse effects have limited its use in the clinic. On activated T cells, IL-2 signals through a quaternary 'high affinity' receptor complex consisting of IL-2, IL-2R alpha (termed CD25... 
CHAIN | ALPHA-RECEPTOR | KINETICS | MULTIDISCIPLINARY SCIENCES | SELECTIVE STIMULATION | COMPLEXES | DYNAMICS | MOLECULAR-CLONING | PROTEINS | EXPRESSION | Surface Plasmon Resonance | Neoplasm Transplantation | Phosphorylation | Cell Proliferation | Humans | Interleukin-2 Receptor beta Subunit - metabolism | Crystallography, X-Ray | Mutant Proteins - pharmacology | STAT5 Transcription Factor - metabolism | Interleukin-2 - immunology | Immunotherapy | Protein Engineering | Killer Cells, Natural - immunology | Interleukin-2 - chemistry | Mutant Proteins - immunology | Binding Sites | Interleukin-2 Receptor alpha Subunit - immunology | Cell Line | Interleukin-2 Receptor alpha Subunit - deficiency | Mice, Inbred C57BL | Mutant Proteins - genetics | Models, Molecular | Directed Molecular Evolution | Molecular Dynamics Simulation | Neoplasms - drug therapy | Interleukin-2 - genetics | Animals | Interleukin-2 Receptor alpha Subunit - chemistry | Interleukin-2 Receptor alpha Subunit - metabolism | Interleukin-2 Receptor beta Subunit - chemistry | T-Lymphocytes - cytology | Neoplasms - immunology | Mutant Proteins - chemistry | Interleukin-2 - pharmacology | Protein Conformation | T-Lymphocytes - immunology | Mice | Mutation | Physiological aspects | Interleukin-2 | Tissue engineering | Methods | Yeast | Engineers | Cytokines | CHEM | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2010, Volume 107, Issue 5, pp. 2171 - 2176
Journal Article
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2013, Volume 38, Issue 1, pp. 13 - 25
... and Castro, 2010 ). This four [alpha]-helix bundle type 1 cytokine (Bazan, 1990 ) was the first type 1 cytokine cloned (Taniguchi et al., 1983 ) and the first type 1... 
BETA-CHAIN | SEVERE COMBINED IMMUNODEFICIENCY | CYTOKINE RECEPTOR | IN-VIVO | REGULATORY T-CELLS | GENE-EXPRESSION | RECEPTOR-ALPHA-CHAIN | MONOCLONAL-ANTIBODY | IMMUNOLOGY | IL-2 RECEPTOR | GAMMA-CHAIN | T-Lymphocyte Subsets - immunology | Humans | X-Linked Combined Immunodeficiency Diseases - genetics | Interleukin Receptor Common gamma Subunit - metabolism | X-Linked Combined Immunodeficiency Diseases - immunology | Interleukin Receptor Common gamma Subunit - immunology | Leukemia-Lymphoma, Adult T-Cell - immunology | T-Lymphocytes, Regulatory - immunology | Receptors, Interleukin-2 - genetics | Interleukin-2 - physiology | T-Lymphocytes, Helper-Inducer - immunology | Immunotherapy | T-Lymphocytes, Helper-Inducer - cytology | CD8-Positive T-Lymphocytes - metabolism | Leukemia-Lymphoma, Adult T-Cell - therapy | Interleukin-2 - metabolism | Leukemia-Lymphoma, Adult T-Cell - genetics | Immune Tolerance | Receptors, Interleukin-2 - metabolism | X-Linked Combined Immunodeficiency Diseases - therapy | Interleukin Receptor Common gamma Subunit - genetics | Cell Differentiation - immunology | Animals | T-Lymphocyte Subsets - metabolism | Interleukin-15 - metabolism | Immunologic Memory | CD8-Positive T-Lymphocytes - immunology | Interleukins | T cells | Cell growth | T cell receptors | Cytokines | Kinases | Immune system
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 4, p. e36316
Journal Article
The Journal of experimental medicine, ISSN 0022-1007, 2012, Volume 209, Issue 13, pp. 2441 - 2453
.... However, PI3K-Akt-independent mechanisms control glucose metabolism in CD8(+) T cells, and the role of mTORC1 has not been... 
MAMMALIAN TARGET | RAPAMYCIN | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | EFFECTOR FUNCTIONS | L-SELECTIN | ACTIVATION | KINASE | RECEPTOR | DIFFERENTIATION | IMMUNOLOGY | LYMPHOCYTES | CD8-Positive T-Lymphocytes - cytology | TOR Serine-Threonine Kinases - metabolism | Multiprotein Complexes | Phosphatidylinositol 3-Kinases - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Hypoxia-Inducible Factor 1 - metabolism | Cell Movement - physiology | Hypoxia-Inducible Factor 1 - genetics | Mechanistic Target of Rapamycin Complex 1 | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mice, Mutant Strains | CD8-Positive T-Lymphocytes - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Cell Differentiation - physiology | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Receptors, Antigen, T-Cell - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Receptors, Chemokine - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Phosphatidylinositol 3-Kinases - genetics | Animals | Proteins - metabolism | Glucose - metabolism | Glycolysis | Interleukin-2 - pharmacology | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Chemokines - metabolism | Mice | CD8-Positive T-Lymphocytes - immunology
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2011, Volume 108, Issue 32, pp. 13224 - 13229
Journal Article
STEM CELLS, ISSN 1066-5099, 01/2008, Volume 26, Issue 1, pp. 212 - 222
Adult bone marrow‐derived mesenchymal stem cells (MSCs) are multipotent cells that are the subject of intense investigation in regenerative medicine. In... 
Immunosuppression | Regulatory T cells | Human leukocyte antigen‐G | Mesenchymal stem cells | Interleukin‐10 | Interleukin-10 | Human leukocyte antigen-G | T-Lymphocyte Subsets - immunology | T-Lymphocytes, Regulatory - metabolism | Humans | Adult Stem Cells - immunology | Lymphocyte Culture Test, Mixed | Mesenchymal Stromal Cells - immunology | T-Lymphocytes, Regulatory - immunology | Histocompatibility Antigens Class I - metabolism | Mesenchymal Stromal Cells - cytology | Flow Cytometry | Forkhead Transcription Factors - metabolism | Bone Marrow Cells - immunology | Killer Cells, Natural - immunology | T-Lymphocytes, Cytotoxic - immunology | Interferon-gamma | Adult Stem Cells - cytology | Enzyme-Linked Immunosorbent Assay | Bone Marrow Cells - cytology | Cell Communication | Mesenchymal Stromal Cells - metabolism | HLA-G Antigens | HLA Antigens - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Microscopy, Confocal | Adult Stem Cells - metabolism | Interleukin-2 Receptor alpha Subunit - metabolism | T-Lymphocytes, Cytotoxic - metabolism | T-Lymphocyte Subsets - metabolism | Killer Cells, Natural - metabolism | Bone Marrow Cells - metabolism | CD4 Antigens - metabolism | T-Lymphocyte Subsets | Adult Stem Cells | Interleukin-2 Receptor alpha Subunit | Killer Cells, Natural | Antigens, CD4 | Histocompatibility Antigens Class I | T-Lymphocytes, Cytotoxic | Mesenchymal Stem Cells | Life Sciences | Bone Marrow Cells | Immunology | T-Lymphocytes, Regulatory | HLA Antigens | Forkhead Transcription Factors
Journal Article