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antibodies, monoclonal - pharmacology (70) 70
lymphocytes (69) 69
pathogenesis (69) 69
psoriasis - immunology (69) 69
signal transduction (69) 69
antibodies, monoclonal - therapeutic use (68) 68
interleukin-12 - metabolism (68) 68
article (67) 67
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activation (64) 64
biochemistry & molecular biology (64) 64
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flow cytometry (63) 63
interleukin-17 - biosynthesis (63) 63
th17 (63) 63
interleukin-12 - immunology (62) 62
lipopolysaccharides - pharmacology (62) 62
analysis (61) 61
cells (61) 61
gene expression (61) 61
signal transduction - drug effects (61) 61
abridged index medicus (60) 60
interleukin-23 - biosynthesis (60) 60
autoimmune inflammation (59) 59
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interleukin-23 subunit p19 (46) 46
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NATURE IMMUNOLOGY, ISSN 1529-2908, 06/2011, Volume 12, Issue 6, pp. 568 - U241
Interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells) require exposure to IL-23 to become encephalitogenic, but the mechanism by which IL-23 promotes... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | TGF-BETA | COLONY-STIMULATING FACTOR | ROR-GAMMA-T | INFLAMMATORY RESPONSES | HELPER-CELLS | REGULATORY T-CELLS | IMMUNOLOGY | IL-23 RECEPTOR | TH17 CELLS | CUTTING EDGE | Interleukin-1beta - pharmacology | Peptide Fragments | Encephalomyelitis, Autoimmune, Experimental - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Coculture Techniques | Encephalomyelitis, Autoimmune, Experimental - immunology | Th1 Cells - immunology | CD11c Antigen - immunology | CD11c Antigen - metabolism | CD4-Positive T-Lymphocytes - immunology | Th1 Cells - metabolism | Th17 Cells - drug effects | Flow Cytometry | Interleukin-23 - metabolism | Encephalomyelitis, Autoimmune, Experimental - chemically induced | Th17 Cells - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Antibodies - immunology | Female | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | Th1 Cells - drug effects | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Myelin-Oligodendrocyte Glycoprotein | Mice, Transgenic | Glycoproteins | Interleukin-23 - immunology | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Interleukin-1 - pharmacology | Mice, Knockout | Antibodies - pharmacology | Transforming Growth Factor beta - pharmacology | Animals | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Interleukin-23 - pharmacology | Th17 Cells - immunology | Mice | CD4-Positive T-Lymphocytes - drug effects
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 11/2013, Volume 86, Issue 9, pp. 1320 - 1327
IL-23 is produced by antigen presenting cells and plays critical roles in immune response in rheumatoid arthritis. In this study, we investigated whether the... 
Cilostazol | RA synovial macrophages | IL-23 | RhoA | TLR2 | RHEUMATOID-ARTHRITIS | ACTIVATION | AUTOIMMUNE INFLAMMATION | ADHESION MOLECULES | KAPPA-B | FIBROBLASTS | ENDOTHELIAL-CELLS | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | RHO-GTPASES | EXPRESSION | Tetrazoles - pharmacology | Nitriles - pharmacology | Humans | Synovial Fluid - metabolism | Lipopolysaccharides - metabolism | Male | NF-kappa B - metabolism | Reference Values | rhoA GTP-Binding Protein - metabolism | Sulfones - pharmacology | Synovial Fluid - drug effects | Case-Control Studies | Arthritis, Rheumatoid - metabolism | Botulinum Toxins - pharmacology | Cyclic AMP - analogs & derivatives | rho-Associated Kinases - metabolism | Arthritis, Rheumatoid - drug therapy | Teichoic Acids - pharmacology | Teichoic Acids - metabolism | Mice, Inbred DBA | Synovial Fluid - cytology | Amides - pharmacology | Knee Joint - metabolism | NF-kappa B - antagonists & inhibitors | Knee Joint - drug effects | Thionucleotides - pharmacology | Toll-Like Receptor 2 - metabolism | Arthritis, Rheumatoid - pathology | Cyclic AMP - pharmacology | Macrophages - metabolism | Animals | Signal Transduction - drug effects | ADP Ribose Transferases - pharmacology | Lipopolysaccharides - pharmacology | Interleukin-23 - biosynthesis | Macrophages - drug effects | Mice | Pyridines - pharmacology | Physiological aspects | Macrophages
Journal Article
Journal Article
Molecular Immunology, ISSN 0161-5890, 05/2014, Volume 59, Issue 1, pp. 10 - 18
Sphingosine-1-phosphate (S1P) modulates many cell functions such as lymphocyte trafficking and signaling as well as keratinocyte proliferation. However, less... 
IL-27 | Dendritic cells | IL-12 | IL-23 | MAPK | Sphingosine-1-phosphate | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISTINCT | IMMUNOLOGY | LYMPHOCYTE EGRESS | SPHINGOSINE 1-PHOSPHATE RECEPTORS | RESPONSES | INHIBITION | DISEASE | TH17 | T-CELLS | PSORIASIS | Receptors, Lysosphingolipid - antagonists & inhibitors | Gene Expression - drug effects | Immunoblotting | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Oxadiazoles - pharmacology | Lysophospholipids - pharmacology | Receptors, Lysosphingolipid - genetics | Bone Marrow Cells - drug effects | Dendritic Cells - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Dendritic Cells - metabolism | Interleukin-12 - biosynthesis | Pyrazoles - pharmacology | Bone Marrow Cells - cytology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Thiophenes - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Animals | Androstadienes - pharmacology | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Interleukin-23 - biosynthesis | Receptors, Lysosphingolipid - agonists | Dendritic Cells - cytology | Mice | Mice, Inbred BALB C | Pyridines - pharmacology | Interleukin-27 - biosynthesis | Bone Marrow Cells - metabolism | Mitogen-Activated Protein Kinases - metabolism | Phosphates | Interleukins | Sphingosine | Index Medicus
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 06/2011, Volume 12, Issue 6, pp. 560 - U248
Although the role of the T(H)1 and T(H)17 subsets of helper T cells as disease mediators in autoimmune neuroinflammation remains a subject of some debate, none... 
ENCEPHALOMYELITIS | TGF-BETA | T(H)17 CELLS | COLONY-STIMULATING FACTOR | MULTIPLE-SCLEROSIS | DENDRITIC CELLS | IFN-GAMMA | FACTOR-DEFICIENT MICE | IN-VIVO | IMMUNOLOGY | TH17 CELLS | Peptide Fragments | Encephalomyelitis, Autoimmune, Experimental - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Interleukin-17 - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | Male | Th1 Cells - immunology | Th1 Cells - metabolism | Th17 Cells - drug effects | Flow Cytometry | Encephalomyelitis, Autoimmune, Experimental - chemically induced | Th17 Cells - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | Female | Interferon-gamma - genetics | Interleukins - pharmacology | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Interleukin-12 - pharmacology | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | Th1 Cells - drug effects | T-Lymphocytes, Helper-Inducer - metabolism | Mice, Inbred C57BL | Cells, Cultured | Interleukin-17 - genetics | Myelin-Oligodendrocyte Glycoprotein | Mice, Transgenic | Glycoproteins | Mice, Inbred Strains | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Mice, Knockout | Animals | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Interleukin-23 - pharmacology | Interferon-gamma - immunology | Th17 Cells - immunology | Mice | Interferon-gamma - pharmacology
Journal Article
FASEB Journal, ISSN 0892-6638, 08/2004, Volume 18, Issue 11, pp. 1318 - 1320
Journal Article
Immunity, ISSN 1074-7613, 06/2012, Volume 36, Issue 6, pp. 1017 - 1030
Interleukin-27 (IL-27) is a key immunosuppressive cytokine that counters T helper 17 (Th17) cell-mediated pathology. To identify mechanisms by which IL-27... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | INFLAMMATION | GRAVES-DISEASE | IL-27 | RECEPTOR | IMMUNOLOGY | PROINFLAMMATORY CYTOKINE PRODUCTION | C-MAF | EXPRESSION | TH1 DIFFERENTIATION | CUTTING EDGE | T-Lymphocyte Subsets - immunology | Interleukin-1beta - pharmacology | T-Lymphocyte Subsets - cytology | B7-H1 Antigen - deficiency | Minor Histocompatibility Antigens | Encephalomyelitis, Autoimmune, Experimental - etiology | Interleukin-17 - physiology | Encephalomyelitis, Autoimmune, Experimental - immunology | Th17 Cells - transplantation | Bystander Effect | CD4-Positive T-Lymphocytes - immunology | Receptors, Cytokine - deficiency | Th17 Cells - drug effects | Myelin Proteins - toxicity | Th17 Cells - metabolism | Myelin Proteins - immunology | Th17 Cells - cytology | Cell Differentiation | Interferon-gamma - genetics | Interleukins - pharmacology | Forkhead Transcription Factors - deficiency | B7-H1 Antigen - physiology | Encephalomyelitis, Autoimmune, Experimental - pathology | Gene Expression Regulation - immunology | Mice, Inbred C57BL | Interleukin-17 - genetics | Myelin-Oligodendrocyte Glycoprotein | Mice, Transgenic | Interleukin-17 - biosynthesis | B7-H1 Antigen - genetics | Mice, Knockout | Transforming Growth Factor beta - pharmacology | Animals | Interleukin-23 - pharmacology | Interleukin-6 - pharmacology | B7-H1 Antigen - biosynthesis | Encephalomyelitis, Autoimmune, Experimental - prevention & control | Mice | Interferon-gamma - biosynthesis | Interleukins | Analysis | Genes | Skin diseases | Arthritis | Skin | T cells | Design | Pathology | Flow cytometry | Scholarships & fellowships | Phosphorylation | Cytokines | Cysts | Rodents | T cell receptors | Software | Gene expression | Experiments
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2015, Volume 212, Issue 10, pp. 1641 - 1662
Journal Article
The Journal of Immunology, ISSN 0022-1767, 11/2009, Volume 183, Issue 10, pp. 6639 - 6645
We determined whether human NK cells could contribute to immune defenses against Mycobacterium tuberculosis through production of IL-22. CD3(-)CD56(+) NK cells... 
T(H)17 CYTOKINE | NATURAL-KILLER-CELLS | ROR-GAMMA-T | INTERFERON-GAMMA | HUMAN MACROPHAGES | MUCOSAL HOST-DEFENSE | NECROSIS-FACTOR-ALPHA | INTRACELLULAR BACTERIUM | IMMUNOLOGY | HUMAN MONOCYTES | INNATE IMMUNITY | Phagosomes - microbiology | RNA, Messenger - immunology | Humans | Mycobacterium tuberculosis - immunology | Tuberculosis - microbiology | RNA, Messenger - metabolism | Mycobacterium tuberculosis - drug effects | Interleukins - metabolism | Phagosomes - immunology | RNA, Small Interfering - immunology | Receptors, Immunologic - agonists | Interleukins - immunology | Killer Cells, Natural - immunology | Interleukins - pharmacology | Receptors, Immunologic - immunology | Macrophages - immunology | Macrophages - microbiology | Interleukin-12 - pharmacology | Killer Cells, Natural - microbiology | Phagosomes - drug effects | Phagosomes - metabolism | Recombinant Proteins - pharmacology | RNA, Messenger - agonists | Tuberculosis - immunology | Interleukin-15 - pharmacology | Macrophages - metabolism | Interleukin-23 - pharmacology | Macrophages - drug effects | Interleukin-18 - pharmacology | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Mycobacterium tuberculosis - growth & development | RNA, Small Interfering - metabolism
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2009, Volume 106, Issue 12, pp. 4793 - 4798
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2010, Volume 160, Issue 4, pp. 810 - 820
Psoriasis is a chronic inflammatory disease affecting 1-3% of the general population. Among psoriatic patients, 5-40% are affected by psoriatic arthritis. Due... 
briakinumab | certolizumab | ustekinumab | psoriatic arthritis | psoriasis | golimumab | Golimumab | Ustekinumab | Briakinumab | Psoriasis | Certolizumab | Psoriatic arthritis | RANDOMIZED CONTROLLED-TRIAL | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | PHASE-III TRIAL | TUMOR-NECROSIS-FACTOR | PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY | CHRONIC PLAQUE PSORIASIS | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | PLACEBO-CONTROLLED TRIAL | LONG-TERM TREATMENT | CLINICAL-RESPONSE | T-Lymphocytes - physiology | Biological Products - pharmacokinetics | Recombinant Fusion Proteins - pharmacology | Recombinant Fusion Proteins - adverse effects | Arthritis, Psoriatic - physiopathology | Humans | Recombinant Fusion Proteins - therapeutic use | Antibodies, Monoclonal - adverse effects | Psoriasis - etiology | Antibodies, Monoclonal - therapeutic use | Biological Products - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Interleukin-23 - antagonists & inhibitors | T-Lymphocytes - drug effects | Arthritis, Psoriatic - drug therapy | Interleukin-12 - antagonists & inhibitors | Immunoglobulin Fragments - therapeutic use | Product Surveillance, Postmarketing | Biological Products - adverse effects | Biological Products - therapeutic use | Psoriasis - immunology | Psoriasis - drug therapy | Antibodies, Monoclonal - pharmacology | Immunoglobulin Fragments - adverse effects | Antibodies, Monoclonal - pharmacokinetics | Immunoglobulin Fragments - pharmacology | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Arthritis, Psoriatic - immunology | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Psoriasis - physiopathology | Recombinant Fusion Proteins - pharmacokinetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Arthritis, Psoriatic - etiology | Chronic Disease | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Arthritis | Drug therapy | Immune system | Reviews
Journal Article